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Showing 337 to 348 of 348 entries
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LENZILUMAB EFFICACY AND SAFETY IN NEWLY HOSPITALIZED COVID-19 SUBJECTS: RESULTS FROM THE LIVE-AIR PHASE 3 RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL.

medRxiv : the preprint server for health sciences

Temesgen Z, Burger CD, Baker J, Polk C, Libertin C, Kelley C, Marconi VC, Orenstein R, Durrant C, Chappell D, Ahmed O, Chappell G, Badley AD.
PMID: 33972949
medRxiv. 2021 May 05; doi: 10.1101/2021.05.01.21256470.

BACKGROUND: Severe COVID-19 pneumonia results from a hyperinflammatory immune response (cytokine storm, CS), characterized by GM-CSF mediated activation and trafficking of myeloid cells, leading to elevation of downstream inflammatory chemokines (MCP-1, IL-8, IP-10), cytokines (IL-6, IL-1), and other markers...

Single-shot large field of view Fourier transform holography with a picosecond plasma-based soft X-ray laser.

Optics express

Wang S, Rockwood A, Wang Y, Chao WL, Naulleau P, Song H, Menoni CS, Marconi M, Rocca JJ.
PMID: 33379696
Opt Express. 2020 Nov 23;28(24):35898-35909. doi: 10.1364/OE.409815.

It is challenging to obtain nanoscale resolution images in a single ultrafast shot because a large number of photons, greater than 10

Field safety study of VANGUARD®crLyme: A vaccine for the prevention of Lyme disease in dogs.

Vaccine: X

Marconi RT, Honsberger N, Teresa Winkler M, Sobell N, King VL, Wappel S, Hoevers J, Xu Z, Millership J.
PMID: 33336186
Vaccine X. 2020 Oct 22;6:100080. doi: 10.1016/j.jvacx.2020.100080. eCollection 2020 Dec 11.

Here we report the results of a large-scale pre-license safety study in which two serials of VANGUARD®crLyme, a vaccine for canine Lyme disease, were tested in its target population (dogs) under the conditions of its intended use. Six-hundred and...

Virologic outcomes among adults with HIV using integrase inhibitor-based antiretroviral therapy.

AIDS (London, England)

Lu H, Cole SR, Westreich D, Hudgens MG, Adimora AA, Althoff KN, Silverberg MJ, Buchacz K, Li J, Edwards JK, Rebeiro PF, Lima VD, Marconi VC, Sterling TR, Horberg MA, Gill MJ, Kitahata MM, Eron JJ, Moore RD.
PMID: 34934020
AIDS. 2022 Feb 01;36(2):277-286. doi: 10.1097/QAD.0000000000003069.

BACKGROUND: Integrase strand transfer inhibitor (InSTI)-based regimens have been recommended as first-line antiretroviral therapy (ART) for adults with HIV. But data on long-term effects of InSTI-based regimens on virologic outcomes remain limited. Here we examined whether InSTI improved long-term...

Resistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africa : An Unblinded Randomized Controlled Trial.

Annals of internal medicine

Siedner MJ, Moosa MS, McCluskey S, Gilbert RF, Pillay S, Aturinda I, Ard K, Muyindike W, Musinguzi N, Masette G, Pillay M, Moodley P, Brijkumar J, Rautenberg T, George G, Gandhi RT, Johnson BA, Sunpath H, Bwana MB, Marconi VC.
PMID: 34698502
Ann Intern Med. 2021 Dec;174(12):1683-1692. doi: 10.7326/M21-2229. Epub 2021 Oct 26.

BACKGROUND: Virologic failure in HIV predicts the development of drug resistance and mortality. Genotypic resistance testing (GRT), which is the standard of care after virologic failure in high-income settings, is rarely implemented in sub-Saharan Africa.OBJECTIVE: To estimate the effectiveness...

Weight gain stopping/switch rules for antiretroviral clinical trials.

AIDS (London, England)

Venter WDF, Sokhela S, Calmy A, Mkhondwane L, Bosch B, Chandiwana N, Hill A, Sekwese K, Mashabane N, Pozniak A, Khoo S, Ali M, Delaporte E, Lalla-Edwards S, Clayden P, Marconi VC, Siedner MJ, Boffito M, Serenata C, Carman M, Collins S.
PMID: 34848585
AIDS. 2021 Dec 15;35:S183-S188. doi: 10.1097/QAD.0000000000003092.

Obesity develops in a substantial number of people initiating and maintaining modern antiretroviral therapy. The comorbidities associated with obesity make significant weight gain and metabolic changes a major consideration in clinical trials studying different regimens' potency and safety. It...

Preservative systems containing essential oils in cosmetic products.

International journal of cosmetic science

Maccioni AM, Anchisi C, Sanna A, Sardu C, Dessì S.
PMID: 18498495
Int J Cosmet Sci. 2002 Feb;24(1):53-9. doi: 10.1046/j.0412-5463.2001.00113.x.

The aim of this study was to evaluate the antimicrobial activity of selected essential oils (Laurus nobilis, Eucalyptus globulus and Salvia officinalis), both alone and in combination, in cosmetic preparations characterized by an increasing risk of microbial contamination, i.e....

Erbium emission in MOS light emitting devices: from energy transfer to direct impact excitation.

Nanotechnology

Ramíırez JM, Ferrarese Lupi F, Jambois O, Berencén Y, Navarro-Urrios D, Anopchenko A, Marconi A, Prtljaga N, Tengattini A, Pavesi L, Colonna JP, Fedeli JM, Garrido B.
PMID: 22414783
Nanotechnology. 2012 Mar 30;23(12):125203. doi: 10.1088/0957-4484/23/12/125203.

The electroluminescence (EL) at 1.54 μm of metal–oxide–semiconductor (MOS) devices withEr3C ions embedded in the silicon-rich silicon oxide (SRSO) layer has been investigated under different polarization conditions and compared with that of erbium doped SiO2 layers. EL time-resolved measurements...

Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers.

Cancer cell international

Turk CM, Fagan-Solis KD, Williams KE, Gozgit JM, Smith-Schneider S, Marconi SA, Otis CN, Crisi GM, Anderton DL, Kilimann MW, Arcaro KF.
PMID: 22574838
Cancer Cell Int. 2012 May 10;12(1):17. doi: 10.1186/1475-2867-12-17.

BACKGROUND: Paralemmin-1 is a phosphoprotein lipid-anchored to the cytoplasmic face of membranes where it functions in membrane dynamics, maintenance of cell shape, and process formation. Expression of paralemmin-1 and its major splice variant (Δ exon 8) as well as...

Cognitively-Based Compassion Training for HIV Immune Non-responders - An Attention-Placebo Randomized Controlled Trial.

Journal of acquired immune deficiency syndromes (1999)

Titanji BK, Tejani M, Farber EW, Mehta CC, Pace TW, Meagley K, Gavegnano C, Harrison T, Kokubun CW, Negi SD, Schinazi RF, Marconi VC.
PMID: 34879006
J Acquir Immune Defic Syndr. 2021 Dec 07; doi: 10.1097/QAI.0000000000002874. Epub 2021 Dec 07.

OBJECTIVE: Chronic inflammation is associated with increased morbidity and mortality for people with HIV (PWH). Psychological stress is an important contributor to this chronic inflammation. We hypothesized that a Cognitively-Based Compassion Training (CBCT) approach could reduce inflammation and psychological...

Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression.

Cancer research

Saltari A, Dzung A, Quadri M, Tiso N, Facchinello N, Hernández-Barranco A, Garcia-Silva S, Nogués L, Stoffel CI, Cheng PF, Turko P, Eichhoff OM, Truzzi F, Marconi A, Pincelli C, Peinado H, Dummer R, Levesque MP.
PMID: 34645608
Cancer Res. 2021 Dec 01;81(23):6044-6057. doi: 10.1158/0008-5472.CAN-21-0117. Epub 2021 Oct 13.

CD271 (NGFR) is a neurotrophin receptor that belongs to the tumor necrosis receptor (TNFR) family. Upon ligand binding, CD271 can mediate either survival or cell death. Although the role of CD271 as a marker of tumor-initiating cells is still...

"Add-Ons" for Assisted Reproductive Technology: Do Patients Get Honest Information from Fertility Clinics' Websites?.

Reproductive sciences (Thousand Oaks, Calif.)

Galiano V, Orvieto R, Machtinger R, Nahum R, Garzia E, Sulpizio P, Marconi AM, Seidman D.
PMID: 33939166
Reprod Sci. 2021 Dec;28(12):3466-3472. doi: 10.1007/s43032-021-00601-7. Epub 2021 Apr 30.

"Add-on" procedures are actively promoted on some fertility clinic websites as proven means to improve IVF success rates, especially for couples with repeated implantation/IVF failures. However, the actual contribution of these interventions to live birth rates remains inconclusive. At...

Showing 337 to 348 of 348 entries