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Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds.

Chemical science

Millward MJ, Ellis E, Ward JW, Clayden J.
PMID: 34163972
Chem Sci. 2020 Dec 14;12(6):2091-2096. doi: 10.1039/d0sc06188c.

Bicyclic or tricyclic nitrogen-containing heterocyclic scaffolds were constructed rapidly by intramolecular nucleophilic aromatic substitution of metallated nitriles tethered by a urea linkage to a series of electronically unactivated heterocyclic precursors. The substitution reaction constitutes a ring expansion, enabled by...

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Millward MJ, Ellis E, Ward JW, et al. Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds. Chem Sci. 2020;12(6):2091-2096doi: 10.1039/d0sc06188c.
Millward, M. J., Ellis, E., Ward, J. W., & Clayden, J. (2020). Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds. Chemical science, 12(6), 2091-2096. https://doi.org/10.1039/d0sc06188c
Millward, Makenzie J, et al. "Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds." Chemical science vol. 12,6 (2020): 2091-2096. doi: https://doi.org/10.1039/d0sc06188c
Millward MJ, Ellis E, Ward JW, Clayden J. Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bonds. Chem Sci. 2020 Dec 14;12(6):2091-2096. doi: 10.1039/d0sc06188c. PMID: 34163972; PMCID: PMC8179327.
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Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer.

JMIR medical informatics

Enriquez JS, Chu Y, Pudakalakatti S, Hsieh KL, Salmon D, Dutta P, Millward NZ, Lurie E, Millward S, McAllister F, Maitra A, Sen S, Killary A, Zhang J, Jiang X, Bhattacharya PK, Shams S.
PMID: 34137725
JMIR Med Inform. 2021 Jun 17;9(6):e26601. doi: 10.2196/26601.

BACKGROUND: There is an unmet need for noninvasive imaging markers that can help identify the aggressive subtype(s) of pancreatic ductal adenocarcinoma (PDAC) at diagnosis and at an earlier time point, and evaluate the efficacy of therapy prior to tumor...

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Enriquez JS, Chu Y, Pudakalakatti S, et al. Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer. JMIR Med Inform. 2021;9(6):e26601doi: 10.2196/26601.
Enriquez, J. S., Chu, Y., Pudakalakatti, S., Hsieh, K. L., Salmon, D., Dutta, P., Millward, N. Z., Lurie, E., Millward, S., McAllister, F., Maitra, A., Sen, S., Killary, A., Zhang, J., Jiang, X., Bhattacharya, P. K., & Shams, S. (2021). Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer. JMIR medical informatics, 9(6), e26601. https://doi.org/10.2196/26601
Enriquez, José S, et al. "Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer." JMIR medical informatics vol. 9,6 (2021): e26601. doi: https://doi.org/10.2196/26601
Enriquez JS, Chu Y, Pudakalakatti S, Hsieh KL, Salmon D, Dutta P, Millward NZ, Lurie E, Millward S, McAllister F, Maitra A, Sen S, Killary A, Zhang J, Jiang X, Bhattacharya PK, Shams S. Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer. JMIR Med Inform. 2021 Jun 17;9(6):e26601. doi: 10.2196/26601. PMID: 34137725; PMCID: PMC8277399.
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Use of core outcome sets was low in clinical trials published in major medical journals.

Journal of clinical epidemiology

Matvienko-Sikar K, Avery K, Blazeby JM, Devane D, Dodd S, Egan AM, Gorst SL, Hughes K, Jacobsen P, Kirkham JJ, Kottner J, Mellor K, Millward CP, Patel S, Quirke F, Saldanha IJ, Smith V, Terwee CB, Young AE, Williamson PR.
PMID: 34715310
J Clin Epidemiol. 2021 Oct 29;142:19-28. doi: 10.1016/j.jclinepi.2021.10.012. Epub 2021 Oct 29.

OBJECTIVES: To examine current practices in late-phase trials published in major medical journals and examine trialists' views about core outcome set (COS) use.STUDY DESIGN AND SETTING: A sequential multi-methods study was conducted. We examined late-phase trials published between October...

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Matvienko-Sikar K, Avery K, Blazeby JM, et al. Use of core outcome sets was low in clinical trials published in major medical journals. J Clin Epidemiol. 2021;142:19-28doi: 10.1016/j.jclinepi.2021.10.012.
Matvienko-Sikar, K., Avery, K., Blazeby, J. M., Devane, D., Dodd, S., Egan, A. M., Gorst, S. L., Hughes, K., Jacobsen, P., Kirkham, J. J., Kottner, J., Mellor, K., Millward, C. P., Patel, S., Quirke, F., Saldanha, I. J., Smith, V., Terwee, C. B., Young, A. E., & Williamson, P. R. (2021). Use of core outcome sets was low in clinical trials published in major medical journals. Journal of clinical epidemiology, 14219-28. https://doi.org/10.1016/j.jclinepi.2021.10.012
Matvienko-Sikar, Karen, et al. "Use of core outcome sets was low in clinical trials published in major medical journals." Journal of clinical epidemiology vol. 142 (2021): 19-28. doi: https://doi.org/10.1016/j.jclinepi.2021.10.012
Matvienko-Sikar K, Avery K, Blazeby JM, Devane D, Dodd S, Egan AM, Gorst SL, Hughes K, Jacobsen P, Kirkham JJ, Kottner J, Mellor K, Millward CP, Patel S, Quirke F, Saldanha IJ, Smith V, Terwee CB, Young AE, Williamson PR. Use of core outcome sets was low in clinical trials published in major medical journals. J Clin Epidemiol. 2021 Oct 29;142:19-28. doi: 10.1016/j.jclinepi.2021.10.012. Epub 2021 Oct 29. PMID: 34715310.
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CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service.

Neuro-oncology advances

Fountain DM, Piper RJ, Poon MTC, Solomou G, Brennan PM, Chowdhury YA, Colombo F, Elmoslemany T, Ewbank FG, Grundy PL, Hasan MT, Hilling M, Hutchinson PJ, Karabatsou K, Kolias AG, McSorley NJ, Millward CP, Phang I, Plaha P, Price SJ, Rominiyi O, Sage W, Shumon S, Silva IL, Smith SJ, Surash S, Thomson S, Lau JY, Watts C, Jenkinson MD.
PMID: 34056602
Neurooncol Adv. 2021 Jan 28;3(1):vdab014. doi: 10.1093/noajnl/vdab014. eCollection 2021.

BACKGROUND: The COVID-19 pandemic has profoundly affected cancer services. Our objective was to determine the effect of the COVID-19 pandemic on decision making and the resulting outcomes for patients with newly diagnosed or recurrent intracranial tumors.METHODS: We performed a...

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Fountain DM, Piper RJ, Poon MTC, et al. CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service. Neurooncol Adv. 2021;3(1):vdab014doi: 10.1093/noajnl/vdab014.
Fountain, D. M., Piper, R. J., Poon, M. T. C., Solomou, G., Brennan, P. M., Chowdhury, Y. A., Colombo, F., Elmoslemany, T., Ewbank, F. G., Grundy, P. L., Hasan, M. T., Hilling, M., Hutchinson, P. J., Karabatsou, K., Kolias, A. G., McSorley, N. J., Millward, C. P., Phang, I., Plaha, P., Price, S. J., Rominiyi, O., Sage, W., Shumon, S., Silva, I. L., Smith, S. J., Surash, S., Thomson, S., Lau, J. Y., Watts, C., Jenkinson, M. D. (2021). CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service. Neuro-oncology advances, 3(1), vdab014. https://doi.org/10.1093/noajnl/vdab014
Fountain, Daniel M, et al. "CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service." Neuro-oncology advances vol. 3,1 (2021): vdab014. doi: https://doi.org/10.1093/noajnl/vdab014
Fountain DM, Piper RJ, Poon MTC, Solomou G, Brennan PM, Chowdhury YA, Colombo F, Elmoslemany T, Ewbank FG, Grundy PL, Hasan MT, Hilling M, Hutchinson PJ, Karabatsou K, Kolias AG, McSorley NJ, Millward CP, Phang I, Plaha P, Price SJ, Rominiyi O, Sage W, Shumon S, Silva IL, Smith SJ, Surash S, Thomson S, Lau JY, Watts C, Jenkinson MD. CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service. Neurooncol Adv. 2021 Jan 28;3(1):vdab014. doi: 10.1093/noajnl/vdab014. eCollection 2021. PMID: 34056602; PMCID: PMC7928638.
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The effects of perinatal fluoxetine exposure on emotionality behaviours and cortical and hippocampal glutamatergic receptors in female Sprague-Dawley and Wistar-Kyoto rats.

Progress in neuro-psychopharmacology & biological psychiatry

Millard SJ, Lum JS, Fernandez F, Weston-Green K, Newell KA.
PMID: 33189859
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jun 08;108:110174. doi: 10.1016/j.pnpbp.2020.110174. Epub 2020 Nov 12.

RATIONALE: There is increasing concern regarding the use of selective serotonin reuptake inhibitors (SSRIs) in pregnancy. Animal studies repeatedly show increased anxiety- and depressive-like behaviours in offspring exposed perinatally to SSRIs, however much of this research is in male...

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Millard SJ, Lum JS, Fernandez F, et al. The effects of perinatal fluoxetine exposure on emotionality behaviours and cortical and hippocampal glutamatergic receptors in female Sprague-Dawley and Wistar-Kyoto rats. Prog Neuropsychopharmacol Biol Psychiatry. 2020;108:110174doi: 10.1016/j.pnpbp.2020.110174.
Millard, S. J., Lum, J. S., Fernandez, F., Weston-Green, K., & Newell, K. A. (2021). The effects of perinatal fluoxetine exposure on emotionality behaviours and cortical and hippocampal glutamatergic receptors in female Sprague-Dawley and Wistar-Kyoto rats. Progress in neuro-psychopharmacology & biological psychiatry, 108110174. https://doi.org/10.1016/j.pnpbp.2020.110174
Millard, Samuel J, et al. "The effects of perinatal fluoxetine exposure on emotionality behaviours and cortical and hippocampal glutamatergic receptors in female Sprague-Dawley and Wistar-Kyoto rats." Progress in neuro-psychopharmacology & biological psychiatry vol. 108 (2021): 110174. doi: https://doi.org/10.1016/j.pnpbp.2020.110174
Millard SJ, Lum JS, Fernandez F, Weston-Green K, Newell KA. The effects of perinatal fluoxetine exposure on emotionality behaviours and cortical and hippocampal glutamatergic receptors in female Sprague-Dawley and Wistar-Kyoto rats. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jun 08;108:110174. doi: 10.1016/j.pnpbp.2020.110174. Epub 2020 Nov 12. PMID: 33189859.
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A phase 1b clinical trial optimizing regulatory T cell depletion in combination with platinum-based chemotherapy in thoracic cancers.

Expert review of anticancer therapy

Cook AM, McDonnell A, Millward MJ, Creaney J, Hasani A, McMullen M, Meniawy T, Robinson BWS, Lake RA, Nowak AK.
PMID: 33509005
Expert Rev Anticancer Ther. 2021 May;21(5):465-474. doi: 10.1080/14737140.2021.1882308. Epub 2021 Feb 09.

No abstract available.

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Cook AM, McDonnell A, Millward MJ, et al. A phase 1b clinical trial optimizing regulatory T cell depletion in combination with platinum-based chemotherapy in thoracic cancers. Expert Rev Anticancer Ther. 2021;21(5):465-474doi: 10.1080/14737140.2021.1882308.
Cook, A. M., McDonnell, A., Millward, M. J., Creaney, J., Hasani, A., McMullen, M., Meniawy, T., Robinson, B. W. S., Lake, R. A., & Nowak, A. K. (2021). A phase 1b clinical trial optimizing regulatory T cell depletion in combination with platinum-based chemotherapy in thoracic cancers. Expert review of anticancer therapy, 21(5), 465-474. https://doi.org/10.1080/14737140.2021.1882308
Cook, Alistair M, et al. "A phase 1b clinical trial optimizing regulatory T cell depletion in combination with platinum-based chemotherapy in thoracic cancers." Expert review of anticancer therapy vol. 21,5 (2021): 465-474. doi: https://doi.org/10.1080/14737140.2021.1882308
Cook AM, McDonnell A, Millward MJ, Creaney J, Hasani A, McMullen M, Meniawy T, Robinson BWS, Lake RA, Nowak AK. A phase 1b clinical trial optimizing regulatory T cell depletion in combination with platinum-based chemotherapy in thoracic cancers. Expert Rev Anticancer Ther. 2021 May;21(5):465-474. doi: 10.1080/14737140.2021.1882308. Epub 2021 Feb 09. PMID: 33509005.
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The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Millard SJ, Bearden CE, Karlsgodt KH, Sharpe MJ.
PMID: 34588607
Neuropsychopharmacology. 2021 Sep 29; doi: 10.1038/s41386-021-01188-y. Epub 2021 Sep 29.

Schizophrenia is a severe psychiatric disorder affecting 21 million people worldwide. People with schizophrenia suffer from symptoms including psychosis and delusions, apathy, anhedonia, and cognitive deficits. Strikingly, schizophrenia is characterised by a learning paradox involving difficulties learning from rewarding...

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Millard SJ, Bearden CE, Karlsgodt KH, et al. The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity. Neuropsychopharmacology. 2021;doi: 10.1038/s41386-021-01188-y.
Millard, S. J., Bearden, C. E., Karlsgodt, K. H., & Sharpe, M. J. (2021). The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, . https://doi.org/10.1038/s41386-021-01188-y
Millard, Samuel J, et al. "The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. (2021). doi: https://doi.org/10.1038/s41386-021-01188-y
Millard SJ, Bearden CE, Karlsgodt KH, Sharpe MJ. The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity. Neuropsychopharmacology. 2021 Sep 29; doi: 10.1038/s41386-021-01188-y. Epub 2021 Sep 29. PMID: 34588607.
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Outreach Medicine as an Experiential Teaching Tool to Improve Veterinary Student and Client Education.

Journal of veterinary medical education

Kim J, Rinke EJ, Matusicky ME, Millward LM.
PMID: 34342523
J Vet Med Educ. 2021 Aug 02;e20200128. doi: 10.3138/jvme-2020-0128. Epub 2021 Aug 02.

Outreach medicine is used to improve students' medical, technical, behavioral, and communication training among health professional schools; it is also used in veterinary schools, but little has been described on its educational impacts among pre-clinical veterinary students. Aiming to...

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Kim J, Rinke EJ, Matusicky ME, et al. Outreach Medicine as an Experiential Teaching Tool to Improve Veterinary Student and Client Education. J Vet Med Educ. 2021;e20200128doi: 10.3138/jvme-2020-0128.
Kim, J., Rinke, E. J., Matusicky, M. E., & Millward, L. M. (2021). Outreach Medicine as an Experiential Teaching Tool to Improve Veterinary Student and Client Education. Journal of veterinary medical education, e20200128. https://doi.org/10.3138/jvme-2020-0128
Kim, Jeffrey, et al. "Outreach Medicine as an Experiential Teaching Tool to Improve Veterinary Student and Client Education." Journal of veterinary medical education vol. (2021): e20200128. doi: https://doi.org/10.3138/jvme-2020-0128
Kim J, Rinke EJ, Matusicky ME, Millward LM. Outreach Medicine as an Experiential Teaching Tool to Improve Veterinary Student and Client Education. J Vet Med Educ. 2021 Aug 02;e20200128. doi: 10.3138/jvme-2020-0128. Epub 2021 Aug 02. PMID: 34342523.
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Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches.

Experimental hematology

Lévesque JP, Summers KM, Millard SM, Bisht K, Winkler IG, Pettit AR.
PMID: 34298116
Exp Hematol. 2021 Aug;100:12-31.e1. doi: 10.1016/j.exphem.2021.07.001. Epub 2021 Jul 21.

The bone marrow (BM) contains a mosaic of niches specialized in supporting different maturity stages of hematopoietic stem and progenitor cells such as hematopoietic stem cells and myeloid, lymphoid, and erythroid progenitors. Recent advances in BM imaging and conditional...

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Lévesque JP, Summers KM, Millard SM, et al. Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches. Exp Hematol. 2021;100:12-31.e1doi: 10.1016/j.exphem.2021.07.001.
Lévesque, J. P., Summers, K. M., Millard, S. M., Bisht, K., Winkler, I. G., & Pettit, A. R. (2021). Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches. Experimental hematology, 10012-31.e1. https://doi.org/10.1016/j.exphem.2021.07.001
Lévesque, Jean-Pierre, et al. "Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches." Experimental hematology vol. 100 (2021): 12-31.e1. doi: https://doi.org/10.1016/j.exphem.2021.07.001
Lévesque JP, Summers KM, Millard SM, Bisht K, Winkler IG, Pettit AR. Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches. Exp Hematol. 2021 Aug;100:12-31.e1. doi: 10.1016/j.exphem.2021.07.001. Epub 2021 Jul 21. PMID: 34298116.
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Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues.

Cell reports

Millard SM, Heng O, Opperman KS, Sehgal A, Irvine KM, Kaur S, Sandrock CJ, Wu AC, Magor GW, Batoon L, Perkins AC, Noll JE, Zannettino ACW, Sester DP, Levesque JP, Hume DA, Raggatt LJ, Summers KM, Pettit AR.
PMID: 34818538
Cell Rep. 2021 Nov 23;37(8):110058. doi: 10.1016/j.celrep.2021.110058.

Mouse hematopoietic tissues contain abundant tissue-resident macrophages that support immunity, hematopoiesis, and bone homeostasis. A systematic strategy to characterize macrophage subsets in mouse bone marrow (BM), spleen, and lymph node unexpectedly reveals that macrophage surface marker staining emanates from...

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Millard SM, Heng O, Opperman KS, et al. Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Rep. 2021;37(8):110058doi: 10.1016/j.celrep.2021.110058.
Millard, S. M., Heng, O., Opperman, K. S., Sehgal, A., Irvine, K. M., Kaur, S., Sandrock, C. J., Wu, A. C., Magor, G. W., Batoon, L., Perkins, A. C., Noll, J. E., Zannettino, A. C. W., Sester, D. P., Levesque, J. P., Hume, D. A., Raggatt, L. J., Summers, K. M., & Pettit, A. R. (2021). Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell reports, 37(8), 110058. https://doi.org/10.1016/j.celrep.2021.110058
Millard, Susan M, et al. "Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues." Cell reports vol. 37,8 (2021): 110058. doi: https://doi.org/10.1016/j.celrep.2021.110058
Millard SM, Heng O, Opperman KS, Sehgal A, Irvine KM, Kaur S, Sandrock CJ, Wu AC, Magor GW, Batoon L, Perkins AC, Noll JE, Zannettino ACW, Sester DP, Levesque JP, Hume DA, Raggatt LJ, Summers KM, Pettit AR. Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Rep. 2021 Nov 23;37(8):110058. doi: 10.1016/j.celrep.2021.110058. PMID: 34818538.
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Use of core outcome sets was low in clinical trials published in major medical journals.

Journal of clinical epidemiology

Matvienko-Sikar K, Avery K, Blazeby JM, Devane D, Dodd S, Egan AM, Gorst SL, Hughes K, Jacobsen P, Kirkham JJ, Kottner J, Mellor K, Millward CP, Patel S, Quirke F, Saldanha IJ, Smith V, Terwee CB, Young AE, Williamson PR.
PMID: 34715310
J Clin Epidemiol. 2021 Oct 29;142:19-28. doi: 10.1016/j.jclinepi.2021.10.012. Epub 2021 Oct 29.

OBJECTIVES: To examine current practices in late-phase trials published in major medical journals and examine trialists' views about core outcome set (COS) use.STUDY DESIGN AND SETTING: A sequential multi-methods study was conducted. We examined late-phase trials published between October...

Cite
Matvienko-Sikar K, Avery K, Blazeby JM, et al. Use of core outcome sets was low in clinical trials published in major medical journals. J Clin Epidemiol. 2021;142:19-28doi: 10.1016/j.jclinepi.2021.10.012.
Matvienko-Sikar, K., Avery, K., Blazeby, J. M., Devane, D., Dodd, S., Egan, A. M., Gorst, S. L., Hughes, K., Jacobsen, P., Kirkham, J. J., Kottner, J., Mellor, K., Millward, C. P., Patel, S., Quirke, F., Saldanha, I. J., Smith, V., Terwee, C. B., Young, A. E., & Williamson, P. R. (2021). Use of core outcome sets was low in clinical trials published in major medical journals. Journal of clinical epidemiology, 14219-28. https://doi.org/10.1016/j.jclinepi.2021.10.012
Matvienko-Sikar, Karen, et al. "Use of core outcome sets was low in clinical trials published in major medical journals." Journal of clinical epidemiology vol. 142 (2021): 19-28. doi: https://doi.org/10.1016/j.jclinepi.2021.10.012
Matvienko-Sikar K, Avery K, Blazeby JM, Devane D, Dodd S, Egan AM, Gorst SL, Hughes K, Jacobsen P, Kirkham JJ, Kottner J, Mellor K, Millward CP, Patel S, Quirke F, Saldanha IJ, Smith V, Terwee CB, Young AE, Williamson PR. Use of core outcome sets was low in clinical trials published in major medical journals. J Clin Epidemiol. 2021 Oct 29;142:19-28. doi: 10.1016/j.jclinepi.2021.10.012. Epub 2021 Oct 29. PMID: 34715310.
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Podoplanin drives dedifferentiation and amoeboid invasion of melanoma.

iScience

de Winde CM, George SL, Crosas-Molist E, Hari-Gupta Y, Arp AB, Benjamin AC, Millward LJ, Makris S, Carver A, Imperatore V, Martínez VG, Sanz-Moreno V, Acton SE.
PMID: 34485858
iScience. 2021 Aug 13;24(9):102976. doi: 10.1016/j.isci.2021.102976. eCollection 2021 Sep 24.

Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. Melanoma cells utilize amoeboid migration as mode of local invasion. Amoeboid invasion is characterized by rounded cell morphology and high actomyosin contractility driven by Rho...

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de Winde CM, George SL, Crosas-Molist E, et al. Podoplanin drives dedifferentiation and amoeboid invasion of melanoma. iScience. 2021;24(9):102976doi: 10.1016/j.isci.2021.102976.
de Winde, C. M., George, S. L., Crosas-Molist, E., Hari-Gupta, Y., Arp, A. B., Benjamin, A. C., Millward, L. J., Makris, S., Carver, A., Imperatore, V., Martínez, V. G., Sanz-Moreno, V., & Acton, S. E. (2021). Podoplanin drives dedifferentiation and amoeboid invasion of melanoma. iScience, 24(9), 102976. https://doi.org/10.1016/j.isci.2021.102976
de Winde, Charlotte M, et al. "Podoplanin drives dedifferentiation and amoeboid invasion of melanoma." iScience vol. 24,9 (2021): 102976. doi: https://doi.org/10.1016/j.isci.2021.102976
de Winde CM, George SL, Crosas-Molist E, Hari-Gupta Y, Arp AB, Benjamin AC, Millward LJ, Makris S, Carver A, Imperatore V, Martínez VG, Sanz-Moreno V, Acton SE. Podoplanin drives dedifferentiation and amoeboid invasion of melanoma. iScience. 2021 Aug 13;24(9):102976. doi: 10.1016/j.isci.2021.102976. eCollection 2021 Sep 24. PMID: 34485858; PMCID: PMC8405990.
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