Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 361 to 372 of 372 entries
Sorted by: Best Match Show Resources per page
Association of Combined Focal 22q11.22 Deletion and IKZF1 Alterations With Outcomes in Childhood Acute Lymphoblastic Leukemia.

JAMA oncology

Mangum DS, Meyer JA, Mason CC, Shams S, Maese LD, Gardiner JD, Downie JM, Pei D, Cheng C, Gleason A, Luo M, Pui CH, Aplenc R, Hunger SP, Loh M, Greaves M, Trede N, Raetz E, Frazer JK, Mullighan CG, Engel ME, Miles RR, Rabin KR, Schiffman JD.
PMID: 34410295
JAMA Oncol. 2021 Oct 01;7(10):1521-1528. doi: 10.1001/jamaoncol.2021.2723.

IMPORTANCE: Alterations in the IKZF1 gene drive B-cell acute lymphoblastic leukemia (B-ALL) but are not routinely used to stratify patients by risk because of inconsistent associations with outcomes. We describe a novel deletion in 22q11.22 that was consistently associated...

Comprehensive characterization of pharmacogenetic variants in TPMT and NUDT15 in children with acute lymphoblastic leukemia.

Pharmacogenetics and genomics

Moriyama T, Yang W, Smith C, Pui CH, Evans WE, Relling MV, Bhatia S, Yang JJ.
PMID: 34412101
Pharmacogenet Genomics. 2022 Feb 01;32(2):60-66. doi: 10.1097/FPC.0000000000000453.

Thiopurines [e.g. 6-mercaptopurine (6MP)] are essential for the cure of acute lymphoblastic leukemia (ALL) but can cause dose-limiting hematopoietic toxicity. Germline variants in drug-metabolizing enzyme genes TPMT and NUDT15 have been linked to the risk of thiopurine toxicity. However,...

Detethering the superficial temporal artery: Application to tension free superficial temporal artery-middle cerebral artery bypasses.

Clinical anatomy (New York, N.Y.)

Mathkour M, Werner C, Scullen T, Fennell VS, Nerva J, Amenta PS, Iwanaga J, Dumont AS, Bui CJ, Mortazavi MM, Hur MS, Tubbs RS.
PMID: 34561915
Clin Anat. 2021 Sep 25; doi: 10.1002/ca.23789. Epub 2021 Sep 25.

Extracranial-intracranial bypass has been shown to be effective in the surgical treatment of moyamoya disease, complex aneurysms, and tumors that involve proximal vasculature in carefully selected patients. Branches of the superficial temporal artery (STA) are used commonly for the...

Integrating Palliative Care Into a Neurosurgical Intensive Care Unit (NS-ICU): A Quality Improvement (QI) Project.

The American journal of hospice & palliative care

Poi CH, Koh MYH, Koh TL, Wong YL, Mei Ong WY, Gu C, Yow FC, Tan HL.
PMID: 34525873
Am J Hosp Palliat Care. 2021 Sep 15;10499091211045616. doi: 10.1177/10499091211045616. Epub 2021 Sep 15.

OBJECTIVES: We conducted a pilot quality improvement (QI) project with the aim of improving accessibility of palliative care to critically ill neurosurgical patients.METHODS: The QI project was conducted in the neurosurgical intensive care unit (NS-ICU). Prior to the QI...

Clinicopathologic and prognostic features of TdT-negative pediatric B-lymphoblastic leukemia.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Klairmont MM, Zhou Y, Cheng C, Pui CH, Jeha S, Gruber TA, Liu Y, Inaba H, Choi JK.
PMID: 34148065
Mod Pathol. 2021 Nov;34(11):2050-2054. doi: 10.1038/s41379-021-00853-3. Epub 2021 Jun 19.

Little is known about B-lymphoblastic leukemia (B-ALL) that lacks expression of terminal deoxynucleotidyl transferase (TdT). To address this, we performed the largest study to date of TdT-negative B-ALL using data from St. Jude Total XV and XVI clinical trials....

CD40LG mutations in Vietnamese patients with X-linked hyper-IgM syndrome; catastrophic anti-phospholipid syndrome as a new complication.

Molecular genetics & genomic medicine

Phan ANL, Pham TTT, Phan XT, Huynh N, Nguyen TM, Cao CTT, Nguyen DT, Luong KTX, Nguyen TTM, Tran ANK, Pham LTT, Nguyen VVT, Swagemakers S, Bui CB, Van Hagen PM.
PMID: 34114358
Mol Genet Genomic Med. 2021 Aug;9(8):e1732. doi: 10.1002/mgg3.1732. Epub 2021 Jun 10.

BACKGROUND: X-linked hyper-IgM syndrome (XHIGM) is a rare primary immunodeficiency caused by CD40 ligand defects.METHODS: We identified three patients with XHIGM in Ho Chi Minh City, Vietnam. Whole-exome sequencing, immunological analyses and western blot were performed to investigate phenotypic...

Antibiotic prophylaxis and the gastrointestinal resistome in paediatric patients with acute lymphoblastic leukaemia: a cohort study with metagenomic sequencing analysis.

The Lancet. Microbe

Margolis EB, Hakim H, Dallas RH, Allison KJ, Ferrolino J, Sun Y, Pui CH, Yao J, Chang TC, Hayden RT, Jeha S, Tuomanen EI, Tang L, Rosch JW, Wolf J.
PMID: 34355208
Lancet Microbe. 2021 Apr;2(4):e159-e167. doi: 10.1016/s2666-5247(20)30202-0. Epub 2021 Feb 15.

BACKGROUND: Although antibiotic prophylaxis with levofloxacin can reduce the risk of serious infection in immunocompromised patients, the potential contribution of prophylaxis to antibiotic resistance is a major drawback. We aimed to identify the effects of levofloxacin prophylaxis, given to...

Impact of Covid-19 partial lockdown on PM.

Environmental science and pollution research international

Nguyen TPM, Bui TH, Nguyen MK, Nguyen TH, Vu VT, Pham HL.
PMID: 33834338
Environ Sci Pollut Res Int. 2021 Apr 08; doi: 10.1007/s11356-021-13792-y. Epub 2021 Apr 08.

Covid-19 lockdowns have improved the ambient air quality across the world via reduced air pollutant levels. This article aims to investigate the effect of the partial lockdown on the main ambient air pollutants and their elemental concentrations bound to...

Zizaane-Type Sesquiterpenoids and Their Rearranged Derivatives from Agarwood of an .

Molecules (Basel, Switzerland)

Yuan JZ, Yang YL, Li W, Yang L, Dai HF, Mándi A, Cai CH, Chen HQ, Dong WH, Kurtán T, Mei WL, Wang H.
PMID: 35011431
Molecules. 2021 Dec 29;27(1). doi: 10.3390/molecules27010198.

Nine new sesquiterpenoids (

Impact of Risk-Stratified Therapy on Health Status in Survivors of Childhood Acute Lymphoblastic Leukemia: A Report from the Childhood Cancer Survivor Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Dixon SB, Chen Y, Yasui Y, Pui CH, Hunger SP, Silverman LB, Ness KK, Green DM, Howell RM, Leisenring WM, Kadan-Lottick NS, Krull KR, Oeffinger KC, Neglia JP, Hudson MM, Robison LL, Mertens AC, Armstrong GT, Nathan PC.
PMID: 34697055
Cancer Epidemiol Biomarkers Prev. 2022 Jan;31(1):150-160. doi: 10.1158/1055-9965.EPI-21-0667. Epub 2021 Oct 25.

BACKGROUND: Prior studies have identified that survivors of childhood acute lymphoblastic leukemia (ALL) report poor health status. It is unknown how risk-stratified therapy impacts the health status of ALL survivors.METHODS: We estimated and compared the prevalence of self-reported poor...

Experimental study on crack characteristics and acoustic emission characteristics in rock-like material with pre-existing cracks.

Scientific reports

Pan JS, Yuan SX, Jiang T, Cui CH.
PMID: 34893657
Sci Rep. 2021 Dec 10;11(1):23790. doi: 10.1038/s41598-021-03162-6.

Grain size composition, crack pattern, and crack length have a significant influence on the crack characteristics, mechanical characteristics, and acoustic emission characteristics of rock masses. In this paper, the crack characteristics, mechanical characteristics, and acoustic emission characteristics of rock...

Excitonic and Valley-Polarization Signatures of Fractional Correlated Electronic Phases in a WSe_{2}/WS_{2} Moiré Superlattice.

Physical review letters

Liu E, Taniguchi T, Watanabe K, Gabor NM, Cui YT, Lui CH.
PMID: 34328773
Phys Rev Lett. 2021 Jul 16;127(3):037402. doi: 10.1103/PhysRevLett.127.037402.

We have measured the reflectance contrast, photoluminescence, and valley polarization of a WSe_{2}/WS_{2} heterobilayer moiré superlattice at gate-tunable charge density. We observe absorption modulation of three intralayer moiré excitons at filling factors ν=1/3 and 2/3. We also observe luminescence...

Showing 361 to 372 of 372 entries