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Showing 169 to 170 of 170 entries
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Understanding treatment-subgroup effect in primary and secondary prevention of cardiovascular disease: An exploration using meta-analyses of individual patient data.

Journal of clinical epidemiology

Torres Roldan VD, Ponce OJ, Urtecho M, Torres GF, Belluzzo T, Montori V, Liu C, Barrera F, Diaz A, Prokop L, Guyatt G, Montori VM.
PMID: 34400257
J Clin Epidemiol. 2021 Nov;139:160-166. doi: 10.1016/j.jclinepi.2021.08.006. Epub 2021 Aug 13.

BACKGROUND AND OBJECTIVE: Recommendations for preventing cardiovascular (CV) disease are currently separated into primary and secondary prevention. We hypothesize that relative effects of interventions for CV prevention are not different across primary and secondary prevention cohorts. Our aim was...

The tails of PKA.

Molecular pharmacology

Taylor SS, Søberg K, Kobori E, Wu J, Pautz S, Herberg FW, Skålhegg BS.
PMID: 34330820
Mol Pharmacol. 2021 Jul 30; doi: 10.1124/molpharm.121.000315. Epub 2021 Jul 30.

The catalytic subunit of PKA is regulated by two tails that each wrap around the N- and C-lobes of the kinase core. While the Ct-Tail is classified as an intrinsically disordered region (IDR), the Nt-Tail is dominated by a...

Showing 169 to 170 of 170 entries