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Showing 25 to 36 of 75 entries
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A Strip Biosensor with Guinea Green B and Fuchsin Basic Color Indicators on a Glass Nanofiber Carrier for the Cholinesterase Detection of Nerve Agents.

ACS omega

Matějovský L, Pitschmann V.
PMID: 31867489
ACS Omega. 2019 Dec 02;4(25):20978-20986. doi: 10.1021/acsomega.9b02153. eCollection 2019 Dec 17.

This paper deals with the innovation of the Czech colorimetric biosensor Detehit designed for the simple, fast, and sensitive detection of nerve agents. The innovation is based on the use of an indicator consisting of a mixture of two...

A condensate-hardening drug blocks RSV replication in vivo.

Nature

Risso-Ballester J, Galloux M, Cao J, Le Goffic R, Hontonnou F, Jobart-Malfait A, Desquesnes A, Sake SM, Haid S, Du M, Zhang X, Zhang H, Wang Z, Rincheval V, Zhang Y, Pietschmann T, Eléouët JF, Rameix-Welti MA, Altmeyer R.
PMID: 34234347
Nature. 2021 Jul;595(7868):596-599. doi: 10.1038/s41586-021-03703-z. Epub 2021 Jul 07.

Biomolecular condensates have emerged as an important subcellular organizing principle

Age-dependent Wnt gene expression in bone and during the course of osteoblast differentiation.

Age (Dordrecht, Netherlands)

Rauner M, Sipos W, Pietschmann P.
PMID: 19424851
Age (Dordr). 2008 Dec;30(4):273-82. doi: 10.1007/s11357-008-9069-9. Epub 2008 Sep 02.

Wnt signaling is vital for osteoblast differentiation and recently has been associated with aging. Because impaired osteoblastogenesis is a cellular characteristic of age-induced bone loss, we investigated whether this process is associated with an altered expression of Wnt signaling-related...

Siglec-F Promotes IL-33-Induced Cytokine Release from Bone Marrow-Derived Eosinophils Independently of the ITIM and ITIM-like Motif Phosphorylation.

Journal of immunology (Baltimore, Md. : 1950)

Westermann S, Dietschmann A, Doehler D, Castiglione K, Bochner BS, Voehringer D, Radtke D.
PMID: 34996839
J Immunol. 2022 Jan 07; doi: 10.4049/jimmunol.2100184. Epub 2022 Jan 07.

Eosinophils are potent innate effector cells associated mainly with type 2 immune responses elicited by helminths and allergens. Their activity needs to be tightly controlled to prevent severe inflammation and tissue damage. Eosinophil degranulation and secretion of inflammatory effector...

Particle Radiation Side-Effects: Intestinal Microbiota Composition Shapes Interferon-γ-Induced Osteo-Immunogenicity.

Radiation research

Maier I, Ruegger PM, Deutschmann J, Helbich TH, Pietschmann P, Schiestl RH, Borneman J.
PMID: 34905619
Radiat Res. 2021 Dec 14; doi: 10.1667/RADE-21-00068.1. Epub 2021 Dec 14.

Microbiota can both negatively and positively impact radiation-induced bone loss. Our prior research showed that compared to mice with conventional gut microbiota (CM), mice with restricted gut microbiota (RM) reduced inflammatory tumor necrosis factor (TNF) in bone marrow, interleukin...

Indications requiring preoperative magnetic resonance imaging before knee arthroscopy.

Archives of medical science : AMS

Roßbach BP, Pietschmann MF, Gülecyüz MF, Niethammer TR, Ficklscherer A, Wild S, Jansson V, Müller PE.
PMID: 25624852
Arch Med Sci. 2014 Dec 22;10(6):1147-52. doi: 10.5114/aoms.2014.47825.

INTRODUCTION: Knee arthroscopy knee is gold standard in diagnosis and simultaneous treatment of knee disorders. But most patients undergo magnetic resonance imaging (MRI) before arthroscopy, although MRI results are not always consistent with arthroscopic findings. This raises the question...

Editorial: Paget's disease of bone.

Wiener medizinische Wochenschrift (1946)

Pietschmann P.
PMID: 27853907
Wien Med Wochenschr. 2017 Feb;167(1):1. doi: 10.1007/s10354-016-0524-4.

No abstract available.

Utilization of Pharmaceutical Technology Methods for the Development of Innovative Porous Metasilicate Pellets with a Very High Specific Surface Area for Chemical Warfare Agents Detection.

Pharmaceutics

Zeman J, Pavloková S, Vetchý D, Staňo A, Moravec Z, Matějovský L, Pitschmann V.
PMID: 34834274
Pharmaceutics. 2021 Nov 04;13(11). doi: 10.3390/pharmaceutics13111860.

Pharmaceutical technology offers various dosage forms that can be applied interdisciplinary. One of them are spherical pellets which could be utilized as a carrier in emerging second-generation detection tubes. This detection system requires carriers with high specific surface area...

Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human Hepatocytes.

Cells

Nicolay W, Moeller R, Kahl S, Vondran FWR, Pietschmann T, Kunz S, Gerold G.
PMID: 34831243
Cells. 2021 Nov 04;10(11). doi: 10.3390/cells10113019.

The liver is targeted by several human pathogenic RNA viruses for viral replication and dissemination; despite this, the extent of innate immune sensing of RNA viruses by human hepatocytes is insufficiently understood to date. In particular, for highly human...

Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements.

Journal of virology

Tegtmeyer B, Vieyres G, Todt D, Lauber C, Ginkel C, Engelmann M, Herrmann M, Pfaller CK, Vondran FWR, Broering R, Vafadarnejad E, Saliba AE, Puff C, Baumgärtner W, Miskey C, Ivics Z, Steinmann E, Pietschmann T, Brown RJP.
PMID: 33658347
J Virol. 2021 Mar 03; doi: 10.1128/JVI.00245-21. Epub 2021 Mar 03.

Transcriptional profiling provides global snapshots of virus-mediated cellular reprogramming, which can simultaneously encompass pro- and antiviral components. To determine early transcriptional signatures associated with HCV infection of authentic target cells, we performed ex vivo infections of adult primary human...

[Development approaches for vaccines against hepatitis C virus infections].

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

Bankwitz D, Krey T, Pietschmann T.
PMID: 35015104
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2022 Jan 11; doi: 10.1007/s00103-021-03477-9. Epub 2022 Jan 11.

The incidence of hepatitis C virus (HCV) infections remains high even more than 10 years after approval of the first direct-acting antivirals for treatment of hepatitis C. In some countries, more people are newly infected with the virus than...

Erratum: Cell culture-derived HCV cannot infect synovial fibroblasts.

Scientific reports

Abd-Elshafy DN, Pietschmann T, Müller-Ladner U, Neumann E, Anggakusuma, Bahgat MM, Pessler F, Behrendt P.
PMID: 27561352
Sci Rep. 2016 Aug 26;6:21441. doi: 10.1038/srep21441.

No abstract available.

Showing 25 to 36 of 75 entries