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NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development.

Cells

Bashiri Dezfouli A, Yazdi M, Pockley AG, Khosravi M, Kobold S, Wagner E, Multhoff G.
PMID: 34943898
Cells. 2021 Dec 01;10(12). doi: 10.3390/cells10123390.

In recent years, cell-based immunotherapies have demonstrated promising results in the treatment of cancer. Chimeric antigen receptors (CARs) arm effector cells with a weapon for targeting tumor antigens, licensing engineered cells to recognize and kill cancer cells. The quality...

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Bashiri Dezfouli A, Yazdi M, Pockley AG, et al. NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development. Cells. 2021;10(12)doi: 10.3390/cells10123390.
Bashiri Dezfouli, A., Yazdi, M., Pockley, A. G., Khosravi, M., Kobold, S., Wagner, E., & Multhoff, G. (2021). NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development. Cells, 10(12), . https://doi.org/10.3390/cells10123390
Bashiri Dezfouli, Ali, et al. "NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development." Cells vol. 10,12 (2021). doi: https://doi.org/10.3390/cells10123390
Bashiri Dezfouli A, Yazdi M, Pockley AG, Khosravi M, Kobold S, Wagner E, Multhoff G. NK Cells Armed with Chimeric Antigen Receptors (CAR): Roadblocks to Successful Development. Cells. 2021 Dec 01;10(12). doi: 10.3390/cells10123390. PMID: 34943898; PMCID: PMC8699535.
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Magnetic Properties of Bacterial Magnetosomes Produced by .

Microorganisms

Gareev KG, Grouzdev DS, Kharitonskii PV, Kirilenko DA, Kosterov A, Koziaeva VV, Levitskii VS, Multhoff G, Nepomnyashchaya EK, Nikitin AV, Nikitina A, Sergienko ES, Sukharzhevskii SM, Terukov EI, Trushlyakova VV, Shevtsov M.
PMID: 34576748
Microorganisms. 2021 Aug 31;9(9). doi: 10.3390/microorganisms9091854.

In this study, the magnetic properties of magnetosomes isolated from lyophilized magnetotactic bacteria

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Gareev KG, Grouzdev DS, Kharitonskii PV, et al. Magnetic Properties of Bacterial Magnetosomes Produced by . Microorganisms. 2021;9(9)doi: 10.3390/microorganisms9091854.
Gareev, K. G., Grouzdev, D. S., Kharitonskii, P. V., Kirilenko, D. A., Kosterov, A., Koziaeva, V. V., Levitskii, V. S., Multhoff, G., Nepomnyashchaya, E. K., Nikitin, A. V., Nikitina, A., Sergienko, E. S., Sukharzhevskii, S. M., Terukov, E. I., Trushlyakova, V. V., & Shevtsov, M. (2021). Magnetic Properties of Bacterial Magnetosomes Produced by . Microorganisms, 9(9), . https://doi.org/10.3390/microorganisms9091854
Gareev, Kamil G, et al. "Magnetic Properties of Bacterial Magnetosomes Produced by ." Microorganisms vol. 9,9 (2021). doi: https://doi.org/10.3390/microorganisms9091854
Gareev KG, Grouzdev DS, Kharitonskii PV, Kirilenko DA, Kosterov A, Koziaeva VV, Levitskii VS, Multhoff G, Nepomnyashchaya EK, Nikitin AV, Nikitina A, Sergienko ES, Sukharzhevskii SM, Terukov EI, Trushlyakova VV, Shevtsov M. Magnetic Properties of Bacterial Magnetosomes Produced by . Microorganisms. 2021 Aug 31;9(9). doi: 10.3390/microorganisms9091854. PMID: 34576748; PMCID: PMC8468085.
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Full endoscopic anterior intrapelvic plate osteosynthesis: a cadaveric feasibility study.

Archives of orthopaedic and trauma surgery

Hartel MJ, Althoff G, Wolter S, Ondruschka B, Dietz E, Frosch KH, Thiesen DM.
PMID: 35041081
Arch Orthop Trauma Surg. 2022 Jan 18; doi: 10.1007/s00402-022-04346-z. Epub 2022 Jan 18.

In this investigation, it was assumed that it must be possible to visualize the intrapelvic aspect as accustomed by pelvic surgeons using the anterior intrapelvic (modified Stoppa) approach. Moreover, it was hypothesized, that plate mountings will not only be...

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Hartel MJ, Althoff G, Wolter S, et al. Full endoscopic anterior intrapelvic plate osteosynthesis: a cadaveric feasibility study. Arch Orthop Trauma Surg. 2022;doi: 10.1007/s00402-022-04346-z.
Hartel, M. J., Althoff, G., Wolter, S., Ondruschka, B., Dietz, E., Frosch, K. H., & Thiesen, D. M. (2022). Full endoscopic anterior intrapelvic plate osteosynthesis: a cadaveric feasibility study. Archives of orthopaedic and trauma surgery, . https://doi.org/10.1007/s00402-022-04346-z
Hartel, Maximilian J, et al. "Full endoscopic anterior intrapelvic plate osteosynthesis: a cadaveric feasibility study." Archives of orthopaedic and trauma surgery vol. (2022). doi: https://doi.org/10.1007/s00402-022-04346-z
Hartel MJ, Althoff G, Wolter S, Ondruschka B, Dietz E, Frosch KH, Thiesen DM. Full endoscopic anterior intrapelvic plate osteosynthesis: a cadaveric feasibility study. Arch Orthop Trauma Surg. 2022 Jan 18; doi: 10.1007/s00402-022-04346-z. Epub 2022 Jan 18. PMID: 35041081.
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Partial-Brain Radiation-Induced Microvascular Cognitive Impairment in Juvenile Murine Unilateral Hippocampal Synaptic Plasticity.

International journal of radiation oncology, biology, physics

Fan H, Sievert W, Hofmann J, Keppler SJ, Steiger K, Puig-Bosch X, Haller B, Rammes G, Multhoff G.
PMID: 34619330
Int J Radiat Oncol Biol Phys. 2021 Oct 04; doi: 10.1016/j.ijrobp.2021.09.041. Epub 2021 Oct 04.

PURPOSE: Radiation-induced cognitive deficits have a severe negative impact on pediatric brain tumor patients. The severity of cognitive symptoms is related to the age of the child when radiation was applied, with the most severe effects seen in the...

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Fan H, Sievert W, Hofmann J, et al. Partial-Brain Radiation-Induced Microvascular Cognitive Impairment in Juvenile Murine Unilateral Hippocampal Synaptic Plasticity. Int J Radiat Oncol Biol Phys. 2021;doi: 10.1016/j.ijrobp.2021.09.041.
Fan, H., Sievert, W., Hofmann, J., Keppler, S. J., Steiger, K., Puig-Bosch, X., Haller, B., Rammes, G., & Multhoff, G. (2021). Partial-Brain Radiation-Induced Microvascular Cognitive Impairment in Juvenile Murine Unilateral Hippocampal Synaptic Plasticity. International journal of radiation oncology, biology, physics, . https://doi.org/10.1016/j.ijrobp.2021.09.041
Fan, Hengyi, et al. "Partial-Brain Radiation-Induced Microvascular Cognitive Impairment in Juvenile Murine Unilateral Hippocampal Synaptic Plasticity." International journal of radiation oncology, biology, physics vol. (2021). doi: https://doi.org/10.1016/j.ijrobp.2021.09.041
Fan H, Sievert W, Hofmann J, Keppler SJ, Steiger K, Puig-Bosch X, Haller B, Rammes G, Multhoff G. Partial-Brain Radiation-Induced Microvascular Cognitive Impairment in Juvenile Murine Unilateral Hippocampal Synaptic Plasticity. Int J Radiat Oncol Biol Phys. 2021 Oct 04; doi: 10.1016/j.ijrobp.2021.09.041. Epub 2021 Oct 04. PMID: 34619330.
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Potential Role of Hsp70 and Activated NK Cells for Prediction of Prognosis in Glioblastoma Patients.

Frontiers in molecular biosciences

Lobinger D, Gempt J, Sievert W, Barz M, Schmitt S, Nguyen HT, Stangl S, Werner C, Wang F, Wu Z, Fan H, Zanth H, Shevtsov M, Pilz M, Riederer I, Schwab M, Schlegel J, Multhoff G.
PMID: 34079819
Front Mol Biosci. 2021 May 17;8:669366. doi: 10.3389/fmolb.2021.669366. eCollection 2021.

Despite rapid progress in the treatment of many cancers, glioblastoma remains a devastating disease with dismal prognosis. The aim of this study was to identify chaperone- and immune-related biomarkers to improve prediction of outcome in glioblastoma. Depending on its...

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Lobinger D, Gempt J, Sievert W, et al. Potential Role of Hsp70 and Activated NK Cells for Prediction of Prognosis in Glioblastoma Patients. Front Mol Biosci. 2021;8:669366doi: 10.3389/fmolb.2021.669366.
Lobinger, D., Gempt, J., Sievert, W., Barz, M., Schmitt, S., Nguyen, H. T., Stangl, S., Werner, C., Wang, F., Wu, Z., Fan, H., Zanth, H., Shevtsov, M., Pilz, M., Riederer, I., Schwab, M., Schlegel, J., & Multhoff, G. (2021). Potential Role of Hsp70 and Activated NK Cells for Prediction of Prognosis in Glioblastoma Patients. Frontiers in molecular biosciences, 8669366. https://doi.org/10.3389/fmolb.2021.669366
Lobinger, Dominik, et al. "Potential Role of Hsp70 and Activated NK Cells for Prediction of Prognosis in Glioblastoma Patients." Frontiers in molecular biosciences vol. 8 (2021): 669366. doi: https://doi.org/10.3389/fmolb.2021.669366
Lobinger D, Gempt J, Sievert W, Barz M, Schmitt S, Nguyen HT, Stangl S, Werner C, Wang F, Wu Z, Fan H, Zanth H, Shevtsov M, Pilz M, Riederer I, Schwab M, Schlegel J, Multhoff G. Potential Role of Hsp70 and Activated NK Cells for Prediction of Prognosis in Glioblastoma Patients. Front Mol Biosci. 2021 May 17;8:669366. doi: 10.3389/fmolb.2021.669366. eCollection 2021. PMID: 34079819; PMCID: PMC8165168.
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Non-targeted effects of photon and particle irradiation and the interaction with the immune system.

Frontiers in oncology

Schmid TE, Multhoff G.
PMID: 22837986
Front Oncol. 2012 Jul 24;2:80. doi: 10.3389/fonc.2012.00080. eCollection 2012.

Ionizing irradiation is an important clinical approach to treat solid tumors. Modern radiation technologies aim to selectively kill tumor cells and protect the surrounding normal tissue. The standard paradigm for radiation effects in cellular systems involves damage of the...

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Schmid TE, Multhoff G. Non-targeted effects of photon and particle irradiation and the interaction with the immune system. Front Oncol. 2012;2:80doi: 10.3389/fonc.2012.00080.
Schmid, T. E., & Multhoff, G. (2012). Non-targeted effects of photon and particle irradiation and the interaction with the immune system. Frontiers in oncology, 280. https://doi.org/10.3389/fonc.2012.00080
Schmid, Thomas E, and Multhoff, Gabriele. "Non-targeted effects of photon and particle irradiation and the interaction with the immune system." Frontiers in oncology vol. 2 (2012): 80. doi: https://doi.org/10.3389/fonc.2012.00080
Schmid TE, Multhoff G. Non-targeted effects of photon and particle irradiation and the interaction with the immune system. Front Oncol. 2012 Jul 24;2:80. doi: 10.3389/fonc.2012.00080. eCollection 2012. PMID: 22837986; PMCID: PMC3402889.
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Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis.

Multiple sclerosis journal - experimental, translational and clinical

Lechner P, Buck D, Sick L, Hemmer B, Multhoff G.
PMID: 29780609
Mult Scler J Exp Transl Clin. 2018 May 02;4(2):2055217318767192. doi: 10.1177/2055217318767192. eCollection 2018.

BACKGROUND: Inflammatory and neurodegenerative processes are hallmarks of multiple sclerosis (MS). The synthesis of the major stress-inducible heat shock protein 70 (Hsp70) is induced by inflammation.OBJECTIVE: The purpose of this study is to determine whether Hsp70 in serum can...

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Lechner P, Buck D, Sick L, et al. Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis. Mult Scler J Exp Transl Clin. 2018;4(2):2055217318767192doi: 10.1177/2055217318767192.
Lechner, P., Buck, D., Sick, L., Hemmer, B., & Multhoff, G. (2018). Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis. Multiple sclerosis journal - experimental, translational and clinical, 4(2), 2055217318767192. https://doi.org/10.1177/2055217318767192
Lechner, Patricia, et al. "Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis." Multiple sclerosis journal - experimental, translational and clinical vol. 4,2 (2018): 2055217318767192. doi: https://doi.org/10.1177/2055217318767192
Lechner P, Buck D, Sick L, Hemmer B, Multhoff G. Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis. Mult Scler J Exp Transl Clin. 2018 May 02;4(2):2055217318767192. doi: 10.1177/2055217318767192. eCollection 2018. PMID: 29780609; PMCID: PMC5954314.
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Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.

Frontiers in immunology

Gunther S, Ostheimer C, Stangl S, Specht HM, Mozes P, Jesinghaus M, Vordermark D, Combs SE, Peltz F, Jung MP, Multhoff G.
PMID: 26579130
Front Immunol. 2015 Nov 02;6:556. doi: 10.3389/fimmu.2015.00556. eCollection 2015.

Heat-shock protein 70 (Hsp70) is frequently found on the plasma membrane of a large number of malignant tumors including non-small cell lung cancer (NSCLC) and gets released into the blood circulation in lipid vesicles. On the one hand, a...

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Gunther S, Ostheimer C, Stangl S, et al. Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer. Front Immunol. 2015;6:556doi: 10.3389/fimmu.2015.00556.
Gunther, S., Ostheimer, C., Stangl, S., Specht, H. M., Mozes, P., Jesinghaus, M., Vordermark, D., Combs, S. E., Peltz, F., Jung, M. P., & Multhoff, G. (2015). Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer. Frontiers in immunology, 6556. https://doi.org/10.3389/fimmu.2015.00556
Gunther, Sophie, et al. "Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer." Frontiers in immunology vol. 6 (2015): 556. doi: https://doi.org/10.3389/fimmu.2015.00556
Gunther S, Ostheimer C, Stangl S, Specht HM, Mozes P, Jesinghaus M, Vordermark D, Combs SE, Peltz F, Jung MP, Multhoff G. Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer. Front Immunol. 2015 Nov 02;6:556. doi: 10.3389/fimmu.2015.00556. eCollection 2015. PMID: 26579130; PMCID: PMC4629690.
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Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.

Frontiers in immunology

Gehrmann M, Cervello M, Montalto G, Cappello F, Gulino A, Knape C, Specht HM, Multhoff G.
PMID: 25071768
Front Immunol. 2014 Jul 01;5:307. doi: 10.3389/fimmu.2014.00307. eCollection 2014.

Members of the heat shock protein 70 (HSP70) family play an important role in assisting protein folding, preventing protein aggregation and transport of proteins across membranes under physiological conditions. Following environmental (i.e., irradiation, chemotherapy), physiological (i.e., cell growth, differentiation),...

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Gehrmann M, Cervello M, Montalto G, et al. Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Front Immunol. 2014;5:307doi: 10.3389/fimmu.2014.00307.
Gehrmann, M., Cervello, M., Montalto, G., Cappello, F., Gulino, A., Knape, C., Specht, H. M., & Multhoff, G. (2014). Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Frontiers in immunology, 5307. https://doi.org/10.3389/fimmu.2014.00307
Gehrmann, Mathias, et al. "Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma." Frontiers in immunology vol. 5 (2014): 307. doi: https://doi.org/10.3389/fimmu.2014.00307
Gehrmann M, Cervello M, Montalto G, Cappello F, Gulino A, Knape C, Specht HM, Multhoff G. Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Front Immunol. 2014 Jul 01;5:307. doi: 10.3389/fimmu.2014.00307. eCollection 2014. PMID: 25071768; PMCID: PMC4076752.
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Activation of PPARα by Fenofibrate Attenuates the Effect of Local Heart High Dose Irradiation on the Mouse Cardiac Proteome.

Biomedicines

Azimzadeh O, Subramanian V, Sievert W, Merl-Pham J, Oleksenko K, Rosemann M, Multhoff G, Atkinson MJ, Tapio S.
PMID: 34944662
Biomedicines. 2021 Dec 06;9(12). doi: 10.3390/biomedicines9121845.

Radiation-induced cardiovascular disease is associated with metabolic remodeling in the heart, mainly due to the inactivation of the transcription factor peroxisome proliferator-activated receptor alpha (PPARα), thereby inhibiting lipid metabolic enzymes. The objective of the present study was to investigate...

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Azimzadeh O, Subramanian V, Sievert W, et al. Activation of PPARα by Fenofibrate Attenuates the Effect of Local Heart High Dose Irradiation on the Mouse Cardiac Proteome. Biomedicines. 2021;9(12)doi: 10.3390/biomedicines9121845.
Azimzadeh, O., Subramanian, V., Sievert, W., Merl-Pham, J., Oleksenko, K., Rosemann, M., Multhoff, G., Atkinson, M. J., & Tapio, S. (2021). Activation of PPARα by Fenofibrate Attenuates the Effect of Local Heart High Dose Irradiation on the Mouse Cardiac Proteome. Biomedicines, 9(12), . https://doi.org/10.3390/biomedicines9121845
Azimzadeh, Omid, et al. "Activation of PPARα by Fenofibrate Attenuates the Effect of Local Heart High Dose Irradiation on the Mouse Cardiac Proteome." Biomedicines vol. 9,12 (2021). doi: https://doi.org/10.3390/biomedicines9121845
Azimzadeh O, Subramanian V, Sievert W, Merl-Pham J, Oleksenko K, Rosemann M, Multhoff G, Atkinson MJ, Tapio S. Activation of PPARα by Fenofibrate Attenuates the Effect of Local Heart High Dose Irradiation on the Mouse Cardiac Proteome. Biomedicines. 2021 Dec 06;9(12). doi: 10.3390/biomedicines9121845. PMID: 34944662.
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Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment.

Signal transduction and targeted therapy

Multhoff G, Vaupel P.
PMID: 33931598
Signal Transduct Target Ther. 2021 Apr 30;6(1):171. doi: 10.1038/s41392-021-00598-0.

No abstract available.

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Multhoff G, Vaupel P. Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment. Signal Transduct Target Ther. 2021;6(1):171doi: 10.1038/s41392-021-00598-0.
Multhoff, G., & Vaupel, P. (2021). Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment. Signal transduction and targeted therapy, 6(1), 171. https://doi.org/10.1038/s41392-021-00598-0
Multhoff, Gabriele, and Vaupel, Peter. "Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment." Signal transduction and targeted therapy vol. 6,1 (2021): 171. doi: https://doi.org/10.1038/s41392-021-00598-0
Multhoff G, Vaupel P. Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment. Signal Transduct Target Ther. 2021 Apr 30;6(1):171. doi: 10.1038/s41392-021-00598-0. PMID: 33931598; PMCID: PMC8087677.
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Membrane Hsp70-A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition.

Frontiers in oncology

Breuninger S, Stangl S, Werner C, Sievert W, Lobinger D, Foulds GA, Wagner S, Pickhard A, Piontek G, Kokowski K, Pockley AG, Multhoff G.
PMID: 30443493
Front Oncol. 2018 Nov 01;8:497. doi: 10.3389/fonc.2018.00497. eCollection 2018.

The presence of circulating tumor cells (CTCs) in the peripheral blood is a pre-requisite for progression, invasion, and metastatic spread of cancer. Consequently, the enumeration and molecular characterization of CTCs from the peripheral blood of patients with solid tumors...

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Breuninger S, Stangl S, Werner C, et al. Membrane Hsp70-A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition. Front Oncol. 2018;8:497doi: 10.3389/fonc.2018.00497.
Breuninger, S., Stangl, S., Werner, C., Sievert, W., Lobinger, D., Foulds, G. A., Wagner, S., Pickhard, A., Piontek, G., Kokowski, K., Pockley, A. G., & Multhoff, G. (2018). Membrane Hsp70-A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition. Frontiers in oncology, 8497. https://doi.org/10.3389/fonc.2018.00497
Breuninger, Stephanie, et al. "Membrane Hsp70-A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition." Frontiers in oncology vol. 8 (2018): 497. doi: https://doi.org/10.3389/fonc.2018.00497
Breuninger S, Stangl S, Werner C, Sievert W, Lobinger D, Foulds GA, Wagner S, Pickhard A, Piontek G, Kokowski K, Pockley AG, Multhoff G. Membrane Hsp70-A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition. Front Oncol. 2018 Nov 01;8:497. doi: 10.3389/fonc.2018.00497. eCollection 2018. PMID: 30443493; PMCID: PMC6223102.
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Showing 13 to 24 of 61 entries