Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 169 to 177 of 177 entries
Sorted by: Best Match Show Resources per page
Reciprocal regulation of chaperone-mediated autophagy and the circadian clock.

Nature cell biology

Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM.
PMID: 34876687
Nat Cell Biol. 2021 Dec 07; doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07.

Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential to circadian strength and adaptability. Here...

Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy.

Breast cancer research : BCR

Cong L, Maishi N, Annan DA, Young MF, Morimoto H, Morimoto M, Nam JM, Hida Y, Hida K.
PMID: 33966638
Breast Cancer Res. 2021 May 10;23(1):51. doi: 10.1186/s13058-021-01423-w.

BACKGROUND: Biglycan is a proteoglycan found in the extracellular matrix. We have previously shown that biglycan is secreted from tumor endothelial cells and induces tumor angiogenesis and metastasis. However, the function of stroma biglycan in breast cancer is still...

Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish.

Toxicology and applied pharmacology

Maciag M, Wnorowski A, Bednarz K, Plazinska A.
PMID: 34838787
Toxicol Appl Pharmacol. 2022 Jan 01;434:115812. doi: 10.1016/j.taap.2021.115812. Epub 2021 Nov 26.

Cardiovascular toxicity represents one of the most common reasons for clinical trial failure. Consequently, early identification of novel cardioprotective strategies could prevent the later-stage drug-induced cardiac side effects. The use of zebrafish (Danio rerio) in preclinical studies has greatly...

Reciprocal regulation of chaperone-mediated autophagy and the circadian clock.

Nature cell biology

Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM.
PMID: 34876687
Nat Cell Biol. 2021 Dec;23(12):1255-1270. doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07.

Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential to circadian strength and adaptability. Here...

IRF3 inhibits IFN-γ-mediated restriction of intracellular pathogens in macrophages independently of IFNAR.

Journal of leukocyte biology

Maciag K, Raychowdhury R, Smith K, Schneider AM, Coers J, Mumbach MR, Schwartz S, Hacohen N.
PMID: 34826345
J Leukoc Biol. 2021 Nov 26; doi: 10.1002/JLB.3A0218-069RR. Epub 2021 Nov 26.

Macrophages use an array of innate immune sensors to detect intracellular pathogens and to tailor effective antimicrobial responses. In addition, extrinsic activation with the cytokine IFN-γ is often required as well to tip the scales of the host-pathogen balance...

Using the Theory of Planned Behaviour to Describe Male Involvement Intention During Childbirth Among Expecting Couples in a Rural Setting: A Cross-Sectional Study From Rukwa Region, Southern Tanzania.

The East African health research journal

Moshi FV, Kibusi SM, Fabian F.
PMID: 34308193
East Afr Health Res J. 2019;3(1):31-41. doi: 10.24248/EAHRJ-D-18-00018. Epub 2019 Jul 30.

BACKGROUND: Male involvement during childbirth can increase utilisation of maternal services and reduce maternal and neonatal mortality. An individual's intention towards such male involvement can be understood through the theory of planned behaviour, which postulates that such intention is...

Output-Specific Adaptation of Habenula-Midbrain Excitatory Synapses During Cocaine Withdrawal.

Frontiers in synaptic neuroscience

Clerke J, Preston-Ferrer P, Zouridis IS, Tissot A, Batti L, Voigt FF, Pagès S, Burgalossi A, Mameli M.
PMID: 33867967
Front Synaptic Neurosci. 2021 Mar 31;13:643138. doi: 10.3389/fnsyn.2021.643138. eCollection 2021.

Projections from the lateral habenula (LHb) control ventral tegmental area (VTA) neuronal populations' activity and both nuclei shape the pathological behaviors emerging during cocaine withdrawal. However, it is unknown whether cocaine withdrawal modulates LHb neurotransmission onto subsets of VTA...

First-line thrombectomy strategy for anterior large vessel occlusions: results of the prospective ETIS egistry.

Journal of neurointerventional surgery

Maïer B, Finitsis S, Bourcier R, Papanagiotou P, Richard S, Marnat G, Sibon I, Dargazanli C, Arquizan C, Blanc R, Piotin M, Lapergue B, Consoli A, Eugene F, Vannier S, Saleme S, Macian F, Clarençon F, Rosso C, Naggara O, Turc G, Viguier A, Cognard C, Wolff V, Pop R, Mazighi M, Gory B.
PMID: 33972458
J Neurointerv Surg. 2021 May 10; doi: 10.1136/neurintsurg-2021-017505. Epub 2021 May 10.

BACKGROUND: The best recanalization strategy for mechanical thrombectomy (MT) remains unknown as no randomized controlled trial has simultaneously evaluated first-line stent retriever (SR) versus contact aspiration (CA) versus the combined approach (SR+CA).OBJECTIVE: To compare the efficacy and safety profiles...

Primary cutaneous lymphomas in children: A prospective study from the Spanish Academy of Dermatology and Venereology (AEDV) Primary Cutaneous Lymphoma Registry.

Pediatric dermatology

Torre-Castro J, Estrach T, Peñate Y, Acebo E, Fernández de Misa R, Blanes M, Suh-Oh HJ, Botella-Estrada R, Torrelo A, García-Doval I, Machan S.
PMID: 34632613
Pediatr Dermatol. 2021 Nov;38(6):1506-1509. doi: 10.1111/pde.14811. Epub 2021 Oct 11.

BACKGROUND/OBJECTIVES: Primary cutaneous lymphomas are rare in pediatric patients. The clinical and histopathological manifestations may differ from those in adults. Due to their low frequency and the insidious clinical picture, the diagnosis is usually delayed. The Spanish Primary Cutaneous...

Showing 169 to 177 of 177 entries