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Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness.

The Journal of experimental medicine

Isringhausen S, Mun Y, Kovtonyuk L, Kräutler NJ, Suessbier U, Gomariz A, Spaltro G, Helbling PM, Wong HC, Nagasawa T, Manz MG, Oxenius A, Nombela-Arrieta C.
PMID: 34709350
J Exp Med. 2021 Dec 06;218(12). doi: 10.1084/jem.20192070. Epub 2021 Oct 28.

Chronic viral infections are associated with hematopoietic suppression, bone marrow (BM) failure, and hematopoietic stem cell (HSC) exhaustion. However, how persistent viral challenge and inflammatory responses target BM tissues and perturb hematopoietic competence remains poorly understood. Here, we combine...

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Isringhausen S, Mun Y, Kovtonyuk L, et al. Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness. J Exp Med. 2021;218(12)doi: 10.1084/jem.20192070.
Isringhausen, S., Mun, Y., Kovtonyuk, L., Kräutler, N. J., Suessbier, U., Gomariz, A., Spaltro, G., Helbling, P. M., Wong, H. C., Nagasawa, T., Manz, M. G., Oxenius, A., & Nombela-Arrieta, C. (2021). Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness. The Journal of experimental medicine, 218(12), . https://doi.org/10.1084/jem.20192070
Isringhausen, Stephan, et al. "Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness." The Journal of experimental medicine vol. 218,12 (2021). doi: https://doi.org/10.1084/jem.20192070
Isringhausen S, Mun Y, Kovtonyuk L, Kräutler NJ, Suessbier U, Gomariz A, Spaltro G, Helbling PM, Wong HC, Nagasawa T, Manz MG, Oxenius A, Nombela-Arrieta C. Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness. J Exp Med. 2021 Dec 06;218(12). doi: 10.1084/jem.20192070. Epub 2021 Oct 28. PMID: 34709350; PMCID: PMC8558839.
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Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion.

eLife

Angulo G, Zeleznjak J, Martínez-Vicente P, Puñet-Ortiz J, Hengel H, Messerle M, Oxenius A, Jonjic S, Krmpotić A, Engel P, Angulo A.
PMID: 33459589
Elife. 2021 Jan 18;10. doi: 10.7554/eLife.59350.

Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation. Here, we show that ICOSL...

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Angulo G, Zeleznjak J, Martínez-Vicente P, et al. Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. Elife. 2021;10doi: 10.7554/eLife.59350.
Angulo, G., Zeleznjak, J., Martínez-Vicente, P., Puñet-Ortiz, J., Hengel, H., Messerle, M., Oxenius, A., Jonjic, S., Krmpotić, A., Engel, P., & Angulo, A. (2021). Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. eLife, 10. https://doi.org/10.7554/eLife.59350
Angulo, Guillem, et al. "Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.59350
Angulo G, Zeleznjak J, Martínez-Vicente P, Puñet-Ortiz J, Hengel H, Messerle M, Oxenius A, Jonjic S, Krmpotić A, Engel P, Angulo A. Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. Elife. 2021 Jan 18;10. doi: 10.7554/eLife.59350. PMID: 33459589; PMCID: PMC7840182.
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CD4 T Cell-Mediated Immune Control of Cytomegalovirus Infection in Murine Salivary Glands.

Pathogens (Basel, Switzerland)

Zangger N, Oderbolz J, Oxenius A.
PMID: 34959486
Pathogens. 2021 Nov 23;10(12). doi: 10.3390/pathogens10121531.

CD4 T cells are well known for their supportive role in CD8 T cell and B cell responses during viral infection. However, during murine cytomegalovirus (MCMV) infection in the salivary glands (SGs), CD4 T cells exhibit direct antiviral effector...

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Zangger N, Oderbolz J, Oxenius A. CD4 T Cell-Mediated Immune Control of Cytomegalovirus Infection in Murine Salivary Glands. Pathogens. 2021;10(12)doi: 10.3390/pathogens10121531.
Zangger, N., Oderbolz, J., & Oxenius, A. (2021). CD4 T Cell-Mediated Immune Control of Cytomegalovirus Infection in Murine Salivary Glands. Pathogens (Basel, Switzerland), 10(12), . https://doi.org/10.3390/pathogens10121531
Zangger, Nathan, et al. "CD4 T Cell-Mediated Immune Control of Cytomegalovirus Infection in Murine Salivary Glands." Pathogens (Basel, Switzerland) vol. 10,12 (2021). doi: https://doi.org/10.3390/pathogens10121531
Zangger N, Oderbolz J, Oxenius A. CD4 T Cell-Mediated Immune Control of Cytomegalovirus Infection in Murine Salivary Glands. Pathogens. 2021 Nov 23;10(12). doi: 10.3390/pathogens10121531. PMID: 34959486.
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Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis.

European journal of immunology

Neumeier D, Pedrioli A, Genovese A, Sandu I, Ehling R, Hong KL, Papadopoulou C, Agrafiotis A, Kuhn R, Shlesinger D, Robbiani D, Han J, Hauri L, Csepregi L, Greiff V, Merkler D, Reddy ST, Oxenius A, Yermanos A.
PMID: 34727578
Eur J Immunol. 2021 Nov 02; doi: 10.1002/eji.202149331. Epub 2021 Nov 02.

Plasma cells and their secreted antibodies play a central role in the long-term protection against chronic viral infection. However, due to experimental limitations, a comprehensive description of linked genotypic, phenotypic, and antibody repertoire features of plasma cells (gene expression,...

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Neumeier D, Pedrioli A, Genovese A, et al. Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis. Eur J Immunol. 2021;doi: 10.1002/eji.202149331.
Neumeier, D., Pedrioli, A., Genovese, A., Sandu, I., Ehling, R., Hong, K. L., Papadopoulou, C., Agrafiotis, A., Kuhn, R., Shlesinger, D., Robbiani, D., Han, J., Hauri, L., Csepregi, L., Greiff, V., Merkler, D., Reddy, S. T., Oxenius, A., & Yermanos, A. (2021). Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis. European journal of immunology, . https://doi.org/10.1002/eji.202149331
Neumeier, Daniel, et al. "Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis." European journal of immunology vol. (2021). doi: https://doi.org/10.1002/eji.202149331
Neumeier D, Pedrioli A, Genovese A, Sandu I, Ehling R, Hong KL, Papadopoulou C, Agrafiotis A, Kuhn R, Shlesinger D, Robbiani D, Han J, Hauri L, Csepregi L, Greiff V, Merkler D, Reddy ST, Oxenius A, Yermanos A. Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis. Eur J Immunol. 2021 Nov 02; doi: 10.1002/eji.202149331. Epub 2021 Nov 02. PMID: 34727578.
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Editorial overview: Viral immunology before COVID-19.

Current opinion in virology

Oxenius A, Zajac AJ.
PMID: 34968790
Curr Opin Virol. 2021 Nov 24;52:217-219. doi: 10.1016/j.coviro.2021.11.010. Epub 2021 Nov 24.

No abstract available.

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Oxenius A, Zajac AJ. Editorial overview: Viral immunology before COVID-19. Curr Opin Virol. 2021;52:217-219doi: 10.1016/j.coviro.2021.11.010.
Oxenius, A., & Zajac, A. J. (2021). Editorial overview: Viral immunology before COVID-19. Current opinion in virology, 52217-219. https://doi.org/10.1016/j.coviro.2021.11.010
Oxenius, Annette, and Zajac, Allan J. "Editorial overview: Viral immunology before COVID-19." Current opinion in virology vol. 52 (2021): 217-219. doi: https://doi.org/10.1016/j.coviro.2021.11.010
Oxenius A, Zajac AJ. Editorial overview: Viral immunology before COVID-19. Curr Opin Virol. 2021 Nov 24;52:217-219. doi: 10.1016/j.coviro.2021.11.010. Epub 2021 Nov 24. PMID: 34968790.
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Showing 73 to 77 of 77 entries