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Showing 493 to 495 of 495 entries
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C5 Variant rs10985126 is Associated with Mortality in Patients with Symptomatic Coronary Artery Disease.

Pharmacogenomics and personalized medicine

Henes JK, Groga-Bada P, Schaeffeler E, Winter S, Hack L, Zdanyte M, Mueller K, Droppa M, Stimpfle F, Gawaz M, Langer H, Schwab M, Geisler T, Rath D.
PMID: 34321906
Pharmgenomics Pers Med. 2021 Jul 21;14:893-903. doi: 10.2147/PGPM.S307827. eCollection 2021.

BACKGROUND: Complement component 5a (C5a) is a highly potent anaphylatoxin with a variety of pro-inflammatory effects. C5a contributes to progression of atherosclerosis and inhibition of the receptor (C5aR) might offer a therapeutic strategy in this regard. Single nucleotide polymorphisms...

Rubella Virus Infected Macrophages and Neutrophils Define Patterns of Granulomatous Inflammation in Inborn and Acquired Errors of Immunity.

Frontiers in immunology

Perelygina L, Faisthalab R, Abernathy E, Chen MH, Hao L, Bercovitch L, Bayer DK, Noroski LM, Lam MT, Cicalese MP, Al-Herz W, Nanda A, Hajjar J, Vanden Driessche K, Schroven S, Leysen J, Rosenbach M, Peters P, Raedler J, Albert MH, Abraham RS, Rangarjan HG, Buchbinder D, Kobrynski L, Pham-Huy A, Dhossche J, Cunningham Rundles C, Meyer AK, Theos A, Atkinson TP, Musiek A, Adeli M, Derichs U, Walz C, Krüger R, von Bernuth H, Klein C, Icenogle J, Hauck F, Sullivan KE.
PMID: 35003119
Front Immunol. 2021 Dec 20;12:796065. doi: 10.3389/fimmu.2021.796065. eCollection 2021.

Rubella virus (RuV) has recently been found in association with granulomatous inflammation of the skin and several internal organs in patients with inborn errors of immunity (IEI). The cellular tropism and molecular mechanisms of RuV persistence and pathogenesis in...

BOB.1/OBF.1 is required during B-cell ontogeny for B-cell differentiation and germinal center function.

European journal of immunology

Betzler AC, Fiedler K, Hoffmann TK, Fehling HJ, Wirth T, Brunner C.
PMID: 34918350
Eur J Immunol. 2021 Dec 08; doi: 10.1002/eji.202149333. Epub 2021 Dec 08.

BOB.1/OBF.1 is a lymphocyte-specific transcriptional co-activator of octamer-dependent transcription. It regulates the expression of genes important for lymphocyte physiology together with the Oct-1 and Oct-2 transcription factors. So far, BOB.1/OBF.1 has been studied in conventional knockout mice, whereby a...

Showing 493 to 495 of 495 entries