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Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.

PloS one

Deshycka R, Sudaryo V, Huang NJ, Xie Y, Smeding LY, Choi MK, Ploegh HL, Lodish HF, Pishesha N.
PMID: 34731223
PLoS One. 2021 Nov 03;16(11):e0259353. doi: 10.1371/journal.pone.0259353. eCollection 2021.

Low plasma levels of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) are associated with decreased low-density lipoprotein (LDL) cholesterol and a reduced risk of cardiovascular disease. PCSK9 binds to the epidermal growth factor-like repeat A (EGFA) domain of LDL receptors (LDLR),...

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Deshycka R, Sudaryo V, Huang NJ, et al. Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity. PLoS One. 2021;16(11):e0259353doi: 10.1371/journal.pone.0259353.
Deshycka, R., Sudaryo, V., Huang, N. J., Xie, Y., Smeding, L. Y., Choi, M. K., Ploegh, H. L., Lodish, H. F., & Pishesha, N. (2021). Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity. PloS one, 16(11), e0259353. https://doi.org/10.1371/journal.pone.0259353
Deshycka, Rhogerry, et al. "Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity." PloS one vol. 16,11 (2021): e0259353. doi: https://doi.org/10.1371/journal.pone.0259353
Deshycka R, Sudaryo V, Huang NJ, Xie Y, Smeding LY, Choi MK, Ploegh HL, Lodish HF, Pishesha N. Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity. PLoS One. 2021 Nov 03;16(11):e0259353. doi: 10.1371/journal.pone.0259353. eCollection 2021. PMID: 34731223; PMCID: PMC8565730.
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Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity.

iScience

Kaur M, Kumar D, Butty V, Singh S, Esteban A, Fink GR, Ploegh HL, Sehrawat S.
PMID: 30388704
iScience. 2018 Nov 30;9:101-119. doi: 10.1016/j.isci.2018.10.013. Epub 2018 Oct 17.

To gain insights into the molecular mechanisms and pathways involved in the activation of γ-herpesvirus (MHV68)-specific T cell receptor transnuclear (TN) CD8

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Kaur M, Kumar D, Butty V, et al. Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity. iScience. 2018;9:101-119doi: 10.1016/j.isci.2018.10.013.
Kaur, M., Kumar, D., Butty, V., Singh, S., Esteban, A., Fink, G. R., Ploegh, H. L., & Sehrawat, S. (2018). Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity. iScience, 9101-119. https://doi.org/10.1016/j.isci.2018.10.013
Kaur, Manpreet, et al. "Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity." iScience vol. 9 (2018): 101-119. doi: https://doi.org/10.1016/j.isci.2018.10.013
Kaur M, Kumar D, Butty V, Singh S, Esteban A, Fink GR, Ploegh HL, Sehrawat S. Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity. iScience. 2018 Nov 30;9:101-119. doi: 10.1016/j.isci.2018.10.013. Epub 2018 Oct 17. PMID: 30388704; PMCID: PMC6214866.
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The use of .

ACS central science

Rashidian M, Keliher E, Dougan M, Juras PK, Cavallari M, Wojtkiewicz GR, Jacobsen J, Edens JG, Tas JM, Victora G, Weissleder R, Ploegh H.
PMID: 26955657
ACS Cent Sci. 2015 Jun 24;1(3):142-147. doi: 10.1021/acscentsci.5b00121. Epub 2015 Jun 03.

We generated

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Rashidian M, Keliher E, Dougan M, et al. The use of . ACS Cent Sci. 2015;1(3):142-147doi: 10.1021/acscentsci.5b00121.
Rashidian, M., Keliher, E., Dougan, M., Juras, P. K., Cavallari, M., Wojtkiewicz, G. R., Jacobsen, J., Edens, J. G., Tas, J. M., Victora, G., Weissleder, R., & Ploegh, H. (2015). The use of . ACS central science, 1(3), 142-147. https://doi.org/10.1021/acscentsci.5b00121
Rashidian, Mohammad, et al. "The use of ." ACS central science vol. 1,3 (2015): 142-147. doi: https://doi.org/10.1021/acscentsci.5b00121
Rashidian M, Keliher E, Dougan M, Juras PK, Cavallari M, Wojtkiewicz GR, Jacobsen J, Edens JG, Tas JM, Victora G, Weissleder R, Ploegh H. The use of . ACS Cent Sci. 2015 Jun 24;1(3):142-147. doi: 10.1021/acscentsci.5b00121. Epub 2015 Jun 03. PMID: 26955657; PMCID: PMC4778250.
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Building a Culture of Health in Our Changing Climate.

American journal of public health

Tait ME, Wójcik OP, Plough AL, Lumpkin JR.
PMID: 29698087
Am J Public Health. 2018 Apr;108:S64-S65. doi: 10.2105/AJPH.2018.304361.

No abstract available.

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Tait ME, Wójcik OP, Plough AL, et al. Building a Culture of Health in Our Changing Climate. Am J Public Health. 2018;108:S64-S65doi: 10.2105/AJPH.2018.304361.
Tait, M. E., Wójcik, O. P., Plough, A. L., & Lumpkin, J. R. (2018). Building a Culture of Health in Our Changing Climate. American journal of public health, 108S64-S65. https://doi.org/10.2105/AJPH.2018.304361
Tait, Margaret E, et al. "Building a Culture of Health in Our Changing Climate." American journal of public health vol. 108 (2018): S64-S65. doi: https://doi.org/10.2105/AJPH.2018.304361
Tait ME, Wójcik OP, Plough AL, Lumpkin JR. Building a Culture of Health in Our Changing Climate. Am J Public Health. 2018 Apr;108:S64-S65. doi: 10.2105/AJPH.2018.304361. PMID: 29698087; PMCID: PMC5922213.
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Nanobodies as .

RSC chemical biology

Harmand TJ, Islam A, Pishesha N, Ploegh HL.
PMID: 34212147
RSC Chem Biol. 2021 Mar 08;2(3):685-701. doi: 10.1039/d1cb00023c.

No abstract available.

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Harmand TJ, Islam A, Pishesha N, et al. Nanobodies as . RSC Chem Biol. 2021;2(3):685-701doi: 10.1039/d1cb00023c.
Harmand, T. J., Islam, A., Pishesha, N., & Ploegh, H. L. (2021). Nanobodies as . RSC chemical biology, 2(3), 685-701. https://doi.org/10.1039/d1cb00023c
Harmand, Thibault J, et al. "Nanobodies as ." RSC chemical biology vol. 2,3 (2021): 685-701. doi: https://doi.org/10.1039/d1cb00023c
Harmand TJ, Islam A, Pishesha N, Ploegh HL. Nanobodies as . RSC Chem Biol. 2021 Mar 08;2(3):685-701. doi: 10.1039/d1cb00023c. PMID: 34212147; PMCID: PMC8190910.
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Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands.

RSC chemical biology

Cheloha RW, Fischer FA, Gardella TJ, Ploegh HL.
PMID: 34977584
RSC Chem Biol. 2021 Oct 11;2(6):1692-1700. doi: 10.1039/d1cb00118c. eCollection 2021 Dec 02.

Antibodies raised against many cell surface proteins, including G protein-coupled receptors, remain important tools for their functional characterization. By linking antibodies to ligands for cell surface proteins, such adducts can be targeted to the surface of a cell type...

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Cheloha RW, Fischer FA, Gardella TJ, et al. Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands. RSC Chem Biol. 2021;2(6):1692-1700doi: 10.1039/d1cb00118c.
Cheloha, R. W., Fischer, F. A., Gardella, T. J., & Ploegh, H. L. (2021). Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands. RSC chemical biology, 2(6), 1692-1700. https://doi.org/10.1039/d1cb00118c
Cheloha, Ross W, et al. "Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands." RSC chemical biology vol. 2,6 (2021): 1692-1700. doi: https://doi.org/10.1039/d1cb00118c
Cheloha RW, Fischer FA, Gardella TJ, Ploegh HL. Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands. RSC Chem Biol. 2021 Oct 11;2(6):1692-1700. doi: 10.1039/d1cb00118c. eCollection 2021 Dec 02. PMID: 34977584; PMCID: PMC8637866.
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An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance.

Proceedings of the National Academy of Sciences of the United States of America

Loftis AR, Zhang G, Backlund C, Quartararo AJ, Pishesha N, Hanna CC, Schissel CK, Garafola D, Loas A, Collier RJ, Ploegh H, Irvine DJ, Pentelute BL.
PMID: 34417313
Proc Natl Acad Sci U S A. 2021 Aug 24;118(34). doi: 10.1073/pnas.2101596118.

When displayed on erythrocytes, peptides and proteins can drive antigen-specific immune tolerance. Here, we investigated a straightforward approach based on erythrocyte binding to promote antigen-specific tolerance to both peptides and proteins. We first identified a robust erythrocyte-binding ligand. A...

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Loftis AR, Zhang G, Backlund C, et al. An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance. Proc Natl Acad Sci U S A. 2021;118(34)doi: 10.1073/pnas.2101596118.
Loftis, A. R., Zhang, G., Backlund, C., Quartararo, A. J., Pishesha, N., Hanna, C. C., Schissel, C. K., Garafola, D., Loas, A., Collier, R. J., Ploegh, H., Irvine, D. J., & Pentelute, B. L. (2021). An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance. Proceedings of the National Academy of Sciences of the United States of America, 118(34), . https://doi.org/10.1073/pnas.2101596118
Loftis, Alexander R, et al. "An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance." Proceedings of the National Academy of Sciences of the United States of America vol. 118,34 (2021). doi: https://doi.org/10.1073/pnas.2101596118
Loftis AR, Zhang G, Backlund C, Quartararo AJ, Pishesha N, Hanna CC, Schissel CK, Garafola D, Loas A, Collier RJ, Ploegh H, Irvine DJ, Pentelute BL. An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34). doi: 10.1073/pnas.2101596118. PMID: 34417313; PMCID: PMC8403921.
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Showing 49 to 55 of 55 entries