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Showing 25 to 26 of 26 entries
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Therapeutic targeting of Aurora A kinase in Philadelphia chromosome-positive ABL tyrosine kinase inhibitor-resistant cells.

Oncotarget

Okabe S, Tauchi T, Tanaka Y, Ohyashiki K.
PMID: 30197758
Oncotarget. 2018 Aug 21;9(65):32496-32506. doi: 10.18632/oncotarget.25985. eCollection 2018 Aug 21.

Abelson murine leukemia viral oncogene homolog (ABL) tyrosine kinase inhibitors (TKIs) have been shown to be effective for treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia patients. However, resistance to ABL TKIs can develop...

Teriflunomide restores 5-azacytidine sensitivity via activation of pyrimidine salvage in 5-azacytidine-resistant leukemia cells.

Oncotarget

Imanishi S, Takahashi R, Katagiri S, Kobayashi C, Umezu T, Ohyashiki K, Ohyashiki JH.
PMID: 29050250
Oncotarget. 2017 Jul 22;8(41):69906-69915. doi: 10.18632/oncotarget.19436. eCollection 2017 Sep 19.

Previous studies showed that downregulation of pyrimidine salvage underlies resistance against 5-azacytidine (AZA), indicating an important role for

Showing 25 to 26 of 26 entries