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Showing 25 to 27 of 27 entries
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Control of satellite cell function in muscle regeneration and its disruption in ageing.

Nature reviews. Molecular cell biology

Sousa-Victor P, García-Prat L, Muñoz-Cánoves P.
PMID: 34663964
Nat Rev Mol Cell Biol. 2021 Oct 18; doi: 10.1038/s41580-021-00421-2. Epub 2021 Oct 18.

Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically and usually by asymmetric cell division to replace myofibres damaged by daily activity and maintain...

Stem cell aging in the skeletal muscle: The importance of communication.

Ageing research reviews

Hong X, Campanario S, Ramírez-Pardo I, Grima-Terrén M, Isern J, Muñoz-Cánoves P.
PMID: 34818593
Ageing Res Rev. 2021 Nov 21;73:101528. doi: 10.1016/j.arr.2021.101528. Epub 2021 Nov 21.

Adult stem cells sustain tissue homeostasis and regeneration; their functional decline is often linked to aging, which is characterized by the progressive loss of physiological functions across multiple tissues and organs. The resident stem cells in skeletal muscle, termed...

CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration.

Stem cell reports

Sreenivasan K, Rodríguez-delaRosa A, Kim J, Mesquita D, Segalés J, Arco PG, Espejo I, Ianni A, Di Croce L, Relaix F, Redondo JM, Braun T, Serrano AL, Perdiguero E, Muñoz-Cánoves P.
PMID: 34450038
Stem Cell Reports. 2021 Sep 14;16(9):2089-2098. doi: 10.1016/j.stemcr.2021.07.022. Epub 2021 Aug 26.

Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the expansion and regenerative functions of...

Showing 25 to 27 of 27 entries