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Showing 25 to 36 of 177 entries
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Bevacizumab Plus FOLFOX-4 Combined With Deep Electro-Hyperthermia as First-line Therapy in Metastatic Colon Cancer: A Pilot Study.

Frontiers in oncology

Ranieri G, Laface C, Laforgia M, De Summa S, Porcelli M, Macina F, Ammendola M, Molinari P, Lauletta G, Di Palo A, Rubini G, Ferrari C, Gadaleta CD.
PMID: 33224885
Front Oncol. 2020 Nov 03;10:590707. doi: 10.3389/fonc.2020.590707. eCollection 2020.

Bevacizumab plus FOLFOX-4 regimen represents the first-line therapy in patients affected by metastatic colorectal cancer (mCRC). Hyperthermia has been considered an effective ancillary treatment for cancer therapy through several anti-tumor mechanisms, sharing with Bevacizumab the inhibition of angiogenesis. Up...

Evolving Factors in Hospital Safety: A Systematic Review and Meta-Analysis of Hospital Adverse Events.

Journal of patient safety

Sauro KM, Machan M, Whalen-Browne L, Owen V, Wu G, Stelfox HT.
PMID: 34469915
J Patient Saf. 2021 Dec 01;17(8):e1285-e1295. doi: 10.1097/PTS.0000000000000889.

OBJECTIVE: This study aimed to estimate the frequency of hospital adverse events (AEs) and explore the rate of AEs over time, and across and within hospital populations.METHODS: Validated search terms were run in MEDLINE and EMBASE; gray literature and...

The Quest for Model Uncertainty Quantification: A Hybrid Ensemble and Variational Data Assimilation Framework.

Water resources research

Abbaszadeh P, Moradkhani H, Daescu DN.
PMID: 31217643
Water Resour Res. 2019 Mar;55(3):2407-2431. doi: 10.1029/2018WR023629. Epub 2019 Mar 25.

This article presents a novel approach to couple a deterministic four-dimensional variational (4DVAR) assimilation method with the particle filter (PF) ensemble data assimilation system, to produce a robust approach for dual-state-parameter estimation. In our proposed method, the Hybrid Ensemble...

Coordinate roles for collagen VI and biglycan in regulating tendon collagen fibril structure and function.

Matrix biology plus

Leiphart RJ, Pham H, Harvey T, Komori T, Kilts TM, Shetye SS, Weiss SN, Adams SM, Birk DE, Soslowsky LJ, Young MF.
PMID: 35036900
Matrix Biol Plus. 2021 Dec 28;13:100099. doi: 10.1016/j.mbplus.2021.100099. eCollection 2022 Feb.

Tendon is a vital musculoskeletal tissue that is prone to degeneration. Proper tendon maintenance requires complex interactions between extracellular matrix components that remain poorly understood. Collagen VI and biglycan are two matrix molecules that localize pericellularly within tendon and...

Nature and prevalence of combinations of mental disorders and their association with excess mortality in a population-based cohort study.

World psychiatry : official journal of the World Psychiatric Association (WPA)

Plana-Ripoll O, Musliner KL, Dalsgaard S, Momen NC, Weye N, Christensen MK, Agerbo E, Iburg KM, Laursen TM, Mortensen PB, Pedersen CB, Petersen LV, Santomauro DF, Vilhjálmsson BJ, Whiteford HA, McGrath JJ.
PMID: 32931098
World Psychiatry. 2020 Oct;19(3):339-349. doi: 10.1002/wps.20802.

The nature and prevalence of combinations of mental disorders and their associations with premature mortality have never been reported in a comprehensive way. We describe the most common combinations of mental disorders and estimate excess mortality associated with these...

Alterations of Subcortical Brain Structures in Paradoxical and Psychophysiological Insomnia Disorder.

Frontiers in psychiatry

Emamian F, Mahdipour M, Noori K, Rostampour M, Mousavi SB, Khazaie H, Khodaie-Ardakani M, Tahmasian M, Zarei M.
PMID: 34025484
Front Psychiatry. 2021 May 07;12:661286. doi: 10.3389/fpsyt.2021.661286. eCollection 2021.

Insomnia disorder (ID) is a common illness associated with mood and cognitive impairments. Subtyping ID is an ongoing debate in sleep medicine, but the underlying mechanisms of each subtype is poorly understood. Growing evidence suggests that subcortical brain structures...

Thrombectomy Complications in Large Vessel Occlusions: Incidence, Predictors, and Clinical Impact in the ETIS Registry.

Stroke

Happi Ngankou E, Gory B, Marnat G, Richard S, Bourcier R, Sibon I, Dargazanli C, Arquizan C, Maïer B, Blanc R, Lapergue B, Consoli A, Vannier S, Spelle L, Denier C, Boulanger M, Gauberti M, Saleme S, Macian F, Clarençon F, Rosso C, Naggara O, Turc G, Ozkul-Wermester O, Papagiannaki C, Viguier A, Cognard C, Lebras A, Evain S, Wolff V, Pop R, Timsit S, Gentric JC, Bourdain F, Veunac L, Eugène F, Finitsis S.
PMID: 34706564
Stroke. 2021 Dec;52(12):e764-e768. doi: 10.1161/STROKEAHA.121.034865. Epub 2021 Oct 28.

BACKGROUND AND PURPOSE: Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated the incidence, risk factors, and clinical implications of thrombectomy complications in daily clinical practice.METHODS: We used data from...

Primary cutaneous lymphomas in children: A prospective study from the Spanish Academy of Dermatology and Venereology (AEDV) Primary Cutaneous Lymphoma Registry.

Pediatric dermatology

Torre-Castro J, Estrach T, Peñate Y, Acebo E, Fernández de Misa R, Blanes M, Suh-Oh HJ, Botella-Estrada R, Torrelo A, García-Doval I, Machan S.
PMID: 34632613
Pediatr Dermatol. 2021 Oct 11; doi: 10.1111/pde.14811. Epub 2021 Oct 11.

BACKGROUND/OBJECTIVES: Primary cutaneous lymphomas are rare in pediatric patients. The clinical and histopathological manifestations may differ from those in adults. Due to their low frequency and the insidious clinical picture, the diagnosis is usually delayed. The Spanish Primary Cutaneous...

Deep learning is widely applicable to phenotyping embryonic development and disease.

Development (Cambridge, England)

Naert T, Çiçek Ö, Ogar P, Bürgi M, Shaidani NI, Kaminski MM, Xu Y, Grand K, Vujanovic M, Prata D, Hildebrandt F, Brox T, Ronneberger O, Voigt FF, Helmchen F, Loffing J, Horb ME, Willsey HR, Lienkamp SS.
PMID: 34739029
Development. 2021 Nov 01;148(21). doi: 10.1242/dev.199664. Epub 2021 Nov 05.

Genome editing simplifies the generation of new animal models for congenital disorders. However, the detailed and unbiased phenotypic assessment of altered embryonic development remains a challenge. Here, we explore how deep learning (U-Net) can automate segmentation tasks in various...

Reciprocal regulation of chaperone-mediated autophagy and the circadian clock.

Nature cell biology

Juste YR, Kaushik S, Bourdenx M, Aflakpui R, Bandyopadhyay S, Garcia F, Diaz A, Lindenau K, Tu V, Krause GJ, Jafari M, Singh R, Muñoz J, Macian F, Cuervo AM.
PMID: 34876687
Nat Cell Biol. 2021 Dec;23(12):1255-1270. doi: 10.1038/s41556-021-00800-z. Epub 2021 Dec 07.

Circadian rhythms align physiological functions with the light-dark cycle through oscillatory changes in the abundance of proteins in the clock transcriptional programme. Timely removal of these proteins by different proteolytic systems is essential to circadian strength and adaptability. Here...

Safety and feasibility report on nonimplantable endovenous valve formation for the treatment of deep vein reflux.

Journal of vascular surgery. Venous and lymphatic disorders

Vasudevan T, Robinson DA, Hill AA, Ouriel K, Holden A, Gagnon J, Machan L, Nammuni I, Thomas SD, Varcoe RL.
PMID: 33359385
J Vasc Surg Venous Lymphat Disord. 2021 Sep;9(5):1200-1208. doi: 10.1016/j.jvsv.2020.12.073. Epub 2021 Jan 19.

OBJECTIVE: Definitive treatment techniques for symptomatic deep venous reflux have been relegated to complex and invasive open surgery which is rarely performed today. The BlueLeaf System provides an endovenous method for the formation of deep venous valves without an...

Validation of a non-motor fluctuations questionnaire in Parkinson's disease.

Revue neurologique

Faggianelli F, Loundou A, Baumstarck K, Nathalie S, Auquier P, Eusebio A, Defebvre L, Brefel-Courbon C, Houeto JL, Maltete D, Tranchant C, Derkinderen P, Geny C, Krystkowiak P, Jean-Philippe B, Macia F, Durif F, Poujois A, Borg M, Azulay JP, Witjas T.
PMID: 34565624
Rev Neurol (Paris). 2021 Sep 24; doi: 10.1016/j.neurol.2021.06.013. Epub 2021 Sep 24.

INTRODUCTION: Non-motor fluctuations (NMF) in Parkinson's disease (PD) remain poorly recognized but have a high impact on patients' quality of life. The lack of assessment tools limits our understanding of NMF, compromising appropriate management. Our objective was to validate...

Showing 25 to 36 of 177 entries