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A Clinical Case of Insulinoma Presenting with Postprandial Hypoglycemia in a Patient with a History of Gastric Bypass Surgery.

Internal medicine (Tokyo, Japan)

Hayashida R, Tsuchiya K, Sekine T, Momose T, Sato F, Sakurada M, Nishida K, Hayashi T, Morita Y, Okada H, Fukushima N, Yamada T, Tsujino M.
PMID: 34645754
Intern Med. 2021 Oct 12; doi: 10.2169/internalmedicine.7428-21. Epub 2021 Oct 12.

A 61-year-old man with a history of total gastrectomy for cancer with Roux-en-Y reconstruction showed severe postprandial hypoglycemia accompanied by endogenous hyperinsulinemia. Abdominal ultrasonography and contrast-enhanced computed tomography showed no abnormal findings in the pancreas. A selective arterial secretagogue...

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Hayashida R, Tsuchiya K, Sekine T, et al. A Clinical Case of Insulinoma Presenting with Postprandial Hypoglycemia in a Patient with a History of Gastric Bypass Surgery. Intern Med. 2021;doi: 10.2169/internalmedicine.7428-21.
Hayashida, R., Tsuchiya, K., Sekine, T., Momose, T., Sato, F., Sakurada, M., Nishida, K., Hayashi, T., Morita, Y., Okada, H., Fukushima, N., Yamada, T., & Tsujino, M. (2021). A Clinical Case of Insulinoma Presenting with Postprandial Hypoglycemia in a Patient with a History of Gastric Bypass Surgery. Internal medicine (Tokyo, Japan), . https://doi.org/10.2169/internalmedicine.7428-21
Hayashida, Ryosuke, et al. "A Clinical Case of Insulinoma Presenting with Postprandial Hypoglycemia in a Patient with a History of Gastric Bypass Surgery." Internal medicine (Tokyo, Japan) vol. (2021). doi: https://doi.org/10.2169/internalmedicine.7428-21
Hayashida R, Tsuchiya K, Sekine T, Momose T, Sato F, Sakurada M, Nishida K, Hayashi T, Morita Y, Okada H, Fukushima N, Yamada T, Tsujino M. A Clinical Case of Insulinoma Presenting with Postprandial Hypoglycemia in a Patient with a History of Gastric Bypass Surgery. Intern Med. 2021 Oct 12; doi: 10.2169/internalmedicine.7428-21. Epub 2021 Oct 12. PMID: 34645754.
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Calorie restriction initiated at a young age activates the Akt/PKC zeta/lambda-Glut4 pathway in rat white adipose tissue in an insulin-independent manner.

Age (Dordrecht, Netherlands)

Park S, Komatsu T, Hayashi H, Yamaza H, Chiba T, Higami Y, Kuramoto K, Shimokawa I.
PMID: 19424853
Age (Dordr). 2008 Dec;30(4):293-302. doi: 10.1007/s11357-008-9071-2. Epub 2008 Sep 03.

Calorie restriction (CR) may exert an anti-aging effect through a metabolic adaptation to limited energy intake. The present study investigated the effect of CR on insulin signaling in response to glucose load in the epididymal adipose tissue of male...

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Park S, Komatsu T, Hayashi H, et al. Calorie restriction initiated at a young age activates the Akt/PKC zeta/lambda-Glut4 pathway in rat white adipose tissue in an insulin-independent manner. Age (Dordr). 2008;30(4):293-302doi: 10.1007/s11357-008-9071-2.
Park, S., Komatsu, T., Hayashi, H., Yamaza, H., Chiba, T., Higami, Y., Kuramoto, K., & Shimokawa, I. (2008). Calorie restriction initiated at a young age activates the Akt/PKC zeta/lambda-Glut4 pathway in rat white adipose tissue in an insulin-independent manner. Age (Dordrecht, Netherlands), 30(4), 293-302. https://doi.org/10.1007/s11357-008-9071-2
Park, Seongjoon, et al. "Calorie restriction initiated at a young age activates the Akt/PKC zeta/lambda-Glut4 pathway in rat white adipose tissue in an insulin-independent manner." Age (Dordrecht, Netherlands) vol. 30,4 (2008): 293-302. doi: https://doi.org/10.1007/s11357-008-9071-2
Park S, Komatsu T, Hayashi H, Yamaza H, Chiba T, Higami Y, Kuramoto K, Shimokawa I. Calorie restriction initiated at a young age activates the Akt/PKC zeta/lambda-Glut4 pathway in rat white adipose tissue in an insulin-independent manner. Age (Dordr). 2008 Dec;30(4):293-302. doi: 10.1007/s11357-008-9071-2. Epub 2008 Sep 03. PMID: 19424853; PMCID: PMC2585642.
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Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals.

Endocrine journal

Suzuki T, Hayashi M, Komatsu T, Tanioka A, Nagasawa M, Tanimura-Inagaki K, Rahman MS, Masuda S, Yusa K, Sakai J, Shibata H, Inagaki T.
PMID: 34261826
Endocr J. 2021 Jul 15; doi: 10.1507/endocrj.EJ21-0255. Epub 2021 Jul 15.

α-Ketoglutarate (α-KG) also known as 2-oxoglutarate (2-OG) is an intermediate metabolite in the tricarboxylic acid (TCA) cycle and is also produced by the deamination of glutamate. It is an indispensable cofactor for a series of 2-oxoglutarate-dependent oxygenases including epigenetic...

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Suzuki T, Hayashi M, Komatsu T, et al. Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals. Endocr J. 2021;doi: 10.1507/endocrj.EJ21-0255.
Suzuki, T., Hayashi, M., Komatsu, T., Tanioka, A., Nagasawa, M., Tanimura-Inagaki, K., Rahman, M. S., Masuda, S., Yusa, K., Sakai, J., Shibata, H., & Inagaki, T. (2021). Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals. Endocrine journal, . https://doi.org/10.1507/endocrj.EJ21-0255
Suzuki, Tomohiro, et al. "Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals." Endocrine journal vol. (2021). doi: https://doi.org/10.1507/endocrj.EJ21-0255
Suzuki T, Hayashi M, Komatsu T, Tanioka A, Nagasawa M, Tanimura-Inagaki K, Rahman MS, Masuda S, Yusa K, Sakai J, Shibata H, Inagaki T. Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals. Endocr J. 2021 Jul 15; doi: 10.1507/endocrj.EJ21-0255. Epub 2021 Jul 15. PMID: 34261826.
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Ostracods had colonized estuaries by the late Silurian.

Biology letters

McGairy A, Komatsu T, Williams M, Harvey THP, Miller CG, Nguyen PD, Legrand J, Yamada T, Siveter DJ, Bush H, Stocker CP.
PMID: 34847752
Biol Lett. 2021 Dec;17(12):20210403. doi: 10.1098/rsbl.2021.0403. Epub 2021 Dec 01.

The fossil record of terrestrialization documents notable shifts in the environmental and physiological tolerances of many animal and plant groups. However, for certain significant components of modern freshwater and terrestrial environments, the transition out of marine settings remains largely...

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McGairy A, Komatsu T, Williams M, et al. Ostracods had colonized estuaries by the late Silurian. Biol Lett. 2021;17(12):20210403doi: 10.1098/rsbl.2021.0403.
McGairy, A., Komatsu, T., Williams, M., Harvey, T. H. P., Miller, C. G., Nguyen, P. D., Legrand, J., Yamada, T., Siveter, D. J., Bush, H., & Stocker, C. P. (2021). Ostracods had colonized estuaries by the late Silurian. Biology letters, 17(12), 20210403. https://doi.org/10.1098/rsbl.2021.0403
McGairy, Anna, et al. "Ostracods had colonized estuaries by the late Silurian." Biology letters vol. 17,12 (2021): 20210403. doi: https://doi.org/10.1098/rsbl.2021.0403
McGairy A, Komatsu T, Williams M, Harvey THP, Miller CG, Nguyen PD, Legrand J, Yamada T, Siveter DJ, Bush H, Stocker CP. Ostracods had colonized estuaries by the late Silurian. Biol Lett. 2021 Dec;17(12):20210403. doi: 10.1098/rsbl.2021.0403. Epub 2021 Dec 01. PMID: 34847752.
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Pseudo-porencephaly Mimicking Multiple Intracerebral Hemorrhages.

Internal medicine (Tokyo, Japan)

Takahashi J, Komatsu T, Sakai K, Iguchi Y.
PMID: 34148964
Intern Med. 2021 Jun 19; doi: 10.2169/internalmedicine.7446-21. Epub 2021 Jun 19.

No abstract available.

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Takahashi J, Komatsu T, Sakai K, et al. Pseudo-porencephaly Mimicking Multiple Intracerebral Hemorrhages. Intern Med. 2021;doi: 10.2169/internalmedicine.7446-21.
Takahashi, J., Komatsu, T., Sakai, K., & Iguchi, Y. (2021). Pseudo-porencephaly Mimicking Multiple Intracerebral Hemorrhages. Internal medicine (Tokyo, Japan), . https://doi.org/10.2169/internalmedicine.7446-21
Takahashi, Junichiro, et al. "Pseudo-porencephaly Mimicking Multiple Intracerebral Hemorrhages." Internal medicine (Tokyo, Japan) vol. (2021). doi: https://doi.org/10.2169/internalmedicine.7446-21
Takahashi J, Komatsu T, Sakai K, Iguchi Y. Pseudo-porencephaly Mimicking Multiple Intracerebral Hemorrhages. Intern Med. 2021 Jun 19; doi: 10.2169/internalmedicine.7446-21. Epub 2021 Jun 19. PMID: 34148964.
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Fabrication of metal nanocluster and nanoparticles in the CaO-Bi2O3-B2O3-Al2O3-TiO2 glass by irradiation of XeCl pulsed laser.

Optics express

Masai H, Mizuno S, Fujiwara T, Mori H, Komatsu T.
PMID: 18542344
Opt Express. 2008 Feb 18;16(4):2614-20. doi: 10.1364/oe.16.002614.

We report the fabrication of nanoparticles that contain metal nanoclusters at the surface of the CaO-Bi(2)O(3)-B(2)O(3)-Al(2)O(3)-TiO2 glass using XeCl laser irradiation. We have demonstrated that the surface morphology such as that containing nanoparticles or a smooth flat surface can...

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Masai H, Mizuno S, Fujiwara T, et al. Fabrication of metal nanocluster and nanoparticles in the CaO-Bi2O3-B2O3-Al2O3-TiO2 glass by irradiation of XeCl pulsed laser. Opt Express. 2008;16(4):2614-20doi: 10.1364/oe.16.002614.
Masai, H., Mizuno, S., Fujiwara, T., Mori, H., & Komatsu, T. (2008). Fabrication of metal nanocluster and nanoparticles in the CaO-Bi2O3-B2O3-Al2O3-TiO2 glass by irradiation of XeCl pulsed laser. Optics express, 16(4), 2614-20. https://doi.org/10.1364/oe.16.002614
Masai, Hirokazu, et al. "Fabrication of metal nanocluster and nanoparticles in the CaO-Bi2O3-B2O3-Al2O3-TiO2 glass by irradiation of XeCl pulsed laser." Optics express vol. 16,4 (2008): 2614-20. doi: https://doi.org/10.1364/oe.16.002614
Masai H, Mizuno S, Fujiwara T, Mori H, Komatsu T. Fabrication of metal nanocluster and nanoparticles in the CaO-Bi2O3-B2O3-Al2O3-TiO2 glass by irradiation of XeCl pulsed laser. Opt Express. 2008 Feb 18;16(4):2614-20. doi: 10.1364/oe.16.002614. PMID: 18542344.
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Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity.

The FEBS journal

Hatakeyama D, Shoji M, Ogata S, Masuda T, Nakano M, Komatsu T, Saitoh A, Makiyama K, Tsuneishi H, Miyatake A, Takahira M, Nishikawa E, Ohkubo A, Noda T, Kawaoka Y, Ohtsuki S, Kuzuhara T.
PMID: 34270849
FEBS J. 2022 Jan;289(1):231-245. doi: 10.1111/febs.16123. Epub 2021 Jul 27.

The post-translational acetylation of lysine residues is found in many nonhistone proteins and is involved in a wide range of biological processes. Recently, we showed that the nucleoprotein of the influenza A virus is acetylated by histone acetyltransferases (HATs),...

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Hatakeyama D, Shoji M, Ogata S, et al. Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity. FEBS J. 2021;289(1):231-245doi: 10.1111/febs.16123.
Hatakeyama, D., Shoji, M., Ogata, S., Masuda, T., Nakano, M., Komatsu, T., Saitoh, A., Makiyama, K., Tsuneishi, H., Miyatake, A., Takahira, M., Nishikawa, E., Ohkubo, A., Noda, T., Kawaoka, Y., Ohtsuki, S., & Kuzuhara, T. (2022). Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity. The FEBS journal, 289(1), 231-245. https://doi.org/10.1111/febs.16123
Hatakeyama, Dai, et al. "Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity." The FEBS journal vol. 289,1 (2022): 231-245. doi: https://doi.org/10.1111/febs.16123
Hatakeyama D, Shoji M, Ogata S, Masuda T, Nakano M, Komatsu T, Saitoh A, Makiyama K, Tsuneishi H, Miyatake A, Takahira M, Nishikawa E, Ohkubo A, Noda T, Kawaoka Y, Ohtsuki S, Kuzuhara T. Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity. FEBS J. 2022 Jan;289(1):231-245. doi: 10.1111/febs.16123. Epub 2021 Jul 27. PMID: 34270849.
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A genetically tractable jellyfish model for systems and evolutionary neuroscience.

Cell

Weissbourd B, Momose T, Nair A, Kennedy A, Hunt B, Anderson DJ.
PMID: 34822783
Cell. 2021 Nov 24;184(24):5854-5868.e20. doi: 10.1016/j.cell.2021.10.021.

Jellyfish are radially symmetric organisms without a brain that arose more than 500 million years ago. They achieve organismal behaviors through coordinated interactions between autonomously functioning body parts. Jellyfish neurons have been studied electrophysiologically, but not at the systems...

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Weissbourd B, Momose T, Nair A, et al. A genetically tractable jellyfish model for systems and evolutionary neuroscience. Cell. 2021;184(24):5854-5868.e20doi: 10.1016/j.cell.2021.10.021.
Weissbourd, B., Momose, T., Nair, A., Kennedy, A., Hunt, B., & Anderson, D. J. (2021). A genetically tractable jellyfish model for systems and evolutionary neuroscience. Cell, 184(24), 5854-5868.e20. https://doi.org/10.1016/j.cell.2021.10.021
Weissbourd, Brandon, et al. "A genetically tractable jellyfish model for systems and evolutionary neuroscience." Cell vol. 184,24 (2021): 5854-5868.e20. doi: https://doi.org/10.1016/j.cell.2021.10.021
Weissbourd B, Momose T, Nair A, Kennedy A, Hunt B, Anderson DJ. A genetically tractable jellyfish model for systems and evolutionary neuroscience. Cell. 2021 Nov 24;184(24):5854-5868.e20. doi: 10.1016/j.cell.2021.10.021. PMID: 34822783; PMCID: PMC8629132.
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Two Novel Endornaviruses Co-infecting a .

Frontiers in microbiology

Uchida K, Sakuta K, Ito A, Takahashi Y, Katayama Y, Omatsu T, Mizutani T, Arie T, Komatsu K, Fukuhara T, Uematsu S, Okada R, Moriyama H.
PMID: 33633714
Front Microbiol. 2021 Feb 03;12:633502. doi: 10.3389/fmicb.2021.633502. eCollection 2021.

Two novel endornaviruses, Phytophthora endornavirus 2 (PEV2) and Phytophthora endornavirus 3 (PEV3) were found in isolates of a

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Uchida K, Sakuta K, Ito A, et al. Two Novel Endornaviruses Co-infecting a . Front Microbiol. 2021;12:633502doi: 10.3389/fmicb.2021.633502.
Uchida, K., Sakuta, K., Ito, A., Takahashi, Y., Katayama, Y., Omatsu, T., Mizutani, T., Arie, T., Komatsu, K., Fukuhara, T., Uematsu, S., Okada, R., & Moriyama, H. (2021). Two Novel Endornaviruses Co-infecting a . Frontiers in microbiology, 12633502. https://doi.org/10.3389/fmicb.2021.633502
Uchida, Keiko, et al. "Two Novel Endornaviruses Co-infecting a ." Frontiers in microbiology vol. 12 (2021): 633502. doi: https://doi.org/10.3389/fmicb.2021.633502
Uchida K, Sakuta K, Ito A, Takahashi Y, Katayama Y, Omatsu T, Mizutani T, Arie T, Komatsu K, Fukuhara T, Uematsu S, Okada R, Moriyama H. Two Novel Endornaviruses Co-infecting a . Front Microbiol. 2021 Feb 03;12:633502. doi: 10.3389/fmicb.2021.633502. eCollection 2021. PMID: 33633714; PMCID: PMC7902037.
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Sendai virus C protein affects macrophage function, which plays a critical role in modulating disease severity during Sendai virus infection in mice.

Microbiology and immunology

Sakuma R, Morita N, Tanaka Y, Koide N, Komatsu T.
PMID: 34859490
Microbiol Immunol. 2021 Dec 03; doi: 10.1111/1348-0421.12956. Epub 2021 Dec 03.

Sendai virus (SeV) accessory protein C limits the generation of double-stranded RNAs, defective interfering RNAs, or both during viral transcription and replication, thereby limiting interferon-β production. Our recent in vitro analyses on murine macrophage cell lines demonstrated that this...

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Sakuma R, Morita N, Tanaka Y, et al. Sendai virus C protein affects macrophage function, which plays a critical role in modulating disease severity during Sendai virus infection in mice. Microbiol Immunol. 2021;doi: 10.1111/1348-0421.12956.
Sakuma, R., Morita, N., Tanaka, Y., Koide, N., & Komatsu, T. (2021). Sendai virus C protein affects macrophage function, which plays a critical role in modulating disease severity during Sendai virus infection in mice. Microbiology and immunology, . https://doi.org/10.1111/1348-0421.12956
Sakuma, Ryusuke, et al. "Sendai virus C protein affects macrophage function, which plays a critical role in modulating disease severity during Sendai virus infection in mice." Microbiology and immunology vol. (2021). doi: https://doi.org/10.1111/1348-0421.12956
Sakuma R, Morita N, Tanaka Y, Koide N, Komatsu T. Sendai virus C protein affects macrophage function, which plays a critical role in modulating disease severity during Sendai virus infection in mice. Microbiol Immunol. 2021 Dec 03; doi: 10.1111/1348-0421.12956. Epub 2021 Dec 03. PMID: 34859490.
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Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy.

Cancers

Nagaoka K, Sun C, Kobayashi Y, Kanaseki T, Tokita S, Komatsu T, Maejima K, Futami J, Nomura S, Udaka K, Nakagawa H, Torigoe T, Kakimi K.
PMID: 35008270
Cancers (Basel). 2021 Dec 27;14(1). doi: 10.3390/cancers14010106.

To develop combination immunotherapies for gastric cancers, immunologically well-characterized preclinical models are crucial. Here, we leveraged two transplantable murine gastric cancer cell lines, YTN2 and YTN16, derived from the same parental line but differing in their susceptibility to immune...

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Nagaoka K, Sun C, Kobayashi Y, et al. Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy. Cancers (Basel). 2021;14(1)doi: 10.3390/cancers14010106.
Nagaoka, K., Sun, C., Kobayashi, Y., Kanaseki, T., Tokita, S., Komatsu, T., Maejima, K., Futami, J., Nomura, S., Udaka, K., Nakagawa, H., Torigoe, T., & Kakimi, K. (2021). Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy. Cancers, 14(1), . https://doi.org/10.3390/cancers14010106
Nagaoka, Koji, et al. "Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy." Cancers vol. 14,1 (2021). doi: https://doi.org/10.3390/cancers14010106
Nagaoka K, Sun C, Kobayashi Y, Kanaseki T, Tokita S, Komatsu T, Maejima K, Futami J, Nomura S, Udaka K, Nakagawa H, Torigoe T, Kakimi K. Identification of Neoantigens in Two Murine Gastric Cancer Cell Lines Leading to the Neoantigen-Based Immunotherapy. Cancers (Basel). 2021 Dec 27;14(1). doi: 10.3390/cancers14010106. PMID: 35008270; PMCID: PMC8750027.
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