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Showing 25 to 36 of 265 entries
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Humoral immune response to Covid-19 vaccination in diabetes: age-dependent but independent of type of diabetes and glycaemic control - the prospective COVAC-DM cohort study.

Diabetes, obesity & metabolism

Sourij C, Tripolt NJ, Aziz F, Aberer F, Forstner P, Obermayer AM, Kojzar H, Kleinhappl B, Pferschy PN, Mader JK, Cvirn G, Goswami N, Wachsmuth N, Eckstein ML, Müller A, Abbas F, Lenz J, Steinberger M, Knoll L, Krause R, Stradner M, Schlenke P, Sareban N, Prietl B, Kaser S, Moser O, Steinmetz I, Sourij H.
PMID: 34984802
Diabetes Obes Metab. 2022 Jan 04; doi: 10.1111/dom.14643. Epub 2022 Jan 04.

AIMS: Immune response to COVID-19 vaccination and a potential impact of glycaemia on antibody levels in people with diabetes remains unclear. We investigated the seroconversion following first and second COVID-19 vaccination in people with type 1 and type 2...

Ischemic and bleeding risk in atrial fibrillation with and without peripheral artery disease and efficacy and safety of full and half-dose Edoxaban vs. Warfarin: insights from ENGAGE AF-TIMI 48.

European heart journal. Cardiovascular pharmacotherapy

Bonaca MP, Antman EM, Cunningham JW, Wiviott SD, Murphy SA, Halperin JL, Weitz JI, Grosso MA, Lanz HJ, Braunwald E, Giugliano RP, Ruff CT.
PMID: 34962979
Eur Heart J Cardiovasc Pharmacother. 2021 Dec 28; doi: 10.1093/ehjcvp/pvab089. Epub 2021 Dec 28.

AIMS: In patients with atrial fibrillation (AF), peripheral artery disease (PAD) is associated with higher rates of stroke and bleeding. Both higher-dose edoxaban (60/30mg) and lower-dose edoxaban (30/15) were non-inferior to warfarin for stroke/systemic embolism (SEE) and significantly reduced...

Reprogramming CBX8-PRC1 function with a positive allosteric modulator.

Cell chemical biology

Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O.
PMID: 34715055
Cell Chem Biol. 2021 Oct 26; doi: 10.1016/j.chembiol.2021.10.003. Epub 2021 Oct 26.

Canonical targeting of Polycomb repressive complex 1 (PRC1) to repress developmental genes is mediated by cell-type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7, and 8). Based on their central role in silencing and their dysregulation associated with human...

Expenditures among young adults with acute lymphoblastic leukemia by site of care.

Cancer

Wolfson JA, Bhatia S, Ginsberg J, Becker LK, Bernstein D, Henk HJ, Lyman GH, Nathan PC, Puccetti D, Wilkes JJ, Winestone LE, Kenzik KM.
PMID: 33465248
Cancer. 2021 Jun 01;127(11):1901-1911. doi: 10.1002/cncr.33413. Epub 2021 Jan 19.

BACKGROUND: Individuals diagnosed with acute lymphoblastic leukemia (ALL) between the ages of 22 and 39 years experience worse outcomes than those diagnosed when they are 21 years old or younger. Treatment at National Cancer Institute-designated Comprehensive Cancer Centers (CCC)...

Risk of Persistent Opioid Use following Major Surgery in Matched Samples of Patients with and without Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Falcone M, Luo C, Chen Y, Birtwell D, Cheatle M, Duan R, Gabriel PE, He L, Ko EM, Lenz HJ, Mirkovic N, Mowery DL, Ochroch EA, Paulson EC, Schriver E, Schnoll RA, Bekelman JE, Lerman C.
PMID: 32859580
Cancer Epidemiol Biomarkers Prev. 2020 Nov;29(11):2126-2133. doi: 10.1158/1055-9965.EPI-20-0628. Epub 2020 Aug 28.

BACKGROUND: The opioid crisis has reached epidemic proportions, yet risk of persistent opioid use following curative intent surgery for cancer and factors influencing this risk are not well understood.METHODS: We used electronic health record data from 3,901 adult patients...

Potential Molecular Cross Talk Among CCR5 Pathway Predicts Regorafenib Responsiveness in Metastatic Colorectal Cancer Patients.

Cancer genomics & proteomics

Suenaga M, Zhang WU, Mashima T, Schirripa M, Cao S, Okazaki S, Berger MD, Miyamoto Y, Barzi A, Yamaguchi T, Lenz HJ.
PMID: 33893084
Cancer Genomics Proteomics. 2021 May-Jun;18(3):317-324. doi: 10.21873/cgp.20262.

BACKGROUND: Genetic variants in the CCL5/CCR5 pathway have been shown to predict regorafenib efficacy in patients with metastatic colorectal cancer (mCRC). This study investigated the biological role of CCL4 and CCL3 gene polymorphisms in patients with refractory mCRC treated...

The Colon Endoscopic Bubble Scale (CEBuS): a two-phase evaluation study.

Endoscopy

Taveira F, Hassan C, Kaminski MF, Ponchon T, Benamouzig R, Bugajski M, de Castelbajac F, Cesaro P, Chergui H, Goran L, Minelli Grazioli L, Janičko M, Januszewicz W, Lamonaca L, Lenz J, Negreanu L, Repici A, Spada C, Spadaccini M, State M, Szlak J, Veseliny E, Dinis-Ribeiro M, Areia M.
PMID: 33285583
Endoscopy. 2020 Dec 07; doi: 10.1055/a-1331-4325. Epub 2020 Dec 07.

BACKGROUND: To date, no scale has been validated to assess bubbles associated with bowel preparation. This study aimed to develop and assess the reliability of a novel scale - the Colon Endoscopic Bubble Scale (CEBuS).METHODS: This was a multicenter,...

Microsatellite Stable Colorectal Liver Metastases-Understanding the Mechanisms of Immune Resistance.

JAMA network open

Gholami S, Grothey A, Lenz HJ.
PMID: 34369996
JAMA Netw Open. 2021 Aug 02;4(8):e2119025. doi: 10.1001/jamanetworkopen.2021.19025.

No abstract available.

Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance).

Clinical cancer research : an official journal of the American Association for Cancer Research

Innocenti F, Sibley AB, Patil SA, Etheridge AS, Jiang C, Ou FS, Howell SD, Plummer SJ, Casey G, Bertagnolli MM, McLeod HL, Auman JT, Blanke CD, Furukawa Y, Venook AP, Kubo M, Lenz HJ, Parker JS, Ratain MJ, Owzar K.
PMID: 32958699
Clin Cancer Res. 2021 Jan 01;27(1):267-275. doi: 10.1158/1078-0432.CCR-20-2021. Epub 2020 Sep 21.

PURPOSE: Irinotecan/5-fluorouracil (5-FU; FOLFIRI) or oxaliplatin/5-FU (FOLFOX), combined with bevacizumab or cetuximab, are approved, first-line treatments for metastatic colorectal cancer (mCRC). We aimed at identifying germline variants associated with survival in patients with mCRC treated with these regimens in...

The Colon Endoscopic Bubble Scale (CEBuS): a two-phase evaluation study.

Endoscopy

Taveira F, Hassan C, Kaminski MF, Ponchon T, Benamouzig R, Bugajski M, de Castelbajac F, Cesaro P, Chergui H, Goran L, Minelli Grazioli L, Janičko M, Januszewicz W, Lamonaca L, Lenz J, Negreanu L, Repici A, Spada C, Spadaccini M, State M, Szlak J, Veseliny E, Dinis-Ribeiro M, Areia M.
PMID: 33285583
Endoscopy. 2022 Jan;54(1):45-51. doi: 10.1055/a-1331-4325. Epub 2020 Dec 07.

BACKGROUND: To date, no scale has been validated to assess bubbles associated with bowel preparation. This study aimed to develop and assess the reliability of a novel scale - the Colon Endoscopic Bubble Scale (CEBuS).METHODS: This was a multicenter,...

IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405.

JNCI cancer spectrum

Guercio BJ, Zhang S, Ou FS, Venook AP, Niedzwiecki D, Lenz HJ, Innocenti F, Pollak MN, Nixon AB, Mullen BC, O'Neil BH, Shaw JE, Polite BN, Benson AB, Atkins JN, Goldberg RM, Brown JC, O'Reilly EM, Mayer RJ, Blanke CD, Fuchs CS, Meyerhardt JA.
PMID: 33426464
JNCI Cancer Spectr. 2020 Aug 27;5(1):pkaa074. doi: 10.1093/jncics/pkaa074. eCollection 2021 Feb.

BACKGROUND: Energy balance-related biomarkers are associated with risk and prognosis of various malignancies. Their relationship to survival in metastatic colorectal cancer (mCRC) requires further study.METHODS: Baseline plasma insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-3, IGFBP-7, C-peptide, and adiponectin were...

Modeling ischemic stroke in a triculture neurovascular unit on-a-chip.

Fluids and barriers of the CNS

Wevers NR, Nair AL, Fowke TM, Pontier M, Kasi DG, Spijkers XM, Hallard C, Rabussier G, van Vught R, Vulto P, de Vries HE, Lanz HL.
PMID: 34906183
Fluids Barriers CNS. 2021 Dec 14;18(1):59. doi: 10.1186/s12987-021-00294-9.

BACKGROUND: In ischemic stroke, the function of the cerebral vasculature is impaired. This vascular structure is formed by the so-called neurovascular unit (NVU). A better understanding of the mechanisms involved in NVU dysfunction and recovery may lead to new...

Showing 25 to 36 of 265 entries