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Showing 853 to 858 of 858 entries
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Journal of neurophysiology

Dubbioso R, Pellegrino G, Ranieri F, Di Pino G, Capone F, Dileone M, Iodice R, Ruggiero L, Tozza S, Uncini A, Manganelli F, Di Lazzaro V.
PMID: 34936818
J Neurophysiol. 2022 Jan 01;127(1):204-212. doi: 10.1152/jn.00268.2021. Epub 2021 Dec 22.

Preclinical studies have demonstrated that brain-derived neurotrophic factor (BDNF) plays a crucial role in the homeostatic regulation of cortical excitability and excitation/inhibition balance. Using transcranial magnetic stimulation techniques, we investigated whether BDNF polymorphism could influence cortical excitability of the...

Mechanisms, Characteristics, and Treatment of Neuropathic Pain and Peripheral Neuropathy Associated with Dinutuximab in Neuroblastoma Patients.

International journal of molecular sciences

Mastrangelo S, Rivetti S, Triarico S, Romano A, Attinà G, Maurizi P, Ruggiero A.
PMID: 34884452
Int J Mol Sci. 2021 Nov 23;22(23). doi: 10.3390/ijms222312648.

Prognosis of metastatic neuroblastoma is very poor. Its treatment includes induction chemotherapy, surgery, high-dose chemotherapy, radiotherapy, and maintenance with retinoic acid, associated with the anti-GD2 monoclonal antibody (ch14.18) dinutuximab. Immunotherapy determined a significant improvement in survival rate and is...

Molecular and histological traits of reduced lysosomal acid lipase activity in the fatty liver.

Cell death & disease

Carotti S, Lettieri-Barbato D, Piemonte F, Ruggiero S, Rosina M, Zalfa F, Zingariello M, Arciprete F, Valentini F, Francesconi M, D'Amico J, De Vincentis A, Baiocchini A, Perrone G, Antonelli-Incalzi R, Morini S, Picardi A, Aquilano K, Vespasiani-Gentilucci U.
PMID: 34795230
Cell Death Dis. 2021 Nov 18;12(12):1092. doi: 10.1038/s41419-021-04382-4.

Recent studies demonstrated reduced blood lysosomal acid lipase (LAL) activity in patients with nonalcoholic fatty liver disease (NAFLD). We aimed to verify hepatic LAL protein content and activity in in vitro and in vivo models of fat overload and...

Cell-of-Origin and Genetic, Epigenetic, and Microenvironmental Factors Contribute to the Intra-Tumoral Heterogeneity of Pediatric Intracranial Ependymoma.

Cancers

Servidei T, Lucchetti D, Navarra P, Sgambato A, Riccardi R, Ruggiero A.
PMID: 34885210
Cancers (Basel). 2021 Dec 03;13(23). doi: 10.3390/cancers13236100.

Intra-tumoral heterogeneity (ITH) is a complex multifaceted phenomenon that posits major challenges for the clinical management of cancer patients. Genetic, epigenetic, and microenvironmental factors are concurrent drivers of diversity among the distinct populations of cancer cells. ITH may also...

Treatment and outcome of intracranial ependymoma after first relapse in AIEOP 2 nd protocol.

Neuro-oncology

Massimino M, Barretta F, Modena P, Johann P, Ferroli P, Antonelli M, Gandola L, Garrè ML, Bertin D, Mastronuzzi A, Mascarin M, Quaglietta L, Viscardi E, Sardi I, Ruggiero A, Boschetti L, Giagnacovo M, Biassoni V, Schiavello E, Chiapparini L, Erbetta A, Mussano A, Giussani C, Mura RM, Barra S, Scarzello G, Scimone G, Carai A, Giangaspero F, Buttarelli FR.
PMID: 34605902
Neuro Oncol. 2021 Oct 04; doi: 10.1093/neuonc/noab230. Epub 2021 Oct 04.

BACKGROUND: More than 40% of patients with intracranial ependymoma need a salvage treatment within 5 years after diagnosis, and no standard treatment is available as yet. We report the outcome after first relapse of 64 patients treated within the...

Neonatal seizures as onset of Inborn Errors of Metabolism (IEMs): from diagnosis to treatment. A systematic review.

Metabolic brain disease

Falsaperla R, Sciuto L, La Spina L, Sciuto S, Praticò AD, Ruggieri M.
PMID: 34403026
Metab Brain Dis. 2021 Dec;36(8):2195-2203. doi: 10.1007/s11011-021-00798-1. Epub 2021 Aug 17.

Neonatal seizures (NS) occur in the first 28 days of life; they represent an important emergency that requires a rapid diagnostic work-up to start a prompt therapy. The most common causes of NS include: intraventricular haemorrhage, hypoxic-ischemic encephalopathy, hypoglycemia,...

Showing 853 to 858 of 858 entries