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Showing 229 to 240 of 240 entries
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Two-Chains Tissue Plasminogen Activator Unifies Met and NMDA Receptor Signalling to Control Neuronal Survival.

International journal of molecular sciences

Hedou E, Douceau S, Chevilley A, Varangot A, Thiebaut AM, Triniac H, Bardou I, Ali C, Maillasson M, Crepaldi T, Comoglio P, Lemarchand E, Agin V, Roussel BD, Vivien D.
PMID: 34948279
Int J Mol Sci. 2021 Dec 15;22(24). doi: 10.3390/ijms222413483.

Tissue-type plasminogen activator (tPA) plays roles in the development and the plasticity of the nervous system. Here, we demonstrate in neurons, that by opposition to the single chain form (sc-tPA), the two-chains form of tPA (tc-tPA) activates the MET...

Changes in diet quality and body weight over 10 years: the Multiethnic Cohort Study.

The British journal of nutrition

Kang M, Boushey CJ, Shvetsov YB, Setiawan VW, Paik HY, Wilkens LR, Le Marchand L, Park SY.
PMID: 33441193
Br J Nutr. 2021 Nov 14;126(9):1389-1397. doi: 10.1017/S000711452100012X. Epub 2021 Jan 14.

High-quality diets have been found to be beneficial in preventing long-term weight gain. However, concurrent changes in diet quality and body weight over time have rarely been reported. We examined the association between 10-year changes in diet quality and...

Risk of Late-Onset Breast Cancer in Genetically Predisposed Women.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Boddicker NJ, Hu C, Weitzel JN, Kraft P, Nathanson KL, Goldgar DE, Na J, Huang H, Gnanaolivu RD, Larson N, Yussuf A, Yao S, Vachon CM, Trentham-Dietz A, Teras L, Taylor JA, Scott CE, Sandler DP, Pesaran T, Patel AV, Palmer JR, Ong IM, Olson JE, O'Brien K, Neuhausen S, Martinez E, Ma H, Lindstrom S, Le Marchand L, Kooperberg C, Karam R, Hunter DJ, Hodge JM, Haiman C, Gaudet MM, Gao C, LaDuca H, Lacey JV, Dolinsky JS, Chao E, Carter BD, Burnside ES, Bertrand KA, Bernstein L, Auer PW, Ambrosone C, Yadav S, Hart SN, Polley EC, Domchek SM, Couch FJ.
PMID: 34292776
J Clin Oncol. 2021 Nov 01;39(31):3430-3440. doi: 10.1200/JCO.21.00531. Epub 2021 Jul 22.

PURPOSE: The prevalence of germline pathogenic variants (PVs) in established breast cancer predisposition genes in women in the general population over age 65 years is not well-defined. However, testing guidelines suggest that women diagnosed with breast cancer over age...

Robust Thrombolytic and Anti-Inflammatory Action of a Constitutively Active ADAMTS13 Variant in Murine Stroke Models.

Blood

South K, Saleh O, Lemarchand E, Coutts G, Smith CJ, Schiessl I, Allan SM.
PMID: 34780600
Blood. 2021 Nov 15; doi: 10.1182/blood.2021012787. Epub 2021 Nov 15.

Advances in our understanding of ADAMTS13 structure, and the conformation changes required for full activity, have rejuvenated the possibility of its use as a thrombolytic therapy. We have tested a novel Ala1144Val ADAMTS13 variant (caADAMTS13) which exhibits constitutive activity,...

Generation of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system.

Stem cell research

Canac R, Caillaud A, Cimarosti B, Girardeau A, Hamamy H, Reversade B, Bonnard C, Al Sayed ZR, David L, Poschmann J, Lemarchand P, Lamirault G, Gaborit N.
PMID: 34929443
Stem Cell Res. 2021 Dec 13;58:102627. doi: 10.1016/j.scr.2021.102627. Epub 2021 Dec 13.

Studies on animal models have shown that Irx5 is an important regulator of cardiac development and that it regulates ventricular electrical repolarization gradient in the adult heart. Mutations in IRX5 have also been linked in humans to cardiac conduction...

Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis.

Scientific reports

Escala-Garcia M, Canisius S, Keeman R, Beesley J, Anton-Culver H, Arndt V, Augustinsson A, Becher H, Beckmann MW, Behrens S, Bermisheva M, Bojesen SE, Bolla MK, Brenner H, Canzian F, Castelao JE, Chang-Claude J, Chanock SJ, Couch FJ, Czene K, Daly MB, Dennis J, Devilee P, Dörk T, Dunning AM, Easton DF, Ekici AB, Eliassen AH, Fasching PA, Flyger H, Gago-Dominguez M, García-Closas M, García-Sáenz JA, Geisler J, Giles GG, Grip M, Gündert M, Hahnen E, Haiman CA, Håkansson N, Hall P, Hamann U, Hartikainen JM, Heemskerk-Gerritsen BAM, Hollestelle A, Hoppe R, Hopper JL, Hunter DJ, Jacot W, Jakubowska A, John EM, Jung AY, Kaaks R, Khusnutdinova E, Koppert LB, Kraft P, Kristensen VN, Kurian AW, Lambrechts D, Le Marchand L, Lindblom A, Luben RN, Lubiński J, Mannermaa A, Manoochehri M, Margolin S, Mavroudis D, Muranen TA, Nevanlinna H, Olshan AF, Olsson H, Park-Simon TW, Patel AV, Peterlongo P, Pharoah PDP, Punie K, Radice P, Rennert G, Rennert HS, Romero A, Roylance R, Rüdiger T, Ruebner M, Saloustros E, Sawyer EJ, Schmutzler RK, Schoemaker MJ, Scott C, Southey MC, Surowy H, Swerdlow AJ, Tamimi RM, Teras LR, Thomas E, Tomlinson I, Troester MA, Vachon CM, Wang Q, Winqvist R, Wolk A, Ziogas A, Michailidou K, Chenevix-Trench G, Bachelot T, Schmidt MK.
PMID: 34611289
Sci Rep. 2021 Oct 05;11(1):19787. doi: 10.1038/s41598-021-99409-3.

Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression and assist treatment. In this analysis, we...

The influence of rivers on marine boron isotopes and implications for reconstructing past ocean pH.

Nature

Lemarchand D, Gaillardet J, Lewin E, Allègre CJ.
PMID: 11140677
Nature. 2000 Dec 21-28;408(6815):951-4. doi: 10.1038/35050058.

Ocean pH is particularly sensitive to atmospheric carbon dioxide content. Records of ocean pH can therefore be used to estimate past atmospheric carbon dioxide concentrations. The isotopic composition of boron (delta11B) contained in the carbonate shells of marine organisms...

Beam-size effects on the measurement of sub-picosecond intrinsic laser induced damage threshold of dielectric oxide coatings.

Applied optics

Stehlík M, Wagner F, Zideluns J, Lemarchand F, Lumeau J, Gallais L.
PMID: 34612960
Appl Opt. 2021 Sep 20;60(27):8569-8578. doi: 10.1364/AO.433935.

Laser-induced damage experiments on

Aggregation-Induced Emission: A Challenge for Computational Chemistry Taking TPA-BMO as an Example*.

Chemphyschem : a European journal of chemical physics and physical chemistry

de Thieulloy L, Le Bras L, Zumer B, Sanz García J, Lemarchand C, Pineau N, Adamo C, Perrier A.
PMID: 34161645
Chemphyschem. 2021 Sep 03;22(17):1802-1816. doi: 10.1002/cphc.202100239. Epub 2021 Jul 12.

A multi-environment computational approach is proposed to study the modulation of the emission behavior of the triphenylamine (Z)-4-benzylidene-2-methyloxazol-5(4H)-one (TPA-BMO) molecule [Tang et al., J. Phys. Chem. C 119, 21875 (2015)]. We aim at (1) proposing a realistic description of...

Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Morra A, Jung AY, Behrens S, Keeman R, Ahearn TU, Anton-Culver H, Arndt V, Augustinsson A, Auvinen PK, Beane Freeman LE, Becher H, Beckmann MW, Blomqvist C, Bojesen SE, Bolla MK, Brenner H, Briceno I, Brucker SY, Camp NJ, Campa D, Canzian F, Castelao JE, Chanock SJ, Choi JY, Clarke CL, Couch FJ, Cox A, Cross SS, Czene K, Dörk T, Dunning AM, Dwek M, Easton DF, Eccles DM, Egan KM, Evans DG, Fasching PA, Flyger H, Gago-Dominguez M, Gapstur SM, García-Sáenz JA, Gaudet MM, Giles GG, Grip M, Guénel P, Haiman CA, Håkansson N, Hall P, Hamann U, Han SN, Hart SN, Hartman M, Heyworth JS, Hoppe R, Hopper JL, Hunter DJ, Ito H, Jager A, Jakimovska M, Jakubowska A, Janni W, Kaaks R, Kang D, Kapoor PM, Kitahara CM, Koutros S, Kraft P, Kristensen VN, Lacey JV, Lambrechts D, Le Marchand L, Li J, Lindblom A, Lubiński J, Lush M, Mannermaa A, Manoochehri M, Margolin S, Mariapun S, Matsuo K, Mavroudis D, Milne RL, Muranen TA, Newman WG, Noh DY, Nordestgaard BG, Obi N, Olshan AF, Olsson H, Park-Simon TW, Petridis C, Pharoah PDP, Plaseska-Karanfilska D, Presneau N, Rashid MU, Rennert G, Rennert HS, Rhenius V, Romero A, Saloustros E, Sawyer EJ, Schneeweiss A, Schwentner L, Scott C, Shah M, Shen CY, Shu XO, Southey MC, Stram DO, Tamimi RM, Tapper W, Tollenaar RAEM, Tomlinson I, Torres D, Troester MA, Truong T, Vachon CM, Wang Q, Wang SS, Williams JA, Winqvist R, Wolk A, Wu AH, Yoo KY, Yu JC, Zheng W, Ziogas A, Yang XR, Eliassen AH, Holmes MD, García-Closas M, Teo SH, Schmidt MK, Chang-Claude J.
PMID: 33500318
Cancer Epidemiol Biomarkers Prev. 2021 Apr;30(4):623-642. doi: 10.1158/1055-9965.EPI-20-0924. Epub 2021 Jan 26.

BACKGROUND: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype.METHODS: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with...

Prediagnostic Neurofilament Light Chain Levels in Amyotrophic Lateral Sclerosis.

Neurology

Bjornevik K, O'Reilly EJ, Molsberry S, Kolonel LN, Le Marchand L, Paganoni S, Schwarzschild MA, Benkert P, Kuhle J, Ascherio A.
PMID: 34380747
Neurology. 2021 Aug 11; doi: 10.1212/WNL.0000000000012632. Epub 2021 Aug 11.

OBJECTIVE: To assess whether plasma neurofilament light chain (NfL) levels are elevated before ALS diagnosis and to evaluate whether pre-diagnostic NfL levels are associated with metabolic alterations.METHODS: We conducted a matched case-control study nested in three large prospective US...

Generation of human induced pluripotent stem cell lines from four unrelated healthy control donors carrying European genetic background.

Stem cell research

Girardeau A, Atticus D, Canac R, Cimarosti B, Caillaud A, Chariau C, Simonet F, Cariou B, Charpentier F, Gourraud JB, Probst V, Belbachir N, Jesel L, Lemarchand P, Barc J, Redon R, Gaborit N, Lamirault G.
PMID: 34999420
Stem Cell Res. 2021 Dec 28;59:102647. doi: 10.1016/j.scr.2021.102647. Epub 2021 Dec 28.

Four human induced pluripotent stem cell (hiPSC) lines have been generated from healthy control European donors, and validated. This resource represents a useful tool for stem cell-based research, as references for developmental studies and disease modeling linked to any...

Showing 229 to 240 of 240 entries