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Showing 841 to 843 of 843 entries
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DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic.

Pharmacological research

Villa A, Brunialti E, Dellavedova J, Meda C, Rebecchi M, Conti M, Donnici L, De Francesco R, Reggiani A, Lionetti V, Ciana P.
PMID: 34798263
Pharmacol Res. 2021 Nov 16;175:105982. doi: 10.1016/j.phrs.2021.105982. Epub 2021 Nov 16.

All the different coronavirus SARS-CoV-2 variants isolated so far share the same mechanism of infection mediated by the interaction of their spike (S) glycoprotein with specific residues on their cellular receptor: the angiotensin converting enzyme 2 (ACE2). Therefore, the...

The Medical Home Initiative in Italy: an Analysis of Changes in Healthcare Utilization.

Journal of general internal medicine

Keith SW, Waters D, Alcusky M, Hegarty S, Jafari N, Lombardi M, Pini M, Maio V.
PMID: 34357575
J Gen Intern Med. 2021 Aug 06; doi: 10.1007/s11606-021-07040-9. Epub 2021 Aug 06.

BACKGROUND: Seventeen medical homes (MHs) were established in the Local Health Authority (LHA) of Parma (about 450,000 residents), Emilia Romagna, Italy, between 2011 and 2016.OBJECTIVE: To estimate the effects of MH implementation on healthcare utilization.DESIGN: We conducted a longitudinal...

BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity.

Molecules (Basel, Switzerland)

Novais P, Silva PMA, Moreira J, Palmeira A, Amorim I, Pinto M, Cidade H, Bousbaa H.
PMID: 34885726
Molecules. 2021 Nov 25;26(23). doi: 10.3390/molecules26237139.

Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work,...

Showing 841 to 843 of 843 entries