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Final results of a phase 1b study of isatuximab short-duration fixed-volume infusion combination therapy for relapsed/refractory multiple myeloma.

Leukemia

Usmani SZ, Karanes C, Bensinger WI, D'Souza A, Raje N, Tuchman SA, Sborov D, Laubach JP, Bianchi G, Kanagavel D, Saleem R, Dubin F, Campana F, Richardson PG.
PMID: 34050260
Leukemia. 2021 Dec;35(12):3526-3533. doi: 10.1038/s41375-021-01262-w. Epub 2021 May 28.

Part B of this phase 1b study (ClinicalTrials.gov number, NCT02283775) evaluated safety and efficacy of a fixed-volume infusion of isatuximab, an anti-CD38 monoclonal antibody, in combination with pomalidomide and dexamethasone (Pd) in relapsed/refractory multiple myeloma patients. Isatuximab (10 mg/kg...

Cite
Usmani SZ, Karanes C, Bensinger WI, et al. Final results of a phase 1b study of isatuximab short-duration fixed-volume infusion combination therapy for relapsed/refractory multiple myeloma. Leukemia. 2021;35(12):3526-3533doi: 10.1038/s41375-021-01262-w.
Usmani, S. Z., Karanes, C., Bensinger, W. I., D'Souza, A., Raje, N., Tuchman, S. A., Sborov, D., Laubach, J. P., Bianchi, G., Kanagavel, D., Saleem, R., Dubin, F., Campana, F., & Richardson, P. G. (2021). Final results of a phase 1b study of isatuximab short-duration fixed-volume infusion combination therapy for relapsed/refractory multiple myeloma. Leukemia, 35(12), 3526-3533. https://doi.org/10.1038/s41375-021-01262-w
Usmani, Saad Z, et al. "Final results of a phase 1b study of isatuximab short-duration fixed-volume infusion combination therapy for relapsed/refractory multiple myeloma." Leukemia vol. 35,12 (2021): 3526-3533. doi: https://doi.org/10.1038/s41375-021-01262-w
Usmani SZ, Karanes C, Bensinger WI, D'Souza A, Raje N, Tuchman SA, Sborov D, Laubach JP, Bianchi G, Kanagavel D, Saleem R, Dubin F, Campana F, Richardson PG. Final results of a phase 1b study of isatuximab short-duration fixed-volume infusion combination therapy for relapsed/refractory multiple myeloma. Leukemia. 2021 Dec;35(12):3526-3533. doi: 10.1038/s41375-021-01262-w. Epub 2021 May 28. PMID: 34050260; PMCID: PMC8632673.
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Anakinra effectiveness in refractory polyserositis: An Italian multicenter study.

Joint bone spine

Lopalco G, Venerito V, Brucato A, Emmi G, Giacomelli R, Cauli A, Piga M, Parronchi P, Nivuori M, Malandrino D, Ruscitti P, Vitiello G, Fabiani C, Cantarini L, Iannone F.
PMID: 34656754
Joint Bone Spine. 2021 Oct 14;89(2):105299. doi: 10.1016/j.jbspin.2021.105299. Epub 2021 Oct 14.

OBJECTIVES: Polyserositis is an inflammatory condition involving different serosal membranes at the same time, specifically the pericardium, pleura, and peritoneum with exudates in the respective cavities. Treatment with non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and glucocorticoids may be effective in...

Cite
Lopalco G, Venerito V, Brucato A, et al. Anakinra effectiveness in refractory polyserositis: An Italian multicenter study. Joint Bone Spine. 2021;89(2):105299doi: 10.1016/j.jbspin.2021.105299.
Lopalco, G., Venerito, V., Brucato, A., Emmi, G., Giacomelli, R., Cauli, A., Piga, M., Parronchi, P., Nivuori, M., Malandrino, D., Ruscitti, P., Vitiello, G., Fabiani, C., Cantarini, L., & Iannone, F. (2021). Anakinra effectiveness in refractory polyserositis: An Italian multicenter study. Joint bone spine, 89(2), 105299. https://doi.org/10.1016/j.jbspin.2021.105299
Lopalco, Giuseppe, et al. "Anakinra effectiveness in refractory polyserositis: An Italian multicenter study." Joint bone spine vol. 89,2 (2021): 105299. doi: https://doi.org/10.1016/j.jbspin.2021.105299
Lopalco G, Venerito V, Brucato A, Emmi G, Giacomelli R, Cauli A, Piga M, Parronchi P, Nivuori M, Malandrino D, Ruscitti P, Vitiello G, Fabiani C, Cantarini L, Iannone F. Anakinra effectiveness in refractory polyserositis: An Italian multicenter study. Joint Bone Spine. 2021 Oct 14;89(2):105299. doi: 10.1016/j.jbspin.2021.105299. Epub 2021 Oct 14. PMID: 34656754.
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