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Showing 313 to 320 of 320 entries
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GluN2B/N-methyl-D-aspartate Receptor Antagonists: Advances in Design, Synthesis, and Pharmacological Evaluation Studies.

CNS & neurological disorders drug targets

Ugale V, Dhote A, Narwade R, Khadse S, Reddy PN, Shirkhedkar A.
PMID: 33687902
CNS Neurol Disord Drug Targets. 2021;20(9):822-862. doi: 10.2174/1871527320666210309141627.

Selective GluN2B/N-methyl-D-aspartate receptor (NMDAR) antagonists have exposed their clinical effectiveness in a cluster of neurodegenerative diseases, such as epilepsy, Alzheimer's disease, Parkinson's disease, pain, and depression. Hence, GluN2B/NMDARs are considered to be a prospective target for the management of...

Presence of toxic metals in rice with human health hazards in Tangail district of Bangladesh.

International journal of environmental health research

Kormoker T, Proshad R, Islam MS, Tusher TR, Uddin M, Khadka S, Chandra K, Sayeed A.
PMID: 32024372
Int J Environ Health Res. 2022 Jan;32(1):40-60. doi: 10.1080/09603123.2020.1724271. Epub 2020 Feb 05.

Rice is the staple food of Bangladeshi people and is consumed at least twice a day. Thus, the presence of toxic metals in rice grains has become a major public health concern in Bangladesh. The present research was conducted...

High-Throughput Digital Image Analysis Reveals Distinct Patterns of Dystrophin Expression in Dystrophinopathy Patients.

Journal of neuropathology and experimental neurology

Torelli S, Scaglioni D, Sardone V, Ellis MJ, Domingos J, Jones A, Feng L, Chambers D, Eastwood DM, Leturcq F, Yaou RB, Urtizberea A, Sabouraud P, Barnerias C, Stojkovic T, Ricci E, Beuvin M, Bonne G, Sewry CA, Willis T, Kulshrestha R, Tasca G, Phadke R, Morgan JE, Muntoni F.
PMID: 34498054
J Neuropathol Exp Neurol. 2021 Oct 26;80(10):955-965. doi: 10.1093/jnen/nlab088.

Duchenne muscular dystrophy (DMD) is an incurable disease caused by out-of-frame DMD gene deletions while in frame deletions lead to the milder Becker muscular dystrophy (BMD). In the last decade several antisense oligonucleotides drugs have been developed to induce...

Glucocorticoids and Androgens Protect From Gastric Metaplasia by Suppressing Group 2 Innate Lymphoid Cell Activation.

Gastroenterology

Busada JT, Peterson KN, Khadka S, Xu X, Oakley RH, Cook DN, Cidlowski JA.
PMID: 33971182
Gastroenterology. 2021 Aug;161(2):637-652.e4. doi: 10.1053/j.gastro.2021.04.075. Epub 2021 May 07.

BACKGROUND & AIMS: The immune compartment is critical for maintaining tissue homeostasis. A weak immune response increases susceptibility to infection, but immune hyperactivation causes tissue damage, and chronic inflammation may lead to cancer development. In the stomach, inflammation damages...

The Cognitive Loads and Usability of Target-based and Steering-based Travel Techniques.

IEEE transactions on visualization and computer graphics

Lai C, Hu X, Aiyaz AA, Segismundo A, Phadke A, McMahan RP.
PMID: 34449386
IEEE Trans Vis Comput Graph. 2021 Nov;27(11):4289-4299. doi: 10.1109/TVCG.2021.3106507. Epub 2021 Oct 29.

Target and steering-based techniques are two common approaches to travel in consumer VR applications. In this paper, we present two within-subject studies that employ a prior dual-task methodology to evaluate and compare the cognitive loads, travel performances, and simulator...

Controllable Solution-Phase Epitaxial Growth of Q1D Sb.

Advanced materials (Deerfield Beach, Fla.)

Jin X, Fang Y, Salim T, Feng M, Yuan Z, Hadke S, Sum TC, Wong LH.
PMID: 34510590
Adv Mater. 2021 Nov;33(44):e2104346. doi: 10.1002/adma.202104346. Epub 2021 Sep 12.

Antimony sulfoselenide (Sb

Maximizing Educational Engagement and Program Exposure for Recruitment to the Integrated and Independent Interventional Radiology Programs in a Virtual Environment.

Academic radiology

Phadke D, Khaja MS, Banathy AK, Clark MR, Grewal S, Kinariwala D, Wilkins LR.
PMID: 34580013
Acad Radiol. 2021 Sep 24; doi: 10.1016/j.acra.2021.09.001. Epub 2021 Sep 24.

Interventional Radiology residency training programs experienced significant impacts secondary to the COVID-19 pandemic. Prospective resident recruitment and resident education were particularly affected due to limitations on in-person gatherings in effort to curb exposure. Finding ways to mitigate the pandemic's...

Enhanced apoptosis as a possible mechanism to self-limit SARS-CoV-2 replication in porcine primary respiratory epithelial cells in contrast to human cells.

Cell death discovery

Nelli RK, Phadke KS, Castillo G, Yen L, Saunders A, Rauh R, Nelson W, Bellaire BH, Giménez-Lirola LG.
PMID: 34893585
Cell Death Discov. 2021 Dec 10;7(1):383. doi: 10.1038/s41420-021-00781-w.

The ability of SARS-CoV to infect different species, including humans, dogs, cats, minks, ferrets, hamsters, tigers, and deer, pose a continuous threat to human and animal health. Pigs, though closely related to humans, seem to be less susceptible to...

Showing 313 to 320 of 320 entries