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Showing 577 to 579 of 579 entries
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Safety and Antitumor Activity of α-PD-L1 Antibody as Monotherapy or in Combination with α-TIM-3 Antibody in Patients with Microsatellite Instability-High/Mismatch Repair-Deficient Tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research

Hollebecque A, Chung HC, de Miguel MJ, Italiano A, Machiels JP, Lin CC, Dhani NC, Peeters M, Moreno V, Su WC, Chow KH, Galvao VR, Carlsen M, Yu D, Szpurka AM, Zhao Y, Schmidt SL, Gandhi L, Xu X, Bang YJ.
PMID: 34465599
Clin Cancer Res. 2021 Dec 01;27(23):6393-6404. doi: 10.1158/1078-0432.CCR-21-0261. Epub 2021 Aug 31.

PURPOSE: Immune checkpoint inhibitors show high response rates and durable clinical benefit in microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) tumors. However, 50%-60% do not respond to single-agent anti-programmed death-1/programmed death ligand 1 (PD-1/PD-L1) antibodies, and approximately 50% of responders relapse within...

The Communication between Ocular Surface and Nasal Epithelia in 3D Cell Culture Technology for Translational Research: A Narrative Review.

International journal of molecular sciences

Aydin M, Dietrich J, Witt J, Finkbeiner MSC, Park JJ, Wirth S, Engeland CE, Paulsen F, Ehrhardt A.
PMID: 34884799
Int J Mol Sci. 2021 Nov 30;22(23). doi: 10.3390/ijms222312994.

There is a lack of knowledge regarding the connection between the ocular and nasal epithelia. This narrative review focuses on conjunctival, corneal, ultrastructural corneal stroma, and nasal epithelia as well as an introduction into their interconnections. We describe in...

Primary immunosuppressive TNI-based conditioning regimens in pediatric patients treated with haploidentical hematopoietic cell transplantation.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

Wegener D, Lang P, Paulsen F, Weidner N, Zips D, Ebinger M, Holzer U, Döring M, Heinzelmann F.
PMID: 34476532
Strahlenther Onkol. 2022 Jan;198(1):66-72. doi: 10.1007/s00066-021-01840-y. Epub 2021 Sep 02.

PURPOSE: This retrospective analysis aims to address the toxicity and efficacy of a modified total nodal irradiation (TNI)-based conditioning regimen before haploidentical hematopoietic cell transplantation (HCT) in pediatric patients.MATERIALS AND METHODS: Patient data including long-term follow-up were evaluated of...

Showing 577 to 579 of 579 entries