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Showing 9985 to 9996 of 23572 entries
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Expanding TNM for lung cancer through machine learning.

Thoracic cancer

Hueman M, Wang H, Liu Z, Henson D, Nguyen C, Park D, Sheng L, Chen D.
PMID: 33713568
Thorac Cancer. 2021 May;12(9):1423-1430. doi: 10.1111/1759-7714.13926. Epub 2021 Mar 13.

BACKGROUND: Expanding the tumor, lymph node, metastasis (TNM) staging system by accommodating new prognostic and predictive factors for cancer will improve patient stratification and survival prediction. Here, we introduce machine learning for incorporating additional prognostic factors into the conventional...

Structure of the Human TELO2-TTI1-TTI2 Complex.

Journal of molecular biology

Kim Y, Park J, Joo SY, Kim BG, Jo A, Lee H, Cho Y.
PMID: 34838521
J Mol Biol. 2022 Jan 30;434(2):167370. doi: 10.1016/j.jmb.2021.167370. Epub 2021 Nov 24.

Phosphatidylinositol 3-kinase-related protein kinases (PIKKs) play critical roles in various metabolic pathways related to cell proliferation and survival. The TELO2-TTI1-TTI2 (TTT) complex has been proposed to recognize newly synthesized PIKKs and to deliver them to the R2TP complex (RUVBL1-RUVBL2-RPAP3-PIH1D1)...

The Cholesterol-Lowering Effect of Capsella Bursa-Pastoris Is Mediated via SREBP2 and HNF-1α-Regulated PCSK9 Inhibition in Obese Mice and HepG2 Cells.

Foods (Basel, Switzerland)

Hwang JT, Choi E, Choi HK, Park JH, Chung MY.
PMID: 33673187
Foods. 2021 Feb 12;10(2). doi: 10.3390/foods10020408.

The objective of the present study was to investigate the mechanism by which capsella bursa-pastoris ethanol extract (CBE), containing 17.5 milligrams of icaritin per kilogram of the extract, and icaritin, mediate hypocholesterolemic activity via the low-density lipoprotein receptor (LDLR)...

Assessing the reproducibility of high temporal and spatial resolution dynamic contrast-enhanced magnetic resonance imaging in patients with gliomas.

Scientific reports

Lim WH, Park JS, Park J, Choi SH.
PMID: 34853347
Sci Rep. 2021 Dec 01;11(1):23217. doi: 10.1038/s41598-021-02450-5.

Temporal and spatial resolution of dynamic contrast-enhanced MR imaging (DCE-MRI) is critical to reproducibility, and the reproducibility of high-resolution (HR) DCE-MRI was evaluated. Thirty consecutive patients suspected to have brain tumors were prospectively enrolled with written informed consent. All...

Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application.

Frontiers in cell and developmental biology

Vasan L, Park E, David LA, Fleming T, Schuurmans C.
PMID: 34291049
Front Cell Dev Biol. 2021 Jul 05;9:681087. doi: 10.3389/fcell.2021.681087. eCollection 2021.

Direct neuronal reprogramming is an innovative new technology that involves the conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent state. The capacity to make new neurons in the brain, which previously was not achievable,...

Phase I Study of Ceralasertib (AZD6738), a Novel DNA Damage Repair Agent, in Combination with Weekly Paclitaxel in Refractory Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kim ST, Smith SA, Mortimer P, Loembé AB, Cho H, Kim KM, Smith C, Willis S, Irurzun-Arana I, Berges A, Hong JY, Park SH, Park JO, Park YS, Lim HY, Kang WK, Kozarewa I, Pierce AJ, Dean E, Lee J.
PMID: 33975862
Clin Cancer Res. 2021 Sep 01;27(17):4700-4709. doi: 10.1158/1078-0432.CCR-21-0251. Epub 2021 May 11.

PURPOSE: Ceralasertib is a potent and selective oral inhibitor of the serine/threonine protein kinase ataxia telangiectasia and Rad3-related (ATR) protein.PATIENTS AND METHODS: Eligible patients with solid tumors, enriched for melanoma, received ceralasertib in combination with a fixed dose of...

Variable-focus optoacoustic lens with wide dynamic range and long focal length by using a flexible polymer nano-composite membrane.

Ultrasonics

Abbasi MA, Faraz M, Joo MG, Son D, Won SM, Ok JG, Park HJ, Baac HW.
PMID: 34343758
Ultrasonics. 2021 Dec;117:106545. doi: 10.1016/j.ultras.2021.106545. Epub 2021 Jul 29.

We demonstrate a variable-focus optoacoustic lens (VFOL) by pneumatically controlling a flexible polymer nano-composite membrane, which can produce laser-generated focused ultrasound (LGFU) with a high peak amplitude (>30 MPa) and a tight focal dimension (several hundred μm) over a...

Association of weekly working hours with poor psychological well-being and moderation by employment status in Korean workers.

Industrial health

Park J, Kim Y.
PMID: 34349050
Ind Health. 2021 Sep 09;59(4):249-259. doi: 10.2486/indhealth.2021-0019. Epub 2021 Aug 05.

We examined the association of weekly working hours with poor psychological wellbeing in Korean workers and the moderating effect of employment status. This secondary analysis examined data from the fifth Korean Working Conditions Survey (2017). There were 30,108 waged...

Impact of Visceral Fat on Survival and Metastasis of Stage III Colorectal Cancer.

Gut and liver

Park JW, Chang SY, Lim JS, Park SJ, Park JJ, Cheon JH, Kim WH, Kim TI.
PMID: 34312323
Gut Liver. 2022 Jan 15;16(1):53-61. doi: 10.5009/gnl20266.

BACKGROUND/AIMS: Previous studies have investigated the relationship between visceral obesity and the risk of colorectal tumors. Visceral obesity may affect the outcome of colorectal cancer (CRC), including survival and metastasis. We investigated the associations between visceral adipose tissue and...

Evaluation of electroporated area using 2,3,5-triphenyltetrazolium chloride in a potato model.

Scientific reports

Jeong S, Kim H, Park J, Kim KW, Sim SB, Chung JH.
PMID: 34650212
Sci Rep. 2021 Oct 14;11(1):20431. doi: 10.1038/s41598-021-99987-2.

Irreversible electroporation (IRE) is a tissue ablation method, uses short high electric pulses and results in cell death in target tissue by irreversibly permeabilizing the cell membrane. Potato is commonly used as a tissue model for electroporation experiments. The...

Peripheral Hybrid CB.

Frontiers in endocrinology

Zawatsky CN, Park JK, Abdalla J, Kunos G, Iyer MR, Cinar R.
PMID: 34650521
Front Endocrinol (Lausanne). 2021 Sep 28;12:744857. doi: 10.3389/fendo.2021.744857. eCollection 2021.

Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting

Reversible pulmonary hypertension in adolescent with left atrial myxoma.

Journal of cardiovascular ultrasound

Kim BK, Cho JN, Park HJ, Hong SP, Son JY, Lee JB, Ryu JK, Choi JY, Chang SG, Kim KS.
PMID: 22259669
J Cardiovasc Ultrasound. 2011 Dec;19(4):221-3. doi: 10.4250/jcu.2011.19.4.221. Epub 2011 Dec 27.

We report a patient of left atrial huge myxoma presenting with severe pulmonary hypertension in adolescents. A patient was a 14-year-old boy presented with sudden onset dyspnea. Transthoracic echocardiographic study revealed the presence of a nodular, 4.34 × 8.11...

Showing 9985 to 9996 of 23572 entries