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Showing 337 to 346 of 346 entries
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Detection of Plasma Cell Disorders by Mass Spectrometry: A Comprehensive Review of 19,523 Cases.

Mayo Clinic proceedings

Dasari S, Kohlhagen MC, Dispenzieri A, Willrich MAV, Snyder MR, Kourelis TV, Lust JA, Mills JR, Kyle RA, Murray DL.
PMID: 34887112
Mayo Clin Proc. 2021 Dec 06; doi: 10.1016/j.mayocp.2021.07.024. Epub 2021 Dec 06.

OBJECTIVES: To verify the analytical performance of a new mass spectrometry-based method, termed MASS-FIX, when screening for plasma cell disorders in a routine clinical laboratory.PATIENTS AND METHODS: Results from 19,523 unique patients tested for an M-protein between July 24,...

Feasibility of Electromagnetic Knee Imaging Verified on ex-vivo Pig Knees.

IEEE transactions on bio-medical engineering

Sultan KS, Mohammed BJ, Manoufali M, Mahmoud A, Mills PC, Abbosh A.
PMID: 34752378
IEEE Trans Biomed Eng. 2021 Nov 09; doi: 10.1109/TBME.2021.3126714. Epub 2021 Nov 09.

OBJECTIVE: The potential of electromagnetic (EM) knee imaging system verified on ex-vivo pig knee joint as an essential step before clinical trials is demonstrated. The system, which includes an antenna array of eight printed biconical elements operating at the...

Making sense of it all: Ethical reflections on the conditions surrounding the first genome-edited babies.

Wellcome open research

Chen Q, Ma Y, Schaefer GO, Xafis V, Labude M, Mills P.
PMID: 34395922
Wellcome Open Res. 2020 Sep 16;5:216. doi: 10.12688/wellcomeopenres.16295.1. eCollection 2020.

In November 2018 the birth of the first genome-edited human beings was announced. The ensuing ethical controversy, institutional investigations and legal proceedings led to the revision of standards, rules and procedures at many levels. Arguably, however, these developments have...

Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients.

Cellular and molecular bioengineering

Courelli V, Ahmad A, Ghassemian M, Pruitt C, Mills PJ, Schmid-Schönbein GW.
PMID: 34900012
Cell Mol Bioeng. 2021 Aug 13;14(6):583-596. doi: 10.1007/s12195-021-00693-w. eCollection 2021 Dec.

INTRODUCTION: Heart failure is associated with degradation of cell functions and extracellular matrix proteins, but the trigger mechanisms are uncertain. Our recent evidence shows that active digestive enzymes can leak out of the small intestine into the systemic circulation...

Improved Uranium Isotope Ratio Analysis in Liquid Sampling-Atmospheric Pressure Glow Discharge/Orbitrap FTMS Coupling through the Use of an External Data Acquisition System.

Journal of the American Society for Mass Spectrometry

Bills JR, Nagornov KO, Kozhinov AN, Williams TJ, Tsybin YO, Marcus RK.
PMID: 33793219
J Am Soc Mass Spectrom. 2021 May 05;32(5):1224-1236. doi: 10.1021/jasms.1c00051. Epub 2021 Apr 01.

Isotope ratio (IR) analysis of natural abundance uranium presents a formidable challenge for mass spectrometry (MS): the required spectral dynamic range needs to enable the quantitatively accurate measurement of the

Cell-Free Mitochondrial DNA as a Potential Biomarker for Astronauts' Health.

Journal of the American Heart Association

Bisserier M, Shanmughapriya S, Rai AK, Gonzalez C, Brojakowska A, Garikipati VNS, Madesh M, Mills PJ, Walsh K, Arakelyan A, Kishore R, Hadri L, Goukassian DA.
PMID: 34666498
J Am Heart Assoc. 2021 Nov 02;10(21):e022055. doi: 10.1161/JAHA.121.022055. Epub 2021 Oct 20.

Background Space travel-associated stressors such as microgravity or radiation exposure have been reported in astronauts after short- and long-duration missions aboard the International Space Station. Despite risk mitigation strategies, adverse health effects remain a concern. Thus, there is a...

Positive Predictive Value of Myelin Oligodendrocyte Glycoprotein Autoantibody Testing.

JAMA neurology

Sechi E, Buciuc M, Pittock SJ, Chen JJ, Fryer JP, Jenkins SM, Budhram A, Weinshenker BG, Lopez-Chiriboga AS, Tillema JM, McKeon A, Mills JR, Tobin WO, Flanagan EP.
PMID: 33900394
JAMA Neurol. 2021 Jun 01;78(6):741-746. doi: 10.1001/jamaneurol.2021.0912.

IMPORTANCE: Myelin oligodendrocyte glycoprotein-IgG1-associated disorder (MOGAD) is a distinct central nervous system-demyelinating disease. Positive results on MOG-IgG1 testing by live cell-based assays can confirm a MOGAD diagnosis, but false-positive results may occur.OBJECTIVE: To determine the positive predictive value (PPV)...

Clinical Utility of Striational Antibodies in Paraneoplastic and Myasthenia Gravis Paraneoplastic Panels.

Neurology

Shelly S, Mills JR, Dubey D, McKeon A, Zekeridou A, Pittock SJ, Harper CM, Naddaf E, Milone M, Mandrekar J, Klein CJ.
PMID: 33903199
Neurology. 2021 Apr 26; doi: 10.1212/WNL.0000000000012050. Epub 2021 Apr 26.

OBJECTIVE: To critically assess the clinical utility of striational antibodies (StrAbs) within paraneoplastic and myasthenia gravis serological evaluations.METHODS: All Mayo Clinic patients tested for StrAbs from January 1RESULTS: 38,502 unique paraneoplastic and 1,899 MG patients were tested. In paraneoplastic...

Reliability, Validity, and Performance Characteristics of Elite Adolescent Athletes at Different Stages of Maturityin the 10 to 5 Repeated Jump Test.

Pediatric exercise science

Baker J, Shillabeer B, Brandner C, Graham-Smith P, Mills P, Read P.
PMID: 34517340
Pediatr Exerc Sci. 2021 Sep 11;1-8. doi: 10.1123/pes.2020-0270. Epub 2021 Sep 11.

PURPOSE: To examine the reliability, validity, and performance characteristics of the 10 to 5 repeated jump test (10-5 RJT) in adolescent male athletes. The 10-5 RJT has been shown to be a valid and reliable test of reactive strength...

Design, development and validation of the RedBrick Health Assessment: a questionnaire-based study.

JRSM short reports

Mills PR, Masloski WS, Bashaw CM, Butler JR, Hillstrom ME, Zimmerman EM.
PMID: 21969882
JRSM Short Rep. 2011 Sep;2(9):71. doi: 10.1258/shorts.2011.011015. Epub 2011 Sep 01.

OBJECTIVES: Health risk assessment (HRA) questionnaires have become a popular tool to help quantify health issues within populations. Over the last decade HRAs have increasingly been delivered in the online environment. The objective of this study was to create...

Showing 337 to 346 of 346 entries