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Showing 133 to 140 of 140 entries
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Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea.

Experimental eye research

Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H.
PMID: 34929160
Exp Eye Res. 2021 Dec 18;215:108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 18.

The cornea is transparent and innervated by a dense collection of sensory nerves originating from the ocular branch of the trigeminal nerve. This study was designed to comprehensively analyze alterations of corneal sub-basal nerve plexus in a mouse model...

Corrigendum to: Formation and immunomodulatory function of meningeal B cell aggregates in progressive CNS autoimmunity.

Brain : a journal of neurology

Mitsdoerffer M, Di Liberto G, Dötsch S, Sie C, Wagner I, Pfaller M, Kreutzfeldt M, Fräßle S, Aly L, Knier B, Busch DH, Merkler D, Korn T.
PMID: 34259834
Brain. 2021 Oct 22;144(9):e83. doi: 10.1093/brain/awab235.

No abstract available.

Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea.

Experimental eye research

Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H.
PMID: 34929160
Exp Eye Res. 2021 Dec 17;108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 17.

The cornea is transparent and innervated by a dense collection of sensory nerves originating from the ocular branch of the trigeminal nerve. This study was designed to comprehensively analyze alterations of corneal sub-basal nerve plexus in a mouse model...

Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis.

European journal of immunology

Neumeier D, Pedrioli A, Genovese A, Sandu I, Ehling R, Hong KL, Papadopoulou C, Agrafiotis A, Kuhn R, Shlesinger D, Robbiani D, Han J, Hauri L, Csepregi L, Greiff V, Merkler D, Reddy ST, Oxenius A, Yermanos A.
PMID: 34727578
Eur J Immunol. 2021 Nov 02; doi: 10.1002/eji.202149331. Epub 2021 Nov 02.

Plasma cells and their secreted antibodies play a central role in the long-term protection against chronic viral infection. However, due to experimental limitations, a comprehensive description of linked genotypic, phenotypic, and antibody repertoire features of plasma cells (gene expression,...

Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea.

Experimental eye research

Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H.
PMID: 34929160
Exp Eye Res. 2021 Dec 18;215:108900. doi: 10.1016/j.exer.2021.108900. Epub 2021 Dec 18.

The cornea is transparent and innervated by a dense collection of sensory nerves originating from the ocular branch of the trigeminal nerve. This study was designed to comprehensively analyze alterations of corneal sub-basal nerve plexus in a mouse model...

White Matter Disruption in Pediatric Traumatic Brain Injury: Results from ENIGMA Pediatric Moderate to Severe Traumatic Brain Injury.

Neurology

Dennis EL, Caeyenberghs K, Hoskinson KR, Merkley TL, Suskauer SJ, Asarnow RF, Babikian T, Bartnik-Olson B, Bickart K, Bigler ED, Ewing-Cobbs L, Figaji A, Giza CC, Goodrich-Hunsaker NJ, Hodges CB, Hovenden Aa ES, Irimia A, Königs M, Levin HS, Lindsey HM, Max JE, Newsome MR, Olsen A, Ryan NP, Schmidt AT, Spruiell MS, Wade BS, Ware AL, Watson CG, Wheeler AL, Yeates KO, Zielinski BA, Kochunov P, Jahanshad N, Thompson PM, Tate DF, Wilde EA.
PMID: 34050006
Neurology. 2021 May 28; doi: 10.1212/WNL.0000000000012222. Epub 2021 May 28.

OBJECTIVE: Our study addressed aims: (1) test the hypothesis that moderate-severe TBI in pediatric patients is associated with widespread white matter (WM) disruption; (2) test the hypothesis that age and sex impact WM organization after injury; and (3) examine...

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy.

Science immunology

Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ.
PMID: 34215680
Sci Immunol. 2021 Jul 02;6(61). doi: 10.1126/sciimmunol.abi7083.

Immunotherapy is revolutionizing cancer treatment but is often restricted by toxicities. What distinguishes adverse events from concomitant antitumor reactions is poorly understood. Here, using anti-CD40 treatment in mice as a model of T

Efficacy of Dapagliflozin on Renal Function and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction: Results of DAPA-HF.

Circulation

Jhund PS, Solomon SD, Docherty KF, Heerspink HJL, Anand IS, Böhm M, Chopra V, de Boer RA, Desai AS, Ge J, Kitakaze M, Merkley B, O'Meara E, Shou M, Tereshchenko S, Verma S, Vinh PN, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Bengtsson O, Langkilde AM, Sjöstrand M, McMurray JJV.
PMID: 33040613
Circulation. 2021 Jan 26;143(4):298-309. doi: 10.1161/CIRCULATIONAHA.120.050391. Epub 2020 Oct 12.

BACKGROUND: Many patients with heart failure and reduced ejection fraction (HFrEF) have chronic kidney disease that complicates pharmacological management and is associated with worse outcomes. We assessed the safety and efficacy of dapagliflozin in patients with HFrEF, according to...

Showing 133 to 140 of 140 entries