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Showing 409 to 412 of 412 entries
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Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with Indolent Non-Hodgkin Lymphoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Foltz JA, Hess BT, Bachanova V, Bartlett NL, Berrien-Elliott MM, McClain E, Becker-Hapak M, Foster M, Schappe T, Kahl B, Mehta-Shah N, Cashen AF, Marin ND, McDaniels K, Moreno C, Mosior M, Gao F, Griffith OL, Griffith M, Wagner JA, Epperla N, Rock AD, Lee J, Petti AA, Soon-Shiong P, Fehniger TA.
PMID: 33832946
Clin Cancer Res. 2021 Jun 15;27(12):3339-3350. doi: 10.1158/1078-0432.CCR-20-4575. Epub 2021 Apr 08.

PURPOSE: N-803 is an IL15 receptor superagonist complex, designed to optimize PATIENTS AND METHODS: Relapsed/refractory patients with indolent non-Hodgkin lymphoma were treated with rituximab and intravenous or subcutaneous N-803 on an open-label, dose-escalation phase I study using a 3+3...

Clinical features, investigations, and outcomes of pediatric limbic encephalitis: A multicenter study.

Annals of clinical and translational neurology

Sabanathan S, Abdel-Mannan O, Mankad K, Siddiqui A, Das K, Carr L, Eltze C, Eyre M, Gadian J, Hemingway C, Kaliakatsos M, Kneen R, Krishnakumar D, Lynch B, Parida A, Rossor T, Taylor M, Wassmer E, Wright S, Lim M, Hacohen Y.
PMID: 35015932
Ann Clin Transl Neurol. 2022 Jan 11; doi: 10.1002/acn3.51494. Epub 2022 Jan 11.

OBJECTIVES: To describe the clinical presentation, investigations, management, and disease course in pediatric autoimmune limbic encephalitis (LE).METHODS: In this retrospective observational study, from the UK Childhood Neuroinflammatory Disease network, we identified children from six tertiary centers with LE

Distal and proximal cis-regulatory elements sense X chromosome dosage and developmental state at the Xist locus.

Molecular cell

Gjaltema RAF, Schwämmle T, Kautz P, Robson M, Schöpflin R, Ravid Lustig L, Brandenburg L, Dunkel I, Vechiatto C, Ntini E, Mutzel V, Schmiedel V, Marsico A, Mundlos S, Schulz EG.
PMID: 34932975
Mol Cell. 2022 Jan 06;82(1):190-208.e17. doi: 10.1016/j.molcel.2021.11.023. Epub 2021 Dec 20.

Developmental genes such as Xist, which initiates X chromosome inactivation, are controlled by complex cis-regulatory landscapes, which decode multiple signals to establish specific spatiotemporal expression patterns. Xist integrates information on X chromosome dosage and developmental stage to trigger X...

IgG.

Journal of neurology, neurosurgery, and psychiatry

Fehmi J, Davies AJ, Walters J, Lavin T, Keh R, Rossor AM, Munteanu T, Delanty N, Roberts R, Bäumer D, Lennox G, Rinaldi S.
PMID: 34400540
J Neurol Neurosurg Psychiatry. 2021 Oct;92(10):1089-1095. doi: 10.1136/jnnp-2021-326343. Epub 2021 Aug 16.

OBJECTIVES: We aimed to define the clinical and serological characteristics of pan-neurofascin antibody-positive patients.METHODS: We tested serum from patients with suspected immune-mediated neuropathies for antibodies directed against nodal/paranodal protein antigens using a live cell-based assay and solid-phase platform. The...

Showing 409 to 412 of 412 entries