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Showing 517 to 523 of 523 entries
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Diverse alterations associated with resistance to KRAS(G12C) inhibition.

Nature

Zhao Y, Murciano-Goroff YR, Xue JY, Ang A, Lucas J, Mai TT, Da Cruz Paula AF, Saiki AY, Mohn D, Achanta P, Sisk AE, Arora KS, Roy RS, Kim D, Li C, Lim LP, Li M, Bahr A, Loomis BR, de Stanchina E, Reis-Filho JS, Weigelt B, Berger M, Riely G, Arbour KC, Lipford JR, Li BT, Lito P.
PMID: 34759319
Nature. 2021 Nov;599(7886):679-683. doi: 10.1038/s41586-021-04065-2. Epub 2021 Nov 10.

Inactive state-selective KRAS(G12C) inhibitors

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Zhao Y, Murciano-Goroff YR, Xue JY, et al. Diverse alterations associated with resistance to KRAS(G12C) inhibition. Nature. 2021;599(7886):679-683doi: 10.1038/s41586-021-04065-2.
Zhao, Y., Murciano-Goroff, Y. R., Xue, J. Y., Ang, A., Lucas, J., Mai, T. T., Da Cruz Paula, A. F., Saiki, A. Y., Mohn, D., Achanta, P., Sisk, A. E., Arora, K. S., Roy, R. S., Kim, D., Li, C., Lim, L. P., Li, M., Bahr, A., Loomis, B. R., de Stanchina, E., Reis-Filho, J. S., Weigelt, B., Berger, M., Riely, G., Arbour, K. C., Lipford, J. R., Li, B. T., & Lito, P. (2021). Diverse alterations associated with resistance to KRAS(G12C) inhibition. Nature, 599(7886), 679-683. https://doi.org/10.1038/s41586-021-04065-2
Zhao, Yulei, et al. "Diverse alterations associated with resistance to KRAS(G12C) inhibition." Nature vol. 599,7886 (2021): 679-683. doi: https://doi.org/10.1038/s41586-021-04065-2
Zhao Y, Murciano-Goroff YR, Xue JY, Ang A, Lucas J, Mai TT, Da Cruz Paula AF, Saiki AY, Mohn D, Achanta P, Sisk AE, Arora KS, Roy RS, Kim D, Li C, Lim LP, Li M, Bahr A, Loomis BR, de Stanchina E, Reis-Filho JS, Weigelt B, Berger M, Riely G, Arbour KC, Lipford JR, Li BT, Lito P. Diverse alterations associated with resistance to KRAS(G12C) inhibition. Nature. 2021 Nov;599(7886):679-683. doi: 10.1038/s41586-021-04065-2. Epub 2021 Nov 10. PMID: 34759319.
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Mild Cognitive Decline Is a Risk Factor for Scam Vulnerability in Older Adults.

Frontiers in psychiatry

Ueno D, Daiku Y, Eguchi Y, Iwata M, Amano S, Ayani N, Nakamura K, Kato Y, Matsuoka T, Narumoto J.
PMID: 34987422
Front Psychiatry. 2021 Dec 20;12:685451. doi: 10.3389/fpsyt.2021.685451. eCollection 2021.

Research on elderly financial exploitation has mostly focused on financial abuse that occurs in families and other types of trusted relationships. As such, little is known about financial frauds and scams perpetrated by strangers. Financial fraud and scam prevention...

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Ueno D, Daiku Y, Eguchi Y, et al. Mild Cognitive Decline Is a Risk Factor for Scam Vulnerability in Older Adults. Front Psychiatry. 2021;12:685451doi: 10.3389/fpsyt.2021.685451.
Ueno, D., Daiku, Y., Eguchi, Y., Iwata, M., Amano, S., Ayani, N., Nakamura, K., Kato, Y., Matsuoka, T., & Narumoto, J. (2021). Mild Cognitive Decline Is a Risk Factor for Scam Vulnerability in Older Adults. Frontiers in psychiatry, 12685451. https://doi.org/10.3389/fpsyt.2021.685451
Ueno, Daisuke, et al. "Mild Cognitive Decline Is a Risk Factor for Scam Vulnerability in Older Adults." Frontiers in psychiatry vol. 12 (2021): 685451. doi: https://doi.org/10.3389/fpsyt.2021.685451
Ueno D, Daiku Y, Eguchi Y, Iwata M, Amano S, Ayani N, Nakamura K, Kato Y, Matsuoka T, Narumoto J. Mild Cognitive Decline Is a Risk Factor for Scam Vulnerability in Older Adults. Front Psychiatry. 2021 Dec 20;12:685451. doi: 10.3389/fpsyt.2021.685451. eCollection 2021. PMID: 34987422; PMCID: PMC8721598.
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Allosteric Inhibition of HER2 by Moesin-Mimicking Compounds Targets HER2-Positive Cancers and Brain Metastases.

Cancer research

Faure C, Djerbi-Bouillié R, Domingot A, Bouzinba-Segard H, Taouji S, Saidi Y, Bernard S, Carallis F, Rothe-Walther R, Lenormand JL, Chevet E, Bourdoulous S.
PMID: 34493594
Cancer Res. 2021 Nov 01;81(21):5464-5476. doi: 10.1158/0008-5472.CAN-21-0162. Epub 2021 Sep 07.

Therapies targeting the tyrosine kinase receptor HER2 have significantly improved survival of patients with HER2

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Faure C, Djerbi-Bouillié R, Domingot A, et al. Allosteric Inhibition of HER2 by Moesin-Mimicking Compounds Targets HER2-Positive Cancers and Brain Metastases. Cancer Res. 2021;81(21):5464-5476doi: 10.1158/0008-5472.CAN-21-0162.
Faure, C., Djerbi-Bouillié, R., Domingot, A., Bouzinba-Segard, H., Taouji, S., Saidi, Y., Bernard, S., Carallis, F., Rothe-Walther, R., Lenormand, J. L., Chevet, E., & Bourdoulous, S. (2021). Allosteric Inhibition of HER2 by Moesin-Mimicking Compounds Targets HER2-Positive Cancers and Brain Metastases. Cancer research, 81(21), 5464-5476. https://doi.org/10.1158/0008-5472.CAN-21-0162
Faure, Camille, et al. "Allosteric Inhibition of HER2 by Moesin-Mimicking Compounds Targets HER2-Positive Cancers and Brain Metastases." Cancer research vol. 81,21 (2021): 5464-5476. doi: https://doi.org/10.1158/0008-5472.CAN-21-0162
Faure C, Djerbi-Bouillié R, Domingot A, Bouzinba-Segard H, Taouji S, Saidi Y, Bernard S, Carallis F, Rothe-Walther R, Lenormand JL, Chevet E, Bourdoulous S. Allosteric Inhibition of HER2 by Moesin-Mimicking Compounds Targets HER2-Positive Cancers and Brain Metastases. Cancer Res. 2021 Nov 01;81(21):5464-5476. doi: 10.1158/0008-5472.CAN-21-0162. Epub 2021 Sep 07. PMID: 34493594.
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Polyphasic Characterisation of Non-Starter Lactic Acid Bacteria from Algerian Raw Camel's Milk and Their Technological Aptitudes.

Food technology and biotechnology

Saidi Y, Del Rio B, Senouci DE, Redruello B, Martinez B, Ladero V, Kihal M, Alvarez MA.
PMID: 33281482
Food Technol Biotechnol. 2020 Sep;58(3):260-272. doi: 10.17113/ftb.58.03.20.6598.

RESEARCH BACKGROUND: Consumption of spontaneously fermented camel´s milk is common in Algeria, making it a feasible source of diverse lactic acid bacteria (LAB) with the potential to be used as adjunct cultures to improve quality and safety of fermented...

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Saidi Y, Del Rio B, Senouci DE, et al. Polyphasic Characterisation of Non-Starter Lactic Acid Bacteria from Algerian Raw Camel's Milk and Their Technological Aptitudes. Food Technol Biotechnol. 2020;58(3):260-272doi: 10.17113/ftb.58.03.20.6598.
Saidi, Y., Del Rio, B., Senouci, D. E., Redruello, B., Martinez, B., Ladero, V., Kihal, M., & Alvarez, M. A. (2020). Polyphasic Characterisation of Non-Starter Lactic Acid Bacteria from Algerian Raw Camel's Milk and Their Technological Aptitudes. Food technology and biotechnology, 58(3), 260-272. https://doi.org/10.17113/ftb.58.03.20.6598
Saidi, Yasmine, et al. "Polyphasic Characterisation of Non-Starter Lactic Acid Bacteria from Algerian Raw Camel's Milk and Their Technological Aptitudes." Food technology and biotechnology vol. 58,3 (2020): 260-272. doi: https://doi.org/10.17113/ftb.58.03.20.6598
Saidi Y, Del Rio B, Senouci DE, Redruello B, Martinez B, Ladero V, Kihal M, Alvarez MA. Polyphasic Characterisation of Non-Starter Lactic Acid Bacteria from Algerian Raw Camel's Milk and Their Technological Aptitudes. Food Technol Biotechnol. 2020 Sep;58(3):260-272. doi: 10.17113/ftb.58.03.20.6598. PMID: 33281482; PMCID: PMC7709455.
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Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease.

Journal of Parkinson's disease

Koinuma T, Hatano T, Kamagata K, Andica C, Mori A, Ogawa T, Takeshige-Amano H, Uchida W, Saiki S, Okuzumi A, Ueno SI, Oji Y, Saito Y, Hori M, Aoki S, Hattori N.
PMID: 33896850
J Parkinsons Dis. 2021;11(3):1221-1235. doi: 10.3233/JPD-202495.

BACKGROUND: Although pathological studies usually indicate pure dopaminergic neuronal degeneration in patients with parkin (PRKN) mutations, there is no evidence to date regarding white matter (WM) pathology. A previous diffusion MRI study has revealed WM microstructural alterations caused by...

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Koinuma T, Hatano T, Kamagata K, et al. Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease. J Parkinsons Dis. 2021;11(3):1221-1235doi: 10.3233/JPD-202495.
Koinuma, T., Hatano, T., Kamagata, K., Andica, C., Mori, A., Ogawa, T., Takeshige-Amano, H., Uchida, W., Saiki, S., Okuzumi, A., Ueno, S. I., Oji, Y., Saito, Y., Hori, M., Aoki, S., & Hattori, N. (2021). Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease. Journal of Parkinson's disease, 11(3), 1221-1235. https://doi.org/10.3233/JPD-202495
Koinuma, Takahiro, et al. "Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease." Journal of Parkinson's disease vol. 11,3 (2021): 1221-1235. doi: https://doi.org/10.3233/JPD-202495
Koinuma T, Hatano T, Kamagata K, Andica C, Mori A, Ogawa T, Takeshige-Amano H, Uchida W, Saiki S, Okuzumi A, Ueno SI, Oji Y, Saito Y, Hori M, Aoki S, Hattori N. Diffusion MRI Captures White Matter Microstructure Alterations in PRKN Disease. J Parkinsons Dis. 2021;11(3):1221-1235. doi: 10.3233/JPD-202495. PMID: 33896850; PMCID: PMC8461664.
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Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow.

Organic process research & development

Brown M, Aljarah M, Asiki H, Leung LMH, Smithen DA, Miller N, Nemeth G, Davies L, Niculescu-Duvaz D, Zambon A, Springer C.
PMID: 33679122
Org Process Res Dev. 2021 Jan 15;25(1):148-156. doi: 10.1021/acs.oprd.0c00361. Epub 2020 Oct 15.

The scale-up of a chiral bicyclic homopiperazine of pharmaceutical interest was investigated. The outcome and safety profile of a key batch ring-expansion step via Schmidt rearrangement was improved using continuous-flow chemistry. The selectivity of nitrogen insertion for the ring...

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Brown M, Aljarah M, Asiki H, et al. Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow. Org Process Res Dev. 2020;25(1):148-156doi: 10.1021/acs.oprd.0c00361.
Brown, M., Aljarah, M., Asiki, H., Leung, L. M. H., Smithen, D. A., Miller, N., Nemeth, G., Davies, L., Niculescu-Duvaz, D., Zambon, A., & Springer, C. (2021). Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow. Organic process research & development, 25(1), 148-156. https://doi.org/10.1021/acs.oprd.0c00361
Brown, Michael, et al. "Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow." Organic process research & development vol. 25,1 (2021): 148-156. doi: https://doi.org/10.1021/acs.oprd.0c00361
Brown M, Aljarah M, Asiki H, Leung LMH, Smithen DA, Miller N, Nemeth G, Davies L, Niculescu-Duvaz D, Zambon A, Springer C. Toward the Scale-Up of a Bicyclic Homopiperazine via Schmidt Rearrangement and Photochemical Oxaziridine Rearrangement in Continuous-Flow. Org Process Res Dev. 2021 Jan 15;25(1):148-156. doi: 10.1021/acs.oprd.0c00361. Epub 2020 Oct 15. PMID: 33679122; PMCID: PMC7928940.
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β-Aminoisobutyric acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway.

IBRO neuroscience reports

Minato T, Nakamura N, Saiki T, Miyabe M, Ito M, Matsubara T, Naruse K.
PMID: 35024688
IBRO Neurosci Rep. 2021 Dec 07;12:65-72. doi: 10.1016/j.ibneur.2021.12.001. eCollection 2022 Jun.

β-Aminoisobutyric acid (BAIBA) is a myokine that is secreted from skeletal muscles by the exercise. Recently, increasing evidence has suggested the multifocal physiological activities of BAIBA. In this study, we investigated whether L-BAIBA has protective effects on rat pheochromocytoma...

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Minato T, Nakamura N, Saiki T, et al. β-Aminoisobutyric acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway. IBRO Neurosci Rep. 2021;12:65-72doi: 10.1016/j.ibneur.2021.12.001.
Minato, T., Nakamura, N., Saiki, T., Miyabe, M., Ito, M., Matsubara, T., & Naruse, K. (2022). β-Aminoisobutyric acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway. IBRO neuroscience reports, 1265-72. https://doi.org/10.1016/j.ibneur.2021.12.001
Minato, Tomomi, et al. "β-Aminoisobutyric acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway." IBRO neuroscience reports vol. 12 (2022): 65-72. doi: https://doi.org/10.1016/j.ibneur.2021.12.001
Minato T, Nakamura N, Saiki T, Miyabe M, Ito M, Matsubara T, Naruse K. β-Aminoisobutyric acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway. IBRO Neurosci Rep. 2021 Dec 07;12:65-72. doi: 10.1016/j.ibneur.2021.12.001. eCollection 2022 Jun. PMID: 35024688; PMCID: PMC8724974.
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Showing 517 to 523 of 523 entries