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Showing 25 to 36 of 87 entries
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Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium.

Frontiers in oncology

Chuang SC, Agudo A, Ahrens W, Anantharaman D, Benhamou S, Boccia S, Chen C, Conway DI, Fabianova E, Hayes RB, Healy CM, Holcatova I, Kjaerheim K, Lagiou P, Lazarus P, Macfarlane TV, Mahimkar MB, Mates D, Matsuo K, Merletti F, Metspalu A, Morgenstern H, Muscat J, Cadoni G, Olshan AF, Purdue M, Ramroth H, Rudnai P, Schwartz SM, Simonato L, Smith EM, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Thomson P, Wei Q, Zaridze D, Zhang ZF, Znaor A, Brennan P, Boffetta P, Hashibe M.
PMID: 22655231
Front Oncol. 2011 Jul 12;1:13. doi: 10.3389/fonc.2011.00013. eCollection 2011.

Previous molecular epidemiological studies on head and neck cancer have examined various single nucleotide polymorphisms (SNPs), but there are very few documented associations. In the International head and neck cancer epidemiology (INHANCE) consortium, we evaluated associations between SNPs in...

Enantioselective Henry reaction catalyzed by Cu(II) salt and bipiperidine.

The Journal of organic chemistry

Noole A, Lippur K, Metsala A, Lopp M, Kanger T.
PMID: 20095538
J Org Chem. 2010 Feb 19;75(4):1313-6. doi: 10.1021/jo902664v.

A complex derived from the enantiomeric bipiperidine and copper(II) acetate hydrate is an efficient catalyst for the enantioselective Henry reaction. The easy availability of both catalyst components, mild reaction conditions, high yield, and good to excellent enantioselectivity make the...

Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia.

Gastroenterology research and practice

Serrano-Fernandez P, Dymerska D, Kurzawski G, Derkacz R, Sobieszczańska T, Banaszkiewicz Z, Roomere H, Oitmaa E, Metspalu A, Janavičius R, Elsakov P, Razumas M, Petrulis K, Irmejs A, Miklaševičs E, Scott RJ, Lubiński J.
PMID: 26101521
Gastroenterol Res Pract. 2015;2015:204089. doi: 10.1155/2015/204089. Epub 2015 May 26.

The continued identification of new low-penetrance genetic variants for colorectal cancer (CRC) raises the question of their potential cumulative effect among compound carriers. We focused on 6 SNPs (rs380284, rs4464148, rs4779584, rs4939827, rs6983267, and rs10795668), already described as risk...

Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants.

European journal of human genetics : EJHG

Leitsalu L, Palover M, Sikka TT, Reigo A, Kals M, Pärn K, Nikopensius T, Esko T, Metspalu A, Padrik P, Tõnisson N.
PMID: 33230308
Eur J Hum Genet. 2021 Mar;29(3):471-481. doi: 10.1038/s41431-020-00760-2. Epub 2020 Nov 23.

Genotype-first approach allows to systematically identify carriers of pathogenic variants in BRCA1/2 genes conferring a high risk of familial breast and ovarian cancer. Participants of the Estonian biobank have expressed support for the disclosure of clinically significant findings. With...

Genetic ancestry changes in Stone to Bronze Age transition in the East European plain.

Science advances

Saag L, Vasilyev SV, Varul L, Kosorukova NV, Gerasimov DV, Oshibkina SV, Griffith SJ, Solnik A, Saag L, D'Atanasio E, Metspalu E, Reidla M, Rootsi S, Kivisild T, Scheib CL, Tambets K, Kriiska A, Metspalu M.
PMID: 33523926
Sci Adv. 2021 Jan 20;7(4). doi: 10.1126/sciadv.abd6535. Print 2021 Jan.

The transition from Stone to Bronze Age in Central and Western Europe was a period of major population movements originating from the Ponto-Caspian Steppe. Here, we report new genome-wide sequence data from 30 individuals north of this area, from...

Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis.

American journal of human genetics

Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJA, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Walter K, Chen L, Yanek L, Becker LC, Peloso GM, Wakabayashi A, Kals M, Metspalu A, Esko T, Fox K, Wallace R, Franceschini N, Matijevic N, Rice KM, Bartz TM, Lyytikäinen LP, Kähönen M, Lehtimäki T, Raitakari OT, Li-Gao R, Mook-Kanamori DO, Lettre G, van Duijn CM, Franco OH, Rich SS, Rivadeneira F, Hofman A, Uitterlinden AG, Wilson JG, Psaty BM, Soranzo N, Dehghan A, Boerwinkle E, Zhang X, Johnson AD, O'Donnell CJ, Johnsen JM, Reiner AP, Ganesh SK, Sankaran VG.
PMID: 27588453
Am J Hum Genet. 2016 Sep 01;99(3):785. doi: 10.1016/j.ajhg.2016.08.002. Epub 2016 Sep 01.

No abstract available.

The Ami and Yami aborigines of Taiwan and their genetic relationship to East Asian and Pacific populations.

European journal of human genetics : EJHG

Tätte K, Metspalu E, Post H, Palencia-Madrid L, Luis JR, Reidla M, Rea A, Tamm E, Moding EJ, de Pancorbo MM, Garcia-Bertrand R, Metspalu M, Herrera RJ.
PMID: 33753914
Eur J Hum Genet. 2021 Jul;29(7):1092-1102. doi: 10.1038/s41431-021-00837-6. Epub 2021 Mar 23.

This article reports on the genetic characteristics of the Ami and Yami, two aboriginal populations of Taiwan. Y-SNP and mtDNA markers as well as autosomal SNPs were utilized to investigate the phylogenetic relationships to groups from MSEA (mainland Southeast...

Mendelian Randomization Identifies the Potential Causal Impact of Dietary Patterns on Circulating Blood Metabolites.

Frontiers in genetics

Taba N, Valge HK, Metspalu A, Esko T, Wilson JF, Fischer K, Pirastu N.
PMID: 34790224
Front Genet. 2021 Nov 01;12:738265. doi: 10.3389/fgene.2021.738265. eCollection 2021.

Nutrition plays an important role in the development and progress of several health conditions, but the exact mechanism is often still unclear. Blood metabolites are likely candidates to be mediating these relationships, as their levels are strongly dependent on...

Enantioselective Michael addition to vinyl phosphonates .

Chemical science

Kaasik M, Martõnova J, Erkman K, Metsala A, Järving I, Kanger T.
PMID: 34163847
Chem Sci. 2021 Apr 26;12(21):7561-7568. doi: 10.1039/d1sc01029h.

An asymmetric Michael addition of malononitrile to vinyl phosphonates was accomplished by hydrogen bond-enhanced bifunctional halogen bond (XB) catalysis. NMR titration experiments were used to demonstrate that halogen bonding, with the support of hydrogen-bonding, played a key role in...

Papua New Guinean Genomes Reveal the Complex Settlement of North Sahul.

Molecular biology and evolution

Brucato N, André M, Tsang R, Saag L, Kariwiga J, Sesuki K, Beni T, Pomat W, Muke J, Meyer V, Boland A, Deleuze JF, Sudoyo H, Mondal M, Pagani L, Gallego Romero I, Metspalu M, Cox MP, Leavesley M, Ricaut FX.
PMID: 34383935
Mol Biol Evol. 2021 Oct 27;38(11):5107-5121. doi: 10.1093/molbev/msab238.

The settlement of Sahul, the lost continent of Oceania, remains one of the most ancient and debated human migrations. Modern New Guineans inherited a unique genetic diversity tracing back 50,000 years, and yet there is currently no model reconstructing...

Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

Nature communications

Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, Faggian A, Bonnefond A, Fadista J, Stathopoulou MG, Isaacs A, Willems SM, Navarro P, Tanaka T, Jackson AU, Montasser ME, O'Connell JR, Bielak LF, Webster RJ, Saxena R, Stafford JM, Pourcain BS, Timpson NJ, Salo P, Shin SY, Amin N, Smith AV, Li G, Verweij N, Goel A, Ford I, Johnson PCD, Johnson T, Kapur K, Thorleifsson G, Strawbridge RJ, Rasmussen-Torvik LJ, Esko T, Mihailov E, Fall T, Fraser RM, Mahajan A, Kanoni S, Giedraitis V, Kleber ME, Silbernagel G, Meyer J, Müller-Nurasyid M, Ganna A, Sarin AP, Yengo L, Shungin D, Luan J, Horikoshi M, An P, Sanna S, Boettcher Y, Rayner NW, Nolte IM, Zemunik T, Iperen EV, Kovacs P, Hastie ND, Wild SH, McLachlan S, Campbell S, Polasek O, Carlson O, Egan J, Kiess W, Willemsen G, Kuusisto J, Laakso M, Dimitriou M, Hicks AA, Rauramaa R, Bandinelli S, Thorand B, Liu Y, Miljkovic I, Lind L, Doney A, Perola M, Hingorani A, Kivimaki M, Kumari M, Bennett AJ, Groves CJ, Herder C, Koistinen HA, Kinnunen L, Faire U, Bakker SJL, Uusitupa M, Palmer CNA, Jukema JW, Sattar N, Pouta A, Snieder H, Boerwinkle E, Pankow JS, Magnusson PK, Krus U, Scapoli C, de Geus EJCN, Blüher M, Wolffenbuttel BHR, Province MA, Abecasis GR, Meigs JB, Hovingh GK, Lindström J, Wilson JF, Wright AF, Dedoussis GV, Bornstein SR, Schwarz PEH, Tönjes A, Winkelmann BR, Boehm BO, März W, Metspalu A, Price JF, Deloukas P, Körner A, Lakka TA, Keinanen-Kiukaanniemi SM, Saaristo TE, Bergman RN, Tuomilehto J, Wareham NJ, Langenberg C, Männistö S, Franks PW, Hayward C, Vitart V, Kaprio J, Visvikis-Siest S, Balkau B, Altshuler D, Rudan I, Stumvoll M, Campbell H, van Duijn CM, Gieger C, Illig T, Ferrucci L, Pedersen NL, Pramstaller PP, Boehnke M, Frayling TM, Shuldiner AR, Peyser PA, Kardia SLR, Palmer LJ, Penninx BW, Meneton P, Harris TB, Navis G, Harst PV, Smith GD, Forouhi NG, Loos RJF, Salomaa V, Soranzo N, Boomsma DI, Groop L, Tuomi T, Hofman A, Munroe PB, Gudnason V, Siscovick DS, Watkins H, Lecoeur C, Vollenweider P, Franco-Cereceda A, Eriksson P, Jarvelin MR, Stefansson K, Hamsten A, Nicholson G, Karpe F, Dermitzakis ET, Lindgren CM, McCarthy MI, Froguel P, Kaakinen MA, Lyssenko V, Watanabe RM, Ingelsson E, Florez JC, Dupuis J, Barroso I, Morris AP, Prokopenko I.
PMID: 33558525
Nat Commun. 2021 Feb 08;12(1):995. doi: 10.1038/s41467-021-21276-3.

No abstract available.

Continental-scale genomic analysis suggests shared post-admixture adaptation in the Americas.

Human molecular genetics

Ongaro L, Mondal M, Flores R, Marnetto D, Molinaro L, Alarcón-Riquelme ME, Moreno-Estrada A, Mabunda N, Ventura M, Tambets K, Hellenthal G, Capelli C, Kivisild T, Metspalu M, Pagani L, Montinaro F.
PMID: 34196708
Hum Mol Genet. 2021 Nov 01;30(22):2123-2134. doi: 10.1093/hmg/ddab177.

American populations are one of the most interesting examples of recently admixed groups, where ancestral components from three major continental human groups (Africans, Eurasians and Native Americans) have admixed within the last 15 generations. Recently, several genetic surveys focusing...

Showing 25 to 36 of 87 entries