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Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through p.

Journal of medicinal chemistry

Bianchini G, Tomassetti M, Lillini S, Sirico A, Bovolenta S, Za L, Liberati C, Novelli R, Aramini A.
PMID: 34762442
J Med Chem. 2021 Nov 25;64(22):16820-16837. doi: 10.1021/acs.jmedchem.1c01647. Epub 2021 Nov 11.

Transient receptor potential melastatin 8 (TRPM8) is crucially involved in pain modulation and perception, and TRPM8 antagonists have been proposed as potential therapeutic approaches for pain treatment. Previously, we developed two TRPM8 antagonists and proposed them as drug candidates...

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Bianchini G, Tomassetti M, Lillini S, et al. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through p. J Med Chem. 2021;64(22):16820-16837doi: 10.1021/acs.jmedchem.1c01647.
Bianchini, G., Tomassetti, M., Lillini, S., Sirico, A., Bovolenta, S., Za, L., Liberati, C., Novelli, R., & Aramini, A. (2021). Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through p. Journal of medicinal chemistry, 64(22), 16820-16837. https://doi.org/10.1021/acs.jmedchem.1c01647
Bianchini, Gianluca, et al. "Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through p." Journal of medicinal chemistry vol. 64,22 (2021): 16820-16837. doi: https://doi.org/10.1021/acs.jmedchem.1c01647
Bianchini G, Tomassetti M, Lillini S, Sirico A, Bovolenta S, Za L, Liberati C, Novelli R, Aramini A. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through p. J Med Chem. 2021 Nov 25;64(22):16820-16837. doi: 10.1021/acs.jmedchem.1c01647. Epub 2021 Nov 11. PMID: 34762442.
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Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex.

The FEBS journal

Spizzichino S, Boi D, Boumis G, Lucchi R, Liberati FR, Capelli D, Montanari R, Pochetti G, Piacentini R, Parisi G, Paone A, Rinaldo S, Contestabile R, Tramonti A, Paiardini A, Giardina G, Cutruzzolà F.
PMID: 34694685
FEBS J. 2021 Oct 25; doi: 10.1111/febs.16248. Epub 2021 Oct 25.

De novo thymidylate synthesis is a crucial pathway for normal and cancer cells. Deoxythymidine monophosphate (dTMP) is synthesized by the combined action of three enzymes: serine hydroxymethyltransferase (SHMT1), dihydrofolate reductase (DHFR) and thymidylate synthase (TYMS), with the latter two...

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Spizzichino S, Boi D, Boumis G, et al. Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex. FEBS J. 2021;doi: 10.1111/febs.16248.
Spizzichino, S., Boi, D., Boumis, G., Lucchi, R., Liberati, F. R., Capelli, D., Montanari, R., Pochetti, G., Piacentini, R., Parisi, G., Paone, A., Rinaldo, S., Contestabile, R., Tramonti, A., Paiardini, A., Giardina, G., & Cutruzzolà, F. (2021). Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex. The FEBS journal, . https://doi.org/10.1111/febs.16248
Spizzichino, Sharon, et al. "Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex." The FEBS journal vol. (2021). doi: https://doi.org/10.1111/febs.16248
Spizzichino S, Boi D, Boumis G, Lucchi R, Liberati FR, Capelli D, Montanari R, Pochetti G, Piacentini R, Parisi G, Paone A, Rinaldo S, Contestabile R, Tramonti A, Paiardini A, Giardina G, Cutruzzolà F. Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex. FEBS J. 2021 Oct 25; doi: 10.1111/febs.16248. Epub 2021 Oct 25. PMID: 34694685.
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Engineering the Oxidative Potency of Non-Heme Iron(IV) Oxo Complexes in Water for C-H Oxidation by a .

Inorganic chemistry

Wegeberg C, Skavenborg ML, Liberato A, McPherson JN, Browne WR, Hedegård ED, McKenzie CJ.
PMID: 33470794
Inorg Chem. 2021 Feb 01;60(3):1975-1984. doi: 10.1021/acs.inorgchem.0c03441. Epub 2021 Jan 20.

A series of iron(IV) oxo complexes, which differ in the donor (CH

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Wegeberg C, Skavenborg ML, Liberato A, et al. Engineering the Oxidative Potency of Non-Heme Iron(IV) Oxo Complexes in Water for C-H Oxidation by a . Inorg Chem. 2021;60(3):1975-1984doi: 10.1021/acs.inorgchem.0c03441.
Wegeberg, C., Skavenborg, M. L., Liberato, A., McPherson, J. N., Browne, W. R., Hedegård, E. D., & McKenzie, C. J. (2021). Engineering the Oxidative Potency of Non-Heme Iron(IV) Oxo Complexes in Water for C-H Oxidation by a . Inorganic chemistry, 60(3), 1975-1984. https://doi.org/10.1021/acs.inorgchem.0c03441
Wegeberg, Christina, et al. "Engineering the Oxidative Potency of Non-Heme Iron(IV) Oxo Complexes in Water for C-H Oxidation by a ." Inorganic chemistry vol. 60,3 (2021): 1975-1984. doi: https://doi.org/10.1021/acs.inorgchem.0c03441
Wegeberg C, Skavenborg ML, Liberato A, McPherson JN, Browne WR, Hedegård ED, McKenzie CJ. Engineering the Oxidative Potency of Non-Heme Iron(IV) Oxo Complexes in Water for C-H Oxidation by a . Inorg Chem. 2021 Feb 01;60(3):1975-1984. doi: 10.1021/acs.inorgchem.0c03441. Epub 2021 Jan 20. PMID: 33470794.
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Showing 145 to 147 of 147 entries