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Showing 13 to 24 of 50 entries
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Cation and anion transport in a dicationic imidazolium-based plastic crystal ion conductor.

The journal of physical chemistry. B

Kidd BE, Lingwood MD, Lee M, Gibson HW, Madsen LA.
PMID: 24495282
J Phys Chem B. 2014 Feb 27;118(8):2176-85. doi: 10.1021/jp4084629. Epub 2014 Feb 18.

Here we investigate the organic ionic plastic crystal 1,2-bis[N-(N'-hexylimidazolium-d2(4,5))]ethane 2PF6(-) in one of its solid plastic crystal phases by means of multinuclear solid-state (SS) NMR and pulsed-field-gradient NMR diffusometry. We quantify distinct cation and anion diffusion coefficients as well...

The μPIVOT: an integrated particle image velocimeter and optical tweezers instrument for microenvironment investigations.

Measurement science & technology

Nève N, Lingwood JK, Zimmerman J, Kohles SS, Tretheway DC.
PMID: 18953424
Meas Sci Technol. 2008;19(9):95403. doi: 10.1088/0957-0233/19/9/095403.

A novel instrument to manipulate and characterize the mechanical environment in and around microscale objects in a fluidic environment has been developed by integrating two laser-based techniques: micron-resolution particle image velocimetry (μPIV) and optical tweezers (OT). This instrument, the...

Plasma Leak From the Circulation Contributes to Poor Outcomes for Preterm Infants: A Working Hypothesis.

Frontiers in neurology

Eiby YA, Lingwood BE, Wright IMR.
PMID: 34408716
Front Neurol. 2021 Aug 02;12:636740. doi: 10.3389/fneur.2021.636740. eCollection 2021.

Preterm infants are at high risk of death and disability resulting from brain injury. Impaired cardiovascular function leading to poor cerebral oxygenation is a significant contributor to these adverse outcomes, but current therapeutic approaches have failed to improve outcome....

Engineered receptor binding domain immunogens elicit pan-sarbecovirus neutralizing antibodies outside the receptor binding motif.

bioRxiv : the preprint server for biology

Hauser BM, Sangesland M, Lam EC, Denis KJS, Feldman J, Yousif AS, Caradonna TM, Kannegieter T, Balazs AB, Lingwood D, Schmidt AG.
PMID: 33330872
bioRxiv. 2021 Jun 29; doi: 10.1101/2020.12.07.415216.

Effective countermeasures are needed against emerging coronaviruses of pandemic potential, similar to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Designing immunogens that elicit broadly neutralizing antibodies to conserved viral epitopes on the major surface glycoprotein, spike, such as the...

COVID-19 neutralizing antibodies predict disease severity and survival.

medRxiv : the preprint server for health sciences

Garcia-Beltran WF, Lam EC, Astudillo MG, Yang D, Miller TE, Feldman J, Hauser BM, Caradonna TM, Clayton KL, Nitido AD, Murali MR, Alter G, Charles RC, Dighe A, Branda JA, Lennerz JK, Lingwood D, Schmidt AG, Iafrate AJ, Balazs AB.
PMID: 33106822
medRxiv. 2020 Oct 20; doi: 10.1101/2020.10.15.20213512.

COVID-19 exhibits variable symptom severity ranging from asymptomatic to life-threatening, yet the relationship between severity and the humoral immune response is poorly understood. We examined antibody responses in 113 COVID-19 patients and found that severe cases resulting in intubation...

Engineering an Antibody V Gene-Selective Vaccine.

Frontiers in immunology

Ronsard L, Yousif AS, Peabody J, Okonkwo V, Devant P, Mogus AT, Barnes RM, Rohrer D, Lonberg N, Peabody D, Chackerian B, Lingwood D.
PMID: 34566992
Front Immunol. 2021 Sep 09;12:730471. doi: 10.3389/fimmu.2021.730471. eCollection 2021.

The ligand-binding surface of the B cell receptor (BCR) is formed by encoded and non-encoded antigen complementarity determining regions (CDRs). Genetically reproducible or 'public' antibodies can arise when the encoded CDRs play deterministic roles in antigen recognition, notably within...

Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies.

Frontiers in immunology

Sangesland M, Lingwood D.
PMID: 34956170
Front Immunol. 2021 Dec 09;12:708882. doi: 10.3389/fimmu.2021.708882. eCollection 2021.

Humoral immunity is seeded by affinity between the B cell receptor (BCR) and cognate antigen. While the BCR is a chimeric display of diverse antigen engagement solutions, we discuss its functional activity as an 'innate-like' immune receptor, wherein genetically...

Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for 'Universal' Influenza Vaccines.

Vaccines

Sangesland M, Lingwood D, Häkli J.
PMID: 33562627
Vaccines (Basel). 2021 Feb 05;9(2). doi: 10.3390/vaccines9020125.

Influenza virus remains a serious public health burden due to ongoing viral evolution. Vaccination remains the best measure of prophylaxis, yet current seasonal vaccines elicit strain-specific neutralizing responses that favor the hypervariable epitopes on the virus. This necessitates yearly...

Rationally designed immunogens enable immune focusing to the SARS-CoV-2 receptor binding motif.

bioRxiv : the preprint server for biology

Hauser BM, Sangesland M, Denis KJS, Windsor IW, Feldman J, Lam EC, Kannegieter T, Balazs AB, Lingwood D, Schmidt AG.
PMID: 33758851
bioRxiv. 2021 Jul 09; doi: 10.1101/2021.03.15.435440.

Eliciting antibodies to surface-exposed viral glycoproteins can lead to protective responses that ultimately control and prevent future infections. Targeting functionally conserved epitopes may help reduce the likelihood of viral escape and aid in preventing the spread of related viruses...

Fecal SARS-CoV-2 RNA is associated with decreased COVID-19 survival.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Das Adhikari U, Eng G, Farcasanu M, Avena LE, Choudhary MC, Triant VA, Flagg M, Schiff AE, Gomez I, Froehle LM, Diefenbach TJ, Ronsard L, Lingwood D, Lee GC, Rabi SA, Erstad D, Velmahos G, Li JZ, Hodin R, Stone JR, Honko AN, Griffiths A, Yilmaz O, Kwon DS.
PMID: 34245255
Clin Infect Dis. 2021 Jul 10; doi: 10.1093/cid/ciab623. Epub 2021 Jul 10.

The clinical significance of SARS CoV-2 RNA in stool remains uncertain. We found that extrapulmonary dissemination of infection to the gastrointestinal (GI) tract, assessed by the presence of SARS-CoV-2 RNA in stool, is associated with decreased COVID-19 survival. Measurement...

Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses.

bioRxiv : the preprint server for biology

Feldman J, Bals J, Altomare CG, St Denis K, Lam EC, Hauser BM, Ronsard L, Sangesland M, Moreno TB, Okonkwo V, Hartojo N, Balazs AB, Bajic G, Lingwood D, Schmidt AG.
PMID: 33594359
bioRxiv. 2021 Jul 09; doi: 10.1101/2021.02.02.429458.

Exposure to a pathogen elicits an adaptive immune response aimed to control and eradicate. Interrogating the abundance and specificity of the naive B cell repertoire contributes to understanding how to potentially elicit protective responses. Here, we isolated naive B...

Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies.

Frontiers in immunology

Sangesland M, Lingwood D.
PMID: 34956170
Front Immunol. 2021 Dec 09;12:708882. doi: 10.3389/fimmu.2021.708882. eCollection 2021.

Humoral immunity is seeded by affinity between the B cell receptor (BCR) and cognate antigen. While the BCR is a chimeric display of diverse antigen engagement solutions, we discuss its functional activity as an 'innate-like' immune receptor, wherein genetically...

Showing 13 to 24 of 50 entries