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Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study.

Multiple sclerosis (Houndmills, Basingstoke, England)

Hartung HP, Derfuss T, Cree BA, Sormani MP, Selmaj K, Stutters J, Prados F, MacManus D, Schneble HM, Lambert E, Porchet H, Glanzman R, Warne D, Curtin F, Kornmann G, Buffet B, Kremer D, Küry P, Leppert D, Rückle T, Barkhof F.
PMID: 34240656
Mult Scler. 2021 Jul 09;13524585211024997. doi: 10.1177/13524585211024997. Epub 2021 Jul 09.

BACKGROUND: The envelope protein of human endogenous retrovirus W (HERV-W-Env) is expressed by macrophages and microglia, mediating axonal damage in chronic active MS lesions.OBJECTIVE AND METHODS: This phase 2, double-blind, 48-week trial in relapsing-remitting MS with 48-week extension phase...

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Hartung HP, Derfuss T, Cree BA, et al. Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study. Mult Scler. 2021;13524585211024997doi: 10.1177/13524585211024997.
Hartung, H. P., Derfuss, T., Cree, B. A., Sormani, M. P., Selmaj, K., Stutters, J., Prados, F., MacManus, D., Schneble, H. M., Lambert, E., Porchet, H., Glanzman, R., Warne, D., Curtin, F., Kornmann, G., Buffet, B., Kremer, D., Küry, P., Leppert, D., Rückle, T., & Barkhof, F. (2021). Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study. Multiple sclerosis (Houndmills, Basingstoke, England), 13524585211024997. https://doi.org/10.1177/13524585211024997
Hartung, Hans-Peter, et al. "Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study." Multiple sclerosis (Houndmills, Basingstoke, England) vol. (2021): 13524585211024997. doi: https://doi.org/10.1177/13524585211024997
Hartung HP, Derfuss T, Cree BA, Sormani MP, Selmaj K, Stutters J, Prados F, MacManus D, Schneble HM, Lambert E, Porchet H, Glanzman R, Warne D, Curtin F, Kornmann G, Buffet B, Kremer D, Küry P, Leppert D, Rückle T, Barkhof F. Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study. Mult Scler. 2021 Jul 09;13524585211024997. doi: 10.1177/13524585211024997. Epub 2021 Jul 09. PMID: 34240656.
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Is genetic liability to ADHD and ASD causally linked to educational attainment?.

International journal of epidemiology

Dardani C, Riglin L, Leppert B, Sanderson E, Rai D, Howe LD, Davey Smith G, Tilling K, Thapar A, Davies NM, Anderson E, Stergiakouli E.
PMID: 34096993
Int J Epidemiol. 2021 Jun 07; doi: 10.1093/ije/dyab107. Epub 2021 Jun 07.

BACKGROUND: The association patterns of Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) with educational attainment (EA) are complex; children with ADHD and ASD are at risk of poor academic outcomes, and parental EA has been associated...

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Dardani C, Riglin L, Leppert B, et al. Is genetic liability to ADHD and ASD causally linked to educational attainment?. Int J Epidemiol. 2021;doi: 10.1093/ije/dyab107.
Dardani, C., Riglin, L., Leppert, B., Sanderson, E., Rai, D., Howe, L. D., Davey Smith, G., Tilling, K., Thapar, A., Davies, N. M., Anderson, E., & Stergiakouli, E. (2021). Is genetic liability to ADHD and ASD causally linked to educational attainment?. International journal of epidemiology, . https://doi.org/10.1093/ije/dyab107
Dardani, Christina, et al. "Is genetic liability to ADHD and ASD causally linked to educational attainment?." International journal of epidemiology vol. (2021). doi: https://doi.org/10.1093/ije/dyab107
Dardani C, Riglin L, Leppert B, Sanderson E, Rai D, Howe LD, Davey Smith G, Tilling K, Thapar A, Davies NM, Anderson E, Stergiakouli E. Is genetic liability to ADHD and ASD causally linked to educational attainment?. Int J Epidemiol. 2021 Jun 07; doi: 10.1093/ije/dyab107. Epub 2021 Jun 07. PMID: 34096993.
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Integrative biochemical, proteomics and metabolomics cerebrospinal fluid biomarkers predict clinical conversion to multiple sclerosis.

Brain communications

Probert F, Yeo T, Zhou Y, Sealey M, Arora S, Palace J, Claridge TDW, Hillenbrand R, Oechtering J, Leppert D, Kuhle J, Anthony DC.
PMID: 33997784
Brain Commun. 2021 Apr 19;3(2):fcab084. doi: 10.1093/braincomms/fcab084. eCollection 2021.

Eighty-five percent of multiple sclerosis cases begin with a discrete attack termed clinically isolated syndrome, but 37% of clinically isolated syndrome patients do not experience a relapse within 20 years of onset. Thus, the identification of biomarkers able to...

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Probert F, Yeo T, Zhou Y, et al. Integrative biochemical, proteomics and metabolomics cerebrospinal fluid biomarkers predict clinical conversion to multiple sclerosis. Brain Commun. 2021;3(2):fcab084doi: 10.1093/braincomms/fcab084.
Probert, F., Yeo, T., Zhou, Y., Sealey, M., Arora, S., Palace, J., Claridge, T. D. W., Hillenbrand, R., Oechtering, J., Leppert, D., Kuhle, J., & Anthony, D. C. (2021). Integrative biochemical, proteomics and metabolomics cerebrospinal fluid biomarkers predict clinical conversion to multiple sclerosis. Brain communications, 3(2), fcab084. https://doi.org/10.1093/braincomms/fcab084
Probert, Fay, et al. "Integrative biochemical, proteomics and metabolomics cerebrospinal fluid biomarkers predict clinical conversion to multiple sclerosis." Brain communications vol. 3,2 (2021): fcab084. doi: https://doi.org/10.1093/braincomms/fcab084
Probert F, Yeo T, Zhou Y, Sealey M, Arora S, Palace J, Claridge TDW, Hillenbrand R, Oechtering J, Leppert D, Kuhle J, Anthony DC. Integrative biochemical, proteomics and metabolomics cerebrospinal fluid biomarkers predict clinical conversion to multiple sclerosis. Brain Commun. 2021 Apr 19;3(2):fcab084. doi: 10.1093/braincomms/fcab084. eCollection 2021. PMID: 33997784; PMCID: PMC8111065.
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Revealing Local Disorder in a Silver-Bismuth Halide Perovskite upon Compression.

The journal of physical chemistry letters

Girdzis SP, Lin Y, Leppert L, Slavney AH, Park S, Chapman KW, Karunadasa HI, Mao WL.
PMID: 33377386
J Phys Chem Lett. 2021 Jan 14;12(1):532-536. doi: 10.1021/acs.jpclett.0c03412. Epub 2020 Dec 30.

The halide double perovskite Cs

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Girdzis SP, Lin Y, Leppert L, et al. Revealing Local Disorder in a Silver-Bismuth Halide Perovskite upon Compression. J Phys Chem Lett. 2020;12(1):532-536doi: 10.1021/acs.jpclett.0c03412.
Girdzis, S. P., Lin, Y., Leppert, L., Slavney, A. H., Park, S., Chapman, K. W., Karunadasa, H. I., & Mao, W. L. (2021). Revealing Local Disorder in a Silver-Bismuth Halide Perovskite upon Compression. The journal of physical chemistry letters, 12(1), 532-536. https://doi.org/10.1021/acs.jpclett.0c03412
Girdzis, Samuel P, et al. "Revealing Local Disorder in a Silver-Bismuth Halide Perovskite upon Compression." The journal of physical chemistry letters vol. 12,1 (2021): 532-536. doi: https://doi.org/10.1021/acs.jpclett.0c03412
Girdzis SP, Lin Y, Leppert L, Slavney AH, Park S, Chapman KW, Karunadasa HI, Mao WL. Revealing Local Disorder in a Silver-Bismuth Halide Perovskite upon Compression. J Phys Chem Lett. 2021 Jan 14;12(1):532-536. doi: 10.1021/acs.jpclett.0c03412. Epub 2020 Dec 30. PMID: 33377386.
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Aging Aggravates Cachexia in Tumor-Bearing Mice.

Cancers

Geppert J, Walth AA, Terrón Expósito R, Kaltenecker D, Morigny P, Machado J, Becker M, Simoes E, Lima JDCC, Daniel C, Berriel Diaz M, Herzig S, Seelaender M, Rohm M.
PMID: 35008253
Cancers (Basel). 2021 Dec 24;14(1). doi: 10.3390/cancers14010090.

BACKGROUND: Cancer is primarily a disease of high age in humans, yet most mouse studies on cancer cachexia are conducted using young adolescent mice. Given that metabolism and muscle function change with age, we hypothesized that aging may affect...

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Geppert J, Walth AA, Terrón Expósito R, et al. Aging Aggravates Cachexia in Tumor-Bearing Mice. Cancers (Basel). 2021;14(1)doi: 10.3390/cancers14010090.
Geppert, J., Walth, A. A., Terrón Expósito, R., Kaltenecker, D., Morigny, P., Machado, J., Becker, M., Simoes, E., Lima, J. D. C. C., Daniel, C., Berriel Diaz, M., Herzig, S., Seelaender, M., & Rohm, M. (2021). Aging Aggravates Cachexia in Tumor-Bearing Mice. Cancers, 14(1), . https://doi.org/10.3390/cancers14010090
Geppert, Julia, et al. "Aging Aggravates Cachexia in Tumor-Bearing Mice." Cancers vol. 14,1 (2021). doi: https://doi.org/10.3390/cancers14010090
Geppert J, Walth AA, Terrón Expósito R, Kaltenecker D, Morigny P, Machado J, Becker M, Simoes E, Lima JDCC, Daniel C, Berriel Diaz M, Herzig S, Seelaender M, Rohm M. Aging Aggravates Cachexia in Tumor-Bearing Mice. Cancers (Basel). 2021 Dec 24;14(1). doi: 10.3390/cancers14010090. PMID: 35008253; PMCID: PMC8750471.
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Is genetic liability to ADHD and ASD causally linked to educational attainment?.

International journal of epidemiology

Dardani C, Riglin L, Leppert B, Sanderson E, Rai D, Howe LD, Davey Smith G, Tilling K, Thapar A, Davies NM, Anderson E, Stergiakouli E.
PMID: 34096993
Int J Epidemiol. 2021 Jun 07; doi: 10.1093/ije/dyab107. Epub 2021 Jun 07.

BACKGROUND: The association patterns of Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) with educational attainment (EA) are complex; children with ADHD and ASD are at risk of poor academic outcomes, and parental EA has been associated...

Cite
Dardani C, Riglin L, Leppert B, et al. Is genetic liability to ADHD and ASD causally linked to educational attainment?. Int J Epidemiol. 2021;doi: 10.1093/ije/dyab107.
Dardani, C., Riglin, L., Leppert, B., Sanderson, E., Rai, D., Howe, L. D., Davey Smith, G., Tilling, K., Thapar, A., Davies, N. M., Anderson, E., & Stergiakouli, E. (2021). Is genetic liability to ADHD and ASD causally linked to educational attainment?. International journal of epidemiology, . https://doi.org/10.1093/ije/dyab107
Dardani, Christina, et al. "Is genetic liability to ADHD and ASD causally linked to educational attainment?." International journal of epidemiology vol. (2021). doi: https://doi.org/10.1093/ije/dyab107
Dardani C, Riglin L, Leppert B, Sanderson E, Rai D, Howe LD, Davey Smith G, Tilling K, Thapar A, Davies NM, Anderson E, Stergiakouli E. Is genetic liability to ADHD and ASD causally linked to educational attainment?. Int J Epidemiol. 2021 Jun 07; doi: 10.1093/ije/dyab107. Epub 2021 Jun 07. PMID: 34096993.
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Genetic liability to rheumatoid arthritis on autism and autistic traits: polygenic risk score and Mendelian randomization analyses.

Translational psychiatry

Ly A, Leppert B, Rai D, Jones H, Dardani C, Stergiakouli E.
PMID: 35022383
Transl Psychiatry. 2022 Jan 12;12(1):18. doi: 10.1038/s41398-021-01772-2.

Higher prevalence of autism in offspring born to mothers with rheumatoid arthritis has been reported in observational studies. We investigated (a) the associations between maternal and offspring's own genetic liability for rheumatoid arthritis and autism-related outcomes in the offspring...

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Ly A, Leppert B, Rai D, et al. Genetic liability to rheumatoid arthritis on autism and autistic traits: polygenic risk score and Mendelian randomization analyses. Transl Psychiatry. 2022;12(1):18doi: 10.1038/s41398-021-01772-2.
Ly, A., Leppert, B., Rai, D., Jones, H., Dardani, C., & Stergiakouli, E. (2022). Genetic liability to rheumatoid arthritis on autism and autistic traits: polygenic risk score and Mendelian randomization analyses. Translational psychiatry, 12(1), 18. https://doi.org/10.1038/s41398-021-01772-2
Ly, Amanda, et al. "Genetic liability to rheumatoid arthritis on autism and autistic traits: polygenic risk score and Mendelian randomization analyses." Translational psychiatry vol. 12,1 (2022): 18. doi: https://doi.org/10.1038/s41398-021-01772-2
Ly A, Leppert B, Rai D, Jones H, Dardani C, Stergiakouli E. Genetic liability to rheumatoid arthritis on autism and autistic traits: polygenic risk score and Mendelian randomization analyses. Transl Psychiatry. 2022 Jan 12;12(1):18. doi: 10.1038/s41398-021-01772-2. PMID: 35022383.
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Factors influencing serum neurofilament light chain levels in normal aging.

Aging

Koini M, Pirpamer L, Hofer E, Buchmann A, Pinter D, Ropele S, Enzinger C, Benkert P, Leppert D, Kuhle J, Schmidt R, Khalil M.
PMID: 34923481
Aging (Albany NY). 2021 Dec 18;13(24):25729-25738. doi: 10.18632/aging.203790. Epub 2021 Dec 18.

OBJECTIVE: Serum neurofilament light (sNfL) is a promising marker for neuro-axonal damage and it is now well known that its levels also increase with higher age. However, the effect of other determinants besides age is still poorly investigated. We...

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Koini M, Pirpamer L, Hofer E, et al. Factors influencing serum neurofilament light chain levels in normal aging. Aging (Albany NY). 2021;13(24):25729-25738doi: 10.18632/aging.203790.
Koini, M., Pirpamer, L., Hofer, E., Buchmann, A., Pinter, D., Ropele, S., Enzinger, C., Benkert, P., Leppert, D., Kuhle, J., Schmidt, R., & Khalil, M. (2021). Factors influencing serum neurofilament light chain levels in normal aging. Aging, 13(24), 25729-25738. https://doi.org/10.18632/aging.203790
Koini, Marisa, et al. "Factors influencing serum neurofilament light chain levels in normal aging." Aging vol. 13,24 (2021): 25729-25738. doi: https://doi.org/10.18632/aging.203790
Koini M, Pirpamer L, Hofer E, Buchmann A, Pinter D, Ropele S, Enzinger C, Benkert P, Leppert D, Kuhle J, Schmidt R, Khalil M. Factors influencing serum neurofilament light chain levels in normal aging. Aging (Albany NY). 2021 Dec 18;13(24):25729-25738. doi: 10.18632/aging.203790. Epub 2021 Dec 18. PMID: 34923481.
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Airborne Gold Nanoparticle Detection Using Photoluminescence Excited with a Continuous Wave Laser.

Applied spectroscopy

Samuelsson P, Snellman M, Magnusson MH, Deppert K, Aldén M, Li Z.
PMID: 34477464
Appl Spectrosc. 2021 Nov;75(11):1402-1409. doi: 10.1177/00037028211042021. Epub 2021 Sep 03.

We report the observation of photoluminescence emission from airborne gold, silver, and copper nanoparticles. A continuous wave 532 nm laser was employed for excitation. Photoluminescence from gold nanoparticles carried in a nitrogen gas flow was both spectrally resolved and...

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Samuelsson P, Snellman M, Magnusson MH, et al. Airborne Gold Nanoparticle Detection Using Photoluminescence Excited with a Continuous Wave Laser. Appl Spectrosc. 2021;75(11):1402-1409doi: 10.1177/00037028211042021.
Samuelsson, P., Snellman, M., Magnusson, M. H., Deppert, K., Aldén, M., & Li, Z. (2021). Airborne Gold Nanoparticle Detection Using Photoluminescence Excited with a Continuous Wave Laser. Applied spectroscopy, 75(11), 1402-1409. https://doi.org/10.1177/00037028211042021
Samuelsson, Per, et al. "Airborne Gold Nanoparticle Detection Using Photoluminescence Excited with a Continuous Wave Laser." Applied spectroscopy vol. 75,11 (2021): 1402-1409. doi: https://doi.org/10.1177/00037028211042021
Samuelsson P, Snellman M, Magnusson MH, Deppert K, Aldén M, Li Z. Airborne Gold Nanoparticle Detection Using Photoluminescence Excited with a Continuous Wave Laser. Appl Spectrosc. 2021 Nov;75(11):1402-1409. doi: 10.1177/00037028211042021. Epub 2021 Sep 03. PMID: 34477464; PMCID: PMC8573696.
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Acute Effects of Continuous and Intermittent Blood Flow Restriction on Movement Velocity During Bench Press Exercise Against Different Loads.

Frontiers in physiology

Wilk M, Gepfert M, Krzysztofik M, Stastny P, Zajac A, Bogdanis GC.
PMID: 33329020
Front Physiol. 2020 Nov 27;11:569915. doi: 10.3389/fphys.2020.569915. eCollection 2020.

This study evaluated the effects of continuous and intermittent blood flow restriction (BFR) with 70% of full arterial occlusion pressure on bar velocity during the bench press exercise against a wide range of resistive loads. Eleven strength-trained males (age:...

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Wilk M, Gepfert M, Krzysztofik M, et al. Acute Effects of Continuous and Intermittent Blood Flow Restriction on Movement Velocity During Bench Press Exercise Against Different Loads. Front Physiol. 2020;11:569915doi: 10.3389/fphys.2020.569915.
Wilk, M., Gepfert, M., Krzysztofik, M., Stastny, P., Zajac, A., & Bogdanis, G. C. (2020). Acute Effects of Continuous and Intermittent Blood Flow Restriction on Movement Velocity During Bench Press Exercise Against Different Loads. Frontiers in physiology, 11569915. https://doi.org/10.3389/fphys.2020.569915
Wilk, Michal, et al. "Acute Effects of Continuous and Intermittent Blood Flow Restriction on Movement Velocity During Bench Press Exercise Against Different Loads." Frontiers in physiology vol. 11 (2020): 569915. doi: https://doi.org/10.3389/fphys.2020.569915
Wilk M, Gepfert M, Krzysztofik M, Stastny P, Zajac A, Bogdanis GC. Acute Effects of Continuous and Intermittent Blood Flow Restriction on Movement Velocity During Bench Press Exercise Against Different Loads. Front Physiol. 2020 Nov 27;11:569915. doi: 10.3389/fphys.2020.569915. eCollection 2020. PMID: 33329020; PMCID: PMC7728989.
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Showing 265 to 274 of 274 entries