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Showing 181 to 188 of 188 entries
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The Future of Disability Research in Australia: Protocol for a Multiphase Research Agenda-Setting Study.

JMIR research protocols

Smith-Merry J, O'Donovan MA, Dew A, Hemsley B, Imms C, Carey G, Darcy S, Ellem K, Gallego G, Gilroy J, Guastella A, Marella M, McVilly K, Plumb J.
PMID: 34706859
JMIR Res Protoc. 2022 Jan 03;11(1):e31126. doi: 10.2196/31126.

BACKGROUND: For people with disabilities to live a good life, it is essential that funded research in health and social care addresses their interests, meets their needs, and fills gaps in our understanding of the impact that services, systems,...

The Future of Disability Research in Australia: Protocol for a Multiphase Research Agenda-Setting Study.

JMIR research protocols

Smith-Merry J, O'Donovan MA, Dew A, Hemsley B, Imms C, Carey G, Darcy S, Ellem K, Gallego G, Gilroy J, Guastella A, Marella M, McVilly K, Plumb J.
PMID: 34706859
JMIR Res Protoc. 2022 Jan 03;11(1):e31126. doi: 10.2196/31126.

BACKGROUND: For people with disabilities to live a good life, it is essential that funded research in health and social care addresses their interests, meets their needs, and fills gaps in our understanding of the impact that services, systems,...

Chronic levetiracetam (Keppra®) treatment increases the reinforcing strength of cocaine in rhesus monkeys.

Pharmacology, biochemistry, and behavior

Czoty PW, Gould RW, O'Donovan CA, Nader MA.
PMID: 34116078
Pharmacol Biochem Behav. 2021 Aug;207:173217. doi: 10.1016/j.pbb.2021.173217. Epub 2021 Jun 08.

BACKGROUND: Drugs that increase inhibitory neuronal activity in the brain have been proposed as potential medications for stimulant use disorders.OBJECTIVE: The present study assessed the ability of chronically administered levetiracetam (Keppra®), a clinically available anticonvulsant drug that increases GABA...

Editorial overview: Neuroscience: Advances in the field.

Current opinion in pharmacology

O'Donovan SM, McCullumsmith R, Shukla R.
PMID: 34942403
Curr Opin Pharmacol. 2021 Dec 20;62:82-84. doi: 10.1016/j.coph.2021.11.004. Epub 2021 Dec 20.

No abstract available.

Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk.

Translational psychiatry

Dimitriadis SI, Perry G, Foley SF, Tansey KE, Jones DK, Holmans P, Zammit S, Hall J, O'Donovan MC, Owen MJ, Singh KD, Linden DE.
PMID: 34785639
Transl Psychiatry. 2021 Nov 16;11(1):592. doi: 10.1038/s41398-021-01678-z.

Gamma oscillations (30-90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric diseases. Magnetoencephalography (MEG) provides highly reliable visual-induced gamma oscillation estimates, both...

DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia.

eLife

Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forti M, Dinan TG, Donohoe G, Gaughran F, Gill M, Gillespie A, Gunasinghe C, Hulshoff HE, Hultman CM, Johansson V, Kahn RS, Kaprio J, Kenis G, Kowalec K, MacCabe J, McDonald C, McQuillin A, Morris DW, Murphy KC, Mustard CJ, Nenadic I, O'Donovan MC, Quattrone D, Richards AL, Rutten BP, St Clair D, Therman S, Toulopoulou T, Van Os J, Waddington JL, Sullivan P, Vassos E, Breen G, Collier DA, Murray RM, Schalkwyk LS, Mill J.
PMID: 33646943
Elife. 2021 Feb 26;10. doi: 10.7554/eLife.58430.

We performed a systematic analysis of blood DNA methylation profiles from 4483 participants from seven independent cohorts identifying differentially methylated positions (DMPs) associated with psychosis, schizophrenia, and treatment-resistant schizophrenia. Psychosis cases were characterized by significant differences in measures of...

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.

Psychological medicine

Johnson EC, Kapoor M, Hatoum AS, Zhou H, Polimanti R, Wendt FR, Walters RK, Lai D, Kember RL, Hartz S, Meyers JL, Peterson RE, Ripke S, Bigdeli TB, Fanous AH, Pato CN, Pato MT, Goate AM, Kranzler HR, O'Donovan MC, Walters JTR, Gelernter J, Edenberg HJ, Agrawal A.
PMID: 34231451
Psychol Med. 2021 Jul 07;1-9. doi: 10.1017/S003329172100266X. Epub 2021 Jul 07.

BACKGROUND: Alcohol use disorder (AUD) and schizophrenia (SCZ) frequently co-occur, and large-scale genome-wide association studies (GWAS) have identified significant genetic correlations between these disorders.METHODS: We used the largest published GWAS for AUD (total cases = 77 822) and SCZ...

Healthcare Professionals Experience of Psychological Safety, Voice, and Silence.

Frontiers in psychology

O'Donovan R, De Brún A, McAuliffe E.
PMID: 33679547
Front Psychol. 2021 Feb 19;12:626689. doi: 10.3389/fpsyg.2021.626689. eCollection 2021.

Healthcare professionals who feel psychologically safe believe it is safe to take interpersonal risks such as voicing concerns, asking questions and giving feedback. Psychological safety is a complex phenomenon which is influenced by organizational, team and individual level factors....

Showing 181 to 188 of 188 entries