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Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model.

Clinical & translational immunology

Brady JL, Harrison LC, Goodman DJ, Cowan PJ, Hawthorne WJ, O'Connell PJ, Sutherland RM, Lew AM.
PMID: 25587392
Clin Transl Immunology. 2014 Dec 19;3(12):e29. doi: 10.1038/cti.2014.28. eCollection 2014 Dec.

Monoclonal antibodies (mAbs) have been a spectacular clinical and commercial success in the treatment of cancer and autoimmune diseases. Many of these mAbs (for example, OKT3, Campath-1H, rituximab and infliximab) are against surface or secreted products of lymphocytes. However,...

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Brady JL, Harrison LC, Goodman DJ, et al. Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model. Clin Transl Immunology. 2014;3(12):e29doi: 10.1038/cti.2014.28.
Brady, J. L., Harrison, L. C., Goodman, D. J., Cowan, P. J., Hawthorne, W. J., O'Connell, P. J., Sutherland, R. M., & Lew, A. M. (2014). Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model. Clinical & translational immunology, 3(12), e29. https://doi.org/10.1038/cti.2014.28
Brady, Jamie L, et al. "Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model." Clinical & translational immunology vol. 3,12 (2014): e29. doi: https://doi.org/10.1038/cti.2014.28
Brady JL, Harrison LC, Goodman DJ, Cowan PJ, Hawthorne WJ, O'Connell PJ, Sutherland RM, Lew AM. Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model. Clin Transl Immunology. 2014 Dec 19;3(12):e29. doi: 10.1038/cti.2014.28. eCollection 2014 Dec. PMID: 25587392; PMCID: PMC4282178.
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Running in the family: A rare diagnosis of familial papillary thyroid cancer.

International journal of surgery case reports

O'Connell L, Prichard RS, O'Reilly E, Skehan S, Gibbons D, McDermott EW.
PMID: 26432498
Int J Surg Case Rep. 2015;16:64-6. doi: 10.1016/j.ijscr.2015.09.018. Epub 2015 Sep 21.

INTRODUCTION: Whilst inherited medullary thyroid cancer has been extensively reported, familial non-medullary thyroid cancer is a rare and less well described clinical entity. Familial forms of the disease demonstrate more aggressive features than sporadic non-medullary thyroid cancer.PRESENTATION OF CASE:...

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O'Connell L, Prichard RS, O'Reilly E, et al. Running in the family: A rare diagnosis of familial papillary thyroid cancer. Int J Surg Case Rep. 2015;16:64-6doi: 10.1016/j.ijscr.2015.09.018.
O'Connell, L., Prichard, R. S., O'Reilly, E., Skehan, S., Gibbons, D., & McDermott, E. W. (2015). Running in the family: A rare diagnosis of familial papillary thyroid cancer. International journal of surgery case reports, 1664-6. https://doi.org/10.1016/j.ijscr.2015.09.018
O'Connell, L, et al. "Running in the family: A rare diagnosis of familial papillary thyroid cancer." International journal of surgery case reports vol. 16 (2015): 64-6. doi: https://doi.org/10.1016/j.ijscr.2015.09.018
O'Connell L, Prichard RS, O'Reilly E, Skehan S, Gibbons D, McDermott EW. Running in the family: A rare diagnosis of familial papillary thyroid cancer. Int J Surg Case Rep. 2015;16:64-6. doi: 10.1016/j.ijscr.2015.09.018. Epub 2015 Sep 21. PMID: 26432498; PMCID: PMC4643435.
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Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1.

Frontiers in oncology

Dunne MR, Ryan C, Nolan B, Tosetto M, Geraghty R, Winter DC, O'Connell PR, Hyland JM, Doherty GA, Sheahan K, Ryan EJ, Fletcher JM.
PMID: 27014625
Front Oncol. 2016 Mar 07;6:50. doi: 10.3389/fonc.2016.00050. eCollection 2016.

T cell infiltration into colorectal tumors has been shown to correlate with improved patient outcomes. However, more detailed information on the makeup and relationships between the infiltrating T cell subsets is lacking. We therefore correlated the extent of immune...

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Dunne MR, Ryan C, Nolan B, et al. Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1. Front Oncol. 2016;6:50doi: 10.3389/fonc.2016.00050.
Dunne, M. R., Ryan, C., Nolan, B., Tosetto, M., Geraghty, R., Winter, D. C., O'Connell, P. R., Hyland, J. M., Doherty, G. A., Sheahan, K., Ryan, E. J., & Fletcher, J. M. (2016). Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1. Frontiers in oncology, 650. https://doi.org/10.3389/fonc.2016.00050
Dunne, Margaret R, et al. "Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1." Frontiers in oncology vol. 6 (2016): 50. doi: https://doi.org/10.3389/fonc.2016.00050
Dunne MR, Ryan C, Nolan B, Tosetto M, Geraghty R, Winter DC, O'Connell PR, Hyland JM, Doherty GA, Sheahan K, Ryan EJ, Fletcher JM. Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1. Front Oncol. 2016 Mar 07;6:50. doi: 10.3389/fonc.2016.00050. eCollection 2016. PMID: 27014625; PMCID: PMC4780371.
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Strong ionization asymmetry in a geometrically symmetric radio frequency capacitively coupled plasma induced by sawtooth voltage waveforms.

Physical review letters

Bruneau B, Gans T, O'Connell D, Greb A, Johnson EV, Booth JP.
PMID: 25860749
Phys Rev Lett. 2015 Mar 27;114(12):125002. doi: 10.1103/PhysRevLett.114.125002. Epub 2015 Mar 26.

The ionization dynamics in geometrically symmetric parallel plate capacitively coupled plasmas driven by radio frequency tailored voltage waveforms is investigated using phase resolved optical emission spectroscopy (PROES) and particle-in-cell (PIC) simulations. Temporally asymmetric waveforms induce spatial asymmetries and offer...

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Bruneau B, Gans T, O'Connell D, et al. Strong ionization asymmetry in a geometrically symmetric radio frequency capacitively coupled plasma induced by sawtooth voltage waveforms. Phys Rev Lett. 2015;114(12):125002doi: 10.1103/PhysRevLett.114.125002.
Bruneau, B., Gans, T., O'Connell, D., Greb, A., Johnson, E. V., & Booth, J. P. (2015). Strong ionization asymmetry in a geometrically symmetric radio frequency capacitively coupled plasma induced by sawtooth voltage waveforms. Physical review letters, 114(12), 125002. https://doi.org/10.1103/PhysRevLett.114.125002
Bruneau, Bastien, et al. "Strong ionization asymmetry in a geometrically symmetric radio frequency capacitively coupled plasma induced by sawtooth voltage waveforms." Physical review letters vol. 114,12 (2015): 125002. doi: https://doi.org/10.1103/PhysRevLett.114.125002
Bruneau B, Gans T, O'Connell D, Greb A, Johnson EV, Booth JP. Strong ionization asymmetry in a geometrically symmetric radio frequency capacitively coupled plasma induced by sawtooth voltage waveforms. Phys Rev Lett. 2015 Mar 27;114(12):125002. doi: 10.1103/PhysRevLett.114.125002. Epub 2015 Mar 26. PMID: 25860749.
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Fatal Pancreatic Necrosis after Pregnancy-Associated Thrombotic Thrombocytopenic Purpura.

Hematology (Amsterdam, Netherlands)

O'Connell N, Martin-Hernandez MP, Chacko J, Duggan C, O'Briain DS, Moriarty J, Browne PV, Mc Cann SR.
PMID: 27419606
Hematology. 2001;6(1):65-8. doi: 10.1080/10245332.2001.11746555.

Thrombotic thrombocytopenic purpura (TTP) is a systemic disease characterised by the presence of microvascular thrombi resulting from endothelial injury and platelet activation. Vascular occlusion leads to the clinical manifestations of ischaemicorgan damage, microangiopathic haemolytic anaemia and thrombocytopenia. Pancreatitis has...

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O'Connell N, Martin-Hernandez MP, Chacko J, et al. Fatal Pancreatic Necrosis after Pregnancy-Associated Thrombotic Thrombocytopenic Purpura. Hematology. 2001;6(1):65-8doi: 10.1080/10245332.2001.11746555.
O'Connell, N., Martin-Hernandez, M. P., Chacko, J., Duggan, C., O'Briain, D. S., Moriarty, J., Browne, P. V., & Mc Cann, S. R. (2001). Fatal Pancreatic Necrosis after Pregnancy-Associated Thrombotic Thrombocytopenic Purpura. Hematology (Amsterdam, Netherlands), 6(1), 65-8. https://doi.org/10.1080/10245332.2001.11746555
O'Connell, N, et al. "Fatal Pancreatic Necrosis after Pregnancy-Associated Thrombotic Thrombocytopenic Purpura." Hematology (Amsterdam, Netherlands) vol. 6,1 (2001): 65-8. doi: https://doi.org/10.1080/10245332.2001.11746555
O'Connell N, Martin-Hernandez MP, Chacko J, Duggan C, O'Briain DS, Moriarty J, Browne PV, Mc Cann SR. Fatal Pancreatic Necrosis after Pregnancy-Associated Thrombotic Thrombocytopenic Purpura. Hematology. 2001;6(1):65-8. doi: 10.1080/10245332.2001.11746555. PMID: 27419606.
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Low Temperature Plasma Causes Double-Strand Break DNA Damage in Primary Epithelial Cells Cultured from a Human Prostate Tumour.

IEEE transactions on plasma science. IEEE Nuclear and Plasma Sciences Society

Hirst AM, Frame FM, Maitland NJ, O'Connell D.
PMID: 26819484
IEEE Trans Plasma Sci IEEE Nucl Plasma Sci Soc. 2014 Sep 09;42(10):2740-2741. doi: 10.1109/TPS.2014.2351453.

Research in the new field of plasma medicine continues to demonstrate the efficacy of low temperature plasmas for numerous biomedical applications. Responses such as reduction in cell viability and cell death for cancer therapy, cell proliferation for wound healing,...

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Hirst AM, Frame FM, Maitland NJ, et al. Low Temperature Plasma Causes Double-Strand Break DNA Damage in Primary Epithelial Cells Cultured from a Human Prostate Tumour. IEEE Trans Plasma Sci IEEE Nucl Plasma Sci Soc. 2014;42(10):2740-2741doi: 10.1109/TPS.2014.2351453.
Hirst, A. M., Frame, F. M., Maitland, N. J., & O'Connell, D. (2014). Low Temperature Plasma Causes Double-Strand Break DNA Damage in Primary Epithelial Cells Cultured from a Human Prostate Tumour. IEEE transactions on plasma science. IEEE Nuclear and Plasma Sciences Society, 42(10), 2740-2741. https://doi.org/10.1109/TPS.2014.2351453
Hirst, Adam M, et al. "Low Temperature Plasma Causes Double-Strand Break DNA Damage in Primary Epithelial Cells Cultured from a Human Prostate Tumour." IEEE transactions on plasma science. IEEE Nuclear and Plasma Sciences Society vol. 42,10 (2014): 2740-2741. doi: https://doi.org/10.1109/TPS.2014.2351453
Hirst AM, Frame FM, Maitland NJ, O'Connell D. Low Temperature Plasma Causes Double-Strand Break DNA Damage in Primary Epithelial Cells Cultured from a Human Prostate Tumour. IEEE Trans Plasma Sci IEEE Nucl Plasma Sci Soc. 2014 Sep 09;42(10):2740-2741. doi: 10.1109/TPS.2014.2351453. PMID: 26819484; PMCID: PMC4724888.
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Interaction between pre-weaning undernutrition and post-weaning environmental enrichment on somatic development and behaviour in male and female rats.

Behavioural processes

Swanson HH, McConnell P, Uylings HB, Van Oyen HG, Van de Poll NE.
PMID: 24923604
Behav Processes. 1983 Mar;8(1):1-20. doi: 10.1016/0376-6357(83)90039-6.

Male and female rats were undernourished from birth to 30 days by restricting access to the lactating mother, and then fed ad libitum. At weaning, underfed and normally suckled controls were permanently housed either in pairs in standard cages...

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Swanson HH, McConnell P, Uylings HB, et al. Interaction between pre-weaning undernutrition and post-weaning environmental enrichment on somatic development and behaviour in male and female rats. Behav Processes. 1983;8(1):1-20doi: 10.1016/0376-6357(83)90039-6.
Swanson, H. H., McConnell, P., Uylings, H. B., Van Oyen, H. G., & Van de Poll, N. E. (1983). Interaction between pre-weaning undernutrition and post-weaning environmental enrichment on somatic development and behaviour in male and female rats. Behavioural processes, 8(1), 1-20. https://doi.org/10.1016/0376-6357(83)90039-6
Swanson, H H, et al. "Interaction between pre-weaning undernutrition and post-weaning environmental enrichment on somatic development and behaviour in male and female rats." Behavioural processes vol. 8,1 (1983): 1-20. doi: https://doi.org/10.1016/0376-6357(83)90039-6
Swanson HH, McConnell P, Uylings HB, Van Oyen HG, Van de Poll NE. Interaction between pre-weaning undernutrition and post-weaning environmental enrichment on somatic development and behaviour in male and female rats. Behav Processes. 1983 Mar;8(1):1-20. doi: 10.1016/0376-6357(83)90039-6. PMID: 24923604.
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Central hyperexcitability in chronic pain.

Pain research & management

O'Connell N.
PMID: 12712989
Pain Res Manag. 2002;7(4):212; author reply 212.

No abstract available.

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O'Connell N. Central hyperexcitability in chronic pain. Pain Res Manag. 2002;7(4):212; author reply 212
O'Connell, N. (2002). Central hyperexcitability in chronic pain. Pain research & management, 7(4), 212; author reply 212.
O'Connell, Neil. "Central hyperexcitability in chronic pain." Pain research & management vol. 7,4 (2002): 212; author reply 212.
O'Connell N. Central hyperexcitability in chronic pain. Pain Res Manag. 2002;7(4):212; author reply 212. PMID: 12712989.
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Gene expression analysis on medium-density oligonucleotide arrays.

Methods in molecular biology (Clifton, N.J.)

Sinibaldi R, O'Connell C, Seidel C, Rodriguez H.
PMID: 11357684
Methods Mol Biol. 2001;170:211-22. doi: 10.1385/1-59259-234-1:211.

No abstract available.

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Sinibaldi R, O'Connell C, Seidel C, et al. Gene expression analysis on medium-density oligonucleotide arrays. Methods Mol Biol. 2001;170:211-22doi: 10.1385/1-59259-234-1:211.
Sinibaldi, R., O'Connell, C., Seidel, C., & Rodriguez, H. (2001). Gene expression analysis on medium-density oligonucleotide arrays. Methods in molecular biology (Clifton, N.J.), 170211-22. https://doi.org/10.1385/1-59259-234-1:211
Sinibaldi, R, et al. "Gene expression analysis on medium-density oligonucleotide arrays." Methods in molecular biology (Clifton, N.J.) vol. 170 (2001): 211-22. doi: https://doi.org/10.1385/1-59259-234-1:211
Sinibaldi R, O'Connell C, Seidel C, Rodriguez H. Gene expression analysis on medium-density oligonucleotide arrays. Methods Mol Biol. 2001;170:211-22. doi: 10.1385/1-59259-234-1:211. PMID: 11357684.
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Comparative Analysis of [Au(en)(2)] and [Pt(en)(2)] non Covalent Binding to Calf Thymus DNA.

Metal-based drugs

Marcon G, O'Connell T, Orioli P, Messori L.
PMID: 18475953
Met Based Drugs. 2000;7(5):253-6. doi: 10.1155/MBD.2000.253.

Reactions of the complexes bisethylendiammine gold(III) and bisethylendiammine platinum(II) with calfthymus DNA were comparatively analysed. Both complexes bind DNA non-covalently most probably on the basis of electrostatic interactions. Binding of either complex at low ratios results into modest modifications...

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Marcon G, O'Connell T, Orioli P, et al. Comparative Analysis of [Au(en)(2)] and [Pt(en)(2)] non Covalent Binding to Calf Thymus DNA. Met Based Drugs. 2000;7(5):253-6doi: 10.1155/MBD.2000.253.
Marcon, G., O'Connell, T., Orioli, P., & Messori, L. (2000). Comparative Analysis of [Au(en)(2)] and [Pt(en)(2)] non Covalent Binding to Calf Thymus DNA. Metal-based drugs, 7(5), 253-6. https://doi.org/10.1155/MBD.2000.253
Marcon, G, et al. "Comparative Analysis of [Au(en)(2)] and [Pt(en)(2)] non Covalent Binding to Calf Thymus DNA." Metal-based drugs vol. 7,5 (2000): 253-6. doi: https://doi.org/10.1155/MBD.2000.253
Marcon G, O'Connell T, Orioli P, Messori L. Comparative Analysis of [Au(en)(2)] and [Pt(en)(2)] non Covalent Binding to Calf Thymus DNA. Met Based Drugs. 2000;7(5):253-6. doi: 10.1155/MBD.2000.253. PMID: 18475953; PMCID: PMC2365231.
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Pulsed-field gel electrophoresis typing of Campylobacter fetus subsp. fetus isolated from sheep abortions in New Zealand.

New Zealand veterinary journal

Mannering SA, West DM, Fenwick SG, Marchant RM, Perkins NR, O'connell K.
PMID: 15768136
N Z Vet J. 2004 Dec;52(6):358-63. doi: 10.1080/00480169.2004.36452.

AIMS: To genotype Campylobacter fetus subsp. fetus isolates cultured from sheep abortions submitted to diagnostic laboratories in New Zealand during the year 2000 breeding season. To compare the types found nationally with those found in the Hawke's Bay region...

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Mannering SA, West DM, Fenwick SG, et al. Pulsed-field gel electrophoresis typing of Campylobacter fetus subsp. fetus isolated from sheep abortions in New Zealand. N Z Vet J. 2004;52(6):358-63doi: 10.1080/00480169.2004.36452.
Mannering, S. A., West, D. M., Fenwick, S. G., Marchant, R. M., Perkins, N. R., & O'connell, K. (2004). Pulsed-field gel electrophoresis typing of Campylobacter fetus subsp. fetus isolated from sheep abortions in New Zealand. New Zealand veterinary journal, 52(6), 358-63. https://doi.org/10.1080/00480169.2004.36452
Mannering, S A, et al. "Pulsed-field gel electrophoresis typing of Campylobacter fetus subsp. fetus isolated from sheep abortions in New Zealand." New Zealand veterinary journal vol. 52,6 (2004): 358-63. doi: https://doi.org/10.1080/00480169.2004.36452
Mannering SA, West DM, Fenwick SG, Marchant RM, Perkins NR, O'connell K. Pulsed-field gel electrophoresis typing of Campylobacter fetus subsp. fetus isolated from sheep abortions in New Zealand. N Z Vet J. 2004 Dec;52(6):358-63. doi: 10.1080/00480169.2004.36452. PMID: 15768136.
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The relationship between anti-HPV-16 IgG seropositivity and cancer of the cervix, anogenital organs, oral cavity and pharynx, oesophagus and prostate in a black South African population.

Infectious agents and cancer

Sitas F, Urban M, Stein L, Beral V, Ruff P, Hale M, Patel M, O'Connell D, Yu XQ, Verzijden A, Marais D, Williamson AL.
PMID: 17331260
Infect Agent Cancer. 2007 Mar 02;2:6. doi: 10.1186/1750-9378-2-6.

BACKGROUND: Human papillomavirus type 16 (HPV-16) infection is an important cause of cervical cancer, other anogenital cancers and, possibly, some oral and pharyngeal cancers. The association of HPV-16 with oesophageal and with prostate cancers has not been firmly established.METHODS:...

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Sitas F, Urban M, Stein L, et al. The relationship between anti-HPV-16 IgG seropositivity and cancer of the cervix, anogenital organs, oral cavity and pharynx, oesophagus and prostate in a black South African population. Infect Agent Cancer. 2007;2:6doi: 10.1186/1750-9378-2-6.
Sitas, F., Urban, M., Stein, L., Beral, V., Ruff, P., Hale, M., Patel, M., O'Connell, D., Yu, X. Q., Verzijden, A., Marais, D., & Williamson, A. L. (2007). The relationship between anti-HPV-16 IgG seropositivity and cancer of the cervix, anogenital organs, oral cavity and pharynx, oesophagus and prostate in a black South African population. Infectious agents and cancer, 26. https://doi.org/10.1186/1750-9378-2-6
Sitas, Freddy, et al. "The relationship between anti-HPV-16 IgG seropositivity and cancer of the cervix, anogenital organs, oral cavity and pharynx, oesophagus and prostate in a black South African population." Infectious agents and cancer vol. 2 (2007): 6. doi: https://doi.org/10.1186/1750-9378-2-6
Sitas F, Urban M, Stein L, Beral V, Ruff P, Hale M, Patel M, O'Connell D, Yu XQ, Verzijden A, Marais D, Williamson AL. The relationship between anti-HPV-16 IgG seropositivity and cancer of the cervix, anogenital organs, oral cavity and pharynx, oesophagus and prostate in a black South African population. Infect Agent Cancer. 2007 Mar 02;2:6. doi: 10.1186/1750-9378-2-6. PMID: 17331260; PMCID: PMC1821007.
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Showing 13 to 24 of 717 entries