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Showing 13 to 24 of 55 entries
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Protein quality control in the endoplasmic reticulum.

F1000prime reports

Koenig PA, Ploegh HL.
PMID: 25184039
F1000Prime Rep. 2014 Jul 08;6:49. doi: 10.12703/P6-49. eCollection 2014.

THE TOPOLOGICAL BARRIERS DEFINED BY BIOLOGICAL MEMBRANES ARE NOT IMPERMEABLE: from small solutes to intact proteins, specialized transport and translocation mechanisms adjust to the cell's needs. Here, we review the removal of unwanted proteins from the endoplasmic reticulum (ER)...

Autosomal Lethal Mutation Frequencies in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America

Plough HH, Child GP.
PMID: 16577788
Proc Natl Acad Sci U S A. 1937 Aug;23(8):435-40. doi: 10.1073/pnas.23.8.435.

No abstract available.

Alternative Amino Acid Requirements in Auxotrophic Mutants of Salmonella Typhimurium.

Proceedings of the National Academy of Sciences of the United States of America

Plough HH, Miller HY, Berry ME.
PMID: 16578395
Proc Natl Acad Sci U S A. 1951 Oct;37(10):640-4. doi: 10.1073/pnas.37.10.640.

No abstract available.

EXPERIMENTS ON TOLERATION OF TEMPERATURE BY DROSOPHILA.

The Journal of general physiology

Plough HH, Strauss MB.
PMID: 19872060
J Gen Physiol. 1923 Nov 20;6(2):167-76. doi: 10.1085/jgp.6.2.167.

1. Most wild stocks of Drosophila melanogaster can be bred indefinitely on banana agar at a temperature of 31 degrees C. There is no relation between the geographical origin of these stocks and their ability to tolerate this temperature....

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Nature

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.
PMID: 26982724
Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16.

No abstract available.

Quantitative Comparison of Mathematical Models to Measure Surface Area of Canine Teeth Prepared to Receive Full Veneer Crowns in Dogs.

Frontiers in veterinary science

Collins CJ, Hetzel SJ, Siverling S, Ploeg HL, Soukup JW.
PMID: 26664960
Front Vet Sci. 2015 Sep 07;2:31. doi: 10.3389/fvets.2015.00031. eCollection 2015.

OBJECTIVE: This study was performed in order to determine if mathematical modeling of the canine teeth in dogs could be utilized to provide an accurate and reliable estimation of crown surface area that could be used in both a...

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL.
PMID: 28270614
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3157-3162. doi: 10.1073/pnas.1701746114. Epub 2017 Mar 07.

Current therapies for autoimmune diseases rely on traditional immunosuppressive medications that expose patients to an increased risk of opportunistic infections and other complications. Immunoregulatory interventions that act prophylactically or therapeutically to induce antigen-specific tolerance might overcome these obstacles. Here...

Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.

PloS one

Deshycka R, Sudaryo V, Huang NJ, Xie Y, Smeding LY, Choi MK, Ploegh HL, Lodish HF, Pishesha N.
PMID: 34731223
PLoS One. 2021 Nov 03;16(11):e0259353. doi: 10.1371/journal.pone.0259353. eCollection 2021.

Low plasma levels of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) are associated with decreased low-density lipoprotein (LDL) cholesterol and a reduced risk of cardiovascular disease. PCSK9 binds to the epidermal growth factor-like repeat A (EGFA) domain of LDL receptors (LDLR),...

Monitoring Motor Symptoms During Activities of Daily Living in Individuals With Parkinson's Disease.

Frontiers in neurology

Thorp JE, Adamczyk PG, Ploeg HL, Pickett KA.
PMID: 30619024
Front Neurol. 2018 Dec 12;9:1036. doi: 10.3389/fneur.2018.01036. eCollection 2018.

This literature review addressed wearable sensor systems to monitor motor symptoms in individuals with Parkinson's disease (PD) during activities of daily living (ADLs). Specifically, progress in monitoring tremor, freezing of gait, dyskinesia, bradykinesia, and hypokinesia was reviewed. Twenty-seven studies...

Aligning Research Priorities to Improve Equity: A Challenge for Health Funders.

The American journal of bioethics : AJOB

Plough AL.
PMID: 30475186
Am J Bioeth. 2018 Nov;18(11):1-2. doi: 10.1080/15265161.2018.1544339.

No abstract available.

Immunology at the millennium: looking forward.

Current opinion in immunology

Ploegh H.
PMID: 10508717
Curr Opin Immunol. 1999 Oct;11(5):490-2. doi: 10.1016/s0952-7915(99)00019-9.

No abstract available.

Noninvasive Immuno-PET Imaging of CD8.

Frontiers in immunology

Rothlauf PW, Li Z, Pishesha N, Xie YJ, Woodham AW, Bousbaine D, Kolifrath SC, Verschoor VL, Ploegh HL.
PMID: 34804069
Front Immunol. 2021 Nov 03;12:777739. doi: 10.3389/fimmu.2021.777739. eCollection 2021.

Immuno-positron emission tomography (immuno-PET) is a noninvasive imaging method that enables tracking of immune cells in living animals. We used a nanobody that recognizes mouse CD8α and labeled it with

Showing 13 to 24 of 55 entries