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Showing 9985 to 9996 of 55544 entries
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Surface Wettability of Nanoparticle Modulated Sonothrombolysis.

Advanced materials (Deerfield Beach, Fla.)

Wu Q, Zhang F, Pan X, Huang Z, Zeng Z, Wang H, Jiao J, Xiong X, Bai L, Zhou D, Liu H.
PMID: 33987928
Adv Mater. 2021 Jun;33(25):e2007073. doi: 10.1002/adma.202007073. Epub 2021 May 13.

Sonodynamic therapy (SDT) is a non-invasive and highly penetrating treatment strategy under ultrasound irradiation. However, uncertainty in the mechanism of SDT has seriously hindered its future clinical application. Here, the mechanism of SDT enhanced by the wettability of nanoparticles...

Artificial intelligence-based detection of epimacular membrane from color fundus photographs.

Scientific reports

Shao E, Liu C, Wang L, Song D, Guo L, Yao X, Xiong J, Wang B, Hu Y.
PMID: 34588493
Sci Rep. 2021 Sep 29;11(1):19291. doi: 10.1038/s41598-021-98510-x.

Epiretinal membrane (ERM) is a common ophthalmological disorder of high prevalence. Its symptoms include metamorphopsia, blurred vision, and decreased visual acuity. Early diagnosis and timely treatment of ERM is crucial to preventing vision loss. Although optical coherence tomography (OCT)...

Occurrence and fate of linear alkylbenzenes and their potential as environmental molecular markers in highly urbanized river systems.

The Science of the total environment

Huang Y, Liu L, Liu G, Gong Y.
PMID: 33341608
Sci Total Environ. 2021 Mar 15;760:143946. doi: 10.1016/j.scitotenv.2020.143946. Epub 2020 Dec 04.

Rapid industrialization, urbanization, and population growth have led to the common occurrence of black-stinking urban rivers. Assessing regional anthropogenic influences is beneficial to develop effective remediation strategies. This study comprehensively investigated the occurrence and fate of linear alkylbenzenes (LABs)...

hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma.

Annals of translational medicine

Gao Y, Liu C, Zhao X, Liu C, Bi W, Jia J.
PMID: 34532379
Ann Transl Med. 2021 Aug;9(15):1242. doi: 10.21037/atm-21-3076.

BACKGROUND: Osteosarcoma (OS) is considered to be the most highly prevalent bone tumor. In the progression of different human cancers, the role of circular RNAs (circRNAs) has been extensively studied. Microarray analysis has indicated that hsa_circ_0000006 expression was lower...

Network pharmacology to unveil the mechanism of Moluodan in the treatment of chronic atrophic gastritis.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhou W, Zhang H, Wang X, Kang J, Guo W, Zhou L, Liu H, Wang M, Jia R, Du X, Wang W, Zhang B, Li S.
PMID: 34883416
Phytomedicine. 2021 Nov 12;95:153837. doi: 10.1016/j.phymed.2021.153837. Epub 2021 Nov 12.

BACKGROUND: Moluodan (MLD) is a traditional Chinese patent medicine for the treatment of chronic atrophic gastritis (CAG). However, the mechanism of action (MoA) of MLD for treating CAG still remain unclear.PURPOSE: Elucidate the MoA of MLD for treating CAG...

Enantioselective Interactions of Anti-Infective 8-Aminoquinoline Therapeutics with Human Monoamine Oxidases A and B.

Pharmaceuticals (Basel, Switzerland)

Chaurasiya ND, Liu H, Doerksen RJ, Nanayakkara NPD, Walker LA, Tekwani BL.
PMID: 33922294
Pharmaceuticals (Basel). 2021 Apr 22;14(5). doi: 10.3390/ph14050398.

8-Aminoquinolines (8-AQs) are an important class of anti-infective therapeutics. The monoamine oxidases (MAOs) play a key role in metabolism of 8-AQs. A major role for MAO-A in metabolism of primaquine (PQ), the prototypical 8-AQ antimalarial, has been demonstrated. These...

Tmprss6-ASO as a tool for the treatment of Polycythemia Vera mice.

PloS one

Casu C, Liu A, De Rosa G, Low A, Suzuki A, Sinha S, Ginzburg YZ, Abrams C, Aghajan M, Guo S, Rivella S.
PMID: 34890402
PLoS One. 2021 Dec 10;16(12):e0251995. doi: 10.1371/journal.pone.0251995. eCollection 2021.

Polycythemia Vera (PV) is a chronic myeloproliferative neoplasm resulting from an acquired driver mutation in the JAK2 gene of hematopoietic stem and progenitor cells resulting in the overproduction of mature erythrocytes and abnormally high hematocrit, in turn leading to...

Virus-induced gene silencing (VIGS) analysis shows involvement of the LsSTPK gene in lettuce (.

Plant signaling & behavior

Wang L, Wu Y, Du W, Yan Z, Qi Z, Tang W, Han Y, Liu C, Fan S, Hao J.
PMID: 33955335
Plant Signal Behav. 2021 Jul 03;16(7):1913845. doi: 10.1080/15592324.2021.1913845. Epub 2021 May 06.

To determine the effect of the serine/threonine protein kinase (STPK) gene on leaf lettuce bolting, we utilized virus-induced gene silencing (VIGS) using the TRV vector to silence the target gene. The 'GB30' leaf lettuce cultivar was the test material,...

Methionine supplementation during a hydrogen peroxide challenge alters components of insulin signaling and antioxidant proteins in subcutaneous adipose explants from dairy cows.

Journal of dairy science

Ma N, Liang Y, Coleman DN, Li Y, Ding H, Liu F, Cardoso FF, Parys C, Cardoso FC, Shen X, Loor JJ.
PMID: 34635354
J Dairy Sci. 2022 Jan;105(1):856-865. doi: 10.3168/jds.2021-20541. Epub 2021 Oct 09.

Enhanced postruminal supply of methionine (Met) during the peripartal period alters protein abundance of insulin, AA, and antioxidant signaling pathways in subcutaneous adipose tissue (SAT). Whether SAT is directly responsive to supply of Met and can induce molecular alterations...

Molecular Characterization of All-Stage and Adult-Plant Resistance Loci Against Powdery Mildew in Winter Wheat Cultivar Liangxing 99 Using BSR-Seq Technology.

Plant disease

Shi X, Wu P, Hu J, Qiu D, Qu Y, Li Y, Liu Y, Gebremariam TG, Xie J, Wu Q, Zhang H, Liu H, Yang L, Sun G, Zhou Y, Liu Z, Li H.
PMID: 34010023
Plant Dis. 2021 Nov 16;PDIS03210664RE. doi: 10.1094/PDIS-03-21-0664-RE. Epub 2021 Nov 16.

Winter wheat cultivar Liangxing 99, which carries gene

Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-.

Acta pharmaceutica Sinica. B

Zhao Z, Li F, Ning J, Peng R, Shang J, Liu H, Shang M, Bao XQ, Zhang D.
PMID: 34589401
Acta Pharm Sin B. 2021 Sep;11(9):2859-2879. doi: 10.1016/j.apsb.2021.03.020. Epub 2021 Mar 13.

Parkinson's disease (PD) is the second most common neurodegenerative disease, but none of the current treatments for PD can halt the progress of the disease due to the limited understanding of the pathogenesis. In PD development, the communication between...

LncRNA RP11-465B22.8 triggers esophageal cancer progression by targeting miR-765/KLK4 axis.

Cell death discovery

Hu R, Bi R, Jiang L, Xiao H, Xie X, Liu H, Hu F.
PMID: 34561425
Cell Death Discov. 2021 Sep 24;7(1):262. doi: 10.1038/s41420-021-00631-9.

LncRNAs play an important role in tumorigenesis and progression; however, the function and mechanisms of lncRNAs in esophageal cancer (EC) remain largely unclear. In this study, we screened the differentially expressed lncRNAs in EC by using RNA-seq and one...

Showing 9985 to 9996 of 55544 entries