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Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic Cystinosis.

International journal of molecular sciences

Bellomo F, De Leo E, Taranta A, Giaquinto L, Di Giovamberardino G, Montefusco S, Rega LR, Pastore A, Medina DL, Di Bernardo D, De Matteis MA, Emma F.
PMID: 34884638
Int J Mol Sci. 2021 Nov 27;22(23). doi: 10.3390/ijms222312829.

Diagnosis and cure for rare diseases represent a great challenge for the scientific community who often comes up against the complexity and heterogeneity of clinical picture associated to a high cost and time-consuming drug development processes. Here we show...

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Bellomo F, De Leo E, Taranta A, et al. Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic Cystinosis. Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222312829.
Bellomo, F., De Leo, E., Taranta, A., Giaquinto, L., Di Giovamberardino, G., Montefusco, S., Rega, L. R., Pastore, A., Medina, D. L., Di Bernardo, D., De Matteis, M. A., & Emma, F. (2021). Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic Cystinosis. International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222312829
Bellomo, Francesco, et al. "Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic Cystinosis." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222312829
Bellomo F, De Leo E, Taranta A, Giaquinto L, Di Giovamberardino G, Montefusco S, Rega LR, Pastore A, Medina DL, Di Bernardo D, De Matteis MA, Emma F. Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic Cystinosis. Int J Mol Sci. 2021 Nov 27;22(23). doi: 10.3390/ijms222312829. PMID: 34884638; PMCID: PMC8657658.
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Current systematic reviews and meta-analyses of COVID-19.

World journal of virology

Nassar M, Nso N, Alfishawy M, Novikov A, Yaghi S, Medina L, Toz B, Lakhdar S, Idrees Z, Kim Y, Gurung DO, Siddiqui RS, Zheng D, Agladze M, Sumbly V, Sandhu J, Castillo FC, Chowdhury N, Kondaveeti R, Bhuiyan S, Perez LG, Ranat R, Gonzalez C, Bhangoo H, Williams J, Osman AE, Kong J, Ariyaratnam J, Mohamed M, Omran I, Lopez M, Nyabera A, Landry I, Iqbal S, Gondal AZ, Hassan S, Daoud A, Baraka B, Trandafirescu T, Rizzo V.
PMID: 34367933
World J Virol. 2021 Jul 25;10(4):182-208. doi: 10.5501/wjv.v10.i4.182.

BACKGROUND: Coronavirus disease 2019 (COVID-19) has left a significant impact on the world's health, economic and political systems; as of November 20, 2020, more than 57 million people have been infected worldwide, with over 1.3 million deaths. While the...

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Nassar M, Nso N, Alfishawy M, et al. Current systematic reviews and meta-analyses of COVID-19. World J Virol. 2021;10(4):182-208doi: 10.5501/wjv.v10.i4.182.
Nassar, M., Nso, N., Alfishawy, M., Novikov, A., Yaghi, S., Medina, L., Toz, B., Lakhdar, S., Idrees, Z., Kim, Y., Gurung, D. O., Siddiqui, R. S., Zheng, D., Agladze, M., Sumbly, V., Sandhu, J., Castillo, F. C., Chowdhury, N., Kondaveeti, R., Bhuiyan, S., Perez, L. G., Ranat, R., Gonzalez, C., Bhangoo, H., Williams, J., Osman, A. E., Kong, J., Ariyaratnam, J., Mohamed, M., Omran, I., Lopez, M., Nyabera, A., Landry, I., Iqbal, S., Gondal, A. Z., Hassan, S., Daoud, A., Baraka, B., Trandafirescu, T., & Rizzo, V. (2021). Current systematic reviews and meta-analyses of COVID-19. World journal of virology, 10(4), 182-208. https://doi.org/10.5501/wjv.v10.i4.182
Nassar, Mahmoud, et al. "Current systematic reviews and meta-analyses of COVID-19." World journal of virology vol. 10,4 (2021): 182-208. doi: https://doi.org/10.5501/wjv.v10.i4.182
Nassar M, Nso N, Alfishawy M, Novikov A, Yaghi S, Medina L, Toz B, Lakhdar S, Idrees Z, Kim Y, Gurung DO, Siddiqui RS, Zheng D, Agladze M, Sumbly V, Sandhu J, Castillo FC, Chowdhury N, Kondaveeti R, Bhuiyan S, Perez LG, Ranat R, Gonzalez C, Bhangoo H, Williams J, Osman AE, Kong J, Ariyaratnam J, Mohamed M, Omran I, Lopez M, Nyabera A, Landry I, Iqbal S, Gondal AZ, Hassan S, Daoud A, Baraka B, Trandafirescu T, Rizzo V. Current systematic reviews and meta-analyses of COVID-19. World J Virol. 2021 Jul 25;10(4):182-208. doi: 10.5501/wjv.v10.i4.182. PMID: 34367933; PMCID: PMC8316876.
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Lysosomal calcium and autophagy.

International review of cell and molecular biology

Medina DL.
PMID: 34253294
Int Rev Cell Mol Biol. 2021;362:141-170. doi: 10.1016/bs.ircmb.2021.03.002. Epub 2021 Apr 20.

Lysosomal calcium is emerging as a modulator of autophagy and lysosomal compartment, an obligatory partner to complete the autophagic pathway. A variety of specific signals such as nutrient deprivation or oxidative stress can trigger lysosomal calcium-mediated nuclear translocation of...

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Medina DL. Lysosomal calcium and autophagy. Int Rev Cell Mol Biol. 2021;362:141-170doi: 10.1016/bs.ircmb.2021.03.002.
Medina, D. L. (2021). Lysosomal calcium and autophagy. International review of cell and molecular biology, 362141-170. https://doi.org/10.1016/bs.ircmb.2021.03.002
Medina, Diego L. "Lysosomal calcium and autophagy." International review of cell and molecular biology vol. 362 (2021): 141-170. doi: https://doi.org/10.1016/bs.ircmb.2021.03.002
Medina DL. Lysosomal calcium and autophagy. Int Rev Cell Mol Biol. 2021;362:141-170. doi: 10.1016/bs.ircmb.2021.03.002. Epub 2021 Apr 20. PMID: 34253294.
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Standardized flow-cytometry-based protocol to simultaneously measure transcription factor levels.

STAR protocols

Manso BA, Medina KL.
PMID: 34041499
STAR Protoc. 2021 May 17;2(2):100485. doi: 10.1016/j.xpro.2021.100485. eCollection 2021 Jun 18.

Transcription factor (TF) expression levels drive developmental programs, including cell fate and function, and their measurement by flow cytometry allows for robust downstream analysis. However, significant batch-to-batch variability between replicative experiments precludes direct comparison of absolute values across experimental...

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Manso BA, Medina KL. Standardized flow-cytometry-based protocol to simultaneously measure transcription factor levels. STAR Protoc. 2021;2(2):100485doi: 10.1016/j.xpro.2021.100485.
Manso, B. A., & Medina, K. L. (2021). Standardized flow-cytometry-based protocol to simultaneously measure transcription factor levels. STAR protocols, 2(2), 100485. https://doi.org/10.1016/j.xpro.2021.100485
Manso, Bryce A, and Medina, Kay L. "Standardized flow-cytometry-based protocol to simultaneously measure transcription factor levels." STAR protocols vol. 2,2 (2021): 100485. doi: https://doi.org/10.1016/j.xpro.2021.100485
Manso BA, Medina KL. Standardized flow-cytometry-based protocol to simultaneously measure transcription factor levels. STAR Protoc. 2021 May 17;2(2):100485. doi: 10.1016/j.xpro.2021.100485. eCollection 2021 Jun 18. PMID: 34041499; PMCID: PMC8141467.
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Automatic identification of small molecules that promote cell conversion and reprogramming.

Stem cell reports

Napolitano F, Rapakoulia T, Annunziata P, Hasegawa A, Cardon M, Napolitano S, Vaccaro L, Iuliano A, Wanderlingh LG, Kasukawa T, Medina DL, Cacchiarelli D, Gao X, di Bernardo D, Arner E.
PMID: 33891873
Stem Cell Reports. 2021 May 11;16(5):1381-1390. doi: 10.1016/j.stemcr.2021.03.028. Epub 2021 Apr 22.

Controlling cell fate has great potential for regenerative medicine, drug discovery, and basic research. Although transcription factors are able to promote cell reprogramming and transdifferentiation, methods based on their upregulation often show low efficiency. Small molecules that can facilitate...

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Napolitano F, Rapakoulia T, Annunziata P, et al. Automatic identification of small molecules that promote cell conversion and reprogramming. Stem Cell Reports. 2021;16(5):1381-1390doi: 10.1016/j.stemcr.2021.03.028.
Napolitano, F., Rapakoulia, T., Annunziata, P., Hasegawa, A., Cardon, M., Napolitano, S., Vaccaro, L., Iuliano, A., Wanderlingh, L. G., Kasukawa, T., Medina, D. L., Cacchiarelli, D., Gao, X., di Bernardo, D., & Arner, E. (2021). Automatic identification of small molecules that promote cell conversion and reprogramming. Stem cell reports, 16(5), 1381-1390. https://doi.org/10.1016/j.stemcr.2021.03.028
Napolitano, Francesco, et al. "Automatic identification of small molecules that promote cell conversion and reprogramming." Stem cell reports vol. 16,5 (2021): 1381-1390. doi: https://doi.org/10.1016/j.stemcr.2021.03.028
Napolitano F, Rapakoulia T, Annunziata P, Hasegawa A, Cardon M, Napolitano S, Vaccaro L, Iuliano A, Wanderlingh LG, Kasukawa T, Medina DL, Cacchiarelli D, Gao X, di Bernardo D, Arner E. Automatic identification of small molecules that promote cell conversion and reprogramming. Stem Cell Reports. 2021 May 11;16(5):1381-1390. doi: 10.1016/j.stemcr.2021.03.028. Epub 2021 Apr 22. PMID: 33891873; PMCID: PMC8185468.
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A novel telencephalon-opto-hypothalamic morphogenetic domain coexpressing Foxg1 and Otp produces most of the glutamatergic neurons of the medial extended amygdala.

The Journal of comparative neurology

Morales L, Castro-Robles B, Abellán A, Desfilis E, Medina L.
PMID: 33386618
J Comp Neurol. 2021 Jul 01;529(10):2418-2449. doi: 10.1002/cne.25103. Epub 2021 Jan 13.

Deficits in social cognition and behavior are a hallmark of many psychiatric disorders. The medial extended amygdala, including the medial amygdala and the medial bed nucleus of the stria terminalis, is a key component of functional networks involved in...

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Morales L, Castro-Robles B, Abellán A, et al. A novel telencephalon-opto-hypothalamic morphogenetic domain coexpressing Foxg1 and Otp produces most of the glutamatergic neurons of the medial extended amygdala. J Comp Neurol. 2021;529(10):2418-2449doi: 10.1002/cne.25103.
Morales, L., Castro-Robles, B., Abellán, A., Desfilis, E., & Medina, L. (2021). A novel telencephalon-opto-hypothalamic morphogenetic domain coexpressing Foxg1 and Otp produces most of the glutamatergic neurons of the medial extended amygdala. The Journal of comparative neurology, 529(10), 2418-2449. https://doi.org/10.1002/cne.25103
Morales, Lorena, et al. "A novel telencephalon-opto-hypothalamic morphogenetic domain coexpressing Foxg1 and Otp produces most of the glutamatergic neurons of the medial extended amygdala." The Journal of comparative neurology vol. 529,10 (2021): 2418-2449. doi: https://doi.org/10.1002/cne.25103
Morales L, Castro-Robles B, Abellán A, Desfilis E, Medina L. A novel telencephalon-opto-hypothalamic morphogenetic domain coexpressing Foxg1 and Otp produces most of the glutamatergic neurons of the medial extended amygdala. J Comp Neurol. 2021 Jul 01;529(10):2418-2449. doi: 10.1002/cne.25103. Epub 2021 Jan 13. PMID: 33386618.
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Showing 313 to 318 of 318 entries