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Showing 25 to 36 of 2228 entries
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Efficacy of Dexmedetomidine in two Different Doses as an Adjuvant to Lignocaine in Patients Scheduled for Surgeries under Axillary Block.

Journal of clinical and diagnostic research : JCDR

Thakur A, Singh J, Kumar S, Rana S, Sood P, Verma V.
PMID: 28571239
J Clin Diagn Res. 2017 Apr;11(4):UC16-UC21. doi: 10.7860/JCDR/2017/23540.9678. Epub 2017 Apr 01.

INTRODUCTION: The effect of adding dexmedetomidine (α2-adrenoceptor agonist) to local anaesthetics in brachial plexus blocks has been evaluated, however there has been no consensus regarding the ideal dose of dexmedetomidine. Without ultrasound axillary block has been considered as the...

Metal-free radical trifluoromethylation of β-nitroalkenes through visible-light photoredox catalysis.

Chemical communications (Cambridge, England)

Midya SP, Rana J, Abraham T, Aswin B, Balaraman E.
PMID: 28597876
Chem Commun (Camb). 2017 Jun 20;53(50):6760-6763. doi: 10.1039/c7cc02589k.

A catalytic method for functional group interconversion is immensely important in modern sciences. Here, we report an efficient catalytic conversion of nitroalkenes to highly stereoselective 1-trifluoromethylalkenes at room temperature. This unprecedented metal-free photocatalytic strategy is simple and operates under...

Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).

Chemical communications (Cambridge, England)

Robb CM, Contreras JI, Kour S, Taylor MA, Abid M, Sonawane YA, Zahid M, Murry DJ, Natarajan A, Rana S.
PMID: 28636052
Chem Commun (Camb). 2017 Jul 04;53(54):7577-7580. doi: 10.1039/c7cc03879h.

Cyclin-dependent kinase 9 (CDK9), a member of the cyclin-dependent protein kinase (CDK) family, is involved in transcriptional elongation of several target genes. CDK9 is ubiquitously expressed and has been shown to contribute to a variety of malignancies such as...

Identification and characterization of a cyclosporin binding cyclophilin from Staphylococcus aureus Newman.

Bioinformation

Polley S, Seal S, Mahapa A, Jana B, Biswas A, Mandal S, Sinha D, Sau K, Sau S.
PMID: 28584448
Bioinformation. 2017 Mar 31;13(3):78-85. doi: 10.6026/97320630013078. eCollection 2017.

Cyclophilins, a class of peptidyl-prolyl cis-trans isomerase (PPIase) enzymes, are inhibited by cyclosporin A (CsA), an immunosuppressive drug. Staphylococcus aureus Newman, a pathogenic bacterium, carries a gene for encoding a putative cyclophilin (SaCyp). SaCyp shows significant homology with other...

Large Transcalvarial Meningioma: Surgical Resection Aided by Preoperative Embolization.

Cureus

Haider AS, Rana H, Lee LK, Shail MS, Leonard D, Khan U, Thakur R, Osumah T, Finn S, Layton KF.
PMID: 28611936
Cureus. 2017 May 08;9(5):e1229. doi: 10.7759/cureus.1229.

Meningiomas are the most common type of primary brain tumors, accounting for about 30% of all brain tumors. Meningiomas originate from the meninges and can be associated with any part of the skull. Classification of meningiomas is based upon...

Plasmacytoid variant of urothelial carcinoma: Diagnostic challenges and role of immunohistochemistry.

International journal of applied & basic medical research

Jairajpuri ZS, Rana S, Ali MA, Jetley S.
PMID: 26539377
Int J Appl Basic Med Res. 2015 Sep-Dec;5(3):217-9. doi: 10.4103/2229-516X.165368.

Plasmacytoid carcinoma of the urinary bladder or plasmacytoid urothelial carcinoma (PUC) is rare and only recently described a histological variant of transitional cell carcinoma. The morphological resemblance of PUC to other malignancies is a source of diagnostic dilemmas and...

Cheminformatics models based on machine learning approaches for design of USP1/UAF1 abrogators as anticancer agents.

Systems and synthetic biology

Wahi D, Jamal S, Goyal S, Singh A, Jain R, Rana P, Grover A.
PMID: 25972987
Syst Synth Biol. 2015 Jun;9(1):33-43. doi: 10.1007/s11693-015-9162-1. Epub 2015 Jan 30.

Cancer cells have upregulated DNA repair mechanisms, enabling them survive DNA damage induced during repeated rapid cell divisions and targeted chemotherapeutic treatments. Cancer cell proliferation and survival targeting via inhibition of DNA repair pathways is currently a very promiscuous...

The Missing C1-C5 Cycloaromatization Reaction: Triplet State Antiaromaticity Relief and Self-Terminating Photorelease of Formaldehyde for Synthesis of Fulvenes from Enynes.

Journal of the American Chemical Society

Mohamed RK, Mondal S, Jorner K, Delgado TF, Lobodin VV, Ottosson H, Alabugin IV.
PMID: 26536479
J Am Chem Soc. 2015 Dec 16;137(49):15441-50. doi: 10.1021/jacs.5b07448. Epub 2015 Dec 03.

The last missing example of the four archetypical cycloaromatizations of enediynes and enynes was discovered by combining a twisted alkene excited state with a new self-terminating path for intramolecular conversion of diradicals into closed-shell products. Photoexcitation of aromatic enynes...

Functional and speech outcomes of superiorly based flap pharyngoplasty combined with radical intravelar veloplasty.

Journal of cleft lip palate and craniofacial anomalies

Ezzat AE, Khalifa RA, Akel MM, El-Shenawy HM.
PMID: 26005709
J Cleft Lip Palate Craniofacial Anomalies. 2015 Jan-Jun;2(1):41-48. doi: 10.4103/2348-2125.150746.

OBJECTIVE: The aim of this study was to evaluate functional and speech outcomes of superiorly based pharyngeal flap (SBF) pharyngoplasty combined with radical intravelar veloplasty (RIVVP) for the management of velopharyngeal insufficiency (VPI) following surgically repaired cleft palate.DESIGN: A...

Realization of a micrometre-scale spin-wave interferometer.

Scientific reports

Rousseau O, Rana B, Anami R, Yamada M, Miura K, Ogawa S, Otani Y.
PMID: 25975283
Sci Rep. 2015 May 15;5:9873. doi: 10.1038/srep09873.

The recent development of spin dynamics opens perspectives for various applications based on spin waves, including logic devices. The first important step in the realization of spin-wave-based logics is the manipulation of spin-wave interference. Here, we present the experimental...

Graphium basitruncatum fungemia in an immunosuppressed child post stem-cell transplantation.

Medical mycology case reports

El Feghaly RE, Sutton DA, Thompson EH, Fu J, Wickes BL, Al-Zubeidi D, Storch GA, Burnham CA.
PMID: 24371733
Med Mycol Case Rep. 2012 May 27;1(1):35-8. doi: 10.1016/j.mmcr.2012.05.003. eCollection 2012.

Graphium basitruncatum is genetically and morphologically distinct from other Graphium and Scedosporium species, and has been reported only once previously as a cause of human disease. We report a case of Graphium basitruncatum fungemia in a two year old...

New Pyrano[2,3-d:6,5-d']dipyrimidine Derivatives-Synthesis, in vitro Cytotoxicity and Computational Studies.

Anti-cancer agents in medicinal chemistry

Maddila S, Naicker K, Gorle S, Rana S, Yalagala K, Maddila SN, Singh M, Singh P, Jonnalagadda SB.
PMID: 26592746
Anticancer Agents Med Chem. 2016;16(8):1031-1037. doi: 10.2174/1871520616666151123095932.

A new series of pyrano[2,3-d:6,5-d']dipyrimidine derivatives were synthesized and evaluated for their in vitro anticancer activity. The structures of all the synthesized compounds were confirmed by 1H NMR, 13C NMR, 15N NMR, HR-MS and FT-IR spectral analyses. The cytotoxic...

Showing 25 to 36 of 2228 entries