Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Jain P, Zhao S, Lee HJ, Hill HA, Ok CY, Kanagal-Shamanna R, Hagemeister FB, Fowler N, Fayad L, Yao Y, Liu Y, Moghrabi OB, Navsaria L, Feng L, Nogueras Gonzalez GM, Xu G, Thirumurthi S, Santos D, Iliescu C, Tang G, Medeiros LJ, Vega F, Avellaneda M, Badillo M, Flowers CR, Wang L, Wang ML.
PMID: 34797699
J Clin Oncol. 2021 Nov 19;JCO2101797. doi: 10.1200/JCO.21.01797. Epub 2021 Nov 19.

PURPOSE: Most patients with mantle cell lymphoma (MCL) are older. In this study, we investigated the efficacy and safety of a chemotherapy-free combination with ibrutinib and rituximab (IR) in previously untreated older patients with MCL (age ≥ 65 years).METHODS:...

Angewandte Chemie (International ed. in English)

Choo KL, Mirabi B, Demmans KZ, Lautens M.
PMID: 34324779
Angew Chem Int Ed Engl. 2021 Sep 20;60(39):21189-21194. doi: 10.1002/anie.202105562. Epub 2021 Aug 18.

Enantioenriched spiro-oxiranes bearing three contiguous stereocenters were synthesized using a rhodium-catalyzed asymmetric addition/aldol/spirocyclization sequence. Starting from a linear substrate, the cascade enabled the formation of a spirocyclic framework in a single step. sp

Open biology

Aliabadi F, Sohrabi B, Mostafavi E, Pazoki-Toroudi H, Webster TJ.
PMID: 33906413
Open Biol. 2021 Apr;11(4):200390. doi: 10.1098/rsob.200390. Epub 2021 Apr 28.

Despite all the other cells that have the potential to prevent cancer development and metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin-proteasome system (UPS) by which they can degrade tumour suppressor proteins and avoid apoptosis. This...