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Fluoroquinolone antibiotics disturb the defense system, gut microbiome, and antibiotic resistance genes of Enchytraeus crypticus.

Journal of hazardous materials

Jin MK, Zhang Q, Zhao WL, Li ZH, Qian HF, Yang XR, Zhu YG, Liu HJ.
PMID: 34736185
J Hazard Mater. 2022 Feb 15;424:127509. doi: 10.1016/j.jhazmat.2021.127509. Epub 2021 Oct 21.

Antibiotic residues from animal manure cause soil pollution and can pose a threat to soil animals. In this study, the toxicological effects of fluoroquinolone antibiotics on Enchytraeus crypticus, including defence response, gut microbiome, and antibiotic resistance genes (ARGs), were...

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Jin MK, Zhang Q, Zhao WL, et al. Fluoroquinolone antibiotics disturb the defense system, gut microbiome, and antibiotic resistance genes of Enchytraeus crypticus. J Hazard Mater. 2021;424:127509doi: 10.1016/j.jhazmat.2021.127509.
Jin, M. K., Zhang, Q., Zhao, W. L., Li, Z. H., Qian, H. F., Yang, X. R., Zhu, Y. G., & Liu, H. J. (2022). Fluoroquinolone antibiotics disturb the defense system, gut microbiome, and antibiotic resistance genes of Enchytraeus crypticus. Journal of hazardous materials, 424127509. https://doi.org/10.1016/j.jhazmat.2021.127509
Jin, Ming-Kang, et al. "Fluoroquinolone antibiotics disturb the defense system, gut microbiome, and antibiotic resistance genes of Enchytraeus crypticus." Journal of hazardous materials vol. 424 (2022): 127509. doi: https://doi.org/10.1016/j.jhazmat.2021.127509
Jin MK, Zhang Q, Zhao WL, Li ZH, Qian HF, Yang XR, Zhu YG, Liu HJ. Fluoroquinolone antibiotics disturb the defense system, gut microbiome, and antibiotic resistance genes of Enchytraeus crypticus. J Hazard Mater. 2022 Feb 15;424:127509. doi: 10.1016/j.jhazmat.2021.127509. Epub 2021 Oct 21. PMID: 34736185.
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A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors.

Acta pharmaceutica Sinica. B

Song Y, Zhao M, Wu Y, Yu B, Liu HM.
PMID: 33777680
Acta Pharm Sin B. 2021 Mar;11(3):750-762. doi: 10.1016/j.apsb.2020.10.021. Epub 2020 Oct 31.

The protein tyrosine phosphatase Src homology phosphotyrosyl phosphatase 2 (SHP2) is implicated in various cancers, and targeting SHP2 has become a promising therapeutic approach. We herein described a robust cross-validation high-throughput screening protocol that combined the fluorescence-based enzyme assay...

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Song Y, Zhao M, Wu Y, et al. A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors. Acta Pharm Sin B. 2020;11(3):750-762doi: 10.1016/j.apsb.2020.10.021.
Song, Y., Zhao, M., Wu, Y., Yu, B., & Liu, H. M. (2021). A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors. Acta pharmaceutica Sinica. B, 11(3), 750-762. https://doi.org/10.1016/j.apsb.2020.10.021
Song, Yihui, et al. "A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors." Acta pharmaceutica Sinica. B vol. 11,3 (2021): 750-762. doi: https://doi.org/10.1016/j.apsb.2020.10.021
Song Y, Zhao M, Wu Y, Yu B, Liu HM. A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors. Acta Pharm Sin B. 2021 Mar;11(3):750-762. doi: 10.1016/j.apsb.2020.10.021. Epub 2020 Oct 31. PMID: 33777680; PMCID: PMC7982506.
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Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes.

ACS omega

Yuan Q, Liu HW, Cai ZJ, Ji SJ.
PMID: 33817511
ACS Omega. 2021 Mar 17;6(12):8495-8501. doi: 10.1021/acsomega.1c00160. eCollection 2021 Mar 30.

An atom- and step-economical strategy for the synthesis of bisphosphinoylaminomethanes is reported. This metal-free bisphosphinylation reaction proceeded smoothly through a base-mediated direct 1,1-bisphosphonation of phosphine oxides and isocyanides under mild conditions. The present method offers a facile, efficient, and...

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Yuan Q, Liu HW, Cai ZJ, et al. Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes. ACS Omega. 2021;6(12):8495-8501doi: 10.1021/acsomega.1c00160.
Yuan, Q., Liu, H. W., Cai, Z. J., & Ji, S. J. (2021). Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes. ACS omega, 6(12), 8495-8501. https://doi.org/10.1021/acsomega.1c00160
Yuan, Qing, et al. "Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes." ACS omega vol. 6,12 (2021): 8495-8501. doi: https://doi.org/10.1021/acsomega.1c00160
Yuan Q, Liu HW, Cai ZJ, Ji SJ. Direct 1,1-Bisphosphonation of Isocyanides: Atom- and Step-Economical Access to Bisphosphinoylaminomethanes. ACS Omega. 2021 Mar 17;6(12):8495-8501. doi: 10.1021/acsomega.1c00160. eCollection 2021 Mar 30. PMID: 33817511; PMCID: PMC8015124.
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Showing 5353 to 5355 of 5355 entries