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Showing 13 to 23 of 23 entries
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A system out of breath: how hypoxia possibly contributes to the pathogenesis of systemic sclerosis.

International journal of rheumatology

van Hal TW, van Bon L, Radstake TR.
PMID: 22162692
Int J Rheumatol. 2011;2011:824972. doi: 10.1155/2011/824972. Epub 2011 Nov 20.

Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular alterations and immunological disturbances and fibrosis, the order of which remains to be fully determined. Clinically, patients show clear signs of hypoxia in skin and internal organs. The low...

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van Hal TW, van Bon L, Radstake TR. A system out of breath: how hypoxia possibly contributes to the pathogenesis of systemic sclerosis. Int J Rheumatol. 2011;2011:824972doi: 10.1155/2011/824972.
van Hal, T. W., van Bon, L., & Radstake, T. R. (2011). A system out of breath: how hypoxia possibly contributes to the pathogenesis of systemic sclerosis. International journal of rheumatology, 2011824972. https://doi.org/10.1155/2011/824972
van Hal, T W, et al. "A system out of breath: how hypoxia possibly contributes to the pathogenesis of systemic sclerosis." International journal of rheumatology vol. 2011 (2011): 824972. doi: https://doi.org/10.1155/2011/824972
van Hal TW, van Bon L, Radstake TR. A system out of breath: how hypoxia possibly contributes to the pathogenesis of systemic sclerosis. Int J Rheumatol. 2011;2011:824972. doi: 10.1155/2011/824972. Epub 2011 Nov 20. PMID: 22162692; PMCID: PMC3228323.
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Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses .

Oncoimmunology

Thordardottir S, Schaap N, Louer E, Kester MG, Falkenburg JH, Jansen J, Radstake TR, Hobo W, Dolstra H.
PMID: 28405517
Oncoimmunology. 2017 Feb 06;6(3):e1285991. doi: 10.1080/2162402X.2017.1285991. eCollection 2017.

Because of the potent graft-versus-tumor (GVT) effect, allogeneic stem cell transplantation (alloSCT) can be a curative therapy for hematological malignancies. However, relapse remains the most frequent cause of treatment failure, illustrating the necessity for development of adjuvant post-transplant therapies...

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Thordardottir S, Schaap N, Louer E, et al. Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses . Oncoimmunology. 2017;6(3):e1285991doi: 10.1080/2162402X.2017.1285991.
Thordardottir, S., Schaap, N., Louer, E., Kester, M. G., Falkenburg, J. H., Jansen, J., Radstake, T. R., Hobo, W., & Dolstra, H. (2017). Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses . Oncoimmunology, 6(3), e1285991. https://doi.org/10.1080/2162402X.2017.1285991
Thordardottir, Soley, et al. "Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses ." Oncoimmunology vol. 6,3 (2017): e1285991. doi: https://doi.org/10.1080/2162402X.2017.1285991
Thordardottir S, Schaap N, Louer E, Kester MG, Falkenburg JH, Jansen J, Radstake TR, Hobo W, Dolstra H. Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses . Oncoimmunology. 2017 Feb 06;6(3):e1285991. doi: 10.1080/2162402X.2017.1285991. eCollection 2017. PMID: 28405517; PMCID: PMC5384421.
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Increased B-cell activating factor (BAFF)/B-lymphocyte stimulator (BLyS) in primary antiphospholipid syndrome is associated with higher adjusted global antiphospholipid syndrome scores.

RMD open

van den Hoogen LL, Palla G, Bekker CPJ, Fritsch-Stork RDE, Radstake TRDJ, van Roon JAG.
PMID: 30018806
RMD Open. 2018 Jul 13;4(2):e000693. doi: 10.1136/rmdopen-2018-000693. eCollection 2018.

No abstract available.

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van den Hoogen LL, Palla G, Bekker CPJ, et al. Increased B-cell activating factor (BAFF)/B-lymphocyte stimulator (BLyS) in primary antiphospholipid syndrome is associated with higher adjusted global antiphospholipid syndrome scores. RMD Open. 2018;4(2):e000693doi: 10.1136/rmdopen-2018-000693.
van den Hoogen, L. L., Palla, G., Bekker, C. P. J., Fritsch-Stork, R. D. E., Radstake, T. R. D. J., & van Roon, J. A. G. (2018). Increased B-cell activating factor (BAFF)/B-lymphocyte stimulator (BLyS) in primary antiphospholipid syndrome is associated with higher adjusted global antiphospholipid syndrome scores. RMD open, 4(2), e000693. https://doi.org/10.1136/rmdopen-2018-000693
van den Hoogen, Lucas L, et al. "Increased B-cell activating factor (BAFF)/B-lymphocyte stimulator (BLyS) in primary antiphospholipid syndrome is associated with higher adjusted global antiphospholipid syndrome scores." RMD open vol. 4,2 (2018): e000693. doi: https://doi.org/10.1136/rmdopen-2018-000693
van den Hoogen LL, Palla G, Bekker CPJ, Fritsch-Stork RDE, Radstake TRDJ, van Roon JAG. Increased B-cell activating factor (BAFF)/B-lymphocyte stimulator (BLyS) in primary antiphospholipid syndrome is associated with higher adjusted global antiphospholipid syndrome scores. RMD Open. 2018 Jul 13;4(2):e000693. doi: 10.1136/rmdopen-2018-000693. eCollection 2018. PMID: 30018806; PMCID: PMC6045704.
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Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome.

Rheumatology (Oxford, England)

van der Linden M, van den Hoogen LL, Westerlaken GHA, Fritsch-Stork RDE, van Roon JAG, Radstake TRDJ, Meyaard L.
PMID: 29608758
Rheumatology (Oxford). 2018 Jul 01;57(7):1228-1234. doi: 10.1093/rheumatology/key067.

OBJECTIVES: Increased release of neutrophil extracellular traps (NETs) is implicated in the activation of plasmacytoid dendritic cells, vascular disease and thrombosis in SLE and APS. However, studies comparing NET release between patients with SLE and APS are lacking. Here...

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van der Linden M, van den Hoogen LL, Westerlaken GHA, et al. Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome. Rheumatology (Oxford). 2018;57(7):1228-1234doi: 10.1093/rheumatology/key067.
van der Linden, M., van den Hoogen, L. L., Westerlaken, G. H. A., Fritsch-Stork, R. D. E., van Roon, J. A. G., Radstake, T. R. D. J., & Meyaard, L. (2018). Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome. Rheumatology (Oxford, England), 57(7), 1228-1234. https://doi.org/10.1093/rheumatology/key067
van der Linden, Maarten, et al. "Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome." Rheumatology (Oxford, England) vol. 57,7 (2018): 1228-1234. doi: https://doi.org/10.1093/rheumatology/key067
van der Linden M, van den Hoogen LL, Westerlaken GHA, Fritsch-Stork RDE, van Roon JAG, Radstake TRDJ, Meyaard L. Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome. Rheumatology (Oxford). 2018 Jul 01;57(7):1228-1234. doi: 10.1093/rheumatology/key067. PMID: 29608758.
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The Transcriptomic Profile of Monocytes from Patients With Sjögren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators.

Frontiers in immunology

Lopes AP, Bekker CPJ, Hillen MR, Blokland SLM, Hinrichs AC, Pandit A, Kruize AA, Radstake TRDJ, van Roon JAG.
PMID: 34413853
Front Immunol. 2021 Aug 03;12:701656. doi: 10.3389/fimmu.2021.701656. eCollection 2021.

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterized by infiltration of the exocrine glands and prominent B cell hyperactivity. Considering the key role of monocytes in promoting B cell hyperactivity, we performed RNA-sequencing analysis of CD14

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Lopes AP, Bekker CPJ, Hillen MR, et al. The Transcriptomic Profile of Monocytes from Patients With Sjögren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators. Front Immunol. 2021;12:701656doi: 10.3389/fimmu.2021.701656.
Lopes, A. P., Bekker, C. P. J., Hillen, M. R., Blokland, S. L. M., Hinrichs, A. C., Pandit, A., Kruize, A. A., Radstake, T. R. D. J., & van Roon, J. A. G. (2021). The Transcriptomic Profile of Monocytes from Patients With Sjögren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators. Frontiers in immunology, 12701656. https://doi.org/10.3389/fimmu.2021.701656
Lopes, Ana P, et al. "The Transcriptomic Profile of Monocytes from Patients With Sjögren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators." Frontiers in immunology vol. 12 (2021): 701656. doi: https://doi.org/10.3389/fimmu.2021.701656
Lopes AP, Bekker CPJ, Hillen MR, Blokland SLM, Hinrichs AC, Pandit A, Kruize AA, Radstake TRDJ, van Roon JAG. The Transcriptomic Profile of Monocytes from Patients With Sjögren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators. Front Immunol. 2021 Aug 03;12:701656. doi: 10.3389/fimmu.2021.701656. eCollection 2021. PMID: 34413853; PMCID: PMC8368727.
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Severe outcome of idiopathic inflammatory mass lesions primarily located in the posterior orbit and orbital apex.

Acta ophthalmologica

Laban KG, Kalmann R, Leguit RJ, Uijttewaal PH, Radstake TRDJ, de Boer JH, van der Veen RLP.
PMID: 33124151
Acta Ophthalmol. 2021 Aug;99(5):e774-e776. doi: 10.1111/aos.14656. Epub 2020 Oct 29.

No abstract available.

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Laban KG, Kalmann R, Leguit RJ, et al. Severe outcome of idiopathic inflammatory mass lesions primarily located in the posterior orbit and orbital apex. Acta Ophthalmol. 2020;99(5):e774-e776doi: 10.1111/aos.14656.
Laban, K. G., Kalmann, R., Leguit, R. J., Uijttewaal, P. H., Radstake, T. R. D. J., de Boer, J. H., & van der Veen, R. L. P. (2021). Severe outcome of idiopathic inflammatory mass lesions primarily located in the posterior orbit and orbital apex. Acta ophthalmologica, 99(5), e774-e776. https://doi.org/10.1111/aos.14656
Laban, Kamil G, et al. "Severe outcome of idiopathic inflammatory mass lesions primarily located in the posterior orbit and orbital apex." Acta ophthalmologica vol. 99,5 (2021): e774-e776. doi: https://doi.org/10.1111/aos.14656
Laban KG, Kalmann R, Leguit RJ, Uijttewaal PH, Radstake TRDJ, de Boer JH, van der Veen RLP. Severe outcome of idiopathic inflammatory mass lesions primarily located in the posterior orbit and orbital apex. Acta Ophthalmol. 2021 Aug;99(5):e774-e776. doi: 10.1111/aos.14656. Epub 2020 Oct 29. PMID: 33124151; PMCID: PMC8451862.
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Reply.

Arthritis & rheumatology (Hoboken, N.J.)

Tao W, Radstake TRDJ, Pandit A.
PMID: 33682325
Arthritis Rheumatol. 2021 Aug;73(8):1569-1570. doi: 10.1002/art.41711. Epub 2021 Jun 17.

No abstract available.

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Tao W, Radstake TRDJ, Pandit A. Reply. Arthritis Rheumatol. 2021;73(8):1569-1570doi: 10.1002/art.41711.
Tao, W., Radstake, T. R. D. J., & Pandit, A. (2021). Reply. Arthritis & rheumatology (Hoboken, N.J.), 73(8), 1569-1570. https://doi.org/10.1002/art.41711
Tao, Weiyang, et al. "Reply." Arthritis & rheumatology (Hoboken, N.J.) vol. 73,8 (2021): 1569-1570. doi: https://doi.org/10.1002/art.41711
Tao W, Radstake TRDJ, Pandit A. Reply. Arthritis Rheumatol. 2021 Aug;73(8):1569-1570. doi: 10.1002/art.41711. Epub 2021 Jun 17. PMID: 33682325.
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Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders.

Frontiers in immunology

Te Velde AA, Bezema T, van Kampen AH, Kraneveld AD, 't Hart BA, van Middendorp H, Hack EC, van Montfrans JM, Belzer C, Jans-Beken L, Pieters RH, Knipping K, Huber M, Boots AM, Garssen J, Radstake TR, Evers AW, Prakken BJ, Joosten I.
PMID: 28018353
Front Immunol. 2016 Dec 12;7:587. doi: 10.3389/fimmu.2016.00587. eCollection 2016.

In order to combat chronic immune disorders (CIDs), it is an absolute necessity to understand the bigger picture, one that goes beyond insights at a one-disease, molecular, cellular, and static level. To unravel this bigger picture we advocate an...

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Te Velde AA, Bezema T, van Kampen AH, et al. Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders. Front Immunol. 2016;7:587doi: 10.3389/fimmu.2016.00587.
Te Velde, A. A., Bezema, T., van Kampen, A. H., Kraneveld, A. D., 't Hart, B. A., van Middendorp, H., Hack, E. C., van Montfrans, J. M., Belzer, C., Jans-Beken, L., Pieters, R. H., Knipping, K., Huber, M., Boots, A. M., Garssen, J., Radstake, T. R., Evers, A. W., Prakken, B. J., & Joosten, I. (2016). Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders. Frontiers in immunology, 7587. https://doi.org/10.3389/fimmu.2016.00587
Te Velde, Anje A, et al. "Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders." Frontiers in immunology vol. 7 (2016): 587. doi: https://doi.org/10.3389/fimmu.2016.00587
Te Velde AA, Bezema T, van Kampen AH, Kraneveld AD, 't Hart BA, van Middendorp H, Hack EC, van Montfrans JM, Belzer C, Jans-Beken L, Pieters RH, Knipping K, Huber M, Boots AM, Garssen J, Radstake TR, Evers AW, Prakken BJ, Joosten I. Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders. Front Immunol. 2016 Dec 12;7:587. doi: 10.3389/fimmu.2016.00587. eCollection 2016. PMID: 28018353; PMCID: PMC5149516.
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Signaling by the inhibitory receptor CD200R is rewired by type I interferon.

Science signaling

van der Vlist M, Ramos MIP, van den Hoogen LL, Hiddingh S, Timmerman LM, de Hond TAP, Kaan ED, van der Kroef M, Lebbink RJ, Peters FMA, Khoury-Hanold W, Fritsch-Stork R, Radstake TRDJ, Meyaard L.
PMID: 34637328
Sci Signal. 2021 Oct 12;14(704):eabb4324. doi: 10.1126/scisignal.abb4324. Epub 2021 Oct 12.

CD200 receptor 1 (CD200R) is an inhibitory immunoreceptor that suppresses Toll-like receptor (TLR)–induced cytokine production through the adaptor protein Dok2 and the GTPase activating protein (GAP) p120-RasGAP, which can be cleaved during mild cellular stress. We found that in...

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van der Vlist M, Ramos MIP, van den Hoogen LL, et al. Signaling by the inhibitory receptor CD200R is rewired by type I interferon. Sci Signal. 2021;14(704):eabb4324doi: 10.1126/scisignal.abb4324.
van der Vlist, M., Ramos, M. I. P., van den Hoogen, L. L., Hiddingh, S., Timmerman, L. M., de Hond, T. A. P., Kaan, E. D., van der Kroef, M., Lebbink, R. J., Peters, F. M. A., Khoury-Hanold, W., Fritsch-Stork, R., Radstake, T. R. D. J., & Meyaard, L. (2021). Signaling by the inhibitory receptor CD200R is rewired by type I interferon. Science signaling, 14(704), eabb4324. https://doi.org/10.1126/scisignal.abb4324
van der Vlist, Michiel, et al. "Signaling by the inhibitory receptor CD200R is rewired by type I interferon." Science signaling vol. 14,704 (2021): eabb4324. doi: https://doi.org/10.1126/scisignal.abb4324
van der Vlist M, Ramos MIP, van den Hoogen LL, Hiddingh S, Timmerman LM, de Hond TAP, Kaan ED, van der Kroef M, Lebbink RJ, Peters FMA, Khoury-Hanold W, Fritsch-Stork R, Radstake TRDJ, Meyaard L. Signaling by the inhibitory receptor CD200R is rewired by type I interferon. Sci Signal. 2021 Oct 12;14(704):eabb4324. doi: 10.1126/scisignal.abb4324. Epub 2021 Oct 12. PMID: 34637328.
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CXCL4 drives fibrosis by promoting several key cellular and molecular processes.

Cell reports

Affandi AJ, Carvalheiro T, Ottria A, de Haan JJ, Brans MAD, Brandt MM, Tieland RG, Lopes AP, Fernández BM, Bekker CPJ, van der Linden M, Zimmermann M, Giovannone B, Wichers CGK, Garcia S, de Kok M, Stifano G, Xu YJ, Kowalska MA, Waasdorp M, Cheng C, Gibbs S, de Jager SCA, van Roon JAG, Radstake TRDJ, Marut W.
PMID: 34986347
Cell Rep. 2022 Jan 04;38(1):110189. doi: 10.1016/j.celrep.2021.110189.

Fibrosis is a major cause of mortality worldwide, characterized by myofibroblast activation and excessive extracellular matrix deposition. Systemic sclerosis is a prototypic fibrotic disease in which CXCL4 is increased and strongly correlates with skin and lung fibrosis. Here we...

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Affandi AJ, Carvalheiro T, Ottria A, et al. CXCL4 drives fibrosis by promoting several key cellular and molecular processes. Cell Rep. 2022;38(1):110189doi: 10.1016/j.celrep.2021.110189.
Affandi, A. J., Carvalheiro, T., Ottria, A., de Haan, J. J., Brans, M. A. D., Brandt, M. M., Tieland, R. G., Lopes, A. P., Fernández, B. M., Bekker, C. P. J., van der Linden, M., Zimmermann, M., Giovannone, B., Wichers, C. G. K., Garcia, S., de Kok, M., Stifano, G., Xu, Y. J., Kowalska, M. A., Waasdorp, M., Cheng, C., Gibbs, S., de Jager, S. C. A., van Roon, J. A. G., Radstake, T. R. D. J., & Marut, W. (2022). CXCL4 drives fibrosis by promoting several key cellular and molecular processes. Cell reports, 38(1), 110189. https://doi.org/10.1016/j.celrep.2021.110189
Affandi, Alsya J, et al. "CXCL4 drives fibrosis by promoting several key cellular and molecular processes." Cell reports vol. 38,1 (2022): 110189. doi: https://doi.org/10.1016/j.celrep.2021.110189
Affandi AJ, Carvalheiro T, Ottria A, de Haan JJ, Brans MAD, Brandt MM, Tieland RG, Lopes AP, Fernández BM, Bekker CPJ, van der Linden M, Zimmermann M, Giovannone B, Wichers CGK, Garcia S, de Kok M, Stifano G, Xu YJ, Kowalska MA, Waasdorp M, Cheng C, Gibbs S, de Jager SCA, van Roon JAG, Radstake TRDJ, Marut W. CXCL4 drives fibrosis by promoting several key cellular and molecular processes. Cell Rep. 2022 Jan 04;38(1):110189. doi: 10.1016/j.celrep.2021.110189. PMID: 34986347.
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ZFP36 family members regulate the pro-inflammatory features of psoriatic dermal fibroblasts.

The Journal of investigative dermatology

Angiolilli C, Leijten EFA, Bekker CPJ, Eeftink E, Giovannone B, Nordkamp MO, van der Wal M, Thijs JL, Vastert SJ, van Wijk F, Radstake TRDJ, van Loosdregt J.
PMID: 34333017
J Invest Dermatol. 2021 Jul 29; doi: 10.1016/j.jid.2021.06.030. Epub 2021 Jul 29.

Dermal fibroblasts are strategically positioned underneath the basal epidermis layer to support keratinocyte proliferation and extracellular matrix production. In inflammatory conditions, these fibroblasts produce cytokines and chemokines that promote the chemoattraction of immune cells into the dermis and the...

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Angiolilli C, Leijten EFA, Bekker CPJ, et al. ZFP36 family members regulate the pro-inflammatory features of psoriatic dermal fibroblasts. J Invest Dermatol. 2021;doi: 10.1016/j.jid.2021.06.030.
Angiolilli, C., Leijten, E. F. A., Bekker, C. P. J., Eeftink, E., Giovannone, B., Nordkamp, M. O., van der Wal, M., Thijs, J. L., Vastert, S. J., van Wijk, F., Radstake, T. R. D. J., & van Loosdregt, J. (2021). ZFP36 family members regulate the pro-inflammatory features of psoriatic dermal fibroblasts. The Journal of investigative dermatology, . https://doi.org/10.1016/j.jid.2021.06.030
Angiolilli, Chiara, et al. "ZFP36 family members regulate the pro-inflammatory features of psoriatic dermal fibroblasts." The Journal of investigative dermatology vol. (2021). doi: https://doi.org/10.1016/j.jid.2021.06.030
Angiolilli C, Leijten EFA, Bekker CPJ, Eeftink E, Giovannone B, Nordkamp MO, van der Wal M, Thijs JL, Vastert SJ, van Wijk F, Radstake TRDJ, van Loosdregt J. ZFP36 family members regulate the pro-inflammatory features of psoriatic dermal fibroblasts. J Invest Dermatol. 2021 Jul 29; doi: 10.1016/j.jid.2021.06.030. Epub 2021 Jul 29. PMID: 34333017.
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