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Showing 181 to 186 of 186 entries
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Impact of Consensus Definitions on Identification of Glomerular Lesions by Light and Electron Microscopy.

Kidney international reports

Haas M, Mirocha J, Amann K, Bajema IM, Barisoni L, Becker JU, Jennette JC, Joh K, Ljubanovic DG, Roberts ISD, Roelofs JJ, Sethi S, Suarez R, Zeng C, Seshan SV.
PMID: 35005316
Kidney Int Rep. 2021 Oct 29;7(1):78-86. doi: 10.1016/j.ekir.2021.10.014. eCollection 2022 Jan.

INTRODUCTION: In 2020, a working group of 13 renal pathologists published consensus definitions for 47 individual glomerular lesions found on light microscopy (LM) and 47 glomerular lesions and 9 normal structures found on electron microscopy (EM).METHODS: To test the...

Proteaphagy is specifically regulated and requires factors dispensable for general autophagy.

The Journal of biological chemistry

Waite KA, Burris A, Vontz G, Lang A, Roelofs J.
PMID: 34919962
J Biol Chem. 2021 Dec 14;298(1):101494. doi: 10.1016/j.jbc.2021.101494. Epub 2021 Dec 14.

Changing physiological conditions can increase the need for protein degradative capacity in eukaryotic cells. Both the ubiquitin-proteasome system and autophagy contribute to protein degradation. However, these processes can be differently regulated depending on the physiological conditions. Strikingly, proteasomes themselves...

The Diagnostic Value of Language Screening in Primary Progressive Aphasia: Validation and Application of the Sydney Language Battery.

Journal of speech, language, and hearing research : JSLHR

Janssen N, Roelofs A, van den Berg E, Eikelboom WS, Holleman MA, In de Braek DMJM, Piguet O, Piai V, Kessels RPC.
PMID: 34875177
J Speech Lang Hear Res. 2022 Jan 12;65(1):200-214. doi: 10.1044/2021_JSLHR-21-00024. Epub 2021 Dec 07.

PURPOSE: The three variants of primary progressive aphasia (PPA) differ in clinical presentation, underlying brain pathology, and clinical course, which stresses the need for early differentiation. However, brief cognitive tests that validly distinguish between all PPA variants are lacking....

Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.

Annals of the rheumatic diseases

Symons RA, Colella F, Collins FL, Rafipay AJ, Kania K, McClure JJ, White N, Cunningham I, Ashraf S, Hay E, Mackenzie KS, Howard KA, Riemen AHK, Manzo A, Clark SM, Roelofs AJ, De Bari C.
PMID: 34844926
Ann Rheum Dis. 2022 Feb;81(2):214-224. doi: 10.1136/annrheumdis-2021-220875. Epub 2021 Nov 29.

OBJECTIVE: We aimed to understand the role of the transcriptional co-factor Yes-associated protein (Yap) in the molecular pathway underpinning the pathogenic transformation of synovial fibroblasts (SF) in rheumatoid arthritis (RA) to become invasive and cause joint destruction.METHODS: Synovium from...

Proteaphagy is specifically regulated and requires factors dispensable for general autophagy.

The Journal of biological chemistry

Waite KA, Burris A, Vontz G, Lang A, Roelofs J.
PMID: 34919962
J Biol Chem. 2021 Dec 14;298(1):101494. doi: 10.1016/j.jbc.2021.101494. Epub 2021 Dec 14.

Changing physiological conditions can increase the need for protein degradative capacity in eukaryotic cells. Both the ubiquitin-proteasome system and autophagy contribute to protein degradation. However, these processes can be differently regulated depending on the physiological conditions. Strikingly, proteasomes themselves...

Three distinct tolerogenic CD14.

Journal of autoimmunity

van Wigcheren GF, Roelofs D, Figdor CG, Flórez-Grau G.
PMID: 33901801
J Autoimmun. 2021 Jun;120:102645. doi: 10.1016/j.jaut.2021.102645. Epub 2021 Apr 23.

Current treatment for patients with autoimmune disorders including rheumatoid arthritis, multiple sclerosis and type 1 diabetes, often consists of long-term drug regimens that broadly dampen immune responses. These non-specific treatments are frequently associated with severe side effects creating an...

Showing 181 to 186 of 186 entries