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Showing 253 to 258 of 258 entries
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The molecular dynamics of possible inhibitors for SARS-CoV-2.

Journal of biomolecular structure & dynamics

Irani AH, Steyn-Ross DA, Steyn-Ross ML, Voss L, Sleigh J.
PMID: 34229582
J Biomol Struct Dyn. 2021 Jul 06;1-10. doi: 10.1080/07391102.2021.1942215. Epub 2021 Jul 06.

The novel coronavirus SARS-CoV-2, responsible for the present COVID-19 global pandemic, is known to bind to the angiotensin converting enzyme-2 (ACE2) receptor in human cells. A possible treatment of COVID-19 could involve blocking ACE2 and/or disabling the spike protein...

The anti-scarring effect of corneal stromal stem cell therapy is mediated by transforming growth factor β3.

Eye and vision (London, England)

Weng L, Funderburgh JL, Khandaker I, Geary ML, Yang T, Basu R, Funderburgh ML, Du Y, Yam GH.
PMID: 33292650
Eye Vis (Lond). 2020 Nov 03;7(1):52. doi: 10.1186/s40662-020-00217-z.

BACKGROUND: Corneal stromal stem cells (CSSC) reduce corneal inflammation, prevent fibrotic scarring, and regenerate transparent stromal tissue in injured corneas. These effects rely on factors produced by CSSC to block the fibrotic gene expression. This study investigated the mechanism...

Magnetic sensitivity of cryptochrome 4 from a migratory songbird.

Nature

Xu J, Jarocha LE, Zollitsch T, Konowalczyk M, Henbest KB, Richert S, Golesworthy MJ, Schmidt J, Déjean V, Sowood DJC, Bassetto M, Luo J, Walton JR, Fleming J, Wei Y, Pitcher TL, Moise G, Herrmann M, Yin H, Wu H, Bartölke R, Käsehagen SJ, Horst S, Dautaj G, Murton PDF, Gehrckens AS, Chelliah Y, Takahashi JS, Koch KW, Weber S, Solov'yov IA, Xie C, Mackenzie SR, Timmel CR, Mouritsen H, Hore PJ.
PMID: 34163056
Nature. 2021 Jun;594(7864):535-540. doi: 10.1038/s41586-021-03618-9. Epub 2021 Jun 23.

Night-migratory songbirds are remarkably proficient navigators

The Application of Biocatalysis in the Preparation and Resolution of Morita-Baylis-Hillman Adducts and Their Derivatives.

Chembiochem : a European journal of chemical biology

Juma WP, Nyoni D, Brady D, Bode ML.
PMID: 34822736
Chembiochem. 2021 Nov 25; doi: 10.1002/cbic.202100527. Epub 2021 Nov 25.

The Morita-Baylis-Hillman (MBH) reaction affords highly functionalised allylic alcohols containing a new stereogenic centre. These MBH adducts are very versatile and have been transformed into a large range of products, some of which have medicinal potential. Several examples of...

Differences in the Prevalence of Screen-Detected Depression After Acute Coronary Syndrome Between Health Systems in the USA: Findings from CODIACS-QoL Randomized Controlled Trial.

Journal of general internal medicine

Moise N, Davidson KW, Clarke GN, Dolor RJ, Margolis KL, Kronish IM.
PMID: 34355350
J Gen Intern Med. 2021 Aug 05; doi: 10.1007/s11606-021-07049-0. Epub 2021 Aug 05.

No abstract available.

Mannosylation of budesonide palmitate nanoprodrugs for improved macrophage targeting.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Pinheiro do Nascimento L, Tsapis N, Reynaud F, Desmaële D, Moine L, Vergnaud J, Abreu S, Chaminade P, Fattal E.
PMID: 34890789
Eur J Pharm Biopharm. 2022 Jan;170:112-120. doi: 10.1016/j.ejpb.2021.12.001. Epub 2021 Dec 07.

In a strategy to improve macrophage targeting of glucocorticoids (GCs) for anti-inflammatory therapy, a so-called nanoprodrug of budesonide palmitate decorated by mannose moieties was designed. The synthesis of budesonide palmitate (BP) was obtained by esterification and mannosylated lipid (DSPE-PEG-Man)...

Showing 253 to 258 of 258 entries