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Showing 49 to 59 of 59 entries
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TMED9-SEC12, an important "contact" for autophagy.

Cell research

Puri C, Rubinsztein DC.
PMID: 34625661
Cell Res. 2021 Oct 08; doi: 10.1038/s41422-021-00579-6. Epub 2021 Oct 08.

No abstract available.

Technical Innovation: The Automated Residency Match Rank List.

Current problems in diagnostic radiology

Strickland C, Rubinstein D.
PMID: 26778579
Curr Probl Diagn Radiol. 2016 May-Jun;45(3):165-7. doi: 10.1067/j.cpradiol.2015.12.003. Epub 2015 Dec 15.

The creation of the final rank list for the National Residency Matching Program every year is a laborious task requiring the time and input of numerous faculty members and residents. This article describes the creation of an automated visual...

Lessons from Animal Models of Arterial Aneurysm.

Aorta (Stamford, Conn.)

Gertz SD, Mintz Y, Beeri R, Rubinstein C, Gilon D, Gavish L, Berlatzky Y, Appelbaum L, Gavish L.
PMID: 26798701
Aorta (Stamford). 2013 Oct 01;1(5):244-54. doi: 10.12945/j.aorta.2013.13-052. eCollection 2013 Oct.

We review the results from the most common animal models of arterial aneurysm, including recent findings from our novel, laparoscopy-based pig model of abdominal aortic aneurysm, that contribute important insights into early pathogenesis. We emphasize the relevance of these...

Cdks regulate autophagy via Vps34.

Molecular cell

Rubinsztein DC.
PMID: 20513423
Mol Cell. 2010 May 28;38(4):483-4. doi: 10.1016/j.molcel.2010.05.013.

In this issue of Molecular Cell, Junying Yuan's group has shown that cyclin-dependent kinases phosphorylate and inactivate Vps34, resulting in autophagy downregulation (Furuya et al., 2010). This phenomenon can explain how autophagy is controlled during mitosis, and has potential...

Using Perseverative Interests to Improve Interactions Between Adolescents with Autism and their Typical Peers in School Settings.

Journal of positive behavior interventions

Koegel R, Fredeen R, Kim S, Danial J, Rubinstein D, Koegel L.
PMID: 24163577
J Posit Behav Interv. 2012 Jul 01;14(3):133-141. doi: 10.1177/1098300712437043.

The literature suggests that adolescents with ASD typically are not socially engaged during unstructured school activities and do not initiate social activities with typically developing peers. This study assessed whether implementing socialization opportunities in the form of lunch clubs...

Association of age at diabetes complication diagnosis with age at natural menopause in women with type 1 diabetes: The Pittsburgh Epidemiology of Diabetes Complications (EDC) Study.

Journal of diabetes and its complications

Yi Y, El Khoudary SR, Buchanich JM, Miller RG, Rubinstein D, Orchard TJ, Costacou T.
PMID: 33446412
J Diabetes Complications. 2021 Mar;35(3):107832. doi: 10.1016/j.jdiacomp.2020.107832. Epub 2021 Jan 02.

OBJECTIVE: Vascular damage is thought to have a role in premature ovarian aging. We thus assessed the association between the presence, and age at onset of, vascular diabetes complications and age at natural menopause in women with type 1...

APC mutational patterns in gastric adenocarcinoma are enriched for missense variants with associated decreased survival.

Genes, chromosomes & cancer

Rubinstein JC, Khan SA, Christison-Lagay ER, Cha C.
PMID: 31353684
Genes Chromosomes Cancer. 2019 Jul 28; doi: 10.1002/gcc.22792. Epub 2019 Jul 28.

Adenomatous polyposis coli (APC) mutations are causally associated with familial adenomatous polyposis (FAP) and are recurrent somatic events across numerous tumor types, including gastric adenocarcinoma. Severity of disease in FAP correlates with specific APC mutations, but the impact of...

Acute Type B Aortic Pathology Mimicking Acute Type A Intramural Hematoma with Organ Malperfusion.

Aorta (Stamford, Conn.)

Levy E, Korach A, Rubinstein C, Gilon D, Shapira OM.
PMID: 27069946
Aorta (Stamford). 2015 Aug 01;3(4):145-50. doi: 10.12945/j.aorta.2015.14.073. eCollection 2015 Aug.

The management of acute Stanford Type A intramural hematoma (IMH) of the aorta remains controversial. Most surgeons advocate emergency surgery in a manner similar to frank acute Type A dissection. Others recommend a conservative approach to this distinct clinicopathological...

A novel endovascular treatment for transcatheter aortic valve embolization.

Journal of vascular surgery cases and innovative techniques

Saltiel A, Rabinovich Y, Rubinstein C, Atamna O, Finkelstein A, Sheick-Yousif B.
PMID: 34805651
J Vasc Surg Cases Innov Tech. 2021 Oct 25;7(4):755-758. doi: 10.1016/j.jvscit.2021.10.010. eCollection 2021 Dec.

In the present report, we have described the case of an 82-year-old obese man who had required transcatheter aortic valve replacement to treat severe symptomatic aortic stenosis. During implantation, the balloon-mounted valve became dislodged and embolized to the ascending...

Transient siRNA-mediated protein knockdown in mouse followed by feeding/starving cycle and liver tissue analysis.

STAR protocols

Wrobel L, Siddiqi FH, Rubinsztein DC.
PMID: 33997814
STAR Protoc. 2021 Apr 27;2(2):100500. doi: 10.1016/j.xpro.2021.100500. eCollection 2021 Jun 18.

We present a protocol for in vivo siRNA-mediated knockdown of a gene of interest in mouse liver using systemic delivery via intravenous injection. We describe a step-by-step protocol for delivery of siRNA particles, with tips on how to optimize...

Autophagy in healthy aging and disease.

Nature aging

Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T, Tavernarakis N, Rubinsztein DC, Partridge L, Kroemer G, Labbadia J, Fang EF.
PMID: 34901876
Nat Aging. 2021 Aug;1(8):634-650. doi: 10.1038/s43587-021-00098-4. Epub 2021 Aug 12.

Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship...

Showing 49 to 59 of 59 entries