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Showing 193 to 201 of 201 entries
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Identification and Evaluation of Serum Protein Biomarkers That Differentiate Psoriatic Arthritis From Rheumatoid Arthritis.

Arthritis & rheumatology (Hoboken, N.J.)

Mc Ardle A, Kwasnik A, Szentpetery A, Hernandez B, Parnell A, de Jager W, de Roock S, FitzGerald O, Pennington SR.
PMID: 34114357
Arthritis Rheumatol. 2022 Jan;74(1):81-91. doi: 10.1002/art.41899. Epub 2021 Nov 23.

OBJECTIVE: To identify serum protein biomarkers that might distinguish patients with early inflammatory arthritis (IA) with psoriatic arthritis (PsA) from those with rheumatoid arthritis (RA) and may be used to support appropriate early intervention.METHODS: The serum proteome of patients...

Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils.

Mucosal immunology

Riffelmacher T, Giles DA, Zahner S, Dicker M, Andreyev AY, McArdle S, Perez-Jeldres T, van der Gracht E, Murray MP, Hartmann N, Tumanov AV, Kronenberg M.
PMID: 33568785
Mucosal Immunol. 2021 May;14(3):679-690. doi: 10.1038/s41385-021-00378-7. Epub 2021 Feb 10.

Inflammatory bowel disease is characterized by an exacerbated intestinal immune response, but the critical mechanisms regulating immune activation remain incompletely understood. We previously reported that the TNF-superfamily molecule TNFSF14 (LIGHT) is required for preventing severe disease in mouse models...

A study protocol for a randomised controlled feasibility trial of an intervention to increase activity and reduce sedentary behaviour in people with severe mental illness: Walking fOR Health (WORtH) Study.

Pilot and feasibility studies

McDonough SM, Howes SC, Dillon M, McAuley J, Brady J, Clarke M, Clarke M, Lait E, McArdle D, O'Neill T, Wilson I, Niven A, Williams J, Tully MA, Murphy MH, McDonough CM.
PMID: 34782018
Pilot Feasibility Stud. 2021 Nov 15;7(1):205. doi: 10.1186/s40814-021-00938-5.

BACKGROUND: People with severe mental illness (SMI) are less physically active and more sedentary than healthy controls, contributing to poorer physical health outcomes in this population. There is a need to understand the feasibility and acceptability, and explore the...

Ring-fused dimethoxybenzimidazole-benzimidazolequinone (DMBBQ): tunable halogenation and quinone formation using NaX/Oxone.

Organic & biomolecular chemistry

Conboy D, Kielty P, Bear JC, Cockcroft JK, Farràs P, McArdle P, Singer RJ, Smith DA, Aldabbagh F.
PMID: 33667287
Org Biomol Chem. 2021 Mar 28;19(12):2716-2724. doi: 10.1039/d1ob00032b. Epub 2021 Mar 05.

Ring-fused benzimidazolequinones are well-known anti-tumour agents, but dimeric ring-fused adducts are new. The alicyclic [1,2-a] ring-fused dimethoxybenzimidazole-benzimidazolequinone (DMBBQ) intermediate allows late-stage functionalization of bis-p-benzimidazolequinones. DMBBQs are chlorinated and brominated at the p-dimethoxybenzene site using nontoxic sodium halide and Oxone...

A Novel HAGE/WT1-ImmunoBody.

Frontiers in oncology

Almshayakhchi R, Nagarajan D, Vadakekolathu J, Guinn BA, Reeder S, Brentville V, Metheringham R, Pockley AG, Durrant L, McArdle S.
PMID: 34262856
Front Oncol. 2021 Jun 28;11:636977. doi: 10.3389/fonc.2021.636977. eCollection 2021.

Many cancers, including myeloid leukaemia express the cancer testis antigen (CTA) DDX43 (HAGE) and/or the oncogene Wilms' tumour (WT1). Here we demonstrate that HAGE/WT1-ImmunoBody

Upregulation of HLA class II in pancreatic beta cells from organ donors with type 1 diabetes.

Diabetologia

Quesada-Masachs E, Zilberman S, Rajendran S, Chu T, McArdle S, Kiosses WB, Lee JM, Yesildag B, Benkahla MA, Pawlowska A, Graef M, Pfeiffer S, Mikulski Z, von Herrath M.
PMID: 34932134
Diabetologia. 2022 Feb;65(2):387-401. doi: 10.1007/s00125-021-05619-9. Epub 2021 Dec 21.

AIMS/HYPOTHESIS: We aimed to characterise and quantify the expression of HLA class II (HLA-II) in human pancreatic tissue sections and to analyse its induction in human islets.METHODS: We immunostained human pancreatic tissue sections from non-diabetic (n = 5), autoantibody...

An overview of the Scientific Advisory Committee on Nutrition's position statement on nutrition and older adults living in the community.

The British journal of nutrition

van Dijk M, Cullum A, Swan G, Peacock E, Fine G, Robinson S, McArdle H, Walls A, Walsh S.
PMID: 33334383
Br J Nutr. 2021 Oct 28;126(8):1164-1167. doi: 10.1017/S0007114520005024. Epub 2020 Dec 18.

No abstract available.

A rare case of melanotic hyperpigmentation of the tongue secondary to radiotherapy.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

Houlihan OA, Rangaswamy G, McArdle O.
PMID: 34211784
Rep Pract Oncol Radiother. 2021 Apr 14;26(2):320-323. doi: 10.5603/RPOR.a2021.0034. eCollection 2021.

Melanotic hyperpigmentation of the mucosa secondary to radiotherapy is a rare occurrence. It is a diagnosis of exclusion. Literature review has identified only two case reports published to date. We present a case of a patient treated at our...

Impact of Two Antibiotic Therapies on Clinical Outcome and Gut Microbiota Profile in Liver Transplant Paediatric Candidates Colonized by Carbapenem-Resistant .

Frontiers in cellular and infection microbiology

Cardile S, Del Chierico F, Candusso M, Reddel S, Bernaschi P, Pietrobattista A, Spada M, Torre G, Putignani L.
PMID: 34970503
Front Cell Infect Microbiol. 2021 Dec 14;11:730904. doi: 10.3389/fcimb.2021.730904. eCollection 2021.

Colonization by multidrug-resistant (MDR) organisms in liver transplant (LT) candidates significantly affects the LT outcome. To date, consensus about patient management is lacking, including microbiological screening indications. This pilot study aimed to evaluate the impact of carbapenem-resistant

Showing 193 to 201 of 201 entries