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Showing 889 to 898 of 898 entries
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Propionate alleviates myocardial ischemia-reperfusion injury aggravated by Angiotensin II dependent on caveolin-1/ACE2 axis through GPR41.

International journal of biological sciences

Deng F, Zhang LQ, Wu H, Chen Y, Yu WQ, Han RH, Han Y, Zhang XQ, Sun QS, Lin ZB, Wang Y, Liu YP, Chen JY, Liu KX, Hu JJ.
PMID: 35002530
Int J Biol Sci. 2022 Jan 01;18(2):858-872. doi: 10.7150/ijbs.67724. eCollection 2022.

Myocardial ischemia/reperfusion (I/R) injury is still a lack of effective therapeutic drugs, and its molecular mechanism is urgently needed. Studies have shown that the intestinal flora plays an important regulatory role in cardiovascular injury, but the specific mechanism has...

Comparative Genomic Analyses Reveal Potential Factors Responsible for the ST6 Oxacillin-Resistant .

Frontiers in microbiology

Chang SC, Lin LC, Lu JJ.
PMID: 34899648
Front Microbiol. 2021 Nov 25;12:765437. doi: 10.3389/fmicb.2021.765437. eCollection 2021.

Oxacillin-resistant

Disseminated nontuberculous mycobacteria infection in human immunodeficiency virus-infected patients.

Chinese medical journal

Liu L, Hu JJ, Lu HZ.
PMID: 34653083
Chin Med J (Engl). 2021 Oct 13;134(23):2838-2840. doi: 10.1097/CM9.0000000000001820.

No abstract available.

Heme oxygenase 1: a novel oncogene in multiple gynecological cancers.

International journal of biological sciences

Lu JJ, Abudukeyoumu A, Zhang X, Liu LB, Li MQ, Xie F.
PMID: 34239353
Int J Biol Sci. 2021 Jun 01;17(9):2252-2261. doi: 10.7150/ijbs.61073. eCollection 2021.

Heme oxygenase 1 (HO-1), also known as heat shock protein 32 (HSP32), is a stress-inducible enzyme. In the past, it was believed to participate in maintaining cell homeostasis, reducing oxidative stress damage and exerting anti-apoptotic effects. When exposed to...

Liver injury associated with acute pancreatitis: The current status of clinical evaluation and involved mechanisms.

World journal of clinical cases

Liu W, Du JJ, Li ZH, Zhang XY, Zuo HD.
PMID: 35004974
World J Clin Cases. 2021 Dec 06;9(34):10418-10429. doi: 10.12998/wjcc.v9.i34.10418.

Acute pancreatitis (AP) is a very common acute disease, and the mortality rate of severe AP (SAP) is between 15% and 35%. The main causes of death are multiple organ dysfunction syndrome and infections. The mortality rate of patients...

A Comparison Study of Machine Learning (Random Survival Forest) and Classic Statistic (Cox Proportional Hazards) for Predicting Progression in High-Grade Glioma after Proton and Carbon Ion Radiotherapy.

Frontiers in oncology

Qiu X, Gao J, Yang J, Hu J, Hu W, Kong L, Lu JJ.
PMID: 33194609
Front Oncol. 2020 Oct 30;10:551420. doi: 10.3389/fonc.2020.551420. eCollection 2020.

BACKGROUND: Machine learning (ML) algorithms are increasingly explored in glioma prognostication. Random survival forest (RSF) is a common ML approach in analyzing time-to-event survival data. However, it is controversial which method between RSF and traditional cornerstone method Cox proportional...

Evaluation of Polygenic Risk Scores for Prediction of Prostate Cancer in Korean Men.

Frontiers in oncology

Oh JJ, Kim E, Woo E, Song SH, Kim JK, Lee H, Lee S, Hong SK, Byun SS.
PMID: 33194723
Front Oncol. 2020 Oct 22;10:583625. doi: 10.3389/fonc.2020.583625. eCollection 2020.

AIMS: The purpose of this study is to evaluate an aggregate influence of prostate cancer (PCa) susceptibility variants on the development of PCa in Korean men by using the polygenic risk score (PRS) approach.METHODS: An analysis of 1,001 cases...

The development of small-molecule inhibitors targeting CD47.

Drug discovery today

Yu WB, Ye ZH, Chen X, Shi JJ, Lu JJ.
PMID: 33197622
Drug Discov Today. 2021 Feb;26(2):561-568. doi: 10.1016/j.drudis.2020.11.003. Epub 2020 Nov 13.

Immunotherapy has become an indispensable part of cancer treatment. A pivotal phagocytosis checkpoint, named cluster of differentiation 47 (CD47), which functions as 'don't eat me' signal to protect cells from phagocytosis upon interaction with signal regulatory protein alpha (SIRPĪ±)...

Genetic Association Between Hypoplastic Left Heart Syndrome and Cardiomyopathies.

Circulation. Genomic and precision medicine

Theis JL, Hu JJ, Sundsbak RS, Evans JM, Bamlet WR, Qureshi MY, O'Leary PW, Olson TM.
PMID: 33325730
Circ Genom Precis Med. 2021 Feb;14(1):e003126. doi: 10.1161/CIRCGEN.120.003126. Epub 2020 Dec 16.

BACKGROUND: Hypoplastic left heart syndrome (HLHS) with risk of poor outcome has been linked to METHODS: Whole genome sequencing was performed in 197 probands with HLHS, 43 family members, and 813 controls. Data were filtered for rare, segregating variants...

The Role of Notch, Hedgehog, and Wnt Signaling Pathways in the Resistance of Tumors to Anticancer Therapies.

Frontiers in cell and developmental biology

Kumar V, Vashishta M, Kong L, Wu X, Lu JJ, Guha C, Dwarakanath BS.
PMID: 33968932
Front Cell Dev Biol. 2021 Apr 22;9:650772. doi: 10.3389/fcell.2021.650772. eCollection 2021.

Resistance to therapy is the major hurdle in the current cancer management. Cancer cells often rewire their cellular process to alternate mechanisms to resist the deleterious effect mounted by different therapeutic approaches. The major signaling pathways involved in the...

Showing 889 to 898 of 898 entries