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Boosting autophagy in the diabetic heart: a translational perspective.

Cardiovascular diagnosis and therapy

Sciarretta S, Boppana VS, Umapathi M, Frati G, Sadoshima J.
PMID: 26543826
Cardiovasc Diagn Ther. 2015 Oct;5(5):394-402. doi: 10.3978/j.issn.2223-3652.2015.07.02.

Diabetes, obesity, and dyslipidemia are main risk factors that promote the development of cardiovascular diseases. These metabolic abnormalities are frequently found to be associated together in a highly morbid clinical condition called metabolic syndrome. Metabolic derangements promote endothelial dysfunction,...

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Sciarretta S, Boppana VS, Umapathi M, et al. Boosting autophagy in the diabetic heart: a translational perspective. Cardiovasc Diagn Ther. 2015;5(5):394-402doi: 10.3978/j.issn.2223-3652.2015.07.02.
Sciarretta, S., Boppana, V. S., Umapathi, M., Frati, G., & Sadoshima, J. (2015). Boosting autophagy in the diabetic heart: a translational perspective. Cardiovascular diagnosis and therapy, 5(5), 394-402. https://doi.org/10.3978/j.issn.2223-3652.2015.07.02
Sciarretta, Sebastiano, et al. "Boosting autophagy in the diabetic heart: a translational perspective." Cardiovascular diagnosis and therapy vol. 5,5 (2015): 394-402. doi: https://doi.org/10.3978/j.issn.2223-3652.2015.07.02
Sciarretta S, Boppana VS, Umapathi M, Frati G, Sadoshima J. Boosting autophagy in the diabetic heart: a translational perspective. Cardiovasc Diagn Ther. 2015 Oct;5(5):394-402. doi: 10.3978/j.issn.2223-3652.2015.07.02. PMID: 26543826; PMCID: PMC4609904.
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Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart.

JACC. Basic to translational science

Ikeda S, Mukai R, Mizushima W, Zhai P, Oka SI, Nakamura M, Del Re DP, Sciarretta S, Hsu CP, Shimokawa H, Sadoshima J.
PMID: 31768477
JACC Basic Transl Sci. 2019 Sep 23;4(5):611-622. doi: 10.1016/j.jacbts.2019.05.006. eCollection 2019 Sep.

Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and...

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Ikeda S, Mukai R, Mizushima W, et al. Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart. JACC Basic Transl Sci. 2019;4(5):611-622doi: 10.1016/j.jacbts.2019.05.006.
Ikeda, S., Mukai, R., Mizushima, W., Zhai, P., Oka, S. I., Nakamura, M., Del Re, D. P., Sciarretta, S., Hsu, C. P., Shimokawa, H., & Sadoshima, J. (2019). Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart. JACC. Basic to translational science, 4(5), 611-622. https://doi.org/10.1016/j.jacbts.2019.05.006
Ikeda, Shohei, et al. "Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart." JACC. Basic to translational science vol. 4,5 (2019): 611-622. doi: https://doi.org/10.1016/j.jacbts.2019.05.006
Ikeda S, Mukai R, Mizushima W, Zhai P, Oka SI, Nakamura M, Del Re DP, Sciarretta S, Hsu CP, Shimokawa H, Sadoshima J. Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart. JACC Basic Transl Sci. 2019 Sep 23;4(5):611-622. doi: 10.1016/j.jacbts.2019.05.006. eCollection 2019 Sep. PMID: 31768477; PMCID: PMC6872826.
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Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy.

Circulation research

Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J.
PMID: 34724805
Circ Res. 2021 Dec 03;129(12):1105-1121. doi: 10.1161/CIRCRESAHA.121.319377. Epub 2021 Nov 02.

RATIONALE: Obesity-associated cardiomyopathy characterized by hypertrophy and mitochondrial dysfunction. Mitochondrial quality control mechanisms, including mitophagy, are essential for the maintenance of cardiac function in obesity-associated cardiomyopathy. However, autophagic flux peaks at around 6 weeks of high-fat diet (HFD) consumption...

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Tong M, Saito T, Zhai P, et al. Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy. Circ Res. 2021;129(12):1105-1121doi: 10.1161/CIRCRESAHA.121.319377.
Tong, M., Saito, T., Zhai, P., Oka, S. I., Mizushima, W., Nakamura, M., Ikeda, S., Shirakabe, A., & Sadoshima, J. (2021). Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy. Circulation research, 129(12), 1105-1121. https://doi.org/10.1161/CIRCRESAHA.121.319377
Tong, Mingming, et al. "Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy." Circulation research vol. 129,12 (2021): 1105-1121. doi: https://doi.org/10.1161/CIRCRESAHA.121.319377
Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J. Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy. Circ Res. 2021 Dec 03;129(12):1105-1121. doi: 10.1161/CIRCRESAHA.121.319377. Epub 2021 Nov 02. PMID: 34724805.
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NAD.

Circulation. Heart failure

Chiao YA, Chakraborty AD, Light CM, Tian R, Sadoshima J, Shi X, Gu H, Lee CF.
PMID: 34374300
Circ Heart Fail. 2021 Aug;14(8):e008170. doi: 10.1161/CIRCHEARTFAILURE.120.008170. Epub 2021 Aug 10.

BACKGROUND: Diabetes is a risk factor for heart failure and promotes cardiac dysfunction. Diabetic tissues are associated with nicotinamide adenine dinucleotide (NADMETHODS: Diabetic stress was induced in mice by streptozotocin. Cardiac function was measured by echocardiography. Heart and plasma...

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Chiao YA, Chakraborty AD, Light CM, et al. NAD. Circ Heart Fail. 2021;14(8):e008170doi: 10.1161/CIRCHEARTFAILURE.120.008170.
Chiao, Y. A., Chakraborty, A. D., Light, C. M., Tian, R., Sadoshima, J., Shi, X., Gu, H., & Lee, C. F. (2021). NAD. Circulation. Heart failure, 14(8), e008170. https://doi.org/10.1161/CIRCHEARTFAILURE.120.008170
Chiao, Ying Ann, et al. "NAD." Circulation. Heart failure vol. 14,8 (2021): e008170. doi: https://doi.org/10.1161/CIRCHEARTFAILURE.120.008170
Chiao YA, Chakraborty AD, Light CM, Tian R, Sadoshima J, Shi X, Gu H, Lee CF. NAD. Circ Heart Fail. 2021 Aug;14(8):e008170. doi: 10.1161/CIRCHEARTFAILURE.120.008170. Epub 2021 Aug 10. PMID: 34374300; PMCID: PMC8373812.
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Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload.

Scientific reports

Shao D, Zhai P, Hu C, Mukai R, Sciarretta S, Del Re D, Sadoshima J.
PMID: 34873220
Sci Rep. 2021 Dec 06;11(1):23469. doi: 10.1038/s41598-021-02846-3.

The Hippo pathway plays a wide variety of roles in response to stress in the heart. Lats2, a component of the Hippo pathway, is phosphorylated by Mst1/2 and, in turn, phosphorylates YAP, causing inactivation of YAP. Lats2 stimulates apoptosis...

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Shao D, Zhai P, Hu C, et al. Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload. Sci Rep. 2021;11(1):23469doi: 10.1038/s41598-021-02846-3.
Shao, D., Zhai, P., Hu, C., Mukai, R., Sciarretta, S., Del Re, D., & Sadoshima, J. (2021). Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload. Scientific reports, 11(1), 23469. https://doi.org/10.1038/s41598-021-02846-3
Shao, Dan, et al. "Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload." Scientific reports vol. 11,1 (2021): 23469. doi: https://doi.org/10.1038/s41598-021-02846-3
Shao D, Zhai P, Hu C, Mukai R, Sciarretta S, Del Re D, Sadoshima J. Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload. Sci Rep. 2021 Dec 06;11(1):23469. doi: 10.1038/s41598-021-02846-3. PMID: 34873220; PMCID: PMC8648781.
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Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart.

Cardiovascular research

Saito T, Hamano K, Sadoshima J.
PMID: 33331644
Cardiovasc Res. 2020 Dec 17; doi: 10.1093/cvr/cvaa340. Epub 2020 Dec 17.

Mitochondria, the primary ATP-producing organelles, are highly abundant in cardiomyocytes. Mitochondrial function readily deteriorates in the presence of stress and, thus, maintenance of mitochondrial quality is essential for sustaining pump function in the heart. Cardiomyocytes under stress attempt to...

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Saito T, Hamano K, Sadoshima J. Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart. Cardiovasc Res. 2020;doi: 10.1093/cvr/cvaa340.
Saito, T., Hamano, K., & Sadoshima, J. (2020). Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart. Cardiovascular research, . https://doi.org/10.1093/cvr/cvaa340
Saito, Toshiro, et al. "Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart." Cardiovascular research vol. (2020). doi: https://doi.org/10.1093/cvr/cvaa340
Saito T, Hamano K, Sadoshima J. Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart. Cardiovasc Res. 2020 Dec 17; doi: 10.1093/cvr/cvaa340. Epub 2020 Dec 17. PMID: 33331644.
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The role of autophagy in death of cardiomyocytes.

Journal of molecular and cellular cardiology

Ikeda S, Zablocki D, Sadoshima J.
PMID: 34919896
J Mol Cell Cardiol. 2021 Dec 14;165:1-8. doi: 10.1016/j.yjmcc.2021.12.006. Epub 2021 Dec 14.

Autophagy mediates cellular quality control mechanisms and energy homeostasis through lysosomal degradation. Autophagy is typically viewed as an adaptive process that allows cells to survive against stress, such as nutrient deprivation and hypoxia. However, autophagy also mediates cell death...

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Ikeda S, Zablocki D, Sadoshima J. The role of autophagy in death of cardiomyocytes. J Mol Cell Cardiol. 2021;165:1-8doi: 10.1016/j.yjmcc.2021.12.006.
Ikeda, S., Zablocki, D., & Sadoshima, J. (2021). The role of autophagy in death of cardiomyocytes. Journal of molecular and cellular cardiology, 1651-8. https://doi.org/10.1016/j.yjmcc.2021.12.006
Ikeda, Shohei, et al. "The role of autophagy in death of cardiomyocytes." Journal of molecular and cellular cardiology vol. 165 (2021): 1-8. doi: https://doi.org/10.1016/j.yjmcc.2021.12.006
Ikeda S, Zablocki D, Sadoshima J. The role of autophagy in death of cardiomyocytes. J Mol Cell Cardiol. 2021 Dec 14;165:1-8. doi: 10.1016/j.yjmcc.2021.12.006. Epub 2021 Dec 14. PMID: 34919896.
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The role of autophagy in death of cardiomyocytes.

Journal of molecular and cellular cardiology

Ikeda S, Zablocki D, Sadoshima J.
PMID: 34919896
J Mol Cell Cardiol. 2021 Dec 14;165:1-8. doi: 10.1016/j.yjmcc.2021.12.006. Epub 2021 Dec 14.

Autophagy mediates cellular quality control mechanisms and energy homeostasis through lysosomal degradation. Autophagy is typically viewed as an adaptive process that allows cells to survive against stress, such as nutrient deprivation and hypoxia. However, autophagy also mediates cell death...

Cite
Ikeda S, Zablocki D, Sadoshima J. The role of autophagy in death of cardiomyocytes. J Mol Cell Cardiol. 2021;165:1-8doi: 10.1016/j.yjmcc.2021.12.006.
Ikeda, S., Zablocki, D., & Sadoshima, J. (2021). The role of autophagy in death of cardiomyocytes. Journal of molecular and cellular cardiology, 1651-8. https://doi.org/10.1016/j.yjmcc.2021.12.006
Ikeda, Shohei, et al. "The role of autophagy in death of cardiomyocytes." Journal of molecular and cellular cardiology vol. 165 (2021): 1-8. doi: https://doi.org/10.1016/j.yjmcc.2021.12.006
Ikeda S, Zablocki D, Sadoshima J. The role of autophagy in death of cardiomyocytes. J Mol Cell Cardiol. 2021 Dec 14;165:1-8. doi: 10.1016/j.yjmcc.2021.12.006. Epub 2021 Dec 14. PMID: 34919896.
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Showing 61 to 68 of 68 entries