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Gene therapy with SOCS1 induces potent preclinical antitumor activities in oral squamous cell carcinoma.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Nakatani K, Serada S, Fujimoto M, Obata K, Ohkawara T, Sasabe E, Yamamoto T, Naka T.
PMID: 34878693
J Oral Pathol Med. 2021 Dec 08; doi: 10.1111/jop.13268. Epub 2021 Dec 08.

BACKGROUND: Constitutive activation of STAT3 promotes oncogenesis and growth of oral squamous cell carcinoma (OSCC). We investigated the mechanism of action of suppressor of cytokine signaling-1 (SOCS1), an endogenous inhibitor of JAK, as gene therapy for OSCC.METHODS: Antitumor effect...

Showing 433 to 433 of 433 entries