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Showing 13 to 24 of 196 entries
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Association of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma.

JAMA oncology

Landgren O, Hofmann JN, McShane CM, Santo L, Hultcrantz M, Korde N, Mailankody S, Kazandjian D, Murata K, Thoren K, Ramanathan L, Dogan A, Rustad E, Lu SX, Akhlaghi T, Kristinsson SY, Björkholm M, Devlin S, Purdue MP, Pfeiffer RM, Turesson I.
PMID: 31318385
JAMA Oncol. 2019 Sep 01;5(9):1293-1301. doi: 10.1001/jamaoncol.2019.1568.

IMPORTANCE: Multiple myeloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS). Risk models that estimate the risk of progression from MGUS to multiple myeloma use data from a single time point, usually the initial workup.OBJECTIVE: To longitudinally...

Association of spinal instability due to metastatic disease with increased mortality and a proposed clinical pathway for treatment.

Journal of neurosurgery. Spine

Sullivan PZ, Albayar A, Ramayya AG, McShane B, Marcotte P, Malhotra NR, Ali ZS, Chen HI, Janjua MB, Saifi C, Schuster J, Grady MS, Jones J, Ozturk AK.
PMID: 32059185
J Neurosurg Spine. 2020 Feb 14;1-8. doi: 10.3171/2019.11.SPINE19775. Epub 2020 Feb 14.

OBJECTIVE: Multidisciplinary treatment including medical oncology, radiation oncology, and surgical consultation is necessary to provide comprehensive therapy for patients with spinal metastases. The goal of this study was to review the use of radiation therapy and/or surgical intervention and...

Exploring patients' and carers' views about the clinical use of ketamine to inform policy and practical decisions: mixed-methods study.

BJPsych open

Jilka S, Murray C, Wieczorek A, Griffiths H, Wykes T, McShane R.
PMID: 31530293
BJPsych Open. 2019 Jul 30;5(5):e62. doi: 10.1192/bjo.2019.52.

BACKGROUND: Only one-third of patients with major depressive disorder achieve remission. One new and promising treatment, ketamine, may prove challenging to implement because of its abuse potential. Although clinicians' views have been sought, we need patients' views before large...

Mucus.

Current biology : CB

McShane A, Bath J, Jaramillo AM, Ridley C, Walsh AA, Evans CM, Thornton DJ, Ribbeck K.
PMID: 34375594
Curr Biol. 2021 Aug 09;31(15):R938-R945. doi: 10.1016/j.cub.2021.06.093.

Mucus is a slimy hydrogel that lines the mucosal surfaces in our body, including the intestines, stomach, eyes, lungs and urogenital tract. This glycoprotein-rich network is truly the jack of all trades. As a barrier, it lubricates surfaces, protects...

Thyroid-optimized and thyroid-sparing radiotherapy in oral cavity and oropharyngeal carcinoma: A dosimetric study.

Technical innovations & patient support in radiation oncology

Wu AK, Damico NJ, Healy E, Kharouta MZ, Khandel G, Deshane A, Sipos J, Eckstein J, Zoller W, Ewing A, Ling S, Wobb J, Mitchell D, Grecula J, Jhawar S, Miller E, Gamez M, Diavolitsis V, Blakaj D, Bhatt AD.
PMID: 34765751
Tech Innov Patient Support Radiat Oncol. 2021 Nov 01;20:28-34. doi: 10.1016/j.tipsro.2021.10.003. eCollection 2021 Dec.

BACKGROUND: Radiation-induced hypothyroidism is a common toxicity of head and neck radiation. Our re-planning study aimed to reduce thyroid dose while maintaining target coverage with IMRT.METHODS: We retrospectively identified patients with oral-cavity (n = 5) and oropharyngeal cancer (n...

Human-Computer Agreement of Electrocardiogram Interpretation for Patients Referred to and Declined for Primary Percutaneous Coronary Intervention: Retrospective Data Analysis Study.

JMIR medical informatics

Iftikhar A, Bond R, Mcgilligan V, Leslie SJ, Knoery C, Shand J, Ramsewak A, Sharma D, McShane A, Rjoob K, Peace A.
PMID: 33650984
JMIR Med Inform. 2021 Mar 02;9(3):e24188. doi: 10.2196/24188.

BACKGROUND: When a patient is suspected of having an acute myocardial infarction, they are accepted or declined for primary percutaneous coronary intervention partly based on clinical assessment of their 12-lead electrocardiogram (ECG) and ST-elevation myocardial infarction criteria.OBJECTIVE: We retrospectively...

A large National Institute for Health Research (NIHR) Biomedical Research Centre facilitates impactful cross-disciplinary and collaborative translational research publications and research collaboration networks: a bibliometric evaluation study.

Journal of translational medicine

Kiparoglou V, Brown LA, McShane H, Channon KM, Shah SGS.
PMID: 34838033
J Transl Med. 2021 Nov 27;19(1):483. doi: 10.1186/s12967-021-03149-x.

BACKGROUND: The evaluation of translational health research is important for various reasons such as the research impact assessment, research funding allocation, accountability, and strategic research policy formulation. The purpose of this study was to evaluate the research productivity, strength...

Telephone Triage Toolkit for Children's cancer services: A quality initiative.

European journal of oncology nursing : the official journal of European Oncology Nursing Society

Hawkins J, Jones P, McShane B, Morris H, Ollett L, Sanderson L.
PMID: 34837802
Eur J Oncol Nurs. 2021 Sep 14;56:102036. doi: 10.1016/j.ejon.2021.102036. Epub 2021 Sep 14.

PURPOSE: Service development to improve patient safety and experience, and improve staff safety and confidence when managing telephone calls from parents or carers of children with cancer in the UK.METHOD: A multi-layered mixed methods approach broadly based on sequential...

Current Perspectives on the Systemic Management of Atopic Dermatitis.

Journal of asthma and allergy

Davari DR, Nieman EL, McShane DB, Morrell DS.
PMID: 34103945
J Asthma Allergy. 2021 Jun 01;14:595-607. doi: 10.2147/JAA.S287638. eCollection 2021.

Atopic dermatitis (AD) is a common disease of childhood, and some patients experience a prolonged clinical course into adolescence and adulthood. Systemic management is required when AD is not adequately controlled with topical medications. Our aim is to provide...

Fine-grained, spatiotemporal datasets measuring 200 years of land development in the United States.

Earth system science data

Uhl JH, Leyk S, McShane CM, Braswell AE, Connor DS, Balk D.
PMID: 34970355
Earth Syst Sci Data. 2021;13(1):119-153. doi: 10.5194/essd-13-119-2021. Epub 2021 Jan 27.

The collection, processing, and analysis of remote sensing data since the early 1970s has rapidly improved our understanding of change on the Earth's surface. While satellite-based Earth observation has proven to be of vast scientific value, these data are...

Ketamine treatment for individuals with treatment-resistant depression: longitudinal qualitative interview study of patient experiences.

BJPsych open

Lascelles K, Marzano L, Brand F, Trueman H, McShane R, Hawton K.
PMID: 33283696
BJPsych Open. 2020 Dec 07;7(1):e9. doi: 10.1192/bjo.2020.132.

BACKGROUND: Ketamine has recently received considerable attention regarding its antidepressant and anti-suicidal effects. Trials have generally focused on short-term effects of single intravenous infusions. Research on patient experiences is lacking.AIMS: To investigate the experiences over time of individuals receiving...

Effect of Capivasertib in Patients With an AKT1 E17K-Mutated Tumor: NCI-MATCH Subprotocol EAY131-Y Nonrandomized Trial.

JAMA oncology

Kalinsky K, Hong F, McCourt CK, Sachdev JC, Mitchell EP, Zwiebel JA, Doyle LA, McShane LM, Li S, Gray RJ, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Conley BA, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT.
PMID: 33377972
JAMA Oncol. 2021 Feb 01;7(2):271-278. doi: 10.1001/jamaoncol.2020.6741.

IMPORTANCE: In the National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH) trial, agents targeting genetic tumor abnormalities are administered to patients. In the NCI-MATCH subprotocol EAY131-Y trial, patients with an AKT1 E17K-mutated metastatic tumor received the pan-AKT inhibitor...

Showing 13 to 24 of 196 entries