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Showing 2449 to 2458 of 2458 entries
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A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams .

Chemical science

Li Y, Zhang CL, Huang WH, Sun N, Hao M, Neumann H, Beller M.
PMID: 34447539
Chem Sci. 2021 Jul 12;12(31):10467-10473. doi: 10.1039/d1sc02212a. eCollection 2021 Aug 11.

β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. Here, we report a novel one-step approach for the synthesis of α-(trifluoromethyl)-β-lactams and related products from fluorinated olefins, anilines and CO. Utilization...

Prognostic value of the nodal yield in elective neck dissections in patients with head and neck carcinomas.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

León X, Venegas MDP, Casasayas M, Rodríguez C, Neumann ED, Holgado A, Quer M.
PMID: 33938992
Eur Arch Otorhinolaryngol. 2021 May 03; doi: 10.1007/s00405-021-06819-0. Epub 2021 May 03.

PURPOSE: The objective of this study is to assess the prognostic capacity of the nodal yield in elective neck dissections performed in patients with head and neck squamous cell carcinomas (HNSCC) without clinical or radiological evidence of regional involvement...

HIV-1 promoter is gradually silenced when integrated into .

PeerJ

Inderbitzin A, Kok YL, Jörimann L, Kelley A, Neumann K, Heinzer D, Cathomen T, Metzner KJ.
PMID: 33282555
PeerJ. 2020 Nov 24;8:e10321. doi: 10.7717/peerj.10321. eCollection 2020.

BACKGROUND: The persistence of the latent HIV-1 reservoir is a major obstacle to curing HIV-1 infection. HIV-1 integrates into the cellular genome and some targeted genomic loci are frequently detected in clonally expanded latently HIV-1 infected cells, for instance,...

HDR Brachytherapy and SBRT as Bridging Therapy to Liver Transplantation in HCC Patients: A Single-Center Experience.

Frontiers in oncology

Walter F, Fuchs F, Gerum S, Rottler MC, Erdelkamp R, Neumann J, Nierer L, Guba M, De Toni EN, Seidensticker M, Ricke J, Belka C, Corradini S.
PMID: 34513694
Front Oncol. 2021 Aug 26;11:717792. doi: 10.3389/fonc.2021.717792. eCollection 2021.

BACKGROUND: In the treatment of patients with HCC awaiting liver transplantation (LT), local ablative treatments (LAT) are available either for downstaging or as bridging treatment. We present our clinical experience with both available radiation-based techniques, brachytherapy (BT), and stereotactic...

Long-Range Regulation of Key Sex Determination Genes.

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation

Migale R, Neumann M, Lovell-Badge R.
PMID: 34753143
Sex Dev. 2021;15(5):360-380. doi: 10.1159/000519891. Epub 2021 Nov 09.

The development of sexually dimorphic gonads is a unique process that starts with the specification of the bipotential genital ridges and culminates with the development of fully differentiated ovaries and testes in females and males, respectively. Research on sex...

Der Pathologe

Horak P, Leichsenring J, Kreutzfeldt S, Kazdal D, Teleanu V, Endris V, Volckmar AL, Renner M, Kirchner M, Heilig CE, Neumann O, Schirmacher P, Fröhling S, Stenzinger A.
PMID: 34605937
Pathologe. 2021 Nov;42(6):602. doi: 10.1007/s00292-021-01002-y.

No abstract available.

De Novo Calculation of the Charge Carrier Mobility in Amorphous Small Molecule Organic Semiconductors.

Frontiers in chemistry

Kaiser S, Neumann T, Symalla F, Schlöder T, Fediai A, Friederich P, Wenzel W.
PMID: 35004618
Front Chem. 2021 Dec 24;9:801589. doi: 10.3389/fchem.2021.801589. eCollection 2021.

Organic semiconductors (OSC) are key components in applications such as organic photovoltaics, organic sensors, transistors and organic light emitting diodes (OLED). OSC devices, especially OLEDs, often consist of multiple layers comprising one or more species of organic molecules. The...

The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice.

International journal of molecular sciences

Awida Z, Bachar A, Saed H, Gorodov A, Ben-Califa N, Ibrahim M, Kolomansky A, Iden JA, Graniewitz Visacovsky L, Liron T, Hiram-Bab S, Brines M, Gabet Y, Neumann D.
PMID: 35008482
Int J Mol Sci. 2021 Dec 21;23(1). doi: 10.3390/ijms23010055.

The two erythropoietin (EPO) receptor forms mediate different cellular responses to erythropoietin. While hematopoiesis is mediated via the homodimeric EPO receptor (EPOR), tissue protection is conferred via a heteromer composed of EPOR and CD131. In the skeletal system, EPO...

Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights?.

Frontiers in pediatrics

Ordonez MV, Neumann S, Caputo M, Curtis S, Biglino G.
PMID: 33748034
Front Pediatr. 2021 Mar 04;8:557407. doi: 10.3389/fped.2020.557407. eCollection 2020.

No abstract available.

Deep Time Course Proteomics of SARS-CoV- and SARS-CoV-2-Infected Human Lung Epithelial Cells (Calu-3) Reveals Strong Induction of Interferon-Stimulated Gene Expression by SARS-CoV-2 in Contrast to SARS-CoV.

Journal of proteome research

Grossegesse M, Bourquain D, Neumann M, Schaade L, Schulze J, Mache C, Wolff T, Nitsche A, Doellinger J.
PMID: 34982558
J Proteome Res. 2022 Jan 04; doi: 10.1021/acs.jproteome.1c00783. Epub 2022 Jan 04.

Severe acute respiratory syndrome (SARS)-CoV and SARS-CoV-2 infections are characterized by remarkable differences, including infectivity and case fatality rate. The underlying mechanisms are not well understood, illustrating major knowledge gaps of coronavirus biology. In this study, protein expression of...

Showing 2449 to 2458 of 2458 entries