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Showing 7333 to 7342 of 7342 entries
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Panax Notoginseng Saponins Protect H9c2 Cells From Hypoxia-reoxygenation Injury Through the Forkhead Box O3a Hypoxia-inducible Factor-1 Alpha Cell Signaling Pathway.

Journal of cardiovascular pharmacology

Liu XW, Lu MK, Zhong HT, Liu JJ, Fu YP.
PMID: 34354001
J Cardiovasc Pharmacol. 2021 Aug 05;78(5):e681-e689. doi: 10.1097/FJC.0000000000001120.

ABSTRACT: Panax notoginseng saponins (PNS) are commonly used in the treatment of cardiovascular diseases. Whether PNS can protect myocardial ischemia-reperfusion injury by regulating the forkhead box O3a hypoxia-inducible factor-1 alpha (FOXO3a/HIF-1α) cell signaling pathway remains unclear. The purpose of...

A SGLT2 Inhibitor Dapagliflozin Alleviates Diabetic Cardiomyopathy by Suppressing High Glucose-Induced Oxidative Stress .

Frontiers in pharmacology

Xing YJ, Liu BH, Wan SJ, Cheng Y, Zhou SM, Sun Y, Yao XM, Hua Q, Meng XJ, Cheng JH, Zhong M, Zhang Y, Lv K, Kong X.
PMID: 34322029
Front Pharmacol. 2021 Jul 12;12:708177. doi: 10.3389/fphar.2021.708177. eCollection 2021.

Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus (DM). One of the hallmarks of the DCM is enhanced oxidative stress in myocardium. The aim of this study was to research the underlying mechanisms involved in the effects...

A simple and sensitive preconcentration strategy by coupling salting-out assisted liquid-liquid extraction with online three-step stacking for the determination of potent anti-tumour compound vinblastine and its precursor in biological samples by capillary electrophoresis.

Journal of chromatography. A

Chu C, Zang Y, Yang F, Zou Y, Li J, Liu EH, Yi T, Yan J, Tong S.
PMID: 34998026
J Chromatogr A. 2021 Dec 30;1664:462794. doi: 10.1016/j.chroma.2021.462794. Epub 2021 Dec 30.

A sensitive capillary electrophoresis strategy was developed by combining salting-out assisted liquid-liquid extraction and online three-step stacking to detect trace quantities of antitumour indole alkaloids in complex biological samples. The proposed strategy fully exploits these two technologies such that...

Emotion matters: Face ensemble perception is affected by emotional states.

Psychonomic bulletin & review

Peng S, Liu CH, Liu W, Yang Z.
PMID: 34327676
Psychon Bull Rev. 2021 Jul 29; doi: 10.3758/s13423-021-01987-w. Epub 2021 Jul 29.

Ensemble coding is the ability of the visual system to extract a summary statistic from a set of stimuli. For example, observers often spontaneously extract an average face identity from a set of faces. Ensemble coding is known to...

Gamma-Ray Observation of the Cygnus Region in the 100-TeV Energy Region.

Physical review letters

Amenomori M, Bao YW, Bi XJ, Chen D, Chen TL, Chen WY, Chen X, Chen Y, Cirennima, Cui SW, Danzengluobu, Ding LK, Fang JH, Fang K, Feng CF, Feng Z, Feng ZY, Gao Q, Gomi A, Gou QB, Guo YQ, Guo YY, He HH, He ZT, Hibino K, Hotta N, Hu H, Hu HB, Huang J, Jia HY, Jiang L, Jiang P, Jin HB, Kasahara K, Katayose Y, Kato C, Kato S, Kawata K, Kozai M, Kurashige D, Labaciren, Le GM, Li AF, Li HJ, Li WJ, Li Y, Lin YH, Liu B, Liu C, Liu JS, Liu LY, Liu MY, Liu W, Liu XL, Lou YQ, Lu H, Meng XR, Munakata K, Nakada H, Nakamura Y, Nakazawa Y, Nanjo H, Ning CC, Nishizawa M, Ohnishi M, Ohura T, Okukawa S, Ozawa S, Qian L, Qian X, Qian XL, Qu XB, Saito T, Sakata M, Sako T, Sako TK, Shao J, Shibata M, Shiomi A, Sugimoto H, Takano W, Takita M, Tan YH, Tateyama N, Torii S, Tsuchiya H, Udo S, Wang H, Wang YP, Wangdui, Wu HR, Wu Q, Xu JL, Xue L, Yamamoto Y, Yang Z, Yao YQ, Yin J, Yokoe Y, Yu NP, Yuan AF, Zhai LM, Zhang CP, Zhang HM, Zhang JL, Zhang X, Zhang XY, Zhang Y, Zhang Y, Zhang Y, Zhao SP, Zhaxisangzhu, Zhou XX.
PMID: 34328784
Phys Rev Lett. 2021 Jul 16;127(3):031102. doi: 10.1103/PhysRevLett.127.031102.

We report observations of gamma-ray emissions with energies in the 100-TeV energy region from the Cygnus region in our Galaxy. Two sources are significantly detected in the directions of the Cygnus OB1 and OB2 associations. Based on their positional...

Dynamic Nutrient Signaling Networks in Plants.

Annual review of cell and developmental biology

Li L, Liu KH, Sheen J.
PMID: 34351784
Annu Rev Cell Dev Biol. 2021 Oct 06;37:341-367. doi: 10.1146/annurev-cellbio-010521-015047. Epub 2021 Aug 05.

Nutrients are vital to life through intertwined sensing, signaling, and metabolic processes. Emerging research focuses on how distinct nutrient signaling networks integrate and coordinate gene expression, metabolism, growth, and survival. We review the multifaceted roles of sugars, nitrate, and...

Phomaligols F-I, polyoxygenated cyclohexenone derivatives from marine-derived fungus Aspergillus flavus BB1.

Bioorganic chemistry

Liu XJ, Li HJ, Ma WZ, Zhang FM, Xu MY, Mahmud T, Lan WJ.
PMID: 34426151
Bioorg Chem. 2021 Oct;115:105269. doi: 10.1016/j.bioorg.2021.105269. Epub 2021 Aug 16.

By tracing the

Population pharmacokinetic model-guided optimization of intravenous voriconazole dosing regimens in critically ill patients with liver dysfunction.

Pharmacotherapy

Lin XB, Lui KY, Guo PH, Liu XM, Liang T, Hu XG, Tong L, Wu JJ, Xia YZ, Chen P, Zhong GP, Chen X, Cai CJ.
PMID: 34655497
Pharmacotherapy. 2022 Jan;42(1):23-33. doi: 10.1002/phar.2634. Epub 2021 Oct 25.

STUDY OBJECTIVES: This study aimed to establish a population pharmacokinetic (PPK) model of intravenous voriconazole (VRC) in critically ill patients with liver dysfunction and to explore the optimal dosing strategies in specific clinical scenarios for invasive fungal infections (IFIs)...

Effects of Angiotensin Receptor-Neprilysin Inhibitor in Arrhythmogenicity Following Left Atrial Appendage Closure in an Animal Model.

Cardiovascular drugs and therapy

Cheng WH, Lugtu IC, Chang SL, Liu SH, Chen SA, Lo LW.
PMID: 33818689
Cardiovasc Drugs Ther. 2021 Aug;35(4):759-768. doi: 10.1007/s10557-021-07174-2. Epub 2021 Apr 05.

PURPOSE: Left atrial appendage (LAA) closure decreases atrial natriuretic peptide (ANP) levels, which indirectly increases the risk of arrhythmogenicity. We aimed to determine the effect of a combined angiotensin receptor-neprilysin inhibitor (ARNi) on arrhythmogenicity following LAA closure in an...

[Review of clinical research in acupuncture and moxibustion from 2010 to 2020 and future prospects].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

Yan SY, Xiong ZY, Liu XY, Liu CZ, Liu BY.
PMID: 35025168
Zhongguo Zhen Jiu. 2022 Jan 12;42(1):116-8. doi: 10.13703/j.0255-2930.20210331-0008.

The progress of Chinese clinical research on acupuncture and moxibustion in recent 10 years was reviewed and analyzed, and corresponding suggestions were put forward for the current problems. In the past 10 years, Chinese clinical research on acupuncture and...

Showing 7333 to 7342 of 7342 entries