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Showing 13 to 22 of 22 entries
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Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma.

Blood cancer journal

Reis-Sobreiro M, Roué G, Moros A, Gajate C, de la Iglesia-Vicente J, Colomer D, Mollinedo F.
PMID: 23727661
Blood Cancer J. 2013 May 31;3:e118. doi: 10.1038/bcj.2013.15.

Recent evidence shows that lipid raft membrane domains modulate both cell survival and death. Here, we have found that the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway is present in the lipid rafts of mantle cell lymphoma (MCL) cells, and this location...

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Reis-Sobreiro M, Roué G, Moros A, et al. Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma. Blood Cancer J. 2013;3:e118doi: 10.1038/bcj.2013.15.
Reis-Sobreiro, M., Roué, G., Moros, A., Gajate, C., de la Iglesia-Vicente, J., Colomer, D., & Mollinedo, F. (2013). Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma. Blood cancer journal, 3e118. https://doi.org/10.1038/bcj.2013.15
Reis-Sobreiro, M, et al. "Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma." Blood cancer journal vol. 3 (2013): e118. doi: https://doi.org/10.1038/bcj.2013.15
Reis-Sobreiro M, Roué G, Moros A, Gajate C, de la Iglesia-Vicente J, Colomer D, Mollinedo F. Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma. Blood Cancer J. 2013 May 31;3:e118. doi: 10.1038/bcj.2013.15. PMID: 23727661; PMCID: PMC3674457.
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Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells.

Oncotarget

Dakir el-H, Mollinedo F.
PMID: 31523391
Oncotarget. 2019 Sep 03;10(51):5313-5331. doi: 10.18632/oncotarget.27123. eCollection 2019 Sep 03.

MicroRNAs (miRNAs, miRs) are short non-coding post-transcriptional regulators of gene expression in normal physiology and disease. Acute myeloid leukemia is characterized by accumulation of malignantly transformed immature myeloid precursors, and differentiation therapy, used to overcome this differentiation blockage, has...

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Dakir el-H, Mollinedo F. Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells. Oncotarget. 2019;10(51):5313-5331doi: 10.18632/oncotarget.27123.
Dakir, e. l. -. H., & Mollinedo, F. (2019). Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells. Oncotarget, 10(51), 5313-5331. https://doi.org/10.18632/oncotarget.27123
Dakir, El-Habib, and Mollinedo, Faustino. "Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells." Oncotarget vol. 10,51 (2019): 5313-5331. doi: https://doi.org/10.18632/oncotarget.27123
Dakir el-H, Mollinedo F. Genome-wide miRNA profiling and pivotal roles of miRs 125a-5p and 17-92 cluster in human neutrophil maturation and differentiation of acute myeloid leukemia cells. Oncotarget. 2019 Sep 03;10(51):5313-5331. doi: 10.18632/oncotarget.27123. eCollection 2019 Sep 03. PMID: 31523391; PMCID: PMC6731105.
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Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of .

Frontiers in oncology

Velásquez C, Mansouri S, Gutiérrez O, Mamatjan Y, Mollinedo P, Karimi S, Singh O, Terán N, Martino J, Zadeh G, Fernández-Luna JL.
PMID: 31649891
Front Oncol. 2019 Oct 10;9:1036. doi: 10.3389/fonc.2019.01036. eCollection 2019.

The transmembrane protein ODZ1 has been associated with the invasive capacity of glioblastoma (GBM) cells through upregulation of RhoA/ROCK signaling, but the mechanisms triggering the ODZ1 pathway remain elusive. In addition, it is widely accepted that hypoxia is one...

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Velásquez C, Mansouri S, Gutiérrez O, et al. Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of . Front Oncol. 2019;9:1036doi: 10.3389/fonc.2019.01036.
Velásquez, C., Mansouri, S., Gutiérrez, O., Mamatjan, Y., Mollinedo, P., Karimi, S., Singh, O., Terán, N., Martino, J., Zadeh, G., & Fernández-Luna, J. L. (2019). Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of . Frontiers in oncology, 91036. https://doi.org/10.3389/fonc.2019.01036
Velásquez, Carlos, et al. "Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of ." Frontiers in oncology vol. 9 (2019): 1036. doi: https://doi.org/10.3389/fonc.2019.01036
Velásquez C, Mansouri S, Gutiérrez O, Mamatjan Y, Mollinedo P, Karimi S, Singh O, Terán N, Martino J, Zadeh G, Fernández-Luna JL. Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of . Front Oncol. 2019 Oct 10;9:1036. doi: 10.3389/fonc.2019.01036. eCollection 2019. PMID: 31649891; PMCID: PMC6795711.
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Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition.

Cancers

Gajate C, Gayet O, Fraunhoffer NA, Iovanna J, Dusetti N, Mollinedo F.
PMID: 34885233
Cancers (Basel). 2021 Dec 05;13(23). doi: 10.3390/cancers13236124.

Pancreatic cancer is one of the most lethal malignancies with a poor and gloomy prognosis and the highest mortality-to-incidence ratio. Pancreatic cancer remains an incurable malignancy, and current therapies are ineffective. We isolated cancer stem cells (CSCs) from the...

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Gajate C, Gayet O, Fraunhoffer NA, et al. Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition. Cancers (Basel). 2021;13(23)doi: 10.3390/cancers13236124.
Gajate, C., Gayet, O., Fraunhoffer, N. A., Iovanna, J., Dusetti, N., & Mollinedo, F. (2021). Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition. Cancers, 13(23), . https://doi.org/10.3390/cancers13236124
Gajate, Consuelo, et al. "Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition." Cancers vol. 13,23 (2021). doi: https://doi.org/10.3390/cancers13236124
Gajate C, Gayet O, Fraunhoffer NA, Iovanna J, Dusetti N, Mollinedo F. Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition. Cancers (Basel). 2021 Dec 05;13(23). doi: 10.3390/cancers13236124. PMID: 34885233; PMCID: PMC8656492.
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Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells.

Oncoscience

Melo-Lima S, Celeste Lopes M, Mollinedo F.
PMID: 25593994
Oncoscience. 2014 Oct 22;1(10):649-64. doi: 10.18632/oncoscience.89. eCollection 2014.

Necroptosis is a regulated necrotic cell death that involves receptor-interacting protein kinases RIPK1 and RIPK3. Here, we report that edelfosine triggers a rapid and massive cell death in human glioblastoma cells with characteristics of necrosis. Only a minor proportion...

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Melo-Lima S, Celeste Lopes M, Mollinedo F. Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells. Oncoscience. 2014;1(10):649-64doi: 10.18632/oncoscience.89.
Melo-Lima, S., Celeste Lopes, M., & Mollinedo, F. (2014). Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells. Oncoscience, 1(10), 649-64. https://doi.org/10.18632/oncoscience.89
Melo-Lima, Sara, et al. "Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells." Oncoscience vol. 1,10 (2014): 649-64. doi: https://doi.org/10.18632/oncoscience.89
Melo-Lima S, Celeste Lopes M, Mollinedo F. Necroptosis is associated with low procaspase-8 and active RIPK1 and -3 in human glioma cells. Oncoscience. 2014 Oct 22;1(10):649-64. doi: 10.18632/oncoscience.89. eCollection 2014. PMID: 25593994; PMCID: PMC4278276.
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Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response.

Annals of translational medicine

Mollinedo F, Gajate C.
PMID: 31576360
Ann Transl Med. 2019 Jul;7:S153. doi: 10.21037/atm.2019.06.40.

No abstract available.

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Mollinedo F, Gajate C. Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response. Ann Transl Med. 2019;7:S153doi: 10.21037/atm.2019.06.40.
Mollinedo, F., & Gajate, C. (2019). Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response. Annals of translational medicine, 7S153. https://doi.org/10.21037/atm.2019.06.40
Mollinedo, Faustino, and Gajate, Consuelo. "Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response." Annals of translational medicine vol. 7 (2019): S153. doi: https://doi.org/10.21037/atm.2019.06.40
Mollinedo F, Gajate C. Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response. Ann Transl Med. 2019 Jul;7:S153. doi: 10.21037/atm.2019.06.40. PMID: 31576360; PMCID: PMC6685885.
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The genome of .

Applications in plant sciences

Mangelson H, Jarvis DE, Mollinedo P, Rollano-Penaloza OM, Palma-Encinas VD, Gomez-Pando LR, Jellen EN, Maughan PJ.
PMID: 31832282
Appl Plant Sci. 2019 Nov 08;7(11):e11300. doi: 10.1002/aps3.11300. eCollection 2019 Nov.

PREMISE: Cañahua is a semi-domesticated crop grown in high-altitude regions of the Andes. It is an A-genome diploid (2METHODS: The reference assembly was developed using a combination of short- and long-read sequencing techniques, including multiple rounds of Hi-C-based proximity-guided...

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Mangelson H, Jarvis DE, Mollinedo P, et al. The genome of . Appl Plant Sci. 2019;7(11):e11300doi: 10.1002/aps3.11300.
Mangelson, H., Jarvis, D. E., Mollinedo, P., Rollano-Penaloza, O. M., Palma-Encinas, V. D., Gomez-Pando, L. R., Jellen, E. N., & Maughan, P. J. (2019). The genome of . Applications in plant sciences, 7(11), e11300. https://doi.org/10.1002/aps3.11300
Mangelson, Hayley, et al. "The genome of ." Applications in plant sciences vol. 7,11 (2019): e11300. doi: https://doi.org/10.1002/aps3.11300
Mangelson H, Jarvis DE, Mollinedo P, Rollano-Penaloza OM, Palma-Encinas VD, Gomez-Pando LR, Jellen EN, Maughan PJ. The genome of . Appl Plant Sci. 2019 Nov 08;7(11):e11300. doi: 10.1002/aps3.11300. eCollection 2019 Nov. PMID: 31832282; PMCID: PMC6858295.
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Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

Chemistry (Weinheim an der Bergstrasse, Germany)

Marín-Ramos NI, Piñar C, Vázquez-Villa H, Martín-Fontecha M, González Á, Canales Á, Algar S, Mayo PP, Jiménez-Barbero J, Gajate C, Mollinedo F, Pardo L, Ortega-Gutiérrez S, Viso A, López-Rodríguez ML.
PMID: 27885731
Chemistry. 2017 Jan 31;23(7):1676-1685. doi: 10.1002/chem.201604905. Epub 2016 Dec 27.

Despite more than three decades of intense effort, no anti-Ras therapies have reached clinical application. Contributing to this failure has been an underestimation of Ras complexity and a dearth of structural information. In this regard, recent studies have revealed...

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Marín-Ramos NI, Piñar C, Vázquez-Villa H, et al. Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling. Chemistry. 2016;23(7):1676-1685doi: 10.1002/chem.201604905.
Marín-Ramos, N. I., Piñar, C., Vázquez-Villa, H., Martín-Fontecha, M., González, �. �., Canales, �. �., Algar, S., Mayo, P. P., Jiménez-Barbero, J., Gajate, C., Mollinedo, F., Pardo, L., Ortega-Gutiérrez, S., Viso, A., & López-Rodríguez, M. L. (2017). Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling. Chemistry (Weinheim an der Bergstrasse, Germany), 23(7), 1676-1685. https://doi.org/10.1002/chem.201604905
Marín-Ramos, Nagore I, et al. "Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 23,7 (2017): 1676-1685. doi: https://doi.org/10.1002/chem.201604905
Marín-Ramos NI, Piñar C, Vázquez-Villa H, Martín-Fontecha M, González Á, Canales Á, Algar S, Mayo PP, Jiménez-Barbero J, Gajate C, Mollinedo F, Pardo L, Ortega-Gutiérrez S, Viso A, López-Rodríguez ML. Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling. Chemistry. 2017 Jan 31;23(7):1676-1685. doi: 10.1002/chem.201604905. Epub 2016 Dec 27. PMID: 27885731.
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Immunological behavior of two alloforms of ATPase fromMicrococcus lysodeikticus.

Current microbiology

Larraga V, Mollinedo F, Muñoz E.
PMID: 27520769
Curr Microbiol. 1980 Jul;3(4):237-41. doi: 10.1007/BF02602455.

Antisera were raised in rabbits to two alloforms of ATPase isolated from two substrains ofMicrococcus lysodeikticus. These alloforms show a similar amino acid composition but differ in the associated carbohydrate components. Similarities and differences in the immunological behavior of...

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Larraga V, Mollinedo F, Muñoz E. Immunological behavior of two alloforms of ATPase fromMicrococcus lysodeikticus. Curr Microbiol. 1980;3(4):237-41doi: 10.1007/BF02602455.
Larraga, V., Mollinedo, F., & Muñoz, E. (1980). Immunological behavior of two alloforms of ATPase fromMicrococcus lysodeikticus. Current microbiology, 3(4), 237-41. https://doi.org/10.1007/BF02602455
Larraga, V, et al. "Immunological behavior of two alloforms of ATPase fromMicrococcus lysodeikticus." Current microbiology vol. 3,4 (1980): 237-41. doi: https://doi.org/10.1007/BF02602455
Larraga V, Mollinedo F, Muñoz E. Immunological behavior of two alloforms of ATPase fromMicrococcus lysodeikticus. Curr Microbiol. 1980 Jul;3(4):237-41. doi: 10.1007/BF02602455. PMID: 27520769.
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Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition.

Cancers

Gajate C, Gayet O, Fraunhoffer NA, Iovanna J, Dusetti N, Mollinedo F.
PMID: 34885233
Cancers (Basel). 2021 Dec 05;13(23). doi: 10.3390/cancers13236124.

Pancreatic cancer is one of the most lethal malignancies with a poor and gloomy prognosis and the highest mortality-to-incidence ratio. Pancreatic cancer remains an incurable malignancy, and current therapies are ineffective. We isolated cancer stem cells (CSCs) from the...

Cite
Gajate C, Gayet O, Fraunhoffer NA, et al. Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition. Cancers (Basel). 2021;13(23)doi: 10.3390/cancers13236124.
Gajate, C., Gayet, O., Fraunhoffer, N. A., Iovanna, J., Dusetti, N., & Mollinedo, F. (2021). Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition. Cancers, 13(23), . https://doi.org/10.3390/cancers13236124
Gajate, Consuelo, et al. "Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition." Cancers vol. 13,23 (2021). doi: https://doi.org/10.3390/cancers13236124
Gajate C, Gayet O, Fraunhoffer NA, Iovanna J, Dusetti N, Mollinedo F. Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition. Cancers (Basel). 2021 Dec 05;13(23). doi: 10.3390/cancers13236124. PMID: 34885233.
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Showing 13 to 22 of 22 entries